Clinical trials: MS
Obesity
Delta Healthy Sprouts: Intervention to Promote Maternal Weight Control and Reduce Childhood Obesity in the MS Delta
The Delta Healthy Sprouts Project is a randomized, controlled trial evaluating the enhancement of an existing Mother, Infant, and Early Childhood Home Visiting Program in 150 African American women in their early second trimester…
- Trial name
- NCT01746394
- Testing
- Parents as Teachers Enhanced, Parents as Teachers
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- USDA, Delta Human Nutrition Research Program
COPD (Chronic Obstructive Pulmonary Disease), ALS (Amyotrophic Lateral Sclerosis)
Psilocybin Therapy for Psychological Distress in Palliative Patients
The goal of this clinical trial is to evaluate whether psilocybin therapy can effectively treat depression and psychological distress in adult patients with COPD, ALS, MS, or APD who have at least 6 months life expectancy.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), ALS (Amyotrophic Lateral Sclerosis), MS (Multiple Sclerosis), Major Depressive Disorder (MDD)
- Trial name
- PsyPal (NCT06782724)
- Testing
- Psilocybin therapy
- Where
- 4 sites in Czechia, Denmark and 2 more
- Volunteers
- 108 people
- Sponsor
- University Medical Center Groningen
Multiple Sclerosis
MSCopilot Users' Feedback in Real Life - Outcomes Regarding Integration in Patients' pathWay and Users' ExpeRience
This US multicenter, prospective cohort study aims to evaluate how MSCopilot can be seamlessly integrated into the current care pathway and identify potential optimizations to enhance its impact on both MS patients and…
- Trial name
- MS-FLOWER (NCT06922942)
- Testing
- MSCopilot Flower mobile application
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Ad scientiam
Multiple Sclerosis
Assessing the Cognitive Benefits of Ozanimod and Their Brain-Biomarkers in MS
The primary objective of this study is to investigate the cognitive benefits of ozanimod in individuals with Multiple Sclerosis (MS).
- Trial name
- NCT06334094
- Testing
- Ozanimod
- Where
- United States
- Sponsor
- The University of Texas at Dallas
Multiple Sclerosis
Serum GFAP, NfL, VEGF and Clinical Progression in Progressive MS
This study aimed to investigate whether the biomarkers GFAP, NfL, and VEGF-recently considered important guides for better understanding the pathophysiology of MS-also serve as indicators of clinical progression in MS.
- Trial name
- NCT07535242
- Volunteers
- 22 people
- Sponsor
- Ondokuz Mayıs University
Multiple Sclerosis
Armergometry to Improve Mobility in MS
Chronic progressive multiple sclerosis patients will be randomised to home-based arm ergometry training for 12 weeks or a waitlist control group which will have access to the treatment after 12 weeks when primary endpoint…
- Trial name
- AMBOS (NCT03147105)
- Testing
- arm ergometry
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Relapsing Multiple Sclerosis, Multiple Sclerosis
Norwegian Study of Oral Cladribine and Rituximab in Multiple Sclerosis (NOR-MS)
The main aim and overall objective of the study is to assess whether rituximab is non-inferior to cladribine for the treatment of relapsing MS.
- Trial name
- NOR-MS (NCT04121403)
- Testing
- Rituximab, Cladribine
- Where
- 11 sites in Norway
- Volunteers
- 267 people
- Sponsor
- Oslo University Hospital
Multiple Sclerosis
Testosterone for Fatigue in Men With MS
Fatigue is a major symptom in people with multiple sclerosis (MS), for which treatments are limited. Several studies have shown that a large proportion of men with MS have low testosterone levels.
- Trial name
- NCT03000127
- Testing
- AndroGel 1 % Topical Gel
- Where
- 2 sites in United States
- Sponsor
- University of California, Los Angeles
Multiple Sclerosis (MS)
Alternative Treatment Paradigm for Natalizumab Trial
This study is being done to determine the difference between natalizumab therapy followed by two different withdrawal strategies using Glatiramer Acetate (GA) treatment paradigms in preventing clinical relapses and other markers…
- Trial name
- ATP (NCT01710228)
- Testing
- methylprednisolone
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Multiple Sclerosis, Relapse
Effect of Ocrelizumab on Brain Innate Immune Microglial Cells Activation in MS Using PET-MRI With 18F-DPA714
Ocrelizumab is a humanized anti-CD20 monoclonal antibody that showed in phase III trials a powerful effect on relapse rate and lesion load accumulation in the relapsing form of multiple sclerosis (RMS).
- Conditions
- Multiple Sclerosis, Relapse, Primary Progressive Multiple Sclerosis
- Trial name
- INN-MS (NCT03691077)
- Testing
- Ocrelizumab
- Where
- France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis
eFIT: An Internet-based Intervention to Increase Physical Activity in Persons With MS
eFIT is a technology-enabled internet based psychosocial intervention to increase physical activity in persons with multiple sclerosis, who are at unique risk for sedentary behaviors and for whom exercise and physical activity…
- Trial name
- eFIT (NCT03829267)
- Testing
- eFIT Intervention, eJournal Intervention, Treatment as usual
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Columbia University
Multiple Sclerosis, Relapsing-Remitting
Polymorphisms of Interleukins, Glypican, and Human Leukocyte Antigen Genes and Treatment Response in Multiple Sclerosis.
HLA-DRB1 * Gene and some genes involved in inflammation and immunity (IL-7R, GPC5, CTSS) have been linked to risk of MS and the response to treatment with immunomodulators.
- Trial name
- WESTEMDRB1 (NCT02769767)
- Testing
- Polymorphism of Interleukins, Glypican, and Human Leukocyte Antigen Genes.
- Where
- Mexico
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Instituto Jalisciense de Cancerologia
Multiple Sclerosis, COVID-19
The United Kingdom Multiple Sclerosis Register Covid-19 Substudy
The aim of the study is to understand the impact of COVID-19 on People with Multiple Sclerosis in the United Kingdom.
- Trial name
- UKMSRCV19 (NCT04354519)
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- Swansea University
Multiple Sclerosis, MS, Clinically Isolated Syndrome
Cohort Study of Clinically Isolated Syndrome and Early Multiple Sclerosis
A majority of patients with multiple sclerosis initially presents with a single demyelinating event, e.g. in the optic nerves, brain, brainstem or spinal cord, referred to as a clinically isolated syndrome (CIS).
- Trial name
- CIS-COHORT (NCT01371071)
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Multiple Sclerosis (MS) - Relapsing-remitting
Synbiotic Supplementation as a Part of Dietary Modification in Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system, influenced by genetic, epigenetic, and immunological factors, as well as environmental factors such as nutrition.
- Trial name
- Synbiotic-MS (NCT07789171)
- Testing
- MNT+Synbiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Hacettepe University
Multiple Sclerosis
Swiss Multiple Sclerosis Cohort-Study
The Swiss MS Cohort Study (SMSC) is a multicentre cohort study that involves 8 Swiss Multiple Sclerosis centres. The key aims of the SMSC are 1.
- Trial name
- SMSC (NCT02433028)
- Where
- 8 sites in Switzerland
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Basel, Switzerland
MS (Multiple Sclerosis)
Association Between Peripheral Immune Biomarkers and Functional Performance in Multiple Sclerosis
The aim of this observational study is to investigate whether certain substances in the blood associated with the immune system are linked to the physical and mental abilities of individuals with multiple sclerosis.
- Trial name
- NCT07831239
- Testing
- Peripheral Immune Biomarkers
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Halic University
Interventional Study
The Novel Use of Treadmill Plus Music in MS Patients Gate Rehabilitation
Multiple sclerosis (MS) is characterized by demyelination andaxonal loss of the central nervous system, which progressively results in neurologic dysfunction and is often accompanied by gaite limitations, reduced fitness, and…
- Trial name
- SMUSIC (NCT04019912)
- Testing
- Gait Training plus music, Traditional Gait Training
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Multiple Sclerosis
COVID-19 Booster Vaccination in Persons With Multiple Sclerosis
The success of the U.S. vaccination program against SARS-Cov-2 is shown by a dramatic drop in infection rates, hospitalizations and deaths.However, it appears that many persons who take medications that chronically suppress the…
- Trial name
- NCT05081271
- Testing
- Homologous booster, Heterologous booster
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Griffin Hospital
Amyotrophic Lateral Sclerosis
Longitudinal Evaluation of Short-Chain Fatty Acid Profiles During the Natural Disease Course and a Mediterranean Diet Intervention in Amyotrophic Lateral Sclerosis Patients
This observational study explored the connection between the gut microbiota and the brain in patients with amyotrophic lateral sclerosis (ALS), specifically the modulation of short-chain fatty acids during disease progression and…
- Trial name
- IMPACT-ALS (NCT07178067)
- Testing
- Mediterranean diet
- Where
- Romania
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures