Clinical trials: Major Depression Disorders
Depressive Disorder, Major
A Study to Evaluate the Effect of Clarithromycin on LY2216684
The study will evaluate the effect of Clarithromycin on the pharmacokinetics (PK) of LY2216684 in healthy participants. Side effects will be documented.
- Trial name
- NCT01460407
- Testing
- LY2216684, Clarithromycin
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder
Prevalence of Major Depression Among Immigrants in Santiago, Chile
The general aim of this study is to explore the prevalence of major depressive disorder and the use of mental health services in the immigrant populations in the Metropolitan Region of Santiago, Chile. The hypotheses are: 1.
- Trial name
- STRING (NCT04114565)
- Where
- Chile
- Volunteers
- 1,092 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Depression - Major Depressive Disorder, Anxiety
Singula Phase 0.1 Primary Care Pilot
This prospective, single-arm, observational pilot study evaluates a clinical decision support system developed by Singula Health for use in primary care.
- Trial name
- NCT07834684
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Singula Health, Inc.
Post Traumatic Stress Disorder, Insomnia Disorder
RESILIENT : A Self-Managed Online Platform for Victims of Sexual Assault
There are 636,000 self-reported cases of sexual assault annually in Canada, and nine out of ten persons who have experienced sexual assault are women.
- Conditions
- Post Traumatic Stress Disorder, Insomnia Disorder, Major Depressive Disorder
- Trial name
- NCT05811897
- Testing
- Self-Managed Online Treatment, Therapist-Assisted Online Treatment
- Where
- Canada
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Laval University
Depression - Major Depressive Disorder, Anxiety
AcceXible Speech-Based Screening for Depression and Anxiety in University Students (UAQ, Mexico)
Major depressive disorder (MDD) and anxiety are increasingly prevalent among university student populations, yet early detection remains reliant on psychometric instruments tied to diagnostic criteria (e.g., PHQ-9, GAD).
- Trial name
- NCT07578142
- Testing
- Accexible
- Where
- Mexico
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Accexible
Major Depressive Disorder
PET Biomarkers in Treatment Resistant Depression
The primary objectives of the study are to test whether brain Mono Amine Oxidase-A (MAO-A) levels are elevated in patients with treatment-resistant major depression, and to explore whether MAO-A brain levels predict treatment…
- Trial name
- NCT01031810
- Testing
- tranylcypromine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder, Depression
Investigating Biological Markers, Targets, and Intervention for Mood Disorders
This multi-modal methods study will investigate neurophysiological, endocrinological, cognitive, psycho-social-emotional markers of disease, and targets for integrative health treatments in mood disorders.
- Conditions
- Major Depressive Disorder, Depression, Stress
- Trial name
- NCT04632498
- Testing
- Mindfulness Based Intervention
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Depression - Major Depressive Disorder
Development of Attentional Biases for Affective Cues in Infants of Mothers With Depression
The goal of this study is to examine attentional biases for facial displays of emotion as a mechanism of risk in infants of mothers with postpartum major depression, and the potential role of infant arousal in the development of…
- Trial name
- NCT06835855
- Testing
- Passive Viewing Task, Interaction Task
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Binghamton University
Depression
Effectiveness of Telephone Versus Face-to-Face CBT in Treating People With Depression
This study will compare the effectiveness of telephone versus face-to-face administration of cognitive behavioral therapy in treating people with depression.
- Trial name
- NCT00498706
- Testing
- Telephone-administered cognitive behavioral therapy (T-CBT), Face-to-face administered CBT (FtF-CBT)
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Partner Assisted Interpersonal Psychotherapy, Treatment as Usual
Partner-Assisted Interpersonal Psychotherapy or Antidepressant Medication for Antenatal Depression
Purpose: To compare a novel psychotherapy, Partner-Assisted Interpersonal Psychotherapy (PA-IPT), with treatment as usual (TAU) in a sample of pregnant women seeking treatment for Major Depressive Disorder (MDD) at the University…
- Trial name
- NCT01732055
- Testing
- Partner-Assisted Interpersonal Psychotherapy, Treatment as Usual
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Healthy
A Phase 1 Study To Investigate The Pharmacokinetics, Safety And Tolerability Of CP-601,927 In Healthy Japanese Subjects
This Phase 1 study is the first clinical trial to be conducted in Japanese subjects. The pharmacokinetics, safety and tolerability of single and multiple doses of CP-601,927 will be evaluated in Japanese, healthy, non-smoking…
- Trial name
- NCT01396135
- Testing
- CP-601,927
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Depressive Disorder, Major, Persistent Depressive Disorder
Effectiveness of an Ecological Momentary Emotion Regulation Intervention
This two-armed randomized controlled trial aims to investigate the effectiveness of an emotion regulation intervention in individuals with and without depressive disorders.
- Conditions
- Depressive Disorder, Major, Persistent Depressive Disorder, Healthy
- Trial name
- NCT06311136
- Testing
- Valence-Specific Ecological Momentary Intervention
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Major Depressive Disorder
Research on Pathophysiology and Treatment in Depression Using Brain Derived Neurotrophic Factor and Amyloid Neuroimaging
Target of the research Based on change of Brain-derived neurotrophic factor and other pro-inflammatory cytokine along with symptom improvement following treatment, the investigators are trying to find the new treatment target…
- Trial name
- NCT02983838
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Major Depressive Disorder
The Impact of Memantine on Electroconvulsive Therapy (ECT): Will it Improve Response and Protect Against Cognitive Problems?
The purpose of this study is to determine whether memantine will enhance the therapeutic of effect on depression and prevent memory and other cognitive problems caused by ECT.
- Trial name
- ECTAug (NCT00988663)
- Testing
- memantine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jerrry L Lewis
Major Depressive Disorder, Inflammation
The Relations Among Endotoxin, Inflammatory Cytokines, Cognitive Markers and Brain MRI Changes in Subjects With Depressive Disorder
Major depressive disorder (MDD) is a chronic mental illness, with 60% lifetime risk of recurrence after the first MDD episode. Despite available treatment options for MDD, only about half to two-thirds of patients respond to…
- Conditions
- Major Depressive Disorder, Inflammation, Cognitive Dysfunction, Endotoxemia
- Trial name
- NCT06203015
- Testing
- The Cambridge Neuropsychological Test Automated Battery., Venous blood samples, brain MRI
- Where
- 2 sites in Lithuania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Traumatic Brain Injury, Major Depressive Disorder
MRI Markers of Feedback Timing During Learning in Individuals with TBI with and Without Clinical Depression
The goal of this proposal is to examine the influence of feedback timing on learning and brain function in individuals with moderate-to-severe traumatic brain injury (TBI), with and without depression.
- Trial name
- NCT05009511
- Testing
- Learning through feedback
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Major Depressive Disorder, Healthy Controls
Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets
The study is investigating dysfunctions in neurocircuitry in regards to irritability with healthy controls (HC) and individuals with Major Depressive Disorder (MDD) by performing MRIs.
- Trial name
- UNIKET (NCT05046184)
- Testing
- Ketamine Hydrochloride, Midazolam injection
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Major Depressive Disorder, Smoking Reduction
Transcranial Magnetic Stimulation Theta Burst (TMS), Depression and Smoking.
This study evaluates de efficacy of Theta Burst Transcranial Magnetic Stimulation (TMS) applied on the left dorsolateral prefrontal cortex in patients with Major Depressive disorder and tobacco consumption.
- Trial name
- NCT05694754
- Testing
- Theta Burst Transcranial Magnetic Stimulation
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dr. Julian Reyes López
Mental Disorders, Severe
Measuring Development of Brain Responses to Vocal Sounds in Babies of Mums With Mental Illness
CAPRI-Voc examines the differences in how speech and environmental sounds are processed in the infant brain as they grow from 9 to 12 months.
- Trial name
- CAPRI-Voc (NCT04350294)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Major Depressive Disorder
Does Fluoxetine Have an Effect on the CNS CRF Systems in Women Abused in Childhood?
The primary objective of this project is to determine whether treatment with the SSRI, fluoxetine versus placebo reverses alterations in the central CRF system induced by early life stress experiences (i.e.
- Trial name
- NCT00208897
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University