Clinical trials: MS, open to volunteers
Multiple Sclerosis, Progressive Multifocal Leukoencephalopathy
Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia
This study will evaluate the risk of progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by John Cunningham virus (JCV), among people with multiple sclerosis who have been treated with ozanimod.
- Trial name
- NCT07732907
- Testing
- Ozanimod
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Bristol-Myers Squibb
Multiple Sclerosis
Intermittent Low Oxygen Breathing: A First Study Testing Different Disease Stages in People Living With MS
This study will look at the safety, tolerability and feasibility of a non-invasive treatment called Acute Intermittent Hypoxia (AIH) in people with Multiple Sclerosis (MS) at different stages of the disease course.
- Trial name
- LOxyMS (NCT07631143)
- Testing
- Acute Intermittent Hypoxia
- Volunteers
- 9 people
- Sponsor
- University of Saskatchewan
Multiple Sclerosis
Prepare the Mind: Can Coaching in Goal-directed Behaviour Increase the Success of Cognitive Rehabilitation in People With MS?
People with Multiple Sclerosis (MS) often experience cognitive difficulties such as memory problems, concentration issues, and reduced processing speed.
- Trial name
- NCT07225868
- Testing
- Conscientiousness Coaching Before Cognitive Rehabilitation
- Where
- 3 sites in United States, Netherlands and 1 more
- Volunteers
- 126 people
- Sponsor
- Universiteit Leiden
Multiple Sclerosis
Blood Flow Restriction And Veterans With MS
There currently is a lack of evidence to support exercise interventions in people with advanced disability due to MS (i.e., need assistance to walk or use a wheelchair).
- Trial name
- BRAVe-MS (NCT05433103)
- Testing
- Low-Load Exercise with Blood Flow Restriction, Low-Load Exercise Control Group
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- VA Office of Research and Development
Stroke, Traumatic Brain Injury
Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis
People with neurological conditions often have difficulty walking, including problems such as foot drop. Functional electrical stimulation (FES) is a treatment that uses electrical signals to activate muscles and support walking.
- Conditions
- Stroke, Traumatic Brain Injury, Multiple Sclerosis
- Trial name
- NCT07492602
- Testing
- Functional Electrical Stimulation, Normal care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Overactive Bladder Syndrome
Impact of TTNS on Bladder Symptoms Among People With MS, A RCT
Background: Neurogenic lower urinary tract dysfunction is common among people with multiple sclerosis (MS). Recent studies showed that bladder storage symptoms are predominant among MS with a pooled prevalence of frequency at…
- Trial name
- NCT06341673
- Testing
- Active Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- Saudi Arabia
- Volunteers
- 72 people
- Sponsor
- Hawra Al-Dandan
Multiple Sclerosis (MS)
Spinal Cord Lesion Detection in Multiple Sclerosis Using Novel MRI Sequences
This study is to evaluate the sensitivity and intra-/inter-observer agreement of the averaged magnetization inversion recovery acquisitions (AMIRA) in spinal cord (SC) Multiple sclerosis (MS) lesion detection and to evaluate the…
- Trial name
- NCT04819737
- Testing
- SC MRI, patient questionnaire
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University Hospital, Basel, Switzerland
Multiple Sclerosis
Smoldering Inflammation in MS
The goal of this observational study is to learn about inflammation in those with relapsing remitting Multiple Sclerosis (MS). The main questions it aims to answer are: How does abnormal neural inflammation compare to cellular…
- Trial name
- NCT06591429
- Testing
- Radiotracer [11C]-CS1P1, Radiotracer [11C]-DPA-713, anti-CD20 MS treatment
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Multiple Sclerosis
Evaluating the Effects of the EXOPULSE Suit on Mobility, Walking Ability, and Balance in People With Multiple Sclerosis
This clinical research study is investigating whether the EXOPULSE Suit, a wearable device that delivers electrical stimulation, can help improve movement difficulties caused by spasticity in adults with multiple sclerosis (MS).
- Trial name
- EXO-MS (NCT07897760)
- Testing
- Electrostimulation suit
- Where
- 2 sites in United States, Germany
- Volunteers
- 100 people
- Sponsor
- Otto Bock Healthcare Products GmbH
Multiple Sclerosis
Body Awareness, Trunk Stability, and Arm Function in MS
The aim of this study is to investigate the relationship between body awareness, trunk stabilization, and upper extremity functionality in patients with Multiple Sclerosis (MS).
- Trial name
- NCT07151534
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Multiple Sclerosis
Repetitive Transcranial Magnetic Stimulation (rTMS) in MS Induced Spastic Paraparesis
Study the impact of rTMS on walking ability in people with Multiple Sclerosis (MS) induced spastic paraparesis and moderate walking disability.
- Trial name
- CeV (NCT07159789)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Clinique Neuro-Outaouais
Multiple Sclerosis
Identification of Factors Related to UI in Patients With MS and EMG Assessment of PFM Activity
The study aimed to explore the link between urinary incontinence (UI) severity in patients with multiple sclerosis (PwMS), electromyography (EMG) findings, and other relevant factors.
- Trial name
- NCT07236684
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Artvin Coruh University
Multiple Sclerosis, Disease Management
Feasibility Study of a Relapse Investigation Questionnaire Administered by an MS Care Coordinator Nurse in Patients With Multiple Sclerosis
This study aims to evaluate a questionnaire used by a specialized nurse to help manage relapses in people with multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Disease Management, Feasibility Studies
- Trial name
- NCT06994026
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier de Gonesse
Progressive Multiple Sclerosis
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)
The main purpose of this study is to assess the efficacy of RO7268489 in adults with progressive multiple sclerosis (PMS) receiving ocrelizumab.
- Trial name
- Mintaka (NCT07282574)
- Testing
- RO7268489, Ocrelizumab
- Where
- 114 sites in Australia, Brazil and 10 more
- Volunteers
- 360 people
- Sponsor
- Hoffmann-La Roche
Multiple Sclerosis
Molecular Imaging of NET Using [C-11]MRB-PET in MS
This study aims to use [C-11]MRB PET (positron emission tomography) imaging to look at brain injury in patients with Multiple Sclerosis (MS) and healthy individuals.
- Trial name
- NCT03207464
- Testing
- [C-11]Methylreboxetine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Primary Progressive Multiple Sclerosis, Secondary Progressive Multiple Sclerosis (SPMS)
Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis
The goal of this clinical trial is to treat male and female participants with two types of Multiple Sclerosis (MS) called primary progressive or secondary progressive MS.
- Conditions
- Primary Progressive Multiple Sclerosis, Secondary Progressive Multiple Sclerosis (SPMS), Multiple Sclerosis, Multiple Sclerosis (MS) Primary Progressive
- Trial name
- IMPACT-MS (NCT07477639)
- Testing
- TRX319, Bendamustine
- Where
- 8 sites in United States
- Volunteers
- 39 people
- Sponsor
- Tr1X, Inc.
Multiple Sclerosis
A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)
The primary objective of the study is to compare the prevalence rate of major congenital malformations (MCM) between 2 cohorts of pregnant participants with MS who are exposed to BRIUMVI® and who are unexposed to BRIUMVI®.
- Trial name
- NCT06433765
- Testing
- No intervention
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- TG Therapeutics, Inc.
Multiple Sclerosis
Cognitive Musical Screening and Therapeutic Innovation in Multiple Sclerosis
This pilot study evaluates the effectiveness of screening and improving cognitive function in patients with multiple sclerosis (MS) using a musical tool, the Ipsilon.
- Trial name
- MS (NCT07552428)
- Testing
- Musical tool (Ipsilon)
- Volunteers
- 32 people
- Sponsor
- Hunter College of City University of New York
Amyotrophic Lateral Sclerosis (ALS), Parkinson Disease (PD)
Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers
This is a Phase 1/2 study to evaluate the safety and tolerability of 18F-OP-801 in subjects with ALS, AD, MS, PD and age-matched HVs.
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Parkinson Disease (PD), Alzheimer Disease (AD), Multiple Sclerosis (MS)
- Trial name
- NCT05395624
- Testing
- 18F-OP-801
- Where
- 3 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ashvattha Therapeutics, Inc.
Multiple Sclerosis
Medication Understanding in MS
The goal of this observational study is to learn how people with multiple sclerosis (MS) understand, organise, and use their medicines at home.
- Trial name
- MUMS (NCT07518381)
- Volunteers
- 80 people
- Sponsor
- University of Nottingham