Clinical trials: Macrosomia
Weight Gain
Weight Gain During Pregnancy - a Randomized Controlled Trial of Intervention to Prevent Excessive Gestational Weight Gain
Excessive weight gain during pregnancy is associated with complications during delivery primarily due to macrosomia (large babies) but also with high levels of weight retention post pregnancy and thereby increased risk of future…
- Trial name
- VIGA (NCT00451425)
- Testing
- motivational intervention in pregnancy
- Where
- Sweden
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Gestational Diabetes, Diabetes
The DNA Methylation of ARHGEF11 in Macrosomia
Background Macrosomia at birth is associated with subsequent susceptibility to obesity, abnormal glucose metabolism, hypertension and dyslipidaemia.
- Conditions
- Gestational Diabetes, Diabetes, Macrosomia, Fetal
- Trial name
- NCT03165643
- Testing
- OGTT
- Volunteers
- 239 people
- Sponsor
- Peking University First Hospital
Obstetric Complication, Ultrasound
The Utility of Customised Growth Charts for Identifying Macrosomia and the Effect of Intervention
Best management of suspected large for gestational age (LGA) fetuses is unclear. In some hospitals women with an LGA fetus by customised growth charts are are offered earlier induction.
- Conditions
- Obstetric Complication, Ultrasound, Induction of Labor Affected Fetus / Newborn, Fetal Growth Complications
- Trial name
- NCT04536753
- Testing
- Induction of labour
- Where
- United Kingdom
- Volunteers
- 845 people
- Sponsor
- Newcastle University
Gestational Diabetes
Active Patient GDM
Among women with GDM, the investigators will determine if a strategy of (1) a website-based information and motivational resource bank; (2) biosensor/ePlatform-based physical activity and GWG tracking; and/or (3) a health coach…
- Trial name
- NCT03802877
- Testing
- Resource bank, ePlatform, Health coach
- Where
- 6 sites in Canada
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Fetal Macrosomatia, Lipid Metabolism Disorders
Influence of TyG Index and TG/HDL-C Ratio on Fetal Macrosomia
Metabolic disorders that can occur during pregnancy, in particular disorders of lipid metabolism and insulin resistance, can have a detrimental effect on pregnancy and the fetus.
- Conditions
- Fetal Macrosomatia, Lipid Metabolism Disorders, Hyperlipidemias
- Trial name
- NCT06463990
- Testing
- TyG index
- Where
- Turkey (Türkiye)
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Gestational Diabetes
Myo-inositol in Obese Pregnant Women
Myo-Inositol is classified as a member of the vitamin B complex. It is a constituent of living cells and is widespread in many food.
- Trial name
- NCT01047982
- Testing
- myo-inositol, folic acid 400 mcg
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- University of Messina
Pregnancy
Relevance of Ultrasound Screening for Foetal Macrosomia
Management of fetal macrosomia is based on a suspicion of macrosomia (no certainty before birth). This management is an artificial induction of labour for an earlier delivery and therefore a lower fetal weight gain.
- Trial name
- USmacro (NCT04443205)
- Testing
- Data record
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- CHU de Reims
Macrosomia, Fetal Weight
Ultrasound Estimation of Fetal Macrosomia at Term: Diagnostic Accuracy Within 24 Hours of Delivery
Obstetric ultrasonography is now an essential tool for monitoring pregnancy. In France, three ultrasounds are recommended during a singleton pregnancy (at 12, 22, and 32 weeks of amenorrhea) to improve maternal and neonatal care.
- Trial name
- ECHO-MACRO (NCT07433751)
- Testing
- Ultrasound estimation of fetal macrosomia at 12 weeks of amenorrhea, Ultrasound estimation of fetal macrosomia at 22 weeks of amenorrhea, Ultrasound estimation of fetal macrosomia at 32 weeks of amenorrhea
- Where
- France
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Henri Duffaut - Avignon
Macrosomia, Fetal, Gestational Diabetes Mellitus in Pregnancy
New Markers of Glycation to Predict Gestational Diabetes Mellitus and Macrosomia.
Gestational diabetes mellitus (GDM) increases the risk of macrosomia and other adverse pregnancy outcomes. Screening strategies are debated: universal vs.
- Trial name
- GLYCAGEST (NCT06048510)
- Testing
- Pregnant women
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Bordeaux
Neonatal Hypoglycemia, Gestational Diabetes
Accuracy of Interstitial Continuous Glucose Sensors in Neonates
Low blood sugar in newborns is common and if prolonged or untreated may place them at increased risk for later learning and behavior challenges.
- Conditions
- Neonatal Hypoglycemia, Gestational Diabetes, Maternal Obesity Complicating Pregnancy, Small-for-gestational Age
- Trial name
- NCT07133906
- Testing
- Continuous glucose monitoring, Cerebral near-infrared spectroscopy
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Body Composition, Feeding; Difficult, Newborn
Role of Body Composition in Large for Gestational Age Infants (LGA) With Oral Feeding Difficulty
Large for Gestational Age (LGA) infants have excess fat-mass (FM) proportion secondary to prolonged in utero exposure to an energy-rich environment.
- Conditions
- Body Composition, Feeding; Difficult, Newborn, Nutrition Disorder, Infant
- Trial name
- NCT04599010
- Testing
- Dietary intervention
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Childhood Overweight
Effects of Lifestyle Intervention on Childhood Outcomes in LGA Infants
Large-for-gestational-age (LGA) infants have a higher risk of metabolic disease later in life, and their postnatal growth in early childhood may be associated with long-term adverse outcomes.
- Trial name
- NCT04661449
- Testing
- Comprehensive lifestyle intervention
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Small for Gestational Age Infant, Large for Gestational Age Infant
"Fetal gRowth AbnorMality dEtection Trial"
The present trial intends to assess the diagnostic accuracy of symphysis fundal height (SFH) as opposed to SFH combined with point of care ultrasound to measure the fetal abdominal circumference (POC-US-AC) in identifying small…
- Conditions
- Small for Gestational Age Infant, Large for Gestational Age Infant, Oligohydramnios, Polyhydramnios
- Trial name
- FRAME (NCT05043753)
- Testing
- Point of care ultrasound to measure the fetal abdominal circumference (POC-US-AC)
- Where
- 3 sites in Italy
- Volunteers
- 1,566 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Gestational Diabetes, Macrosomia, Fetal
Artificial Intelligence and Gestacional Diabetes
Artificial intelligence (AI) technology can assist medical teams in remote monitoring and continuing education of women with gestational diabetes (GDM), potentially improving adherence to interventions and impacting outcomes.
- Trial name
- NCT07345143
- Testing
- monitoring model for women with gestacional diabetes using pharmacological therapy
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- JOSE FERNANDO VILELA-MARTIN
Macrosomia, Induction of Labour
Induction of Labour for LGA fœtus in Women Without Insulin-treated Diabetes.
A french study published in 2015 (DAME) showed a decrease of shoulder dystocia and an increase of spontaneous vaginal delivery when the non insulin-treated diabetes patients with large-for-date fetus were induced.
- Conditions
- Macrosomia, Induction of Labour, Non-insulin-dependent Diabetes
- Trial name
- NCT03355040
- Testing
- induction of labour
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Pregnancy, Pregnancy in Diabetes
Exploration of the Lipid Metabolism During the Diabetic Pregnancies
Justification: Intrauterine exposure to type 1 or type 2 diabetes increase the risk of macrosomia (35 % to 50 % versus 10 % in general population) despite a good glycemic control.
- Conditions
- Pregnancy, Pregnancy in Diabetes, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
- Trial name
- DIAMANT (NCT00639964)
- Testing
- blood tests, diet questionnaire, umbilical cord blood collect
- Where
- France
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Gestational Diabetes, Pregnancy Related
Glycemic Observation and Metabolic Outcomes in Mothers and Offspring
The overarching goal of Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs) is to perform a comprehensive, longitudinal description of maternal glycemia over the course of pregnancy and to evaluate how…
- Trial name
- GO MOMs (NCT04860336)
- Testing
- Observational
- Where
- 9 sites in United States
- Volunteers
- 2,179 people
- Sponsor
- Northwestern University
Large for Gestational Age Baby, Macrosomia, Fetal
A First Trimester Prediction Model for Large for Gestational Age Infants: a Preliminary Study
Large for gestational age infants (LGA) have increased risks of adverse short-term perinatal outcomes. This study aims to develop a multivariable prediction model for the risk of giving birth to a LGA baby, by using biochemical…
- Trial name
- PreMoLGA (NCT04838431)
- Testing
- Blood sample and ultrasound at first trimester
- Where
- Italy
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Small for Gestational Age at Delivery, Post-term Infant, Not Heavy-for-dates
Breast Milk Zinc Transfer to Appropriate- and Small-for-gestational-age Bangladeshi Infants
Data collected from this study will provide information on the breast milk zinc concentration, maternal and infant zinc status, and transfer of zinc from mothers breast milk to infants during first six months of life.
- Trial name
- NCT01728766
- Testing
- Small for gestational age at delivery, Post-term Infant, Not Heavy-for-dates
- Where
- Bangladesh
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Gestational Diabetes Mellitus in Pregnancy, Macrosomia, Fetal
Late Gestational Diabetes Mellitus Diagnosis in Obese Women
In the current work, we aim to perform a prospective study that will investigate the relationship between maternal obesity (BMI >30 kg/m2) and morbid obesity (BMI >35 kg/m2) with a late GDM diagnosis (>32 weeks), with an emphasis…
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Macrosomia, Fetal, Dystocia, Shoulder, Neonatal Jaundice
- Trial name
- NCT05510518
- Testing
- oral glucose tolerance test (OGTT)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Western Galilee Hospital-Nahariya