Clinical trials: Macular Holes
Intraocular Pressure,, Postoperative Complications
Primary Vitrectomy for the Treatment of Retinal Detachment in Highly Myopic
Purpose: To assess the functional and anatomical outcome of primary vitrectomy without scleral buckling for rhegmatogenous retinal detachment (RRD) in highly myopic eyes with axial length over 30 mm.
- Trial name
- NCT01480505
- Testing
- Pars plana vitrectomy with gas tamponade
- Where
- France
- Volunteers
- 840 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Macular Holes
Position Related Changes in Macular Hole Morphology Before and After Surgery
Macular hole is a full thickness retinal defect in the very centre of the retina that gives the sharpest vision. The condition causes a substantial deterioration of visual acuity, and operative measures are necessary in order to…
- Trial name
- NCT04676217
- Testing
- Postoperative positioning advice
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Helse Stavanger HF
Macular Holes
Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane Flap in Idiopathic Large Macular Holes
The human amniotic membrane (hAM) patch, introduced by Rizzo et al. in 2018, showed a 100% anatomical success rate for large or failed macular holes over a 6-month follow-up.
- Trial name
- MACROHOLE (NCT06433284)
- Testing
- 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade, 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling with amniotic membrane hydrogel filling and SF6 tamponade
- Where
- Thailand
- Volunteers
- 26 people
- Sponsor
- Walailak University
Macular Hole
Effects of Different Area of Internal Limiting Membrane Peeling (ILM) Peeling on Anatomical Outcomes in Macular Hole Surgery
The purpose of this study is to determine the effects of two different internal limiting membrane (ILM) peeling area on anatomical closure outcomes after macular hole surgery measured by optical coherence tomography (OCT).
- Trial name
- NCT02930369
- Testing
- ILM peeling surgery
- Volunteers
- 128 people
- Sponsor
- Peking University People's Hospital
Macular Hole, Epiretinal Membrane
Safety and Efficacy of Double Staining With Brilliant Blue G for Macular Surgery
Study designed to evaluate the safety and efficacy of double staining with brilliant blue G 0.025% as an adjuvant to macular surgery. Patients undergoing surgery for macular hole or epiretinal membrane will be included.
- Trial name
- NCT01820520
- Testing
- brilliant blue G
- Where
- Mexico
- Volunteers
- 22 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Macular Holes, Vitrectomy
Postoperative Same Day Closure of Giant Macular Hole With Silicone Oil
Patients with stage 3 and 4 macular holes of size \>700 microns who underwent pars plana vitrectomy, Internal limiting Membrane peeling and silicone oil tamponade were followed at day 1 , 2 weeks and 1 month post silicone oil…
- Trial name
- GiantMH-SO (NCT06915948)
- Testing
- Macular Hole Surgery
- Where
- India
- Volunteers
- 32 people
- Sponsor
- Ahalia Foundation Eye Hospital
Vitrectomy, Retinal Detachment
Pars Plana Vitrectomy With 25-gauge 20000 Cpm, Bevel-tip Cutter
Report efficiency and clinical outcomes using 25-gauge, bevel-tip, 20000 cut per minute vitrectomy probe among eyes with various vitreo-retinal diseases
- Conditions
- Vitrectomy, Retinal Detachment, Vitreous Hemorrhage, Macular Holes
- Trial name
- HYPE (NCT04404296)
- Testing
- 25-gauge, bevel-tip, 20000 cut per minute pars plana vitrectomy
- Where
- Philippines
- Volunteers
- 50 people
- Sponsor
- Peregrine Eye and Laser Institute
Macular Holes
Duration of Face Down Positioning for Full-Thickness Macular Hole Repair
A full-thickness macular hole is when there is a small gap that opens in the center part of the retina (the light-sensitive layer of tissue in the back of the eye).
- Trial name
- NCT06000111
- Testing
- 3 Days of face-down positioning, 7 Days of face-down positioning
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Idiopathic Macular Hole, Surgery
Study of Surgery in Patients With Idiopathic Macular Hole
The purpose of this study is to determine the effects of two different internal limiting membrane peeling with distinct diameters after macular hole surgery on anatomical closure grades.
- Trial name
- NCT02905409
- Testing
- ILM peeling surgery
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Peking University People's Hospital
High Myopia, Macular Holes
High Myopia Macular Hole and Retinal Detachment Treated With Double ILM Flaps
From July 2015 to December 2015, clinical record of 8 consecutive cases of macular hole with retinal detachment in high myopia treated with combined inverted and free ILM flap insertion into the hole were retrospectively…
- Conditions
- High Myopia, Macular Holes, Retinal Detachment
- Trial name
- NCT03174639
- Testing
- Inverted and free ILM insertion
- Volunteers
- 8 people
- Sponsor
- National Taiwan University Hospital
Macular Hole
Alleviated Positioning for Small Macular Holes
Rational of the study: There are arguments to think that the closure of macular holes can be obtained without a strict positioning under certain conditions, i.e.
- Trial name
- NCT00190164
- Testing
- Macular hole surgery with alleviated positioning, Macular hole surgery with no alleviated positioning
- Where
- France
- Volunteers
- 69 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Macular Pucker, Macular Hole
Brilliant Blue Versus Indocyanine Green
A study of non-inferiority design comparing brilliant blue and indocyanine green as intraoperative dye in macular pucker and macular hole.
- Conditions
- Macular Pucker, Macular Hole, Vitreoretinal Surgery
- Trial name
- NCT01083004
- Testing
- Indocyanine green, Brilliant blue arm
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Macular Hole Retinal Detachment
Inverted Internal Limiting Membrane Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes
To evaluate efficacy of vitrectomy with inverted internal limiting membrane (ILM) flap technique for macular hole retinal detachment (MHRD) in highly myopic eyes, and to demonstrate postoperative clinical course of MHRD after…
- Trial name
- NCT02896972
- Testing
- Vitrectomy
- Volunteers
- 32 people
- Sponsor
- Kyorin University
Full Thickness Macular Hole
Protocol for RCT of Posturing in Phacovitrectomy for Full Thickness Macular Hole (FTMH)
The purpose of this study is to determine the effect of postoperative posturing on the outcome of macular hole surgery. Current practice is divided; some individuals are advised to posture face-down for 10 days and others are…
- Trial name
- NCT01020760
- Testing
- Face down posture
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Greater Glasgow and Clyde
Retinal Diseases, Fuchs Endothelial Dystrophy
DISCOVER Study: Microscope-integrated Intraoperative OCT Study
Optical coherence tomography (OCT )provides high resolution information regarding the anatomic structure of the tissues of the eye in a cross-sectional and 3 dimensional view.
- Conditions
- Retinal Diseases, Fuchs Endothelial Dystrophy, Macular Hole, Epiretinal Membrane
- Trial name
- DISCOVER (NCT02423213)
- Where
- United States
- Volunteers
- 2,911 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Diabetic Retinopathy, Retinal Vein Occlusion
Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph
Blindness can be caused by many ocular diseases, such as diabetic retinopathy, retinal vein occlusion, age-related macular degeneration, pathologic myopia and glaucoma.
- Conditions
- Diabetic Retinopathy, Retinal Vein Occlusion, Retinal Artery Occlusion, Central Serous Chorioretinopathy
- Trial name
- NCT04723160
- Testing
- Software assisted imaging diagnosis
- Where
- 5 sites in China
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Visionary Intelligence Ltd.
Macular Holes, Microperymetry
The Application of M-charts and Microperimetry for the Assessment of Visual Function in Patients After Vitrectomy Due to the Full Thickness Macular Hole.
To examine the relationship between morphological and functional results in eyes after vitrectomy due to the full thickness macular hole (FTMH).
- Conditions
- Macular Holes, Microperymetry, Vitrectomy, M-charts
- Trial name
- NCT03701542
- Testing
- Microperymetry, M-charts
- Volunteers
- 22 people
- Sponsor
- Medical University of Lublin
Macular Holes
Small Macular Holes Treated With Air
Non-inferiority trial comparing intraocular air and gas tamponade for closure of macular holes.
- Trial name
- NCT06211907
- Testing
- Postoperative intraocular tamponade
- Where
- 7 sites in Greece, Norway and 1 more
- Volunteers
- 132 people
- Sponsor
- Helse Stavanger HF
Macular Holes
GaslEss Macular Hole Surgery
Macular holes are a hole in the centre of the retina, the light-sensing layer in the back of the eye. They cause a central 'blind spot' in the vision, which can be very disabling for patients.
- Trial name
- GEM (NCT06079593)
- Testing
- Gasless Macular hole surgery, Standard Macular hole surgery
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust