Clinical trials: Magnetoencephalography (MEG)
Normal Physiology
Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array
Background: Brain activity produces magnetic fields. These fields can be measured outside the head. Existing technology, called MEG, measures these fields. Researchers are testing a new type of magnetic field sensor called OPM.
- Trial name
- NCT04950309
- Testing
- SQUID MEG, OPM MEG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cognition
Study to Test the Usefulness of Magnetoencephalography (MEG) Imaging of Cognition in Children and Adolescents
The primary objective of this protocol is to test the feasibility and utility of obtaining magnetoencephalography (MEG) recordings in healthy children and also in children who have a psychiatric or developmental disorder.
- Trial name
- NCT00924300
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Real HD-tDCS, Sham HD-tDCS
Determining the Specificity of High Definition Electrical Brain Stimulation Using Simultaneous Magnetoencephalography
Non-invasive human brain stimulation using weak transcranial direct-current stimulation (tDCS) has been thousands of times in research studies over the past fifteen years as a therapy to help improve the effectiveness of repeated…
- Conditions
- Real HD-tDCS, Sham HD-tDCS, Visual Task, Motor Task
- Trial name
- NCT02060708
- Testing
- HD-tDCS
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Epilepsy (Treatment Refractory), Epilepsy in Children
OPM MEG in Pre-surgical Mapping for Patients With Epilepsy
Magnetoencephalography, or "MEG", is a brain-scanning method which has been available for many years. It is used in the UK and worldwide to help patients with epilepsy, who need surgery to resolve their seizures.
- Conditions
- Epilepsy (Treatment Refractory), Epilepsy in Children, Epilepsy in Youth
- Trial name
- NCT07378397
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Aston University
Autism Spectrum Disorder (ASD)
Non-Helium Magnetoencephalography in Autism Spectrum Disorder
The goal of this observational study is to learn how brain activity in children with autism spectrum disorder (ASD) differs from typical developing children using magnetoencephalography (MEG).
- Trial name
- NCT07064967
- Testing
- Magnetoencephalography
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Alzheimer's Disease
Improved Diagnosis of Alzheimer's Disease Using Magnetoencephalography (MEG)
The current study is intended to enrich and extend the database of Alzheimer's Disease (AD) and healthy control (HC) MEG scans and will include patients meeting DSM-IV-TR criteria for dementia of Alzheimer's type, and age- and…
- Trial name
- NCT00973518
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Orasi Medical, Inc.
Severe Permanent Uni or Bilateral Non-pulsatile Tinnitus, Without Associated Vestibular Pathology
Evaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS)
This pilot study aims at evaluating the effectiveness of the treatment of unilateral or bilateral, non-pulsatile, disabling, tinnitus, without vestibular dysfunction, using Deep Brain Stimulation (DBS) of the parieto-insular…
- Conditions
- Severe Permanent Uni or Bilateral Non-pulsatile Tinnitus, Without Associated Vestibular Pathology, Resistant to Therapeutic Failure, With or Without Hearing Loss
- Trial name
- TINNOP3-DBS (NCT04296097)
- Testing
- DBS
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Grenoble
Healthy Volunteers
Adjustment Exploratory Protocols and Functional Evaluation of New Non Invasive Devices in Healthy Volunteers
Parameters, sequences or paradigms optimisation in view of data quality and relevancy improvement.
- Trial name
- MAP-EFNI (NCT02790411)
- Testing
- Imaging devices, New Non Invasive Devices
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Epilepsy
Evaluation of the FYNA Research OPM MEG Device for Locating Epileptic Foci as Part of Pre-surgical Assessment of Epilepsy
The success of epilepsy surgery depends largely on the reliability of the preoperative localization of the epileptogenic zone. The conventional method for determining the area to be removed is based on a complex assessment…
- Trial name
- EPI-OPM (NCT07281222)
- Testing
- MEG OPM, MEG SQUID
- Where
- 3 sites in France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Primary Progressive Aphasia
HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms
This study aims to evaluate the effectiveness of a therapy called High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for the treatment of the language deficits experienced by people with a type of Primary…
- Trial name
- NCT03805659
- Testing
- HD-tDCS
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Medical College of Wisconsin
Brain Activity
Brain Activity by Magnetoencephalography for Children
Investigate the differences in activation of brain networks during performing functional tasks for children with attention deficit hyperactivity disorder with developmental delays and typical development
- Trial name
- NCT04629482
- Testing
- Brain networks activity
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Chronic Pain
Imaging Non-brain Electromagnetic Activity in Healthy Adults Using MEG
The primary purpose of this study is to determine the effectiveness of the Magnetoencephalography (MEG) instrument to record electrical activity from parts of the body other than the brain.
- Trial name
- BODMEG (NCT03232723)
- Testing
- Whole-cortex MEG System (with optional EEG)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Depression, Major Depressive Disorder
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
Background: Most drugs that treat mood disorders take a long time to work. Ketamine works within hours. A dose can last for a week or more. Certain receptors in the brain might help ketamine work.
- Conditions
- Depression, Major Depressive Disorder, Major Depression
- Trial name
- NCT03973268
- Testing
- Arm 1, 2, 3 device interventions, Arm 2 Interventions, Arm 1, 2, 3 drug Interventions
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Mental Health (NIMH)
Autoimmune Encephalitis (AE), Acute Disseminated Encephalomyelitis
OPM- MEG in Non-immune And iMmune-medIated Neurological Disease
Over the past 20 years, doctors have gotten much better at spotting and treating brain conditions caused by the immune system attacking the body. These include illnesses like autoimmune encephalitis, ADEM, and multiple sclerosis.
- Conditions
- Autoimmune Encephalitis (AE), Acute Disseminated Encephalomyelitis, Multiple Sclerosis
- Trial name
- O-MEG-A-MIND (NCT07689682)
- Testing
- OPM- Magnetoencephalography
- Where
- 2 sites in United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aston University
Healthy Volunteers
Spatial and Dynamic Characterization of Brain Activity for Language and Posture (Verticality) During Normal Aging. Magnetoencephalography (MEG) Study (MEG-AGING)
Depending on the point of view, different definitions of aging have been proposed. Thus, at the biological level, aging corresponds to a natural physiological process that leads to the progressive degeneration of cells and the…
- Trial name
- MEG-AGING (NCT04036162)
- Testing
- Cognitive tasks
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Schizophrenia, Normal Physiology
Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers
The purpose of this study is to use brain imaging technology to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers.
- Trial name
- NCT00004571
- Where
- United States
- Volunteers
- 3,273 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Autism Disorder
MEG Study of Acute STX209 Effects in ASD
This is a single-site, randomized, acute dose-response study to determine whether STX209 produces a dose-dependent significant change in MEG target parameters compared to baseline as well as compared to placebo treatment.
- Trial name
- NCT02278328
- Testing
- STX209 (15mg), STX209 (30mg)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Timothy Roberts
Deep Brain Stimulation, Parkinson Disease
The BRAINMAP-DBS Study: BRain Network AnalysIs usiNg 7-Tesla MRI and MAgnetoencephalograPhy for Deep Brain Stimulation
Rationale: Deep brain stimulation (DBS) is an effective treatment for essential tremor and Parkinson's disease. The effect of DBS relies on the modulation of dysfunctional motor brain networks and on average 50% motor improvement…
- Conditions
- Deep Brain Stimulation, Parkinson Disease, Essential Tremor, Magnetoencephalography (MEG)
- Trial name
- BRAINMAP-DBS (NCT06932692)
- Testing
- magnetoencephalography
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Fibromyalgia
Brain Rhythms in Fibromyalgia: A Magnetoencephalography (MEG) Study
The long-term purpose of the investigator's research is to understand the pathophysiological basis of chronic pain. This will help provide a framework for the development of effective treatments.
- Trial name
- FMP (NCT02159300)
- Testing
- experience brain activity recording
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Mild Traumatic Brain Injury (mTBI), Post-traumatic Stress Disorder
Transcranial Electrical Stimulation for mTBI
mTBI is a leading cause of sustained physical, cognitive, emotional, and behavioral deficits in OEF/OIF/OND Veterans and the general public.
- Trial name
- TESmTBI (NCT03244475)
- Testing
- TES
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development