Clinical trials: MTOR
Aging
Rapalog Pharmacology (RAP PAC) Study
The objective of RAP PAC is to identify safe and effective weekly dose(s) for the mTOR inhibitors sirolimus and everolimus that intervene on the underlying fundamental biology of aging.
- Trial name
- NCT05949658
- Testing
- Sirolimus, Everolimus
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Aging, Insulin Resistance
Everolimus Aging Study
The objective of this project is to determine if mTORC1 inhibition by 24 weeks of daily (0.5 mg/day) or weekly (5 mg/week) everolimus can safely improve physiological and molecular hallmarks of aging in humans.
- Trial name
- EVERLAST (NCT05835999)
- Testing
- Everolimus 0.5 MG once per day, Everolimus 5 MG once per week
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Muscle Atrophy, Age-Related Sarcopenia
Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)
As people age, muscle mass and function is lost and exercise training is an important way to reduce the effects of this and remain independent.
- Trial name
- Rapamune (NCT05414292)
- Testing
- Rapamune (sirolimus) 1Mg Tablet, Unilateral resistance exercise training
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sarcopenia
Nutritional and Contractile Regulation of Muscle Growth
Muscle wasting, which involves the loss of muscle tissue, is common in many conditions, such as cancer, AIDS, trauma, kidney failure, bone fracture, and sepsis.
- Trial name
- NCT00891696
- Testing
- Rapamycin, Amino acid supplementation, Low-intensity resistance exercise
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cardiometabolic Health
How Animal and Plant Protein Shakes Change the Body's Nutrient and Health Responses
The goal of this clinical trial is to learn how different protein types affect the body's metabolism and immune system in healthy adults.
- Trial name
- NCT07121010
- Testing
- Animal-Based Protein Smoothie, Plant-Based Protein Smoothie, Plant-Based Protein Smoothie with Leucine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
RAS Mutation, Neurofibromatosis 1
RASopathy Biorepository
The RASopathies are a group of developmental disorders caused by genetic changes in the genes that compose the Ras/mitogen activated protein kinase (MAPK) pathway. New RASopathies are being diagnosed frequently.
- Conditions
- RAS Mutation, Neurofibromatosis 1, Noonan Syndrome, Noonan Syndrome With Multiple Lentigines
- Trial name
- NCT04395495
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Neurofibromatosis 2, Meningioma
AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas
The goal of this clinical research study is to learn if the study drug AZD2014 can shrink growing or symptomatic meningiomas.
- Trial name
- NCT02831257
- Testing
- AZD2014
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Aging
Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly
The ability to mount an effective immune response declines with age, leaving the elderly increasingly susceptible to infectious diseases and cancer.
- Trial name
- NCT02874924
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Insulin Sensitivity
mTOR as Mediator of Insulin Sensitivity Study
The study investigates the role of mTOR in mediating enhancement of muscle insulin sensitivity following a single bout of exercise.
- Trial name
- NCT05233722
- Testing
- Exercise, Insulin infusion, Rapamycin
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Muscle Synthesis
Protein Blends (Soy, Whey and Casein) for Muscle Synthesis
Soy protein is a high quality, plant-based protein that is comparable to milk, meat and eggs. Soy protein has a digestion rate (intermediate) compared to whey (fast) and casein (slow).
- Trial name
- NCT01358305
- Testing
- Protein Blend
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- DuPont Nutrition and Health
Obesity, Metabolic Disease
mTORC1 and Autophagy in Human Brown Adipocytes
The long term goal is to identify the potential therapeutic targets for the treatment of obesity and its associated disorders by studying the driving factors of activation of brown adipose tissue (BAT) in human adults.
- Trial name
- mTORHBFC (NCT04206124)
- Testing
- Brown Fat Harvest During Anterior Neck Surgery
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Aging
MTOR Inhibitors in Older Adults
Over the past decades, healthcare systems face significant challenges to meet the needs of an aging population due to progressive debility, functional decline and chronic diseases development.
- Trial name
- NCT06727305
- Testing
- Sirolimus 0.5 Mg Oral Tablet, Sirolimus 1Mg Oral Tablet, Sirolimus 2 MG Oral Tablet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Aging
RESTOR: PK/PD mTORi Inhibition in Older Adults
As people get older, there are changes in their cells and tissues that may affect their ability to function. This can lead to increased death and age-associated disorders, like heart disease, cancer, and Alzheimer's disease.
- Trial name
- RESTOR (NCT06658093)
- Testing
- Rapamycin, Everolimus
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Epilepsy
Application of Novel Diagnostic and Therapeutical Methods in Epilepsy and Neurodevelopmental Abnormalities in Children.
Epilepsy affects 1% of the world's population and 6 million people in Europe. The estimated total cost of €20 billion in Europe in 2014 makes epilepsy a significant socioeconomic burden.
- Trial name
- EPIMARKER (NCT03486366)
- Testing
- non interventional trial
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Aging
Effect of mTOR Inhibition & Other Metabolism Modulating Interventions on the Elderly [SubStudy Rapa & cMRI to Evaluate Cardiac Function]
The ability to mount an effective immune response declines with age, leaving the elderly increasingly susceptible to infectious diseases and cancer.
- Trial name
- mTOR (NCT04742777)
- Testing
- rapamycin
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Cognitive Impairment, Mild, Alzheimer Disease
Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway
Evaluation of central nervous system penetration of orally administered Rapamune (RAPA) in older adults with Mild Cognitive Impairment (MCI) or early Alzheimer's disease (AD) and investigate associated safety, tolerability…
- Trial name
- CARPE_DIEM (NCT04200911)
- Testing
- Rapamune
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Atherosclerosis
Leucine, mTOR and Athero
High protein low carbohydrate diets have become popular in recent years to help facilitate weight loss. It is controversial if these diets are associated with an increased risk of cardiovascular disease.
- Trial name
- HPL (NCT05470218)
- Testing
- Meal
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Overweight and Obese Adults
Effects of Obesity on Autophagy and mTORC1 Signalling in Skeletal Muscle
It is well known that individuals living with overweight or obesity are not able to activate skeletal muscle growth processes to the same extent as lean individuals following activities such as weightlifting (resistance exercise)…
- Trial name
- NCT07774676
- Testing
- Skeletal muscle biopsy, venous blood sampling, Protein-Rich Beverage
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Dietary Protein
Dietary Protein and Monocyte/Macrophage Mammalian Target of Rapamycin (mTOR) Signaling
High protein low carbohydrate diets have become popular in recent years to help facilitate weight loss. It is controversial if these diets are associated with an increased risk of cardiovascular disease.
- Trial name
- mTOR (NCT03946774)
- Testing
- Dietary protein shake
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy Participants
Assessment of the Safety, Tolerability and Pharmacokinetics of AV078 in Healthy Volunteers
This Phase 1 study in healthy adult volunteers is planned to evaluate the safety, tolerability, and pharmacokinetics (PK) of AV078, a selective inhibitor of mammalian target of rapamycin complex 1 (mTORC1).
- Trial name
- NCT06205381
- Testing
- AV078, Itraconazole, Midazolam
- Where
- 2 sites in Australia
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Aeovian Pharmaceuticals, Inc.