Clinical trials: Macula Hole
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Glaucoma, Macular Disease
Novel Glaucoma Diagnostics
The purpose of this research is to evaluate novel technologies for the assessment of ocular structure and function, including the scanning device called Optical Coherence Tomography (OCT).
- Trial name
- NCT00286637
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Wills Eye
no Obvious Abnormalities, Diabetic Retinopathy (DR)
Retinal Clinical Assessment With AI-derived Quantitative Information
This randomized controlled trial evaluates whether providing clinicians with AI-derived quantitative retinal information improves the quality and efficiency of retinal clinical assessment.
- Conditions
- no Obvious Abnormalities, Diabetic Retinopathy (DR), AMD, Cup-to-disc Ratio Bigger Than 0.5
- Trial name
- NCT07291960
- Testing
- AI-derived retinal quantitative information-assisted reporting
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Macular Holes, Macular Pucker
Efficacy and Safety Evaluation of MONOBLUE DUAL View and MONOBLUE ILM View Vital Stains
In this study, the investigators aim to collect data regarding the efficiency and safety of two dyes used intraoperatively in vitrectomy to stain intraocular tissues.
- Conditions
- Macular Holes, Macular Pucker, Vitreomacular Traction
- Trial name
- NewBlueDyes (NCT05517473)
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Macular Holes, Intraocular Lens Opacification
Oral Sedation in Vitreoretinal Surgery
The purpose of this study is to compare the efficacy of oral sedation to intravenous sedation with anesthesiology support and monitoring.
- Conditions
- Macular Holes, Intraocular Lens Opacification, Vitrectomy, Vitreous Hemorrhage
- Trial name
- NCT04346095
- Testing
- Oral Sedatives with or Without Analgesia, Intravenous Sedatives with or Without Analgesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rocky Vista University, LLC
Ophthalmopathy
Single Superior ILM/ERM Flap for the FTMH.
In this study, the investigators will make the only upper flap either from the internal limiting membrane or from the epiretinal membrane to cover the full thickness macular hole.
- Trial name
- NCT05494242
- Testing
- Surgical intervention
- Where
- Iraq
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Omer Othman Abdullah
Idiopathic Macular Holes
Brillant Blue Versus Indocyanine Green for Macular Hole Surgery
Macular Hole Surgery with two different Dyes
- Trial name
- NCT00757471
- Testing
- Brillant Blue, Indocyanine Green
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Retinal Detachment, Macular Pucker
Zeiss RESIGHT Disposable Lenses Evaluation Study
To evaluate the intra-operative efficacy of a new intra-operative viewing device.
- Conditions
- Retinal Detachment, Macular Pucker, Macular Holes, Vitreomacular Traction
- Trial name
- RESIGHT (NCT05860985)
- Testing
- ZEISS disposable
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Macular Holes
Treatment of Challenging Macular Holes Using Plasma Rich in Growth Factors
Aim of the Study:To report the structural and visual outcomes of plasma rich in growth factors in closure of challenging macular holes
- Trial name
- NCT06115005
- Testing
- Plasma rich in growth factors ( PRGF )
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Minia University
Age-Related Macular Degeneration, Geographic Atrophy
Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO
To conduct a precision study to assess the microperimetry function of the Spectral OCT/SLO. The study will assess variability across measurements taken by three different operator-device configuration across clinical sites…
- Conditions
- Age-Related Macular Degeneration, Geographic Atrophy, Diabetic Retinopathy, Macular Edema
- Trial name
- NCT01692938
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Idiopathic Macular Hole
Unveiling Preclinical Idiopathic Macular Hole Formation
A macular hole is a rupture in the macula. In terms of pathogenesis, as much as 80% are idiopathic (Idiopathic Macular Hole, IMH).
- Trial name
- IMH_2012 (NCT02180633)
- Testing
- Optical Coherence Tomography Scan
- Where
- 7 sites in Portugal
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Epiretinal Membrane, Macular Holes
Comparative Study of Sharkskin Versus Grieshaber Forceps During ILM Peeling
The purpose of this study is to compare the performance and anatomic outcomes of the Sharkskin internal limiting membrane (ILM) forceps and the Grieshaber ILM forceps in macular surgery.
- Trial name
- NCT04459949
- Testing
- Sharkskin, Grieshaber
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Retinal Diseases, Fuchs Endothelial Dystrophy
DISCOVER Study: Microscope-integrated Intraoperative OCT Study
Optical coherence tomography (OCT )provides high resolution information regarding the anatomic structure of the tissues of the eye in a cross-sectional and 3 dimensional view.
- Conditions
- Retinal Diseases, Fuchs Endothelial Dystrophy, Macular Hole, Epiretinal Membrane
- Trial name
- DISCOVER (NCT02423213)
- Where
- United States
- Volunteers
- 2,911 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Macular Holes
MSC-Exos Promote Healing of MHs
Purpose: To assess the safety and efficacy of mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exos) for promoting healing of large and refractory macular holes (MHs).
- Trial name
- MSCs (NCT03437759)
- Testing
- exosomes derived from mesenchymal stem cells (MSC-Exo)
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Ocular Inflammation
PGE2 Levels in Patient Treated With NSAIDs
The aim of this study is to determine vitreous levels of nonsteroidal antinflammatory drugs (NSAIDs) and prostaglandinE2 (PGE2) in eyes scheduled for vitrectomy. All patients received the study drugs for 3 days before surgery.
- Trial name
- NCT03597867
- Testing
- Dicloftil, Nevanac, Indom
- Where
- Italy
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Macular Holes, Visual Acuity Gain
Impact of C3F8 or SF6 Use and Length of Face-down Positioning (7 vs 14 Days Respectively) in Macular Hole Surgery
The primary purpose of the study was to compare the macular hole closure and visual acuity gain following vitrectomy using SF6 gas tamponade with 7 days of face-down positioning versus C3F8 gas tamponade with 14 days of face-down…
- Conditions
- Macular Holes, Visual Acuity Gain, Cataract, Complications
- Trial name
- NCT02073266
- Testing
- Macular hole surgery using a 25 G pars plana vitrectomy, ILM peeling, fluid-air exchange followed by air-gas exchange with SF6 or C3F8.
- Where
- Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Glaucoma, Macular Pucker
Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) Study
Since the introduction of vitrectomy in 1971, this procedure has become the third most frequently performed ophthalmic surgery. Approximately 225,000 vitrectomies are performed annually in the United States and indications…
- Conditions
- Glaucoma, Macular Pucker, Macula Hole, Vitreomacular Traction
- Trial name
- PROVE (NCT01162356)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Retinal Detachment, Epiretinal Membrane
PIONEER: Intraoperative and Perioperative OCT Study
OCT provides high-resolution information regarding the anatomic structure of the tissues of the eye in a 2-dimensional and 3-dimensional view. Much of this information is not able to be recognized by a clinician.
- Conditions
- Retinal Detachment, Epiretinal Membrane, Macular Hole, Fuchs Endothelial Dystrophy
- Trial name
- PIONEER (NCT02423161)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Macula Hole
Macular Hole Surgery With Temporal Inverted Internal Limiting Membrane Flap (MARTIAL)
Since 1991, idiopathic macular holes (MH) can benefit from an effective treatment initially involving pars plana vitrectomy, stripping of epiretinal membranes and intraocular gas tamponade followed by facedown positioning.
- Trial name
- MARTIAL (NCT03287102)
- Testing
- Macular hole surgery
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Diabetic Retinopathy, Retinal Vein Occlusion
Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph
Blindness can be caused by many ocular diseases, such as diabetic retinopathy, retinal vein occlusion, age-related macular degeneration, pathologic myopia and glaucoma.
- Conditions
- Diabetic Retinopathy, Retinal Vein Occlusion, Retinal Artery Occlusion, Central Serous Chorioretinopathy
- Trial name
- NCT04723160
- Testing
- Software assisted imaging diagnosis
- Where
- 5 sites in China
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Visionary Intelligence Ltd.