Clinical trials: Major Depressive Disorder, Remitted
Depression, Involutional
Function of Catecholamines in the Brain During Depression
This study will explore brain function related to depressive symptoms and will examine DNA for genes that may be involved in depressive disorders, particularly genes that regulate synthesis and metabolism of the brain…
- Trial name
- NCT00082030
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Unipolar Depression
Cognitive Enhancement in Unipolar Depression With Yoga
It is evident from recent studies that cognitive deficits persist even after remission of depressive episode. Hence, in this study, the investigators would like to see whether specific Yoga practice will help in enhancing…
- Trial name
- NCT06472492
- Testing
- Adjuvant yoga intervention
- Where
- India
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Depression, Depressive Disorder
Web-based Self-help Intervention for Adolescents With Acute or Remitted Major Depressive Disorder
This study aims to evaluate the feasibility and effectiveness of a web-based self-help intervention in adolescents with acute or remitted major depressive disorder.
- Conditions
- Depression, Depressive Disorder, Depressive Symptoms, Depressive Disorder, Major
- Trial name
- NCT04994470
- Testing
- Two-week web-based self-help intervention based on principles of positive psychology, Two-week web-based text messages containing fun facts
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Depressive Disorder, Depression in Adolescence
Evaluation of a Website to Improve Depression Literacy in Parents of Adolescents With Depression
The aim of this study is to evaluate the efficacy and acceptability of the website "ich bin alles" (https://www.ich-bin-alles.de/) to improve depression literacy (knowledge about depression, which aid the recognition, treatment…
- Trial name
- NCT05335564
- Testing
- General information about depression
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Depression
Brain Markers of Depression Vulnerability: the Case of Prefrontal Haemodynamic Response
Functional near infrared spectroscopy (fNIRS) offers a cheap and reliable tool to investigate prefrontal brain activation in the healthy and diseased human brain.
- Trial name
- NCT05427578
- Testing
- fNIRS measurement
- Where
- Hong Kong
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dr Georg Kranz
Mild Cognitive Impairment (MCI), Major Depressive Disorder, Remitted
Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment
The goal of this observational study is to validate the Creyos online cognitive assessment platform in individuals with mild cognitive impairment, or remitted major depressive disorder.
- Conditions
- Mild Cognitive Impairment (MCI), Major Depressive Disorder, Remitted, Healthy Controls Group - Age and Sex-matched
- Trial name
- Creyos-MD (NCT06780917)
- Where
- 3 sites in Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder (MDD)
Predictors of Relapse in Major Depressive Disorder (PERFORM-D)
Major depressive disorder (MDD) is a common condition involving recurring periods of depression. One of the major challenges faced by people with MDD is that the episodes of depression tend to recur even after they are…
- Trial name
- PERFORM-D (NCT06746155)
- Where
- 9 sites in Canada
- Volunteers
- 252 people
- Sponsor
- Abraham Nunes
Depression - Major Depressive Disorder
Discontination of Antidepressants in Remitted Depression
Overprescribing and long-term use of antidepressants (ADs) are common and may increase the risk of adverse effects and withdrawal symptoms when discontinuation is attempted.
- Trial name
- DISCARD (NCT07393919)
- Testing
- Hyperbolic tapering, Linear tapering
- Volunteers
- 150 people
- Sponsor
- Universita di Verona
Major Depression in Remission
Online Cognitive Control Training for Remitted Depressed Patients
This study evaluates the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients.
- Trial name
- NCT03278756
- Testing
- Cognitive control training, Active control training
- Where
- Belgium
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University Ghent
Major Depression in Remission
Cognitive Control Training for Remitted Depressed Patients
The purpose of this study is to explore the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients.
- Trial name
- NCT02407652
- Testing
- Cognitive Control Training, Low Cognitive Load Training
- Where
- Belgium
- Volunteers
- 68 people
- Sponsor
- University Ghent
Major Depression in Remission, Healthy
Predicting Illness Trajectories In Fully Remitted Major Depression Using Concurrent TBS/fNIRS
Major depressive disorder (MDD) is the world's leading cause of disability according to the World Health Organization. MDD is highly recurrent, even if clinical remission is reached after successful treatment.
- Trial name
- TBS/fNIRS (NCT05579015)
- Testing
- Theta-burst stimulation (TBS), telephone interviews
- Where
- China
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Depression, Involutional, Healthy
Serotonin Function During Depression
Serotonin is a chemical involved in regulation of emotions, anxiety, sleep, stress hormones, and other body functions. The purpose of this study is to use a procedure called tryptophan depletion to study the function of serotonin…
- Trial name
- NCT00033787
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder, Depression in Adolescence
Evaluation of a Website to Improve Depression Literacy in Adolescents With Depression
The aim of this study is to evaluate the efficacy and acceptability of the website "ich bin alles" (https://www.ich-bin-alles.de/) to improve depression literacy (knowledge about depression, which aid the recognition, treatment…
- Trial name
- NCT05300204
- Testing
- Self-help strategies for depression, General information about depression
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Bipolar Disorder, Cognitive Impairment
Effects of Erythropoietin on Cognition and Neural Activity in Mood Disorders
The present trial consists of 2 sub-studies that investigate important novel aspects of treatment with erythropoietin (EPO) on cognitive dysfunction in bipolar disorder (BD) and recurrent unipolar depressive disorder (UD)…
- Conditions
- Bipolar Disorder, Cognitive Impairment, Unipolar Depression
- Trial name
- PreTEC-EPO (NCT03315897)
- Testing
- Erythropoietin, Saline
- Where
- Denmark
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Lars Vedel Kessing
Major Depressive Disorder
A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorder
This study employs functional magnetic resonance imaging to compare brain activation patterns during a depressive episode in patients diagnosed with bipolar disorder, major depressive disorder, and a group of healthy control…
- Trial name
- NCT00188942
- Testing
- Fluoxetine+Olanzapine, Olanzapine, Functional Magnetic Resonance Imaging
- Where
- 2 sites in Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Major Depressive Disorder
Follow-up Study of Transcranial Direct Current Stimulation to Treat Major Depressive Disorder
The investigators purpose is to follow remitted patients from their previous study using transcranial direct current stimulation (tDCS); as to verify whether this treatment prevents relapse.
- Trial name
- NCT01149213
- Testing
- transcranial direct current stimulation
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- University of Sao Paulo
Current Major Depressive Disorder, Healthy
Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder
This study will evaluate emotional processing biases in the brain while viewing facial expressions in adults with current or remitted major depressive disorder and healthy volunteers.
- Conditions
- Current Major Depressive Disorder, Healthy, Remitted Major Depressive Disorder
- Trial name
- NCT00071123
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder, Cognitive Impairment
Modafinil's Effects on Cognition in Remitted MDD
Cognitive difficulties such as indecisiveness or inability to concentrate are core symptoms of depression with up to 90% of untreated depressed individuals experiencing these symptoms.
- Trial name
- NCT03620253
- Testing
- Modafinil
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Unity Health Toronto
Major Depression in Remission
Effects of Booster Sessions on Depression Vulnerability Following Cognitive Control Training
The current study aims to examine the impact of booster sessions of cognitive control training (CCT) on indicators of depression vulnerability.
- Trial name
- NCT05557760
- Testing
- Cognitive Control Training (CCT), Cognitive Control Training (CCT) + Booster Sessions
- Where
- 2 sites in Belgium
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University Ghent
Major Depressive Disorder
Blame Rebalance fMRI Feedback Proof-of-concept
The investigators have shown that decoupling of brain networks when feeling guilty is the first potential functional neuroimaging biomarker of risk of major depression.
- Trial name
- GUIMRINFB1 (NCT01920490)
- Testing
- GUILT-INCREASE-CORRELATION, GUILT-STABILIZE-CORRELATION
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- D'Or Institute for Research and Education