Clinical trials: Macronutrients
Postnatal Growth Disorder
Target Fortification of Breast Milk: How Often Breast Milk Needs to be Measured?
It has been observed that target fortification on different schedules leads to meal to meal variation. It changes the ratio of protein to energy and the percentage of carbohydrate to non-protein energy which may, affect growth.
- Trial name
- TFO2 (NCT02865941)
- Testing
- Fortification with modular protein, Fortification with modular carbohydrate, Fortification with modular fat
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- McMaster Children's Hospital
Healthy
The Effect of Macronutrients on Fibroblast Growth Factor 21 (FGF21) Secretion
The aim of this randomized cross-over study is to investigate how consumption of protein and fat affects the FGF21 response triggered by sucrose.
- Trial name
- NCT05061485
- Testing
- Sucrose, Sucrose + protein, Sucrose + fat
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Postprandial Lipemia, Postprandial Glycemia
Exploring the Effects of Varying Fat:Carbohydrate Diet Permutations on Gastric Emptying and Metabolic Status Using Human Postprandial Model
The aim of this clinical trial is to investigate the effects of the meals moderated by fat and carbohydrate (CHO) quality along with varying macronutrient distribution (CHO: fat) on gut physiology and metabolic outcomes using the…
- Conditions
- Postprandial Lipemia, Postprandial Glycemia, Gastric Emptying
- Trial name
- NCT05977244
- Testing
- FIJA, F1JB, F2JA
- Where
- 3 sites in Malaysia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Malaysia Palm Oil Board
Prodromal Alzheimer's Disease, Alzheimer Disease
COGNIFOOD-Changing the Carbohydrate/Fat-ratio to Prevent Cognitive Decline and Alzheimer Pathology: A Pilot Study
A 2-arm (sequence), 2-period, 2-treatments, single blinded (outcome assessor), randomized crossover-trial (12+12 weeks with immediate contrast) comparing a low-carbohydrate-high-fat diet (LCHF) with a high-carbohydrate-low-fat…
- Conditions
- Prodromal Alzheimer's Disease, Alzheimer Disease, Mild Cognitive Impairment, Neurocognitive Disorders
- Trial name
- NCT06105320
- Testing
- LCHF, HCLF
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska University Hospital
Personalized Nutrition
N=1 Trials of Individual Variability in Post-prandial Glycemic Responses to Diets of Varying Macronutrient Composition
The key objective of this study is to identify the most suitable diet (i.e. high protein, high fat, low GI, high GI) for an individual.
- Trial name
- NCT05402085
- Testing
- High Protein Diet, High Fat Diet, High Carbohydrate-Low Glycemic Index Diet
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Healthy Lifestyle
Protein-Distinct Macronutrient-Equivalent Diet 1
Plant-based diets are naturally low in Methionine (Met), and also low in precursor molecules (e.g L-carnitine, choline, betaine, etc.) producing microbiota-mediated proatherogenic TMAO.
- Trial name
- PRODMED1 (NCT05577858)
- Testing
- Meat based, Pulse based
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Healthy
Short-term Regulation of Energy and Macronutrient Balance: Impact of Energy Flux
Aim of the study is to investigate the impact of energy flux (achieved by changes in physical activity) under the conditions of energy balance, caloric restriction and overfeeding in healthy subjects.
- Trial name
- EF (NCT03361566)
- Testing
- physical activity, energy intake
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Obesity, Diabetes
The Effect of Macronutrients in the Diet on Digestive and Cardiovascular Health
This study examined the effect of a 5-day HFD supplemented with specific fatty acids on gastrointestinal transit, appetite, food intake and substrate utilization.
- Conditions
- Obesity, Diabetes, Cardiovascular Diseases
- Trial name
- NCT01510223
- Testing
- Olive oil, Olive oil and fish powder, Olive oil and macadamia oil
- Where
- Ireland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Healthy, Focus: Effect of Processing on Energy Value of Almonds
The Effect of Processing on the Measured Energy Value of Almonds in the Human Diet
The objective of this study is to measure the effect of processing (roasting, slicing, or grinding) on the energy value of almonds in the human diet and study molecular mechanisms that may help explain the beneficial health…
- Trial name
- NCT02034383
- Testing
- Control, Whole Almonds, Roasted Whole Almonds
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- David Baer
Diet Habit, Dietary Habits
Polish Infants and Toddler Nutritional Study
A cross-sectional study representative of the Polish population of children aged 5 months to 6 years conducted in the cross-sectional study model, the main objective of which is to assess the nutritional value of the diet of…
- Conditions
- Diet Habit, Dietary Habits, Diet, Healthy, Children
- Trial name
- PITNUTS (NCT06417151)
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Fundacja Nutricia
Diabetes
Effect of Macronutrient Supplementation on Glycemic Index of Pita Bread
Glycemic index (GI) of food is known to be positively associated with the development of several diseases including type 2 diabetes, cardiovascular disease and age-related macular degeneration.
- Trial name
- NCT02598986
- Testing
- Macronutrient supplementation
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Nutrition, Ketogenic Diet
Dietary Macronutrients and Gut Microbiota, Inflammation, and Metabolic Markers
This 12-week randomized controlled trial will investigate the effects of dietary patterns with different macronutrient compositions on gut microbiota, intestinal inflammation, gene expression, and metabolic health in healthy…
- Conditions
- Nutrition, Ketogenic Diet, Gene Expression, Diet
- Trial name
- DIETMICRO (NCT07672691)
- Testing
- Ketogenic Diet (KD), Vegetarian Diet (VD), Control Diet (CD)
- Where
- 2 sites in Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Healthy
Health Impacts of Sustainable Ingredient Selection in the Food and Drink Industry - ALTERNATIVE PROTEIN STUDY
Summary This research will examine the nutritional effects of supplementing diets with alternative plant sources of protein with potential to be grown in Scotland.
- Trial name
- NCT01898351
- Testing
- Fava bean, Lupin, Beef meat, Green pea, Hemp, Buckwheat
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Muscle Protein Synthesis
Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis
Muscle mass is normally maintained through the regulated balance between the processes of protein synthesis (i.e. making new muscle proteins) and protein breakdown (breaking down old muscle proteins).
- Trial name
- NCT01885429
- Testing
- Positive Control, Negative Control, Low Protein Low Leucine Spike
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Gastrointestinal Hormones
Impact of Macronutrient Composition of Energy-restricted Diet and Exercise on Body Composition and Appetite Hormones.
The main aim of this study is to investigate the effect of energy-restricted low and high-carbohydrate diet combined with exercise training on appetite regulatory hormones, subjective appetite and energy intake in overweight and…
- Trial name
- NCT06022315
- Testing
- caloric restrction high carbohydrate low fat diet with exercise training program, caloric restrction high fat low carbohydrate diet with exercise training program
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Diabetes Mellitus, Type 2, Overweight and Obesity
Cut Down on Carbohydrate Usage in the Diet of Type 2 Diabetes. The Hypo-energetic Study
Scientific evidence for the dietary treatment of type 2 diabetes (T2D) is insufficient, which is why the investigators aim to reform dietary recommendation to the overweight or obese patient with type 2 diabetes.
- Trial name
- CutDM-Hypo (NCT03814694)
- Testing
- CRHP Diet, CD Diet
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Bispebjerg Hospital
Metabolic Syndrome (MetS), Psychiatric Disorders
The Impact of the Mediterranean Diet on Anthropometric Indices, Lipid Profiles, Energy Metabolism Signaling Proteins and Inflammatory Cytokines in Psychiatric Patients With Metabolic Syndrome
Background: Dietary modifications, like changing macronutrient distribution and improving food quality, are the main therapeutic approaches for managing oxidative stress, inflammation, and metabolic syndrome.
- Conditions
- Metabolic Syndrome (MetS), Psychiatric Disorders, Mediterranean Diet, Inflammatory Cytokines
- Trial name
- NCT07164014
- Testing
- Mediterranean diet, Hospital diet
- Where
- Saudi Arabia
- Volunteers
- 144 people
- Sponsor
- King Saud University
Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis
A Double-blind, Randomized, Multicenter, Cross-over Study to Compare the Effect of Creon N and Creon® on Fat Digestion in Subjects ≥ 12 Years of Age With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis
maldigestion of dietary macronutrients (pancreas not producing enough enzymes for digestion of fat, sugars and proteins) in Cystic Fibrosis
- Trial name
- NCT02137382
- Testing
- Creon®, Creon N
- Where
- 7 sites in Hungary, Spain
- Volunteers
- 41 people
- Sponsor
- Abbott
Postprandial Hyperglycemia, Metabolic Disorder, Glucose
Westlake N-of-1 Trials for Macronutrient Intake
This is a dietary intervention study in students and staff of Westlake University, which is designed to provide evidence in support of N-of-1 methods as an approach to advance personalized nutrition.
- Trial name
- WE-MACNUTR (NCT04125602)
- Testing
- High fat low carbohydrate diet, Low fat high carbohydrate diet
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Westlake University
Obesity, Body Composition
Study of Macronutrients and Heart Disease Risk
The objective of this trial is to examine the long-term effects of a diet low in carbohydrates, as compared to one low in fat, on cardiovascular disease risk factors, including blood pressure (BP), body weight and composition…
- Conditions
- Obesity, Body Composition, Blood Pressure, Cardiovascular Diseases
- Trial name
- MACRO (NCT00609271)
- Testing
- low carbohydrate diet, low fat diet
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Tulane University Health Sciences Center