Clinical trials: Macronutrients
Gastrointestinal Digestion, Healthy
Clinical Trial on Digestive Enzymes: Effects on Post-Meal Response to High-Macronutrient Meals
This study aims to show how digestive enzyme supplements help the body break down fats, proteins, and carbohydrates, especially after eating a high-macronutrient meal.
- Conditions
- Gastrointestinal Digestion, Healthy, Gastrointestinal Wellbeing, Gastrointestinal Supplements
- Trial name
- NCT06949735
- Testing
- Digestive Enzyme Blend
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pancap Pharma Inc.
Pediatric Obesity
PrOtein and WEight Loss in teenageRs
The aim of the proposed study is to provide important data on weight loss efficacy in overweight and obese adolescents on an isocaloric higher protein diet vs a lower protein diet utilizing the U.S.
- Trial name
- POWER (NCT02079831)
- Testing
- Energy Restriction, Higher protein, Lower Protein
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Insulin Resistance, Type 2 Diabetes
The Influence of Overfeeding Different Macronutrients on Whole-body Insulin Sensitivity
This study will investigate the effect of high-carbohydrate vs. high-fat overfeeding (130% of energy requirements) on whole body insulin sensitivity.
- Conditions
- Insulin Resistance, Type 2 Diabetes, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT03863431
- Testing
- High-fat diet, High-carbohydrate diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Nutrition, Absorption
Bioavailability From Chickpea Meals in Ileostomists?
The matrix of a food can significantly affect how well humans can absorb and use nutrients. Plants like fruits, vegetables, nuts, grains, and legumes have cell walls that form a network around their cells.
- Conditions
- Nutrition, Absorption, Polyphenolic Compounds and Metabolism, Polyphenols Absorption Profile
- Trial name
- NCT06921811
- Testing
- Intact chickpeas, Broken chickpeas
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Cystic Fibrosis
Development Of An Innovative Panel of Methods To Measure Intestinal Macronutrient Digestion, Absorption, and Function
Malnutrition is a significant problem in children and adults with Cystic fibrosis (CF). An impaired intestinal digestion and absorption capacity is one of the main factors responsible for the malnutrition in CF.
- Trial name
- NCT01494909
- Testing
- Ensure plus
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Bariatric Surgery (Gastric Bypass), Overweight
The Effect of Different Macronutrients on Gastrointestinal Hormone Secretion After Gastric Bypass Operation
The purpose of this study is to determine the type of macronutrient (carbohydrate, lipid or protein) that most potently stimulates the endogen secretion of different gut hormones (primary outcome = Glucagon-Like peptide-1) in…
- Trial name
- NCT02372526
- Testing
- Mealtest: High protein 200 kcal 200 ml liquid meal consumed during 10 minutes, Mealtest: High fat 200 kcal 200 ml liquid meal consumed during 10 minutes, Mealtest: High carbohydrate 200 kcal 200 ml liquid meal consumed during 10 minutes
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kirstine Nyvold Bojsen-Moeller
Diabetes
Food Intake and Appetite in the Children of Mothers With Diabetes
This protocol is for study of the effect of inhibition of parasympathetic outflow on insulin secretion and glucose metabolism. Insulin secretion will be measured during infusions of escalating doses of atropine.
- Trial name
- NCT00339313
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
PYY, Ghrelin
The Effect of Breakfast With Different Macronutrient Composition on PYY, Ghrelin, GLP-1,Glucose Level, VAS for Hunger, VAS for Satiety and Ad Libitum Intake 4 Hours After Breakfast in Obese Women
Gut hormones, such as PYY and ghrelin, are associated with appetite control and obesity. Protein is thought to be the most satieting nutrient and could affect production of several gut hormones.
- Conditions
- PYY, Ghrelin, Appetite, Gut Hormones
- Trial name
- NCT03697486
- Testing
- diet with different composition
- Where
- Indonesia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Cardiovascular Diseases, Heart Diseases
INTERMAP: International Population Study on Macronutrients and BP
To investigate the relationship between dietary factors, especially macronutrients, and blood pressure in an international, multicenter observational study.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005271
- Volunteers
- 4,680 people
- Sponsor
- Northwestern University
Dietary Habits, Endotoxemia
Effect of Monosaccharides on Intestinal Barrier Function
The aim of the present study is to determine the effect of monosaccharides on intestinal barrier function in healthy subjects.
- Trial name
- ENDO-META (NCT03482284)
- Testing
- Dietary Intervention
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Ina Bergheim
Metabolic Syndrome
Dairy Macronutrient Effects on the Metabolic Syndrome
The investigators examined the effects of 4-week dietary protein intake in mixed meals at two levels of protein amount on whole body glucose metabolisms in older adults with metabolic syndrome.
- Trial name
- NCT02885935
- Testing
- Recommended protein intake, Elevated protein intake
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Metabolic Syndrome X, Liver Diseases
Effects of Macronutrients on Hepatic Lipids, Plasma Triglycerides, and Insulin Sensitivity
The purpose of this study is to assess how the macronutrient composition of the diet effects lipid and glucose metabolism intrahepatic lipids insulin sensitivity in healthy lean subjects and in subjects with a high metabolic risk…
- Trial name
- MACRONUTR (NCT00523562)
- Testing
- diet intervention
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Obesity
Effects of Macronutrient Diet on Brain Activity
This study will evaluate the effect of macronutrient diets on brain activity in homeostatic and mesolimbic reward regions.
- Trial name
- NCT02300857
- Testing
- Low carbohydrate diet, Moderate carbohydrate diet, High carbohydrate diet
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dietary Manipulation
Dietary Macronutrient Manipulation and Substrate Oxidation During Exercise
This study will investigate the effect of dietary macronutrient manipulation on glycogen (stored carbohydrate) levels in the muscle and substrate oxidation during exercise.
- Trial name
- NCT02605291
- Testing
- Diet with a different macronutrient content A, Diet with a different macronutrient content B, Diet with a different macronutrient content C
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Obesity
Developmental Adaptation to an Obesogenic Environment
The purpose of this study was to evaluate whether birth weight is related to the demand for dietary protein in adult survivors of severe acute malnutrition (Kwashiorkor and Marasmus), and that leveraging of protein intake is…
- Trial name
- NCT02257593
- Testing
- Dietary protein
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Obesity
Nighttime Macronutrient Choice and Combined Resistance and High-intensity Interval Training
Obesity is recognized as a major public health concern because of its link to potential fatal complications arising from metabolic and cardiovascular diseases.
- Trial name
- NCT01830946
- Testing
- Whey Protein, Combined Resistance and High-Intensity Interval training, Casein Protein
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Florida State University
Metabolic Rate, Plasma Glucose
Acute Effects of Different Macronutrient Compositions and Meal Distributions of the Food
About thirty participants, of varying degrees of obesity or being non-obese, without serious concomitant diseases consume either a high- or a low- carbohydrate beverage.
- Conditions
- Metabolic Rate, Plasma Glucose, Serum Insulin, Serum Triglycerides
- Trial name
- DIT2 (NCT02622490)
- Testing
- two test meals with two different macronutrient compositions
- Where
- Sweden
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Obesity, Brain Function
Food Intake-Related Brain and Metabolic Responses in Obesity
This study is a prospective, single-center, randomized, controlled, crossover intervention trial. A total of 60 participants, including 30 patients with obesity and 30 healthy controls, will be enrolled.
- Conditions
- Obesity, Brain Function, Metabolomics, Feeding Behavior
- Trial name
- NCT07392905
- Testing
- Glucose Liquid Meal, Fat Liquid Meal, Protein Liquid Meal
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Obesity
Macronutrient Relations and Weight Loss in Obese Subjects
The burden of overweight and obesity has dramatically increased during the last decades. High carbohydrate intake, particularly refined carbohydrates, probably increase the risk of obesity, type 2 diabetes, and metabolic…
- Trial name
- NCT00868387
- Testing
- energy-restricted, CHO-restricted diet, energy-restricted, CHO-rich diet
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Type 1 Diabetes
Closed-loop Control of Postprandial Glucose Levels After Meals With Different Macronutrients Content in Adults With Type 1 Diabetes
Carbohydrates are the main determinant of post-meal glucose excursion. However, fat and protein have been shown to also impact the postprandial glucose control, adding to the complexity of meal insulin calculation.
- Trial name
- NCT02774876
- Testing
- Patient's insulin pump, Insulin, Dexcom G4 Platinum glucose sensor
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Institut de Recherches Cliniques de Montreal