Clinical trials: Macular Edema, Diabetic
Diabetic Macular Edema
Comparing the Effectiveness and Costs of Bevacizumab to Ranibizumab in Patients With Diabetic Macular Edema (BRDME)
The primary objective is to demonstrate the non-inferiority of bevacizumab to ranibizumab in the treatment of patients with DME (OCT central area thickness > 275 μm) as determined by the change in best-corrected visual acuity…
- Trial name
- BRDME (NCT01635790)
- Testing
- Ranibizumab, Bevacizumab
- Where
- Netherlands
- Volunteers
- 246 people
- Sponsor
- Prof. dr. R.O. Schlingemann
Diabetic Macular Edema
Comparison of Single Intravitreal Injection of Triamcinolone or Bevacizumab for the Treatment of Diabetic Macular Edema
The purpose of this study is to compare a single intravitreal injection of 4.0 mg of triamcinolone acetonide and 1.25 mg of bevacizumab for the treatment of diabetic macular edema.
- Trial name
- Tribeva-DME (NCT00874744)
- Testing
- Bevacizumab, Triamcinolone acetonide
- Volunteers
- 13 people
- Sponsor
- Universidade Federal de Goias
Diabetic Macular Edema
Phase 1 Study of VEGF Trap in Patients With Diabetic Macular Edema
To assess the ocular and systemic safety and tolerability of a single intravitreal injection of VEGF Trap in patients with diabetic macular edema.
- Trial name
- NCT00320814
- Testing
- VEGF Trap-Eye
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Regeneron Pharmaceuticals
Macular Edema
Safety and Efficacy Study of Dexamethasone Versus Ranibizumab in Patients With Diabetic Macular Edema
This study will compare the safety and efficacy of the 700 ug dexamethasone intravitreal implant with ranibizumab 0.5 mg intravitreal injections in patients with diabetic macular edema (DME).
- Trial name
- NCT01492400
- Testing
- dexamethasone Intravitreal Implant, ranibizumab
- Where
- 13 sites in United States, Belgium and 10 more
- Volunteers
- 363 people
- Sponsor
- Allergan
Severe Diabetic Macular Oedema
Anti-vascular Endothelial Growth Factor (Anti-VEGF) Monotherapy vs Anti-VEGF Followed by Subthreshold Micropulse Laser for Treating Severe Diabetic Macular Oedema When the Central Retina Goes <400 Microns
The macula is the centre of the retina; it gives central sight, colour and fine detail. People with diabetes may develop diabetic macular oedema (DMO).
- Trial name
- DAME (NCT06985706)
- Testing
- Subthreshold Micropulse Laser (SML), Anti-VEGF Monotherapy (standard care)
- Where
- 22 sites in United Kingdom
- Volunteers
- 264 people
- Sponsor
- Belfast Health and Social Care Trust
Macular Edema
A Study to Evaluate the Effectiveness of Intravitreal Aflibercept in Patients With Diabetic Macular Edema and/or Macular Edema Secondary to Retinal Vein Occlusion, Which Either Have or Have Not Been Pretreated for Their Disease
AURIGA is designed to collect data from routine clinical practice on the effectiveness and utilization of intravitreal aflibercept in the treatment of visual impairment due to diabetic macular edema (DME) or macula edema…
- Trial name
- AURIGA (NCT03161912)
- Testing
- Aflibercept (Eylea, BAY86-5321)
- Where
- 11 sites in China, Egypt and 9 more
- Volunteers
- 2,481 people
- Sponsor
- Bayer
Diabetic Macular Edema
Efficacy Study of Triamcinolone and Bevacizumab Intravitreal for Treatment of Diabetic Macular Edema
Triamcinolone and Bevacizumab Intravitreal for Treatment of Diabetic Macular Edema
- Trial name
- ATEMD (NCT00737971)
- Testing
- Bevacizumab intravitreal, Triamcinolone, Triamcinolone + Bevacizumab
- Where
- Brazil
- Volunteers
- 142 people
- Sponsor
- Rubens Belfort Jr.
Diabetic Macular Edema (DME)
Efficacy Comparison of DExamethasone Intravitreal Implant Combined With Aflibercept Versus Aflibercept Monotherapy in Treatment-naïve Inflammatory Diabetic Macular Edema Patients
This is a 12-month, prospective, randomized controlled, multi-center, open-label, superiority designed study. Treatment-Naïve DME patient with inflammatory biomarkers, who meet the inclusion and exclusion criteria, will be…
- Trial name
- DECADE (NCT07438119)
- Testing
- Combination Therapy with Aflibercept Intravitreous Injection (2mg) and Dexamethasone Intravitreal Implant, Aflibercept Intravitreous Injection (2mg) Monotherapy
- Volunteers
- 114 people
- Sponsor
- Kun Liu
Diabetic Macular Edema
Diabetic Macular Edema: Relevance of Staging Progression on Therapeutic Outcome
Retrospective multi-center observational study on functional and morphological outcome of initial therapy for DME according to ESASO Morphologic Classification.
- Trial name
- NCT05080803
- Testing
- intravitreal administration of bevacizumab/ranibizumab/aflibercept/desamethazone
- Where
- Switzerland
- Volunteers
- 608 people
- Sponsor
- European School of Advanced Studies in Ophthalmology
Diabetic Macular Edema (DME)
A Randomized, Phase 2 Study of Oral BGE-102 in Participants With Center-Involved Diabetic Macular Edema
The purpose of this study is to learn about the effects of BGE-102 on change in vision in participants with center-involved diabetic macular edema (CI-DME).
- Trial name
- QUELL-DME (NCT07812090)
- Testing
- Oral BGE-102, Anti-VEGF
- Where
- 16 sites in United States
- Volunteers
- 180 people
- Sponsor
- BioAge Labs, Inc.
Vitreomacular Traction Maculopathy, Eye Diseases
Intravitreal Microplasmin in Patients Undergoing Surgical Vitrectomy
The purpose of this trial is to evaluate the safety and preliminary efficacy of different doses and several exposure times of intravitreal microplasmin in the setting of pars plana vitrectomy for vitreomacular traction…
- Trial name
- NCT00123279
- Testing
- Microplasmin
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 60 people
- Sponsor
- ThromboGenics
Neovascular Age-related Macular Degeneration, Age-related Macular Degeneration
SD-OCT Angiography
The objective of this study is to image retinal vascular alterations in patients with retinal disease using the AngioVue OCT-A system and understand the information these images provide.
- Conditions
- Neovascular Age-related Macular Degeneration, Age-related Macular Degeneration, Diabetic Retinopathy, Retinal Vein Occlusion
- Trial name
- NCT02510885
- Testing
- AngioVue SD-OCT
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Duke University
Blepharoptosis, Age-Related Macular Degeneration
Blepharoptosis After Repeated Intravitreal Anti-VEGF Injections: A Prospective Study
Intravitreal anti-VEGF injections are a mainstay of treatment for retinal diseases such as neovascular age-related macular degeneration, diabetic macular edema and retinal vein occlusion, and usually require repeated…
- Conditions
- Blepharoptosis, Age-Related Macular Degeneration, Diabetic Macular Edema
- Trial name
- NCT07821450
- Testing
- Repeated intravitreal anti-VEGF injection with eyelid speculum
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Abdulkadir Küçük
Diabetic Retinopathy, Macular Degeneration
Intravitreal Infliximab for Diabetic Macular Edema (DME) and Choroidal Neovascularization (CNV)
Injections of medicine into the middle of the eye (intravitreal injections) are commonly used in a multitude of retinal diseases.
- Trial name
- ITVR (NCT00695682)
- Testing
- intravitreal injection of infliximab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Retina Research Foundation
Diabetic Macular Edema
Post Marketing Study to Evaluate the Safety and Effectiveness of Brolucizumab in Patients With Diabetic Macular Edema.
The purpose of this study is to generate additional safety and effectiveness data in Indian Diabetic macular edema (DME) patients that more closely resemble the real-world population intended to be treated with Brolucizumab.
- Trial name
- NCT05959304
- Testing
- brolucizumab
- Where
- 8 sites in India
- Volunteers
- 66 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Macular Edema, Cystoid Macular Edema, Chorodial Neovascularzation, Posterior Uveitis
Suprachoroidal Injection of Triamcinolone Acetonide Using Custom Made Needle to Treat Retinal Disorders
Injection in the Suprachoroidal space has potential of increasing the efficacy of the drug upto six times with direct effect on retinal tissues sparing the crystalline lens and trabecular meshwork.
- Trial name
- NCT03606733
- Testing
- Custom suorachoroidal needle
- Where
- Syria
- Volunteers
- 100 people
- Sponsor
- Marashi Eye Clinic
Diabetic Macular Edema
A Study to Investigate Vamikibart (RO7200220) in Diabetic Macular Edema
Study BP43445 is a phase II, multicenter, randomized, double-masked, active comparator-controlled study to investigate the efficacy, safety, tolerability, pharmacokinetics, and pharmacodynamics of vamikibart administered…
- Trial name
- NCT05151731
- Testing
- Vamikibart, Ranibizumab
- Where
- 74 sites in United States, Argentina and 7 more
- Volunteers
- 394 people
- Sponsor
- Hoffmann-La Roche
Retinopathy, Diabetic
A Phase 2 Clinical Study to Investigate Effects of Darapladib in Subjects With Diabetic Macular Edema
The purpose of this study is to characterize the systemic and ocular safety and tolerability, pharmacokinetics, exploratory efficacy and pharmacodynamics of 3 months of repeat administration of oral darapladib in diabetic macular…
- Trial name
- NCT01506895
- Testing
- darapladib
- Where
- 16 sites in Australia, Denmark and 3 more
- Volunteers
- 54 people
- Sponsor
- GlaxoSmithKline
Diabetic Macular Edema
Safety and Efficacy Study of Conbercept in Diabetic Macular Edema (DME) (Sailing)
This study is designed to assess safety and efficacy of intravitreal injection of Conbercept on visual acuity and anatomic outcomes in patients with diabetic macular edema (DME) .
- Trial name
- NCT02194634
- Testing
- Conbercept, Laser
- Where
- 17 sites in China
- Volunteers
- 248 people
- Sponsor
- Chengdu Kanghong Biotech Co., Ltd.
Macular Edema, Cystoid, Vision Disorders
Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema
This study is undertaken to determine the effect of intravitreal long acting dexamethasone implant, (Ozurdex®) in improving outcome of cataract surgery in patients with diabetic macular edema.
- Conditions
- Macular Edema, Cystoid, Vision Disorders, Diabetic Macular Edema, Cystoid Macular Edema Following Cataract Surgery
- Trial name
- NCT01546402
- Testing
- Dexamethasone Drug delivery system (Ozurdex), Cataract surgery
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh