Clinical trials: Major Depression Disorders
Major Depressive Disorder
Regulation of Affect and Physiology in Depression
Although treatments for depression are effective for many people, not everyone responds to treatment. This lack of treatment response could be due, in part, to the presence of multiple underlying causes of people's depression.
- Trial name
- RAPID (NCT06345859)
- Testing
- Heart rate variability biofeedback
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Major Depressive Disorder, Anxiety Disorder
The Development of Skin Adhesive Patches for the Monitoring and Prediction of Mental Disorders
development of skin adhesive patches for the monitoring and prediction of mental disorders
- Trial name
- NCT02690324
- Testing
- cognitive stress (serial 7)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Depressive Disorder, Major
A Study of GW856553X For the Treatment of Depression
GW856553 is a novel compound, currently in development for the treatment of Major Depressive Disorder (MDD), and other indications.
- Trial name
- NCT00569062
- Testing
- GW856553X
- Where
- 15 sites in Estonia, India and 1 more
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
General Psychopathology, Fatigue
An Energetic View on Creativity, Psychopathology and Intelligence: The Brain2Business Study
The interventional part of the study aims to assess the acute effect of the Brain2Business (B2B) tool on creative thinking (primary objective) in adults with psychological disorders.
- Conditions
- General Psychopathology, Fatigue, Depressive Disorder, Major
- Trial name
- B2B (NCT05544877)
- Testing
- Integrated 5-day Gratitude Exercise and Behavioral Activation Program
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Psychiatrische Dienste Thurgau
Anxiety Disorders, Major Depressive Disorder
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
Study Description: This study examines relations between neurocognitive and clinical features of pediatric anxiety disorders. The study uses neuro-cognitive tasks, functional magnetic resonance imaging (fMRI), as well as magneto…
- Trial name
- NCT00018057
- Testing
- Attention Bias Modification Training, Fluoxetine, Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Multiple Sclerosis, Depressive Disorder, Major
Depression and Immune Function in Multiple Sclerosis (MS)
Depression is one of the most common symptoms of multiple sclerosis (MS) with a life-time prevalence of major depressive disorder (MDD) of up to 50%.
- Trial name
- DENIM (NCT02740296)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Depression - Major Depressive Disorder, Bipolar
Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health Trajectories
Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health (BLOOM) is a project that aims to overcome age and diagnostic boundaries to generate person-specific longitudinal profiles of mental…
- Conditions
- Depression - Major Depressive Disorder, Bipolar, Psychosis, Eating Disorder NOS
- Trial name
- BLOOM (NCT06978452)
- Where
- Canada
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Depressive; Episode, Major, Depression, Postpartum
Diagnostic Accuracy of the Stepped Screening Protocol and Its Screening Tools in the Perinatal Period.
It is known that 1 in 5 women experience psychological difficulties during their pregnancy or in the first year after giving birth.
- Conditions
- Depressive; Episode, Major, Depression, Postpartum, Anxiety Disorders, Obsessive-Compulsive Disorder
- Trial name
- DAS (NCT05961306)
- Testing
- SCID 5
- Where
- 2 sites in Belgium
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Major Depression Disorder
Molecular Signatures of TMS Response in Treatment-Resistant Depression
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option for treatment-resistant depression (TRD).
- Trial name
- PROMET_TMS (NCT07039370)
- Testing
- TMS
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Major Depressive Disorder
International Study to Predict Optimised Treatment - in Depression
The aim of this study is to identify genetic, physical (brain) and psychological (cognitive) markers (or combinations of them) that predict specific response to a range of antidepressants treatment (Escitalopram, Venlafaxine…
- Trial name
- iSPOT-D (NCT00693849)
- Testing
- Escitalopram, Sertraline, Venlafaxine-XR
- Where
- 20 sites in United States, Australia and 3 more
- Volunteers
- 2,688 people, healthy volunteers welcome
- Sponsor
- BRC Operations Pty. Ltd.
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Glutamate Probes in Adolescent Depression
The purpose of this study is to learn if measures of brain chemicals from a brain scan called Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) and brain activity (known as cortical excitability and inhibition) collected by…
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Major Depressive Disorder, Remitted
- Trial name
- GPII (NCT02307617)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Depression, Major Depressive Disorder
Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression
Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD.
- Conditions
- Depression, Major Depressive Disorder, Cardiovascular Disease, Coronary Artery Disease
- Trial name
- NCT00818506
- Where
- Denmark
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Major Depressive Disorder
Enhancing Psychotherapy for Mood Disorders With Whole Body Hyperthermia
According to the 2005 National Comorbidity Survey-Replication study, approximately 20.9 million American adults, or 9.5 percent of the population over the age of 18 suffer from mood disorders including major depressive disorder…
- Trial name
- NCT02021149
- Testing
- High intensity whole-body infrared heating, Psychotherapy, Questionnaires
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Charles (Chuck) Raison
Major Depressive Episode, Covid19
Neuroinflammation in COVID-19 and Depression
The purpose of this study is to use state of the art brain imaging technology to investigate neuroinflammation in participants with depression after the respiratory symptoms of coronavirus disease 2019 (COVID-19) have passed.
- Trial name
- NCT04854785
- Testing
- [18F]FEPPA PET scan, [11C]SL25.1188 PET scan
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Type1diabetes, Depressive Symptoms
Type 1 Diabetes and Depression: Role of Brain Glutamate
The goal of this study is to examine the effect of chronic and acute hyperglycemia in type 1 diabetes mellitus (T1DM) on brain glutamate levels using magnetic resonance spectroscopy (MRS), and associations of brain glutamate with…
- Conditions
- Type1diabetes, Depressive Symptoms, Major Depressive Disorder
- Trial name
- NCT05355285
- Testing
- Glucose Clamp
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Major Depressive Disorder
Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD).
- Trial name
- NCT05523817
- Testing
- Intermittent Theta Burst Stimulation (iTBS)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Treatment Resistant Depression
Ketamine Frequency Treatment for Major Depressive Disorder
Depression is a wide spread illness. Depression contributes most significantly to national health care costs. While the number and types of treatments used for depression have expanded over the years, even with an increased range…
- Trial name
- NCT00646087
- Testing
- Ketamine, Ketamine/Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Essentia Health
Major Depressive Episode
Depressive Symptoms and Subjective Stress in the Course of the Menstrual Cycle - an Ambulatory Assessment Study.
Background: Major changes in female sex hormone concentrations influence the development of depressive symptoms in women. This hypothesis has been thoroughly investigated with regard to the menopause, the postpartal phase and…
- Trial name
- DepCy (NCT04086316)
- Where
- Germany
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Freie Universität Berlin
Major Depressive Disorder, Healthy Volunteer
First-In-Human (FIH), Single Ascending Dose (SAD) Study and Multiple Ascending Dose (MAD) Study of SP-101 Injection
The goal of this First-In-Human (FIH) trial is to learn about safety, tolerability and pharmacokinetics of single and multiple ascending doses of SP-101 in healthy adult volunteers.
- Trial name
- NCT07334249
- Testing
- SP-101 injection
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Synphatec (Shanghai) Biopharmaceutical Technology Co., Ltd.
Major Depression
Neuroimaging Sleep and Mood in Depression
This study will investigate how sleep and mood are related in patients with depression and in healthy controls. It will use MRI-based measures of brain function to determine how neural systems are modulated by sleep and sleep…
- Trial name
- NCT05497414
- Testing
- Sleep deprivation
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus