Clinical trials: Major Depressive Disorder, completed
Depressive Disorder, Major
A Safety Study in Participants With Major Depressive Disorder
The primary objective of this study is to evaluate the long-term safety and tolerability of LY2216684 administered once daily (QD) in the adjunctive treatment with a selective serotonin reuptake inhibitor (SSRI) for up to…
- Trial name
- NCT01155661
- Testing
- LY2216684 (edivoxetine), SSRI
- Where
- 48 sites in United States, Brazil and 5 more
- Volunteers
- 608 people
- Sponsor
- Eli Lilly and Company
Depressive Disorder, Major
AndroGel in Men With Major Depression and Incomplete Response to Antidepressant Treatment
We hypothesize that AndroGel may offer some relief to subjects with low or borderline testosterone levels who suffer from depression and have failed to respond to a trial of a standard antidepressant.
- Trial name
- NCT00304746
- Testing
- Testosterone gel
- Where
- 2 sites in United States, Israel
- Volunteers
- 100 people
- Sponsor
- Mclean Hospital
Major Depressive Disorder
Sertraline Versus Escitalopram in South Asian Participants With Moderate to Severe Major Depressive Disorder
Objective: The aim of this randomized controlled trial was to compare the efficacy and safety of sertraline and escitalopram in participants with moderate to severe major depressive disorder (MDD).
- Trial name
- NCT05950061
- Testing
- Sertraline, Escitalopram
- Where
- Pakistan
- Volunteers
- 744 people
- Sponsor
- KRL Hospital, Islamabad
Depression, Major Depressive Disorder
Study Evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) In The Treatment Of Child And Adolescent Outpatients With Major Depressive Disorder
The primary purpose of this study is to test the safety and tolerability of single ascending doses of Desvenlafaxine Succinate Sustained-Release (DVS SR) in both child and adolescent outpatients with major depressive disorder.
- Trial name
- NCT00619619
- Testing
- Desvenlafaxine Succinate Sustained-Release Tablets (DVS SR)
- Where
- 9 sites in United States
- Volunteers
- 59 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Major Depressive Episode
Predict MDE Outcomes After MST
This trial attempts to explore the treatment outcome of magnetic seizure therapy (MST) for major depressive episode. Half of the participants will receive MST, while the other half will receive electroconvulsive therapy (ECT).
- Trial name
- NCT03841019
- Testing
- Magpro X100 + Option, ThymatronSystem Ⅳ Electroconvulsive System
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Shanghai Mental Health Center
Depression, Bipolar Depression
Efficacy of Convulsive Therapies During Continuation
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) and two different forms of electroconvulsive therapy (ECT) in sustaining response during and after a course of continuation treatment.
- Conditions
- Depression, Bipolar Depression, Unipolar Depression, Treatment Resistant Depression
- Trial name
- CORRECT-C (NCT03711019)
- Testing
- Magnetic Seizure Therapy (MST), RUL-UB ECT, Bitemporal ECT
- Where
- 3 sites in Canada
- Volunteers
- 106 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
Study of Ibuprofen Effects on Brain Function
The aim of this project is to determine whether the acute oral administration of Ibuprofen changes the activation pattern in the amygdala and other brain structures during functional magnetic resonance imaging.
- Trial name
- NCT02507219
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Depressive Disorder, Major
European Deep Brain Stimulation (DBS) Depression Study
To evaluate the effects of two different programming settings of deep brain stimulation (DBS) in the subgenual white matter (Brodmann Area 25 WM) as an adjunctive treatment for treatment resistant Major Depressive Disorder…
- Trial name
- NCT01331330
- Testing
- Deep Brain Stimulation
- Where
- 5 sites in France, Israel and 1 more
- Volunteers
- 9 people
- Sponsor
- Abbott Medical Devices
Fibromyalgia
Duloxetine Versus Placebo for Fibromyalgia
The primary purpose of this study is to determine if duloxetine reduces pain severity in patients with fibromyalgia.
- Trial name
- NCT00489073
- Testing
- duloxetine
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder
Modeling Multi-level Dyadic Behavior to Transform the Science and Practice of Psychotherapy Process and Outcome.
This is a short-term longitudinal study of psychotherapy process. Participants will be treated with 8 sessions of psychotherapy over the course of 8 to 12 weeks.
- Trial name
- DAPPeR (NCT03594773)
- Testing
- Cognitive Behavioral Therapy, Interpersonal Psychotherapy
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Neuroimaging Study of Bupropion Treatment in Patients With Major Depressive Disorder
The current study is being conducted in patients with major depression. The study aims to 1) investigate the combined effects of selective serotonin reuptake inhibitor (SSRI) and bupropion compared to SSRI alone on the…
- Trial name
- NCT01541475
- Testing
- Bupropion, Escitalopram, Escitalopram
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Ewha Womans University
Depressive Disorder, Major
A Study to Investigate the Antidepressant Mechanism-of-action of JNJ-42847922 in Participants With Major Depressive Disorder
The purpose of this study is to explore if the magnitude of treatment effect (JNJ-42847922; placebo) on symptoms of depression (as measured by Hamilton rating scale for depression-17 [HDRS17], Sleep item-adjusted HDRS17…
- Trial name
- NCT03374475
- Testing
- JNJ-42847922 20mg, JNJ-42847922 40mg
- Where
- 14 sites in United States, Belgium and 3 more
- Volunteers
- 140 people
- Sponsor
- Janssen Research & Development, LLC
Major Depressive Disorder, Bipolar Disorder
Brain Mechanisms of Human Motivation
This study aims to investigate reward learning across the mood disorder spectrum and to investigate the predictive validity of reward learning for subsequent symptom severity.
- Trial name
- NCT01976975
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depression, Anxiety Disorder
A Working Memory Training to Decrease Rumination in Depressed and Anxious Individuals
Dysfunctioning executive functioning, including working memory (WM), is related to rumination. Findings show that working memory capacity (WMC) can be increased by training.
- Trial name
- NCT02119975
- Testing
- Working memory training
- Where
- Netherlands
- Volunteers
- 98 people
- Sponsor
- Erasmus Medical Center
Depression - Major Depressive Disorder, Anxiety
Feasibility and Acceptability of an E-learning Dialectical Behavior Therapy Skills Course
Dialectical behavior therapy (DBT) is a comprehensive, third-wave psychological intervention designed for patients with complex and severe behavioral, emotional, and interpersonal dysfunction.
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Depression, Stress
- Trial name
- NCT07088939
- Testing
- dialectical behavior therapy
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- University of Windsor
Major Depressive Disorder, Drug Abuse
Ketamine IV Classic Protocol : Five Years Follow up
Patients who suffer from MDD recieved ketamnie (2014-15) in open study will be addressed and there depression mood will be evaluated using the rating scale that were used in the original research.
- Conditions
- Major Depressive Disorder, Drug Abuse, Medications, Relapse
- Trial name
- NCT04824157
- Testing
- Non
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Sheba Medical Center
Major Depressive Disorder
Multimodal Imaging of ECT Effects
The project aims to investigate markers of neural activity and connectivity, neurochemistry, hypothalamic-pituitary-adrenal (HPA) axis activity, inflammation and neuronal plasticity underlying treatment response and remission…
- Trial name
- NCT02871141
- Testing
- electroconvulsive therapy, Antidepressant
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- Charite University, Berlin, Germany
Bipolar Disorder, Major Depressive Disorder
A Pilot Study of Prophylactic Management of Lamotrigine in Pregnant Women
Pregnant women who are taking lamotrigine will be evaluated monthly during pregnancy including a clinical evaluation and a blood draw for lamotrigine levels at each visit.
- Conditions
- Bipolar Disorder, Major Depressive Disorder, Schizo Affective Disorder
- Trial name
- NCT03774641
- Testing
- Lamictal
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Anxiety, Depression - Major Depressive Disorder
An Interactive Mobile Health (mHealth) App as Intervention for High Anxiety and Depression in College Students
The goal of this clinical trial is to learn if a mobile health app called mHELP can help college students manage anxiety, stress, and depression.
- Conditions
- Anxiety, Depression - Major Depressive Disorder, Stress
- Trial name
- NCT07017569
- Testing
- Mobile health application
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Texas A&M University
Depression
Nurse-led Case Management for Diabetes and Cardiovascular Disease Patients With Depression
This study will evaluate the effectiveness of a nurse-led case management intervention in improving disease control and depression symptoms in adults with diabetes and/or heart disease who are also depressed.
- Trial name
- NCT00468676
- Testing
- Nurse-led case management, Treatment as usual
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- University of Washington
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.