Clinical trials: Macula Off
Retinal Detachment, Proliferative Vitreoretinopathy
Internal Limiting Membrane Peeling in Retinal Detachment Surgery
Despite advances in surgical techniques over the recent decades, proliferative vitreoretinopathy (PVR) remains the main obstacle to successful rhegmatogenous retinal detachment (RRD) repair, accounting for nearly 75% of all…
- Trial name
- IMPURITY (NCT05538156)
- Testing
- Control group, Intervention group
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Retinal Detachment With Multiple Breaks, Unspecified Eye, Proliferative Vitreoretinopathy
Intravitreal Aflibercept for the Prevention of Proliferative Vitreoretinopathy Following Retinal Detachment Repair
The primary objective of the study is to determine if serial intravitreal aflibercept injections (IAI) improve the single surgery anatomic success rate following surgical repair of primary, macula involving rhegmatogenous retinal…
- Trial name
- PREVENT-PVR (NCT04580147)
- Testing
- Intravitreal aflibercept injection
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- M. Ali Khan, MD
Rhegmatogenous Retinal Detachment - Macula Off
A Study to Evaluate the Safety and Tolerability of ONL1204 in Patients With Macula-off, Rhegmatogenous Retinal Detachment
The purpose of this study is to evaluate the safety and tolerability of ONL1204 in participants with Macula-off, Rhegmatogenous Retinal Detachment (RRD).
- Trial name
- NCT03780972
- Testing
- ONL1204, Intravitreal Injection, Collection of ocular fluids
- Where
- 4 sites in Australia
- Volunteers
- 14 people
- Sponsor
- ONL Therapeutics
Rhegmatogenous Macula-off Retinal Detachment
Corneal Endothelial Cell Changes In Silicon Filled Eye
The aim of this study is to evaluate corneal endothelial cell changes after pars plana vitrectomy in Rhegmatogenous Retinal detachment , compare the results using different silicon oil viscositites , and assess whether these…
- Trial name
- Endothelium (NCT07418606)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Retinal Detachment, Vitrectomy
Functional and Morphological Results of Rhegmatogenous Retinal Detachment Treated With Vitrectomy
To examine morphological and functional results after pars plana vitrectomy (PPV) with SF6 gas tamponade due to macula-on and macula-off rhegmatogenous retinal detachment (RRD) during six months of the follow-up.
- Trial name
- NCT03902795
- Testing
- Microperimetry, M-charts
- Where
- Poland
- Volunteers
- 62 people
- Sponsor
- Medical University of Lublin
Retinal Detachment Rhegmatogenous
Use of Preoperative Gas in Eyes With Macula-off Rhegmatogenous Retinal Detachment (RRD)
The purpose of this study is to evaluate whether a preoperative intraocular gas injection improves visual outcomes in patients with a macula-off rhegmatogenous retinal detachment (RRD).
- Trial name
- NCT07855770
- Testing
- Intravitreal 100% C3F8 Injection, Pars plana vitrectomy or pars plana vitrectomy with scleral buckle
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- Wills Eye
Retinal Detachment
The Influence of Postoperative Postures on Persistent Sub-foveal Fluid After Scleral Buckle Surgery
The purpose of this study is to evaluate whether postoperative postures influence persistent sub-foveal fluid after scleral buckle surgery
- Trial name
- NCT02294708
- Testing
- postoperative postures
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Rhegmatogenous Retinal Detachment - Macula Off
Acute Retinal Detachment Repair With the iSeelr™ Retinal Detachment Repair System
This study is a first-in-human clinical trial testing a new treatment for rhegmatogenous retinal detachments. The new treatment called retinal thermofusion uses a special laser device called iSeelr™ during surgery.
- Trial name
- NCT06468397
- Testing
- iSeelr™
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Photofuse Pty Ltd
Retinal Detachment
Nicotinamide Riboside Oral Supplementation in Macula Off Retinal Detachment
Retinal detachment occurs when fluid separates the retina (a thin, light sensing tissue) from its usual attachment at the back of the eye.
- Trial name
- NOMAD (NCT06587945)
- Testing
- Nicotinamide Riboside, Vitrectomy and Gas tamponade
- Where
- 5 sites in Australia
- Volunteers
- 144 people
- Sponsor
- Center for Eye Research Australia
Retinal Detachment, Metamorphopsia
Effect of Type of Head Positioning on Retinal Displacement in Vitrectomy for Retinal Detachment
Patients may experience metamorphopsia, or image distortion, after having vitrectomy to repair their rhegmatogenous retinal detachments especially those with a detached macula.
- Trial name
- DIAMOND (NCT04035343)
- Testing
- Face down positioning, Supine positioning
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Unity Health Toronto
Rhegmatogenous Retinal Detachment
Comparative Study Between Three Different Techniques in Drainage of SRF During PPV in RRD
The study will investigate and compare the three techniques in drainage of subretinal fluid in patients with macula off RRD: namely using the original break, performing a posterior drainage retinotomy and using PFC with drainage…
- Trial name
- NCT06324305
- Testing
- Pars plana vitrectomy (PPV) and drainage of subretinal fluid
- Volunteers
- 66 people
- Sponsor
- Ain Shams University
Rhegmatogenous Macula-off Retinal Detachment
Safety and Efficacy of Brimonidine Tartrate Posterior Segment Drug Delivery System in Improving Visual Function
This study will evaluate the efficacy and safety of the Brimo PS DDS® Applicator System (200 μg and 400 μg brimonidine tartrate) on visual function in patients with previous rhegmatogenous macula-off retinal detachment.
- Trial name
- NCT00972374
- Testing
- 400 ug Brimonidine Implant, 200 ug Brimonidine Implant
- Where
- 6 sites in United States, India and 4 more
- Volunteers
- 44 people
- Sponsor
- Allergan
Retinal Detachment
Rasagiline (Azilect) - Neuroprotection for Macula-off Retinal Detachment
This randomised, double-blind, placebo-controlled clinical trial investigates the neuroprotective effect of rasagiline in patients suffering from a retinal detachment affecting central vision.
- Trial name
- NCT02068625
- Testing
- Rasagiline
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Rhegmatogenous Retinal Detachment - Macula Off
A Phase 2 Study to Assess the Safety and Efficacy of Intravitreal ONL1204 Ophthalmic Solution in Subjects With Mac-off Retinal Detachment
The goal of this Phase 2 clinical trial is to learn about ONL1204 Ophthalmic Solution in terms of safety and how well the drug works in patients that have a macula-off (central point of vision) rhegmatogenous retinal detachment…
- Trial name
- NCT05730218
- Testing
- ONL1204 Ophthalmic Solution
- Where
- 36 sites in United States
- Volunteers
- 136 people
- Sponsor
- ONL Therapeutics
Retinitis Pigmentosa, Macula Off
Transcorneal Electrical Stimulation Therapy for Retinal Disease
Transcorneal stimulation may enable neurons to survive degeneration processes via enhanced secretion of neurotrophic substances and direct stimulation of neurons.
- Conditions
- Retinitis Pigmentosa, Macula Off, Primary Open Angle Glaucoma, Hereditary Macular Degeneration
- Trial name
- NCT00804102
- Testing
- Transcorneal Electrical Stimulation, DTL-electrode attached without energy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Okuvision GmbH