Clinical trials: Major Depressive Disorder, Recurrent, in Remission
Major Depressive Disorder
VA Augmentation and Switching Treatments for Improving Depression Outcomes
The overall purpose is to determine research based 'next-steps' for outpatients with major depressive disorder who have not had satisfactory outcomes to standard 'first-step' treatments.
- Trial name
- VAST-D (NCT01421342)
- Testing
- Switching: Bupropion-SR, Augmenting: Antidepressant + Bupropion-SR, Augmenting: Antidepressant + Aripiprazole
- Where
- 35 sites in United States
- Volunteers
- 1,522 people
- Sponsor
- VA Office of Research and Development
Depression
Comparing Various Treatments for Achieving and Maintaining Remission of Depression
This study will evaluate the effectiveness of five combinations of drug therapy and psychotherapy in maintaining remission of depression symptoms in people with recurrent major depression.
- Trial name
- NCT00227955
- Testing
- Imipramine, Interpersonal Psychotherapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder, Recurrent, in Remission
Light and Ion Maintenance In Treatment for Depression (LIMIT-D): Feasibility Study
Antidepressants are widely used as first-line treatments for major depressive disorder (MDD). Clinical guidelines recommend 6-24 months of "maintenance" antidepressant treatment, after patients achieve symptom remission, to…
- Trial name
- NCT05423275
- Testing
- Negative ion therapy, Light therapy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Depressive Symptoms, Major Depressive Disorder, Recurrent, in Remission
The Effects of the Be Mindful Intervention in Previously Depressed Individuals Experiencing Subclinical Symptoms
This study is designed to help individuals cope with their current depressive symptoms by providing them access to a 4-week online Mindfulness-Based Cognitive Therapy: Be Mindful.
- Trial name
- NCT04740879
- Testing
- Be Mindful
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- State University of New York at Buffalo
Major Depressive Disorder
SPD489 in Adults With Persistent Executive Function Impairments (EFI) and Partial or Full Remission of Recurrent Major Depressive Disorder
To evaluate the efficacy of SPD489 for the treatment of executive function impairments (EFI) when used as an adjunct to stable, standard therapy in the setting of partial or full remission from recurrent Major Depressive Disorder…
- Trial name
- NCT00985725
- Testing
- SPD489 (Lisdexamfetamine dimesylate)
- Where
- 33 sites in United States
- Volunteers
- 143 people
- Sponsor
- Shire
Major Depressive Disorder, Recurrent, in Remission, Depressive Symptoms
Reducing Residual Depressive Symptoms With Web-based Mindful Mood Balance
Many patients report residual depressive symptoms despite seemingly successful treatment. With the investigators' previous funding, we developed - Mindful Mood Balance - an online treatment that targets RDS by teaching specific…
- Trial name
- NCT02190968
- Testing
- Usual Depression Care, Mindful Mood Balance
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- University of Toronto
Depression, Depressive Disorder, Major
Decentering and Relapse/Recurrence in MBCT for Depression in Adults
Objective: "Decentering" is defined as the ability to observe one's thoughts and feelings as temporary, objective events in the mind, and is increasingly regarded as a candidate mechanism in mindfulness-based interventions.
- Conditions
- Depression, Depressive Disorder, Major, Depression in Remission
- Trial name
- NCT05111665
- Testing
- Mindfulness-based Cognitive Therapy (MBCT), Relaxation Group Therapy (RGT), Treatment as usual (TAU)
- Where
- Canada
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Major Depressive Disorder, Recurrent, in Remission, Major Depressive Disorder, Recurrent, Mild
Mindfulness-Based Cognitive Therapy (MBCT) for the Prevention of Depression Relapse or Recurrence Using Videoconference
Objectives: To evaluate the clinical- and cost-effectiveness of two delivery formats of mindfulness-based cognitive therapy (MBCT) - (i) MBCT delivered through eight videoconference group sessions (group MBCT), and (ii) MBCT…
- Conditions
- Major Depressive Disorder, Recurrent, in Remission, Major Depressive Disorder, Recurrent, Mild, Major Depressive Disorder, Recurrent, Moderate
- Trial name
- BECOME (NCT06832605)
- Testing
- Group Mindfulness-Based Cognitive Therapy, Mindfulness-Based Cognitive Therapy Self-Help, Treatment as Usual (TAU)
- Where
- 5 sites in Spain
- Volunteers
- 342 people
- Sponsor
- Fundació Sant Joan de Déu
Depressive Disorder, Major, Recurrence
Study Evaluating Venlafaxine ER in Recurrent Depression
The purpose of this study is to review the long-term comparative efficacy of venlafaxine ER in achieving and sustaining remission (wellness) in patients with recurrent major depression
- Trial name
- NCT00046020
- Testing
- Venlafaxine ER
- Volunteers
- 1,096 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Major Depressive Disorder
Algorithm Guided Treatment Strategies for Major Depressive Disorder
The purpose of this study is to compare treatment outcomes between measurement based Algorithm Guided Treatment and Treatment As Usual strategies in a Chinese population with major depressive disorder.
- Trial name
- AGTs-MDD (NCT01764867)
- Testing
- Escitalopram, Mirtazapine, modified electroconvulsive therapy
- Where
- China
- Volunteers
- 1,080 people
- Sponsor
- Shanghai Mental Health Center
Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission
Prevention of Alzheimer's Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression (PACt-MD)
This 7-year randomized controlled trial will compare the efficacy of non-invasive brain stimulation (trans-cranial Direct Current Stimulation - tDCS) combined with cognitive remediation (CR) versus sham ("placebo") tDCS combined…
- Conditions
- Mild Cognitive Impairment, Major Depressive Disorder, Recurrent, In Remission, Major Depressive Disorder, Single Episode, in Full Remission
- Trial name
- PACt-MD (NCT02386670)
- Testing
- tDCS + CR
- Where
- 5 sites in Canada
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
Follow-up Study of Transcranial Direct Current Stimulation to Treat Major Depressive Disorder
The investigators purpose is to follow remitted patients from their previous study using transcranial direct current stimulation (tDCS); as to verify whether this treatment prevents relapse.
- Trial name
- NCT01149213
- Testing
- transcranial direct current stimulation
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- University of Sao Paulo
Major Depressive Disorder (MDD)
Predictors of Relapse in Major Depressive Disorder (PERFORM-D)
Major depressive disorder (MDD) is a common condition involving recurring periods of depression. One of the major challenges faced by people with MDD is that the episodes of depression tend to recur even after they are…
- Trial name
- PERFORM-D (NCT06746155)
- Where
- 9 sites in Canada
- Volunteers
- 252 people
- Sponsor
- Abraham Nunes