Clinical trials: Major Depressive Disorder, completed
Major Depressive Disorder
Deficits in Emotion Regulation Skills as a Maintaining Factor in Major Depressive Disorder
The primary aim of the study is to evaluate the efficacy of a systematic training of general affect regulation skills (ART) on the reduction of depressive symptom in individuals meeting criteria for major depressive disorder…
- Trial name
- NCT01330485
- Testing
- Affect Regulation Training, Common Factor Control Condition
- Where
- 3 sites in Germany
- Volunteers
- 218 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Depressive Disorder, Depression - Major Depressive Disorder
Enhancing Depression Literacy and Reducing Stigma in Adolescents Through Social Media
Depression is a highly common mental disorder that often begins in adolescence. Despite its high burden and negative consequences, few young people seek professional help due to, e.g., low mental health literacy and fear of…
- Conditions
- Depressive Disorder, Depression - Major Depressive Disorder, Depression in Adolescence
- Trial name
- NCT07061600
- Testing
- "ich bin alles", Instagram profile that provides educational content
- Where
- Germany
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Depressive Disorder, Major, Major Depressive Disorder (MDD)
Study Of GW679769 In Major Depressive Disorder
This is a placebo-controlled, fixed dose study that will evaluate the efficacy and safety of GW679769 in subjects with major depressive disorder.
- Trial name
- NCT00102492
- Testing
- GW679769
- Where
- 31 sites in United States, Canada
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Depression
Feasibility, Safety and Efficacy of Deep Brain Stimulation for Depression
The purpose of this investigation is to obtain a preliminary indication of the feasibility, safety and efficacy of capsular deep brain stimulation (DBS) as a treatment for intractable depression.
- Trial name
- NCT00555698
- Testing
- Deep Brain Stimulations for Depression
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Ali Rezai, MD
Depression
Trigeminal Nerve Stimulation for Depression: Dose Finding
This study will aim to examine the use of external trigeminal nerve stimulation (TNS) as an adjunctive treatment for adults with major depressive disorder (MDD) when added onto antidepressant medications.
- Trial name
- NCT01343563
- Testing
- Trigeminal Nerve Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
SARS-CoV Infection, Anxiety
COVID-19-Related Health and Practices Among Dental Hygienists
As dental practices reopen their practices during a global pandemic, the risk of 2019 novel coronavirus (COVID-19) infection that dental hygienists face in providing dental care remains unknown.
- Conditions
- SARS-CoV Infection, Anxiety, Depression, Occupational Problems
- Trial name
- NCT04542915
- Testing
- No intervention
- Where
- United States
- Volunteers
- 6,976 people, healthy volunteers welcome
- Sponsor
- American Dental Association
Depression
Imaging Biomarkers for TMS Treatment of Depression
The purpose of this research is to learn more about how rTMS works to reduce the symptoms of depression. This information can be used to improve the effectiveness of the treatment.
- Trial name
- NCT01900314
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Depression, Cognition
Feasibility and Efficacy of a Digital Neurotherapy Protocol for Management of Depression, Cognition, and Quality of Life in Cancer Survivors
This is a prospective, randomized clinical study to evaluate the feasibility and efficacy of a digital neurotherapy on depression, cognition, and quality of life in two groups of patients with major medical illness: 1) a sample…
- Conditions
- Depression, Cognition, Quality of Life
- Trial name
- NCT04961047
- Testing
- Digital neurotherapy (DNT) Treatment, Wait list control group
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Yale University
Depression
Testosterone Antidepressant Augmentation in Women
The investigators' hypotheses are: Low-dose testosterone augmentation improves depressive symptoms in women with Major Depressive Disorder (MDD) and antidepressant partial/nonresponse, adjunctive low-dose testosterone is safe and…
- Trial name
- NCT01783574
- Testing
- Testosterone
- Where
- 2 sites in United States
- Volunteers
- 101 people
- Sponsor
- Massachusetts General Hospital
Depressive Disorder, Major
A Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Disorder (MDD)
The purpose of this study to evaluate the efficacy of SAGE-217 in the treatment of participants with MDD.
- Trial name
- NCT04442490
- Testing
- SAGE-217
- Where
- 39 sites in United States
- Volunteers
- 543 people
- Sponsor
- Biogen
Major Depressive Disorder
Goal Achievement After a Change to Vortioxetine in Adults With Major Depressive Disorder
The purpose of this study is to determine the effectiveness of treatment with vortioxetine on participant goal achievement after a change in antidepressant medication for the treatment of major depressive disorder (MDD).
- Trial name
- NCT02972632
- Testing
- Vortioxetine
- Where
- 25 sites in United States
- Volunteers
- 123 people
- Sponsor
- Takeda
Major Depressive Disorder
Citalopram Titration in Early Non-responder Patients With Major Depressive Disorders
Major depressive disorder is a common mental disorder and the leading cause of disability worldwide. According to the Canadian Network for Mood and Anxiety Treatment, early improvement following an antidepressant treatment is…
- Trial name
- CRY-MOOD (NCT03899285)
- Testing
- Citalopram 20mg or 40 mg (phase 2)
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Major Depressive Disorder
Optimisation of ECT Based on ASTI vs Narcotrend
The Electro-Convulsion-Therapy (ECT) is a well accepted treatment option in severe depression. The quality of ECT is evaluated basing on minimal seizure duration (>15sec), the sympathic response and the postictal EEG-suppression.
- Trial name
- NCT04657575
- Testing
- Narcotrend
- Where
- Austria
- Volunteers
- 31 people
- Sponsor
- Medical University Innsbruck
Depressive Disorder, Major
Efficacy Study of Transcranial Direct Current Stimulation to Treat Major Depressive Disorder
The purpose of this study is to determine whether transcranial direct current stimulation is an effective treatment for major depression, when compared (and combined) to sertraline and placebo.
- Trial name
- SELECT-TDCS (NCT01033084)
- Testing
- transcranial direct current stimulation, Sertraline
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo
Major Depressive Disorder, Neuroinflammation
The Effect of Celecoxib on Neuroinflammation in MDD
Major depressive disorder (MDD) affects an estimated 350 million people worldwide and is a leading contributor to global disease burden.
- Trial name
- NCT04814355
- Testing
- Celecoxib 400 mg
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stony Brook University
Major Depressive Disorder
Pentoxifylline as an Adjunct to Citalopram in Adult Patients With Major Depressive Disorder
The aim of this study is to test if combining the antidepressant Citalopram with Pentoxifylline (PTX), a medicine with anti-inflammatory and phosphodiesterase inhibitory properties, enhanced antidepressant efficacy in adult…
- Trial name
- NCT05271084
- Testing
- Citalopram (tablet) 20 mg + Pentoxifylline (tablet) 400Mg
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- Hawler Medical University
Depression
Study Evaluating the Effects of DVS SR and Paroxetine on the Pharmacokinetics of Desipramine in Healthy Subjects
The purpose of this study is to evaluate the effects of multiple doses of DVS SR and paroxetine on the pharmacokinetics of a single dose of desipramine in healthy subjects.
- Trial name
- NCT00329147
- Testing
- desvenlafaxine SR, desipramine, paroxetine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Major Depressive Disorder
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-068)(COMPLETED)
A clinical study to determine the efficacy and safety of an investigational medication (MK0869) in the treatment of depression.
- Trial name
- NCT00035048
- Testing
- aprepitant
- Volunteers
- 540 people
- Sponsor
- Merck Sharp & Dohme LLC
Major Depressive Disorder
A Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - FORWARD-5 Study
This study will evaluate the efficacy and safety of ALKS 5461.
- Trial name
- NCT02218008
- Testing
- ALKS 5461
- Where
- 44 sites in United States, Canada and 2 more
- Volunteers
- 407 people
- Sponsor
- Alkermes, Inc.
Depressive Disorder, Major
Outcomes in MEasurement-Based Treatment
The primary objective for this study is to assess the impact of a measurement based treatment program (MBT) on Major Depressive Disorder (MDD) remission rates in patients whose primary care provider (PCP) receives monthly…
- Trial name
- COMET (NCT01141387)
- Volunteers
- 914 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
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