Clinical trials: Major Depressive Disorder, completed
Premenstrual Syndrome
Altered Calcium and Vitamin D in PMDD or Severe PMS
Osteoporosis has become one of the most widely recognized disorders of our times affecting an estimated 25 million women in this country.
- Trial name
- NCT00005119
- Testing
- Measures of calcium and bone turnover
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Depressive Symptoms, Esketamine
Esketamine and Perioperative Depressive Symptoms
Perioperative depressive symptoms (PDS) are common in population undergoing surgery, and this would be sharpened especially for complicated, high-risk major surgery.
- Conditions
- Depressive Symptoms, Esketamine, Perioperative Complication, Major Surgery
- Trial name
- NCT04425473
- Testing
- Esketamine, Normal saline
- Where
- China
- Volunteers
- 435 people
- Sponsor
- Beijing Tiantan Hospital
Major Depressive Disorder
Metyrapone as Additive Treatment in Major Depression
The purpose of this study is to test whether metyrapone is an effective and safe augmenting agent in the treatment of major depression.
- Trial name
- NCT00125554
- Testing
- Metyrapone
- Where
- Germany
- Volunteers
- 63 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Depression
AZD6765 for Treatment Resistant Depression
The purpose of this study is to determine whether treatment with AZD6765 will have an antidepressant effect with patients who have treatment resistant depression.
- Trial name
- NCT00491686
- Testing
- AZD6765
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- AstraZeneca
Affective Disorder, Major Depressive Disorder
The Effect of IPS-MA- A Modified Early Supported Employment Intervention for Individuals With Mood or Anxiety Disorders
The aim of the present study, is to evaluate the effect of a supported employment intervention, IPS-modified for people with mood and anxiety (IPS-MA) on employment or education, when offered to people with onset mood or anxiety…
- Conditions
- Affective Disorder, Major Depressive Disorder, Bipolar Disorder, Anxiety Disorder
- Trial name
- NCT01721824
- Testing
- The IPS-MA method
- Where
- Denmark
- Volunteers
- 326 people
- Sponsor
- Amager Hospital
Major Depressive Disorder
Mechanisms of Emotion Regulation Underlying Successful CBT in Depression
This research aims to elucidate mechanisms through which change occurs during cognitive behavior therapy (CBT) for depression. Assessing meta-cognitive processes of self-knowledge (top-down), electrophysiological and behavioral…
- Trial name
- NCT04328103
- Testing
- Cognitive Behavior Therapy (CBT), Nonspecific Supportive Therapy (PBO)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- New York State Psychiatric Institute
Depressive Disorder, Depressive Disorder, Major
Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.
Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits.
- Trial name
- NCT02741622
- Testing
- High aerobic intensity training (HIT), Long slow distance training (LSD)
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- St. Olavs Hospital
Depressive Disorder, Major
A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant
The purpose of this study is to assess the efficacy of seltorexant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in participants with major depressive disorder with insomnia…
- Trial name
- NCT04533529
- Testing
- Seltorexant
- Where
- 122 sites in United States, Brazil and 9 more
- Volunteers
- 588 people
- Sponsor
- Janssen Research & Development, LLC
Major Depressive Disorder
A Safety and Effectiveness Study of JNJ-18038683 in Patients With Moderate to Severe Depression
The purpose of this study is to evaluate the safety and effectiveness of JNJ-18038683 compared to escitalopram and placebo in patients with moderate to severe depression.
- Trial name
- NCT00566202
- Testing
- Escitalopram, JNJ-18038683
- Where
- 26 sites in United States
- Volunteers
- 67 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Depressive Disorders, Psychotic Disorders
Safety of Org 34517 900 mg in Patients Who Received Org 34517 in a Previous Trial (Study 28133/P05842)
Patients who participated in the previous trial 28130, who were eligible, were entered into this trial. Patients who were randomized to placebo in the previous trial 28130 continued on placebo while patients who were randomized…
- Conditions
- Depressive Disorders, Psychotic Disorders, Depression
- Trial name
- NCT00844922
- Testing
- SCH 900636
- Volunteers
- 16 people
- Sponsor
- Merck Sharp & Dohme LLC
Infant, Newborn, Hypoxia, Brain
Preemie Hypothermia for Neonatal Encephalopathy
This study is a randomized, controlled trial to assess safety and effectiveness of whole body hypothermia for 72 hours in preterm infants 33-35 weeks gestational age (GA) who present at <6 hours postnatal age with moderate to…
- Conditions
- Infant, Newborn, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Encephalopathy, Hypoxic-Ischemic
- Trial name
- NCT01793129
- Testing
- Hypothermia, Normothermic Control
- Where
- 18 sites in United States
- Volunteers
- 168 people
- Sponsor
- NICHD Neonatal Research Network
Depression
Neurorestorative Effects of Electroconvulsive Therapy (ECT) in Patients With Severe Late Life Depression
To study the potential neurorestorative effects of electroconvulsive therapy (ECT) in depressed patients by measuring brain derived neurotrophic factor (BDNF) serum levels and hippocampal volumes in severely depressed patients…
- Trial name
- NCT02667353
- Testing
- ECT, Etomidate, Succinylcholine
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bipolar Disorder, Depression
Antidepressant Therapy in Treating Bipolar Type II Major Depression
This study will compare the safety and effectiveness of antidepressant therapy versus mood stabilizing therapy in treating people with bipolar type II major depression.
- Trial name
- NCT00602537
- Testing
- Venlafaxine, Lithium Carbonate
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Pennsylvania
Anxiety Disorders, Depressive Disorder, Major
Auricular Acupuncture vs. Progressive Muscle Relaxation in Patients With Anxiety Disorders or Major Depressive Disorder.
The purpose of this study is to determine whether auricular acupuncture (AA) according to the NADA protocol and progressive muscle relaxation (PMR) differ in their effectiveness of treating people with anxiety disorders or major…
- Trial name
- NCT02340351
- Testing
- Auricular acupuncture, Progressive muscle relaxation
- Volunteers
- 136 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Major Depression, Dysthymia
Treatment of Depression Following Multiple Brain Tests
The main purpose of this study is to correlate brain testing with treatment outcome.
- Trial name
- NCT00296777
- Testing
- Escitalopram, Bupropion, Imipramine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder
Home-based tDCS in Major Depressive Disorder
The investigators propose a study of telehealth supervised, caregiver-delivered, home-based transcranial direct current stimulation (tDCS) for antidepressant treatment of patients with an acute depressive episode.
- Trial name
- MoodStim (NCT04799405)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Hebrew SeniorLife
Major Depression
Evaluation of a Natural Experiment to Improve Statewide Depression Care in Minnesota (MN)
The study will evaluate a unique natural experiment that aims to transform the primary care of patients with depression. The experiment's aim is to cause statewide implementation of an evidence-based care model for depression by…
- Trial name
- DIAMOND (NCT00781703)
- Testing
- DIAMOND depression care model
- Volunteers
- 2,631 people
- Sponsor
- HealthPartners Institute
Depression
Cognitive Behavioral Therapy for the Treatment of Depression-Related Insomnia
This study will determine the effectiveness of cognitive behavioral therapy (CBT) in treating insomnia symptoms that are secondary to depression.
- Trial name
- NCT00255905
- Testing
- Cognitive behavioral therapy (CBT) for insomnia, Clinician monitoring
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Rochester
Depression
Shortened Depression Assessment Study
Participants will be asked to fill out an online questionnaire about their demographics information and all 42 items from the Depression Anxiety Stress Scale (DASS-42).
- Trial name
- NCT05123794
- Where
- Canada
- Volunteers
- 39,000 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Schizophrenia, Schizoaffective Disorder
Lifestyle Intervention for Young Adults With Serious Mental Illness
This is a four year project evaluating the effectiveness of a group-based lifestyle intervention (PeerFIT) supported by mobile health (mHealth) technology and social media compared to Basic Education in fitness and nutrition…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT02815813
- Testing
- PeerFIT, BEAT
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
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