Clinical trials: Major Hepatectomy
Liver Diseases, Liver Neoplasms
Quality of Life After Liver Resection
Patients with malignant diseases are increasingly receiving more extensive hepatic resections, with im-proved preoperative and postoperative care leading to a reduced postoperative morbidity and mortality.
- Trial name
- NCT00681499
- Where
- Switzerland
- Volunteers
- 198 people
- Sponsor
- University of Bern
Anesthesia, Surgery
Optimized Strict Fluid Management Helps Improve Endpoints After Liver Dissection
During hepatectomy, surgeons often prefer to restrict fluid intake, believing that this can lower central venous pressure (CVP) and reduce intraoperative blood loss.
- Trial name
- SHIELD-pilot (NCT07440121)
- Testing
- restrictive fluid infusion, preload, nitro
- Volunteers
- 90 people
- Sponsor
- Zhihong LU
Hepatocellular Carcinoma
Radiation Major Hepatectomy to Selectively Treat Large Unifocal Hepatocellular Carcinoma
The RESCUE trial is a prospective, single-arm clinical study to evaluate the efficacy and safety of ablative radioembolization using Yttrium-90.
- Trial name
- RESCUE (NCT06178198)
- Testing
- Ablative radioembolization using Yttrium-90 resin microspheres
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Cholangiocarcinoma, Surgical Treatment
Surgical Treatment of Hilar Cholangiocarcinoma: Minor or Major Liver Resection?
The investigators conducted a prospective study to determine the safety and efficacy of minor and major hepatectomy selected by predetermined criteria in 138 patients with hilar cholangiocarcinoma.
- Conditions
- Cholangiocarcinoma, Surgical Treatment, Hepatectomy
- Trial name
- NCT00733200
- Testing
- Minor or Major Liver Resection
- Sponsor
- Huazhong University of Science and Technology
Liver Resection, Cancer
Regeneration of Liver: Portal Vein Embolization Versus Radiofrequency Assisted Ligation for Liver Hypertrophy (REBIRTH)
The aim of this study is to compare two different techniques (portal vein embolization and radiofrequency assisted liver partition with portal vein ligation) for increasing liver volume prior to major liver resection.
- Trial name
- REBIRTH (NCT02216773)
- Testing
- Radiofrequency assisted liver partition with portal vein ligation (RALPP), Portal vein embolization (PVE)
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- Imperial College London
Major Hepatectomy
Evaluation of Trans-Hepatic Flow Changes in Major Hepatectomy
Changes in trans-hepatic flow after major and extended hepatectomy (EH) can lead to small for size and flow syndrome (SFSF), which is associated with a significantly higher rate of morbidity and mortality.
- Trial name
- THEFLOW (NCT03762876)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Heidelberg
Hepatocellular Carcinoma Stage I, Recurrence
Impact of Hepatectomy on HCC Recurrence
Hepatectomy is the first option for the treatment of hepatocellular carcinoma(HCC) at CNLC Ib stage. HCC patients who undergo curative hepatectomy may experience varying remnant liver volumes and thus leads to different…
- Trial name
- HCC (NCT06390228)
- Testing
- Major hepatectomy
- Where
- China
- Volunteers
- 197 people
- Sponsor
- Anhui Medical University
Liver Diseases
Risk Factors for Major Complications After Liver Resection
The aim of this study is to determine the risk factors for major complications following liver resection in the setting of a general surgery-teaching department in Morocco, North Africa
- Trial name
- NCT03967067
- Testing
- liver resection
- Where
- Morocco
- Volunteers
- 213 people
- Sponsor
- Moroccan Society of Surgery
Biliary Tract Cancer
A Phase I Study of Adjuvant Chemotherapy With GC in Biliary Tract Cancer Undergoing Resection Without Major Hepatectomy
To decide maximum tolerated dose and recommended dose of treatment using gemcitabine plus cisplatin combination therapy in patients with biliary tract cancer undergoing resection without major hepatectomy.
- Trial name
- NCT01297998
- Testing
- gemcitabine , cisplatin
- Where
- Japan
- Volunteers
- 24 people
- Sponsor
- Kansai Hepatobiliary Oncology Group
Liver Cancer, Surgery
Nutrition and Exercise Prehabilitation to Reduce Morbidity Following Major Liver Surgery in Sarcopenic Patients
NEXPREM is a single-center non-blinded randomized controlled trial investigating preoperative exercise and nutrition for sarcopenic patients in major hepatic surgery for liver malignancies.
- Conditions
- Liver Cancer, Surgery, Sarcopenia
- Trial name
- NEXPREM (NCT05281211)
- Testing
- Nutrition, Exercise
- Where
- 2 sites in Italy
- Volunteers
- 70 people
- Sponsor
- San Camillo Hospital, Rome
Pain, Postoperative
Erector Spinae Plane Block With Ropivacaine for Major Upper Abdominal Surgery
Prospective, single-centre, randomized, controlled, open-label, evaluator-blinded, superiority trial.
- Trial name
- NCT04702685
- Testing
- Ropivacaine
- Where
- Kazakhstan
- Volunteers
- 50 people
- Sponsor
- Nazarbayev University Medical Center
Colon or Colorectal Resection, Partial or Total Gastrectomy
Development and Validation of a Predictive Score for Surgical Site Infections
More than 8 millions surgical interventions are carried out each year in France. Postoperative complications, in particular infectious, can occur in 10 to 60% of cases and are the cause of postoperative revision in 30% of cases…
- Conditions
- Colon or Colorectal Resection, Partial or Total Gastrectomy, Pancreaticoduodenectomy, Hepatectomy
- Trial name
- SPRED (NCT05523713)
- Testing
- Peripheral venous blood samples
- Where
- 4 sites in France
- Volunteers
- 283 people
- Sponsor
- Hopital Foch
Liver Regeneration
To Study Effect of Injection Pentoxifylline on Liver Growth After Major Liver Surgery
Posthepatectomy liver failure (PHLF) remains a significant life-threatening problem after major hepatectomies. Pentoxifylline is shown to have potent vasodilating properties for peripheral blood vessels, along with the hepatic…
- Trial name
- NCT07085806
- Testing
- Pentoxifylline (also known as oxpentifylline), Plasmalyte
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Major Abdominal Surgery, Colorectal Surgery
Automated Versus Manual Fluid Management for High Risk Abdominal Surgical Patient. A Prospective, Randomized Trial
Dynamic parameters like pulse pressure variation have been shown to be accurate predictors of fluid responsiveness. Hemodynamic optimization based on fluid management and stroke volume optimization have been shown to improve…
- Conditions
- Major Abdominal Surgery, Colorectal Surgery, Hepatectomy, Pancreatectomy
- Trial name
- CL vs CP (NCT01950845)
- Testing
- Closed loop automated System (LIR®: learning intravenous resuscitator), manual current practice by anesthesiologist team
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Hospices Civils de Lyon
Liver Neoplasms, Hepatectomy
Phlebotomy to Prevent Blood Loss in Major Hepatic Resections
Major liver resection is associated with substantial intraoperative blood loss. Blood loss in elective liver surgery is a significant factor of perioperative morbidity and mortality, as well as possibly long-term oncologic…
- Trial name
- PRICE (NCT02548910)
- Testing
- Phlebotomy, Citrated whole blood collection bag
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- Ottawa Hospital Research Institute
Liver Metastasis Colon Cancer
Simultaneous Portal and Hepatic Vein Versus Portal Vein Embolizations for Hypertrophy of the Future Liver Remnant
The hypothesis is that liver venous deprivation (LVD) could strongly improve hypertrophy of the future remnant liver (FRL) at 3 weeks, as compared to portal vein embolization (PVE) in patient with liver metastases from…
- Trial name
- HYPER-LIV01 (NCT03841305)
- Testing
- Liver preparation before major hepatectomy
- Where
- 12 sites in France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Montpellier
Liver Diseases
Major Hepatectomy and Vascular Clamping
A major hepatectomy consists of the resection of 3 or more liver segments. Its indications are mainly secondary malignant lesions, then primary malignant lesions, benign lesions and septic resections.
- Trial name
- HMCV (NCT06501742)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Complications
Preoperative Glucocorticoid Use in Major Hepatectomy
Background: Reducing postoperative complications remains a dominant challenge for all clinicians. By minimizing the incidence of adverse outcomes, health care costs and patient recovery can be improved.
- Trial name
- NCT01997658
- Testing
- Methylprednisolone
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Calgary
Coagulation; Intravascular, Fluid Electrolyte Disorders
Effect of Human Plasma Protein Transfusion With and Without Crystalloids During Major Liver Resection Surgeries
Evaluation of acid-base and electrolyte changes after administration of commonly used colloid solutions (plasma protein fraction contains 5% albumin), and crystalloids (saline 0.9% and lactated ringers solutions) is the primary…
- Trial name
- NCT05033704
- Testing
- 5% human plasma protein fraction (PPF)
- Where
- Qatar
- Volunteers
- 48 people
- Sponsor
- Hamad Medical Corporation
Liver Failure, Major Hepatectomy
Pneumatic Reversible Portal Vein Diameter Modulation After Major Hepatectomy
This ring aimed to preserve an intra-hepatic porto-caval gradient inferior to 5 mm Hg during and after major hepatectomy (48h) to protect the liver during the initial phases of liver regeneration.
- Trial name
- MODHEP1 (NCT02390713)
- Testing
- MID-AVR
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris