Clinical trials: Magnetic Resonance Imaging (MRI), Functional
Breast Cancer
Assessing Treatment Response in Breast Cancer With Functional Imaging
Patients with large primary operable breast cancers are offered chemotherapy prior to surgery to shrink the tumour and enable breast conserving surgery.
- Trial name
- NCT02688257
- Testing
- MRI, Ultrasound
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom
Anxiety Disorder, Obsessive-Compulsive Disorder
Definitive Selection of Neuroimaging Biomarkers in Anxiety Disorder and Obsessive-compulsive Disorder: A Longitudinal Functional Magnetic Resonance Imaging （fMRI） Study With Paroxetine Treatment
To explore reliable neuroimaging biomarkers for anxiety disorder and OCD,and whether there are shared imaging biomarkers between different subtypes of anxiety disorder and OCD, the investigators included30 drug-naive general…
- Trial name
- NCT03894085
- Testing
- Paroxetine
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Central South University
Attention Deficit Hyperactivity Disorder, ADHD
Imaging Stimulant and Non Stimulant Treatments for ADHD: A Network Based Approach
The growing number of medications used to treat attention-deficit/hyperactivity disorder (ADHD) raises important questions about whether different medications have similar or different therapeutic mechanisms of action.
- Trial name
- NCT01678209
- Testing
- fMRI scans, Atomoxetine arm, Methylphenidate arm
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Healthy Young and Elderly Volunteers
Effects of Intravenous (IV) Citalopram on Emotional Brain Activity in Healthy Young and Elderly Adults
Antidepressant medications known as selective serotonin reuptake inhibitors (SSRIs) are most commonly prescribed to treat depression and anxiety.
- Trial name
- NCT01216449
- Testing
- Intravenous Citalopram, Normal Saline
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Rotman Research Institute at Baycrest
Dyslexia, Developmental, Reading
Enhancing Letter-Speech Sound Learning and Reading Network Activation With Transcranial Electrical Stimulation
This study investigates the effects of transcranial electrical stimulation (tES) on the brain and its potential to enhance reading-related learning.
- Conditions
- Dyslexia, Developmental, Reading, Dyslexia, Learning
- Trial name
- LexiStim (NCT07546292)
- Testing
- Transcranial random noise stimulation
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Silvia Brem
Neurofeedback, Cognitive Training
Neurofeedback Removal of Emotional Information From Mind
This project will examine whether individuals can be trained, using real-time feedback about brain function during neuroimaging, to effectively remove thoughts from mind by providing them with a sense of what it feels like to…
- Conditions
- Neurofeedback, Cognitive Training, Memory, Short-Term, Functional Magnetic Resonance Imaging (fMRI)
- Trial name
- remtrain (NCT06460207)
- Testing
- fMRI neurofeedback
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Pulmonary Disease, Pulmonary Hypertension
Natural History Study of Biomarkers in Pulmonary Arterial Hypertension
Background: High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a rare disorder. Some people have disease-associated PAH and some have PAH from an unknown cause.
- Trial name
- NCT01730092
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Amyotrophic Lateral Sclerosis
Study of Structural and Functional Brain Connectivity Changes in ALS (CoALS-II)
This study will try to understand the difference in brain structure between ALS patients and healthy people of similar age. ALS is a condition affecting the nervous system with disruption of the brain networks.
- Trial name
- CoALS-II (NCT05404867)
- Testing
- fMRI
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Healthy Aging
Evaluating the Neurocomputational Mechanisms of Explore-Exploit Decision Making in Older Adults
The full experiment involves participants coming into the lab on five separate occasions for neuropsychological testing, a decision making battery, functional and structural MRI, and two TMS sessions for stimulation of the target…
- Trial name
- NCT05178381
- Testing
- Continuous theta burst transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Orthotopic Neobladder
The Supraspinal Control of Lower Urinary Tract Function in Patients With Orthotopic Sigmoid Neobladder.
Orthotopic sigmoid neobladder surgery is one of the ideal urinary diversion methods after radical cystectomy.In recent years, functional imaging studies have revealed brain regions related to urinary system function, but brain…
- Trial name
- NCT05558111
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Irritable Bowel Syndrome
Pilot Study of the Physiological Effects of an Integrative Medicine Approach in Irritable Bowel Syndrome
Although underutilized, what is emerging as one of the best ways of evaluating inflammation in the body, particularly in difficult to observe regions, is through the use of Fluorodeoxyglucose (FDG) positron emission tomography…
- Trial name
- IBS (NCT03370614)
- Testing
- IBS Group, Healthy Control Group
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Healthy Children, Preterm Birth
Executive Training and Brain in Children
The purpose of this study is to determine whether a daily executive training to cognitive inhibition, working memory or mindfulness as compared to an active control condition has a near- and far-transfer impact on brain and…
- Trial name
- APEX (NCT02989116)
- Testing
- Inhibition training, Working memory training, Mindfulness training
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Urinary Incontinence
Functional Assessment and Muscle Evaluation Through Exercise Trial
The purpose of this study is to decrease rates of urinary incontinence in older women by building strength in the pelvic and lower body muscle through exercise and rehabilitation.
- Trial name
- FAME (NCT03166150)
- Testing
- Multi-modal rehabilitation program, Pelvic Floor Physical therapy
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Howard University
Cerebrovascular Circulation, Magnetic Resonance Imaging
Brain Blood Flow Responses During Exercise
Brain blood flow will be measured during exercise using magnetic resonance imaging.
- Trial name
- NCT05864950
- Testing
- MRI
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy
Latin American Multicenter Cardiovascular Magnetic Resonance Reference Study
This study was designed to investigate the physiological properties of adult heart using cardiovascular magnetic resonance imaging in normal volunteers in Latin America.
- Trial name
- NCT01030549
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Obsessive-Compulsive Disorder
Control and Reward Circuits in Obsessive Compulsive Disorder
The purpose of this study is to examine the brain functioning of OCD patients and healthy controls before and after treatment with Exposure and Response Prevention (EXRP) therapy.
- Trial name
- NCT02221518
- Testing
- Exposure & Response Prevention (EX/RP)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Memory Disturbances
Functional Magnetic Resonance Imaging Study of Jaw-tapping Movement on Memory Function
The purpose of this study is to examine the possibility of using jaw-tapping training as a self-exercise for developing memory and preventing dementia in elderly subjects with memory disturbances using functional magnetic…
- Trial name
- NCT01873664
- Testing
- Jaw-tapping
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Brain Glioma, Midazolam
The Effects of Mild Sedation on Motor Function Networks in Patients With Brian Gliomas
It has been shown through functional MRI (Magnetic Resonance Imaging) that patients with gliomas in eloquent areas have compensated neurological function by virtue of brain post-injury reorganization.
- Conditions
- Brain Glioma, Midazolam, Dexmedetomidine
- Trial name
- NCT03984240
- Testing
- Midazolam, Dexmedetomidine
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Gender Identity Disorder
Effects of Sex Steroid Hormones on Human Brain Function, Structure and Connectivity
This ultrahigh-field MRI study gives us the unique opportunity to measure changes in brain function and structure induced by long-term opposite-sex steroid hormone administration in transsexual subjects. Our aim is 1.
- Trial name
- NCT01292785
- Testing
- Hormones
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cocaine Dependence
Pharmacologic MRI in Cocaine Addiction
In the proposed study, the investigators will assess the brain response to medication probes the investigators have previously studied with SPECT.
- Trial name
- phMRI (NCT01652378)
- Testing
- ondansetron, lidocaine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center