Clinical trials: Major Hepatectomy
Liver Carcinoma Resectable
Trans-parenchymal Compressing Suture in Major Liver Resection
Non-anatomical liver resection with appropriate resection margin was regarded as a potential curative treatment for selected major hepatic carcinoma due to preserving maximal normal liver, especially in cirrhotic patients.
- Trial name
- NCT03215290
- Testing
- TCS
- Volunteers
- 382 people
- Sponsor
- Tongji Hospital
Hepatobiliary Cancer, Pancreatic Cancer
Impact of Comprehensive Geriatric Management on Morbidity and Quality of Life in Elderly Patients Undergoing Major Hepatectomy and Pancreaticoduodenectomy for Cancer
The worldwide incidence of hepatobiliary and pancreatic (HPB) cancers is dramatically increasing especially for pancreatic cancer. Increasing age is associated with increased cancer risk.
- Trial name
- HPB70+ (NCT06999512)
- Testing
- Comprehensive Geriatric Assessment
- Where
- 12 sites in France
- Volunteers
- 526 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Regeneration, Reversible Portal Vein Embolization
Reversible Portal Vein Embolization Before Major Hepatectomy
The aim of this study is to prospectively evaluate the tolerance and efficiency of a new technique of preoperative selective portal vein embolization (PVE) in patients requiring major hepatic resection.
- Trial name
- EMBORES (NCT02945059)
- Testing
- Selective reversible portal vein embolization
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatocellular Carcinoma
Laparoscopic Versus Open Major Hepatectomy for HCC Hepatectomy for Hepatocellular Carcinoma
Background: Hepatocellular carcinoma (HCC) is the sixth most common malignancy in the world. Major hepatectomy (resection of > 3 liver segments) is needed if tumor is close to major blood vessels within liver.
- Trial name
- AP-LAPO (NCT04852211)
- Testing
- Open or laparoscopic surgery
- Where
- Hong Kong
- Volunteers
- 212 people
- Sponsor
- Chinese University of Hong Kong
Portal Vein Occlusion, Cholangiocarcinoma, Perihilar
Portal Vein Embolization Using Coils Plus TAGM vs Multiple Coils for Patients With Perihilar Cholangiocarcinoma or Hepatocellular Carcinoma
The aim of this study is to investigate the differences of safety and liver hypertrophy between portal vein embolization (PVE) using coils plus tris-acryl gelatin microspheres (TAGM) and multiple coils in patients with perihilar…
- Conditions
- Portal Vein Occlusion, Cholangiocarcinoma, Perihilar, Hepatocellular Carcinoma, Liver; Hypertrophy, Acute
- Trial name
- NCT04386772
- Testing
- PVE with coils plus TAGM, PVE with multiple coils
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Major Liver Resection
Trial Using Octreotide to Enhance Liver Recovery After Hepatectomy
This will be a prospective, randomized, double blind trial enrolling patients who will undergo major liver resection. Patients will be randomized in a 1:1 ratio to receive either octreotide or placebo in the postoperative period.
- Trial name
- NCT03179995
- Testing
- Octreotide
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Fox Chase Cancer Center
Hepatic Insufficiency, Blood Coagulation Disorders
Major Liver Resection: Early Clotting Disorders and Functional Impairment.
The aim of this study is to evaluate early clotting disorders through thromboelastogram and anticoagulant proteins levels (maybe also endothelial markers) and liver function by indocyanine green clearance after major liver…
- Trial name
- NCT02813538
- Testing
- Indocyanine green clearance, Thromboelastometry
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Liver Function
Improving Glycogen Liver Content Will Improve Post-operative Liver Function in Patients Undergoing Major Liver Resections
We would like to study the effect of preserving liver glycogen storage by using intravenous dextrose infusion on postoperative liver function and complications after major liver resections.
- Trial name
- NCT00774098
- Testing
- dextrose 10% (D10W ®) infusion, hyperinsulinemic normoglycemic clamp, high calorie diet 35 kcal/kg
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Liver Neoplasms, Postoperative Complications
Intraoperative Continuous Terlipressin Infusion is Associated With Reduced Severe Postoperative Complications After Laparoscopic Hepatectomy: a Prospective Propensity Score-matched Cohort Study
Liver resection is an important surgical treatment for patients with liver diseases. Despite advances in surgical and anesthetic management, postoperative complications remain a major concern and may affect patient recovery.
- Trial name
- NCT07719933
- Testing
- terlipressin
- Where
- China
- Volunteers
- 161 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hepatectomy, Surgical Blood Loss, Terlipressin
Effects of Terlipressin on Blood Loss and Transfusion Requirements During Major Liver Resection.
To evaluate the effects of Terlipressin infusion on blood loss \& transfusion requirements in cirrhotic patients undergoing major liver resections.
- Trial name
- NCT02588716
- Testing
- Terlipressin, normal saline
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Assiut University
Hepatocellular Carcinoma
Hepatectomy Versus Radiofrequency Ablation for Hepatocellular Carcinoma Adjacent to Major Blood Vessels
This study will compare and analyze the difference between hepatectomy at deep and complex sites(adjacent to major blood vessels) of patients with HCC and PRFA prognosis, recovery after treatment as well as incidence of…
- Trial name
- NCT00814242
- Testing
- surgical resection, percutaneous radiationfrequency ablation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Liver Surgery, Minimal Invasive Surgery
High Versus Low Pneumoperitoneum PressUre for Parenchymal Transection in Minimally Invasive Major Liver Surgery
Minimally invasive techniques in liver surgery gain popularity as they facilitate postoperative recovery while achieving comparable oncologic outcomes to the open approach.
- Conditions
- Liver Surgery, Minimal Invasive Surgery, Major Liver Resection
- Trial name
- PPULS (NCT06770803)
- Testing
- High Pressure Pneumoperitoneum, Low Pressure Pneumoperitoneum
- Volunteers
- 132 people
- Sponsor
- University Hospital Heidelberg
Biliary Tract Cancer
A Phase I Study of Adjuvant Chemotherapy With GS in Biliary Tract Cancer Undergoing Resection Without Major Hepatectomy
To decide maximum tolerated dose and recommended dose of treatment using gemcitabine plus S-1 combination therapy in patients with biliary tract cancer undergoing resection without major hepatectomy
- Trial name
- NCT01713387
- Testing
- Gemcitabine, S-1
- Where
- Japan
- Volunteers
- 38 people
- Sponsor
- Kansai Hepatobiliary Oncology Group
Pancreatic Resection, Liver Resection
Enhanced Perioperative Mobilization (EPM) Trial
Randomized Controlled Trial to monitor and increase the postoperative mobilization of the patients undergoing major visceral surgery by giving a continuous autofeedback of the step count using activity tracking wristbands.
- Conditions
- Pancreatic Resection, Liver Resection, Gastric Resection, Colorectal Resection
- Trial name
- EPMIII (NCT02834338)
- Testing
- activity tracking for autofeedback
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- Technische Universität Dresden
Hepatic Disease, Surgery-Complications
Prolonged Hypercoagulability Following Major Liver Resection for Malignancy
This clinical trial will investigate the ability of thromboelastrogrpahy (TEG®) to detect hypercoagulability after liver surgery and will examine the effect of extended thromboprophylaxis (medical treatment to prevent the…
- Conditions
- Hepatic Disease, Surgery-Complications, Hypercoagulability, Thrombosis
- Trial name
- PRIORITY (NCT06153394)
- Testing
- Redesca (enoxaparin sodium for injection), Fragmin (dalteparin)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Western University, Canada
Fluid Management
Stroke Volume Variation-guided Fluid Infusion in Major Liver Tumour Resection
Studies have demonstrated that the rate of change in stroke volume variation (SVV) can be used to determine the volume of body fluids during major abdominal surgery.
- Trial name
- NCT05361252
- Testing
- SVV-guided fluid management
- Where
- Taiwan
- Volunteers
- 118 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Post-Hepatectomy Liver Failure, Liver Failure
CT Volumetry and Hepatic Vascular Deformation Mapping to Predict Post-Hepatectomy Liver Failure
Removing a large part of the liver (major hepatectomy) can cure primary and secondary liver cancers, but it carries the risk of post-hepatectomy liver failure (PHLF), a serious complication in which the liver left behind - the…
- Conditions
- Post-Hepatectomy Liver Failure, Liver Failure, Liver Neoplasms, Carcinoma, Hepatocellular
- Trial name
- BEYOND-SIZE (NCT07727759)
- Testing
- Preoperative CT volumetry with hepatic vascular deformation mapping (VDM)
- Where
- 3 sites in Egypt
- Volunteers
- 1,070 people
- Sponsor
- Minia University
Blood Loss, Surgical
Tranexamic Acid Versus Placebo to Reduce Perioperative Bleeding After Major Hepatectomy
Blood loss was reported as a prognostic risk factor of morbidity and overall survival after hepatic resection. The aim of this study prospective randomized was compare the efficacy of the administration of tranexamic acid versus…
- Trial name
- NCT00657384
- Testing
- acid tranexamic, Nacl 0.9%
- Where
- 4 sites in France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Strasbourg, France
Gastrointestinal Hemorrhage, Postoperative Hemorrhage
The Major Bleeding Risk Following Hepatectomy
This study examined long-term incidence rates of major bleeding associated with hepatectomy. The investigators used data from Taiwan's National Health Insurance Research Database.
- Conditions
- Gastrointestinal Hemorrhage, Postoperative Hemorrhage, Surgery--Complications
- Trial name
- NCT04748081
- Testing
- hepatectomy
- Where
- Taiwan
- Volunteers
- 5,265 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H)
Implementation of a Pain Management Plan in Major Open Abdominal Surgeries.
Introduction: Major abdominal surgery encompasses a broad range of surgical procedures in heterogeneous patient populations.Management of postoperative pain has received keen attention in recent years with considerable concurrent…
- Conditions
- Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H), Colectomy Left/Right/Total Under Laparotomy, Hepatectomy
- Trial name
- NCT07901582
- Testing
- Epidural administered opioid
- Where
- Greece
- Volunteers
- 58 people
- Sponsor
- National and Kapodistrian University of Athens