Clinical trials: Major Depression Disorders
Major Depressive Disorder, Recurrent, Depressive Episode
Confirmation Bias Towards Treatments of Depressive Disorders in Social Tagging
The study examines whether people primarily want to confirm their prior attitudes in health-related information search, in an online environment using social tags for navigation.
- Conditions
- Major Depressive Disorder, Recurrent, Depressive Episode, Depressive Disorder, Major, Depression
- Trial name
- NCT03899168
- Testing
- Social Tag Popularity, Confidence in Prior Attitudes, Source Credibility
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Leibniz-Institut für Wissensmedien
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Hypoactive Sexual Desire Disorder, Female Sexual Arousal Disorder
Effects of Early Abuse on Adult Intimate Relationships
This study is designed to help us better understand the factors that affect the sexual lives of women who have been sexually mistreated during childhood.
- Conditions
- Hypoactive Sexual Desire Disorder, Female Sexual Arousal Disorder, Female Orgasmic Disorder, Major Depressive Disorder
- Trial name
- NCT01803802
- Testing
- Expressive writing
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Major Depressive Disorder
miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome
The purpose of this study is to examine whether neural-derived exosomal miRNAs are differentially expressed that are specific to suicidal ideation or behavior, and which by affecting specific miRNA targets and pathways, are…
- Trial name
- NCT02418195
- Testing
- ketamine
- Where
- United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Major Depressive Disorder
Dose Escalation, Double-Blind Treatment With Duloxetine Hydrochloride Once Daily Dosing for Evaluation of Safety in Major Depression
The Purposes of this Study are to determine: The safety of duloxetine and any side effects that might be associated with it. Whether duloxetine can help patients with major depression.
- Trial name
- NCT00042575
- Testing
- Duloxetine
- Where
- 9 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder
A Study of Individualized Diagnosis and Treatment for Major Depressive Disorder With Atypical Features
The lifetime prevalence of major depressive disorder (MDD) is 10%~20%. Worldwide, nearly 340 million individuals have suffered the torture of depression.
- Trial name
- NCT04209166
- Testing
- SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/ Serotonin and Norepinephrine Reuptake Inhibitors), SSRIs/SNRIs+Mood Stabilizer, SSRIs/SNRIs+Quetiapine
- Where
- 5 sites in China
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Depression, Anhedonia
Dimensional Approach to Evaluate Reward Processing in Major Depressive Disorder Pre- and Post-Desvenlafaxine Treatment
Anhedonia (the lack of pleasure in normally pleasurable things) is a common symptom of major depressive disorder (MDD), and it may impact how patients with depression experience reward.
- Trial name
- NCT02859103
- Testing
- Desvenlafaxine
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Major Depressive Disorder
Epigenetic Regulation of BDNF in Major Depression
The investigators will (1) detect the associations between brain-derived neurotrophic factor (BDNF) DNA methylation, histone modification, depressive symptoms, suicidal behavior and antidepressant responses in major depressive…
- Trial name
- NCT01182103
- Where
- Taiwan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Treatment Resistant Depression (TRD), Transcranial Magnetic Stimulation
Accelerated Transcranial Magnetic Stimulation in Treatment-Resistant Depressed Patients
Depression is the leading cause of disability worldwide and around 800,000 suicides occur each year. According to the World Health Organization, major depressive disorder (MDD) is expected to be the leading cause of the global…
- Conditions
- Treatment Resistant Depression (TRD), Transcranial Magnetic Stimulation, Accelerated Protocol, Sham-controlled
- Trial name
- NCT06783361
- Testing
- Transcranial Magnetic Stimulation with figure-eight coil
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Major Depressive Disorder (MDD)
Investigating Functional Changes in the Frontotemporal Cortex of Patients With Major Depressive Disorder Following Electroconvulsive Therapy or Magnetic Seizure Therapy Using Functional Near-infrared Spectroscopy (fNIRS)
Against the clinical backdrop of the growing global burden of neuropsychiatric disorders, the rapid rise in depression prevalence, and the frequent association of these conditions with cognitive impairment, this study highlights…
- Trial name
- NCT07533773
- Testing
- Electroconvulsive Therapy, Magnetic Seizure Therapy
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Anhui Medical University
Major Depressive Disorder
Testing the Neuroscience of Guided Learning in Depression
Major depression is a prevalent and impairing illness. To better understand the basic science and treatment of depression, the investigators study the behavioral and brain processes associated with learning in depression and how…
- Trial name
- NCT03203954
- Testing
- Standard Learning, Guided Learning: Instructed statistics, Guided Learning: Changing statistics
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Major Depressive Disorder
Action Tendencies and Prognosis in Major Depressive Disorder
Predicting the prognosis and treatment responses in individuals with major depressive disorder (MDD) is currently based on trial and error, because some treatments work for some individuals, but not others.
- Trial name
- NCT04593537
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- King's College London
Major Depression
The Brain on Whole Body Hyperthermia: A Neuroimaging Study
The investigators have observed in an open trial that a single session of whole body hyperthermia (WBH) induced rapid antidepressant effects that persisted for at least a week in patients with major depression (MDD) severe enough…
- Trial name
- NCT02062840
- Testing
- High intensity whole-body infrared heating, Low intensity whole-body infrared heating, Functional Magnetic Resonance Imaging (fMRI) and electrocardiogram (EKG)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Major Depressive Disorder, Major Depressive Episode
Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder (MDD) (DEPARRESTCLIN)
Predictive factors and biomarkers of response to antidepressants in major depressive disorder are scarce. Beta-arrestins are proteins which inhibit G Protein Coupled Receptors and desensitize serotonergic and dopaminergic…
- Trial name
- DEPARRESTCLIN (NCT02051413)
- Testing
- Venlafaxine extended release
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Bipolar Disorder, Major Depression
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
Background: Mood disorders, such as bipolar disorder, can have serious effects on a person s life. People with bipolar disorder are more likely to have heart disease and abuse substances.
- Conditions
- Bipolar Disorder, Major Depression, Migraine
- Trial name
- NCT05669703
- Where
- United States
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
Mindfulness-Based Cognitive Therapy Effect on Depression and C-Reactive Protein Levels After 8 Weeks of Treatment
This study will investigate the efficacy of an 8-week course in Mindfulness-Based Cognitive Therapy (MBCT) for adults with major depressive disorder (MDD) by ;measuring change from baseline to completion of treatment at 8 weeks…
- Trial name
- NCT02385786
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Major Depressive Disorder
Safety and Tolerability of Zelquistinel in Normal Human Volunteers
To evaluate the safety and tolerability of single ascending doses of zelquistinel in normal human volunteers
- Trial name
- NCT04981561
- Testing
- zelquistinel
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Syndeio Biosciences, Inc
Depression
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
Background: Major depressive disorder (MDD) is a psychiatric condition. People with MDD have occasional bouts of depressive symptoms; these bouts are called major depressive episodes (MDEs).
- Trial name
- NCT05703685
- Testing
- Lung scan, Apremilast, 18F-PF-06445974
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Major Depressive Disorder
Tai Chi Training for Treating Depressed Chinese Americans
The goal of this research is to evaluate whether Tai Chi merits further investigation as a non-pharmacological therapy in the treatment of Major Depressive Disorder (MDD).
- Trial name
- NCT01263730
- Testing
- Tai Chi
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital