Clinical trials: Macrocirculation
Child, Only, Essential Hypertension
Juvenile Essential Arterial Hypertension and Vascular Function
The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact…
- Trial name
- NCT05109013
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Diabetes Mellitus Type 2
Effects of Empagliflozin + Linagliptin vs Metformin + Insulin Glargine on Renal and Vascular Changes in Type 2 Diabetes
Diabetes mellitus is a wide-spread disease accompanied by strongly increased morbidity and mortality due to micro- and macrovascular complications.
- Trial name
- ELMI (NCT02752113)
- Testing
- Empagliflozin and Linagliptin, Metformin and Insulin sc
- Where
- Germany
- Volunteers
- 101 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
n-3 Polyunsaturated Fatty Acids
N-3 Polyunsaturated Fatty Acids Enriched Chicken Meet and Cardiovascular Function
Evidence from multiple experimental, epidemiological, and clinical studies indicate that n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert their cardiovascular (CV) protective effect, at least in part, by improving vascular…
- Trial name
- NCT05725486
- Testing
- N-3 PUFAs Chicken Meet, Regular Chicken Meet
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Burns
Fluid Shifts During Resuscitation: Impacts on Macrocirculation and Microcirculation
Fluid resuscitation in burn patients is associated with major macrocirculatory and microcirculatory disturbances that have been poorly described.
- Trial name
- NCT00326729
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Montreal Burn Centre
Cardiovascular Diseases
Exploring the Long-term Cardiovascular Effects of Vaping
Smoking is the "leading, preventable death-cause worldwide", being responsible for almost 700,000 deaths in the E.U. annually. Therefore, implementing successful, long-term smoking cessation strategies is a long-term priority for…
- Trial name
- LIGER (NCT05757934)
- Where
- United Kingdom
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Thrombophilia
Arterial Microcirculation, Macrocirculation and Thrombophilias
Rationale: To analyse the arterial state of women with thrombophilia by techniques studying micro and arterial macrocirculation because of a reported and still discussed increase risk in cardio-vascular events in these women.
- Trial name
- MICMAC (NCT01160159)
- Testing
- Tests, Healthy volunteers
- Where
- France
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Negative-Pressure Wound Therapy, Edema
Impact of Negative Pressure Wound Therapy on Free Muscle Flaps
Aim of the study is to prove the utility and safety of the negative pressure wound therapy (NPWT) in the postoperative management of free flaps.
- Conditions
- Negative-Pressure Wound Therapy, Edema, Free Flap, Microcirculation
- Trial name
- NCT02526342
- Testing
- V.A.C. UltraTM (KCI®,San Antonio, Texas, USA)
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Ulf Dornseifer, MD
Coronary Artery Disease
Effect of Cocoa Flavanols on Vascular Function
Endothelial dysfunction is associated with a higher incidence of adverse cardiovascular events in patients with coronary artery disease (CAD).
- Trial name
- Cocoa (NCT00553774)
- Testing
- Cocoa Flavanols
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Salt; Excess, Pregnancy Related
Dietary Salt During Pregnancy and Maternal Vascular Function
The main goal of this study is to investigate the association of dietary salt intake during pregnancy with systemic micro- and macrovascular reactivity and uteroplacental vascular function of the mother, and to examine the…
- Trial name
- NCT05048225
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Carnosine
Carnosine Supplementation and Cardiovascular Function
Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It was originally discovered in skeletal muscle where it is present in larger amounts than in other tissues, but it is also found in high…
- Trial name
- NCT05723939
- Testing
- Carnosine supplementation, Controls
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Septic Shock, Sepsis
Vasopressor Use Improves Macrocirculation, But What Are Its Effects on Microcirculation?
To manage the treatment in the intensive care unit for patients with septic shock, central venous oxygen saturation (scvO2) is used as a macrocirculatory indicator, with a target value of 70% or higher being recommended.
- Conditions
- Septic Shock, Sepsis, Tissue Ischemia, Hemodynamic Instability
- Trial name
- NCT07312071
- Testing
- Vascular Occlusion Test
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Smoking Cessation, Cardiovascular Diseases
E-cigarettes and Cardiovascular Function
The large current uptake of e-cigarettes (2.8 million U.K. users in 2016; 26), the continuous involvement of e-cigarettes (which potentially affects their contents as well), the uncertainty about their medium- and longer-term…
- Conditions
- Smoking Cessation, Cardiovascular Diseases, Microcirculation, Macrocirculation
- Trial name
- ISME-NRT (NCT03061253)
- Testing
- Electronic Cigarette and behavioural change support., Nicotine-Free Electronic Cigarette and behavioural change support., Nicotine Replacement Therapy and behavioural change support.
- Where
- United Kingdom
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Wound Healing, Leg and Foot Ulcers, Macrocirculation, Microcirculation
The Effects of Intermittent Negative Pressure on Wound Healing and Peripheral Circulation in Spinal Cord Injured Subjects
This is a pilot study to evaluate the treatment effect of INP on wound healing and tissue perfusion for a larger randomized controlled trial (RCT).
- Trial name
- NCT02866708
- Testing
- Intermittent negative pressure device
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- Oslo University Hospital
Kangaroo Mother Care Method
Effect of Kangaroo Position on Electromyographic Activity, Macrocirculation and Microcirculation of Preterm Newborns
Growing evidences indicates that the Kangaroo Mother Method is associated with health benefits for the child and her mother. Improvements have been found in physiological parameters of the preterm infants assisted by the method.
- Trial name
- NCT03611088
- Testing
- Kangaroo Position.
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Venous Stasis, Deep Venous Thrombosis
Comparison of the Effects of Lower Limb Immobilisation With Cast and Orthosis
In this study we are going to measure the blood flow in the lower limbs under cast immobilisation and also under mobilisation with an orthosis.
- Trial name
- NCT03420664
- Testing
- Orthosis VACOped, Below knee cast
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital