Clinical trials: Magnetic Resonance Spectroscopy Imaging
Obesity
Hyperpolarized Xenon-129 Magnetic Resonance Imaging and Spectroscopy of Brown Fat: Healthy Adult Volunteer Pilot Study
The primary goal of this study is to evaluate the feasibility of detecting Brown Adipose Tissue (BAT) in healthy subjects by using hyperpolarized xenon gas MRI.
- Trial name
- NCT02220426
- Testing
- Xenon
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
ADHD - Attention Deficit Disorder With Hyperactivity
Brain Stimulation and Attention Control in Children With ADHD
The goal of this clinical trial is to learn if brain stimulation can help children ages 6 to 12 with attention-deficit/hyperactivity disorder (ADHD) improve their attention and self-control.
- Trial name
- NCT07182344
- Testing
- Intermittent Theta Burst Stimulation to Right DLPFC
- Where
- 2 sites in Kazakhstan
- Volunteers
- 40 people
- Sponsor
- Neurolab Plus
Normal Physiology
Development of 3T Magnetic Resonance Research Methods for NIA Studies
Background: Magnetic resonance imaging (MRI) studies provide important information on the structure and function of various body systems, including the brain, muscles, joints, heart, and blood vessels.
- Trial name
- NCT01324206
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Stroke, Motor Cortex; Lesion
Imaging Laterality in Chronic Stroke Patients
In healthy individuals, unimanual movement (with either the left or right hand) is associated with activity in a network of predominantly contralateral brain regions, including the primary motor cortex (PMC).
- Trial name
- NCT03584425
- Testing
- Rasch modified version of the Fugl-Meyer Motor assessment, Anatomical image acquisition, Functional MRI task and acquisition
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Lead Exposure
MR Assessment of Brain Function Altered by Lead Exposure
Exposure to lead during pregnancy, infancy, and childhood increases the individual likelihood of impaired school performance, increased impulsiveness, aggression, and delinquent behavior.
- Trial name
- NCT00283647
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Inflammation, Fatigue
Effects of Riluzole on CNS Glutamate and Fatigue in Breast Cancer Survivors With High Inflammation
The goal of the proposed research is to determine whether riluzole, a drug that increases glutamate reuptake, will decrease central nervous system (CNS) glutamate in breast cancer survivors with increased inflammation and…
- Trial name
- NCT02796755
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Angina, Heart Disease
Impact of Ranolazine on Myocardial Ischemia Detected by High-Field 3T Cardiovascular Magnetic Resonance (CMR) Imaging and P-31 Spectroscopy
Evaluation of use of ranolazine in patients with stable heart pain with cardiac magnetic resonance imaging (CMRI) and phosphorous-31 magnetic resonance spectroscopy (31P MRS).
- Trial name
- NCT01804543
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Westside Medical Associates of Los Angeles
Polycystic Ovary Syndrome
Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS)
The aim to evaluate whether activation of the hypothalamic-pituitary-gonadal axis in PCOS is associated with transient microstructural and metabolic changes in the female hypothalamus using MRI approaches to assess water…
- Trial name
- MRI-PCOS (NCT03043924)
- Testing
- Cyproterone Acetate + estradiol, Levonorgestrel, Ethinyl Estradiol 0.1-0.02Mg Oral Tablet
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Treatment-Resistant Depression
Functional and Neurochemical Correlates of Treatment Response in Major Depressive Disorder
This is an ancillary study to a clinical trial that is being conducted at Massachusetts General Hospital. Investigators at MGH are conducting a clinical trial to test the efficacy of ziprasidone together with escitalopram for…
- Trial name
- NCT01598324
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mclean Hospital
Genotype, Allelic Frequencies of Genetic Markers
Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers
The purpose of this study is to use brain imaging technology to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers.
- Conditions
- Genotype, Allelic Frequencies of Genetic Markers, Brain Mapping, Brain Disease
- Trial name
- NCT00001284
- Where
- United States
- Volunteers
- 2,802 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy
Magnetic Resonance Imaging and Spectroscopy at High Field
Evaluating novel MR imaging techniques on volunteers.
- Trial name
- NCT00611013
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Major Depressive Disorder
Use of Multiple Brain Imaging Modalities (PET and MRS) to Identify Metabolic Abnormalities in Major Depression
Several lines of evidence support the existence of an underlying abnormality in brain energy metabolism may play a key role in the biology of mood disorders.
- Trial name
- NCT01465165
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Paul Carlson
Primary Progressive Aphasia(PPA)
Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia
This is a monocenter randomized controlled clinical trial with cross-over arm - assessor blinded. The aims is investigating the effects of the speech language therapy (SLT) alone vs SLT + non-invasive brain stimulation (STIM)…
- Trial name
- NCT06921265
- Testing
- Training with Speech Language Therapy, Standard rTMS, Targeted rTMS
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
HIV, Cardiovascular Disease
Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology
Background: Antiretroviral therapy has increased the lifespan of people with human immunodeficiency virus (HIV), but recent research suggests that people with HIV also have an increased risk of developing cardiovascular disease.
- Trial name
- NCT01089114
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Traumatic Brain Injury
A Pilot Trial of Citicoline in Individuals With Mild Traumatic Brain Injury (mTBI)
This investigation will explore the impact of 8 weeks of citicoline treatment on cognitive function, clinical state and substance use in 40 individuals with mild traumatic brain injury (mTBI).
- Trial name
- NCT01591759
- Testing
- Citicoline
- Where
- United States
- Sponsor
- Mclean Hospital
Primary Progressive Multiple Sclerosis
Clinical Trial of Idebenone in Primary Progressive Multiple Sclerosis (IPPoMS)
Background: Multiple sclerosis (MS) is an inflammatory disorder of the central nervous system that progressively weakens and destroys the pathways of the nervous system.
- Trial name
- IPPoMS (NCT00950248)
- Testing
- Idebenone
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Parkinson Disease, Idiopathic Parkinson Disease
Effect of Meditation and Controls and Subjects With Parkinson's Disease on Brain Activity Measured by fMRI With FDOPA
The purpose of this research is to use 18 F Fluorodopa positron emission tomography (FDOPA PET) to measure dopamine function, and utilize magnetic resonance imaging (MRI) to measure inflammatory and oxidative stress markers in…
- Trial name
- FDOPAOM (NCT05103618)
- Testing
- [F-18] Fluorodopa Positron Emission Tomography, OM Meditation
- Where
- United States
- Sponsor
- Andrew Newberg
Cancer
Lactate Imaging as a Tumour Biomarker
This project is designed to investigate whether measurements of lactate in tumours, made using a magnetic resonance technique similar to MRI, is an effective non-invasive method to detect whether some new targeted drugs are…
- Trial name
- NCT01881386
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Neurodegenerative Diseases, Mild Cognitive Impairment
Magnetic Resonance Imaging (MRI) of Brain Iron in Neurodegenerative Disease
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis are recognized as a major health concern at the present time.
- Trial name
- NCT00249080
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Prostatic Neoplasm
High Field Magnetic Resonance Spectroscopy Imaging for Follow Up of Prostate Cancer Post Brachytherapy Implantation
The purpose of this study is to establish the correct scanning parameters for obtaining good quality 3 Tesla (3T) magnetic resonance spectroscopy images (MRSI) of the prostate gland before and after brachytherapy implantation for…
- Trial name
- NCT00126854
- Testing
- Magnetic Resonance Spectroscopy Imaging
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- AHS Cancer Control Alberta