Clinical trials: Major Non-cardiac Surgery
Fat Consumption, Inflammatory Markers
Preoperative Dietary Fat Consumption and Baseline Inflammatory Markers
This single-center, prospective pilot study will examine dietary fat consumption and its relationship with inflammatory markers before surgery and the incidence of perioperative neurocognitive disorders in older surgical…
- Trial name
- D&D (NCT07442981)
- Testing
- Inflammatory markers test in blood prior to surgery, Inflammatory markers test in CSF (cerebrospinal fluid), MOCA test
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Ohio State University
Intraoperative Hypotension
Advanced Cardiovascular Management in Major Non-cardiac Surgery.
This is a single center, randomised and controlled clinical triaI whose aim is to predict and treat in advance, intraoperative hypotension episodes.
- Trial name
- NCT07134530
- Testing
- HPI-driven intraoperative hemodynamic management strategy, GDT strategy
- Where
- Italy
- Volunteers
- 534 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Non-Dialysis Dependent Severe Renal Dysfunction, Cardiovascular Disease
Preop Hemodialysis or Intraop Ultrafiltration for Patients With Severe Renal Dysfunction Undergoing Open Heart Surgery
The purpose of this study is to determine whether preoperative hemodialysis or intraoperative modified ultrafiltration are effective for patients with non-dialysis dependent severe renal dysfunction undergoing open heart surgery.
- Trial name
- SeRenaD-CPB (NCT00720967)
- Testing
- Open Heart Surgery (OHS), Intraoperative Modified Ultrafiltration (MUF), Hemodialysis (HD)
- Where
- 7 sites in France, Germany and 3 more
- Volunteers
- 450 people
- Sponsor
- University Hospital, Geneva
Ventricular Dysfunction, Left, Major Adverse Cardiac Events
Echo-guided Hemodynamic Management Strategy in Elderly Patients Undergoing Noncardiac Surgery
Elderly patients are the fastest growing surgical population and have an increased risk of postoperative cardiac problems. Diastolic dysfunction, or the reduced ability of the heart' s ventricles to fill completely, is common in…
- Trial name
- NCT01780727
- Testing
- EGHEM
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Nebraska
Obesity, Morbid
ECG Triggered Dual Source CT for Non-invasive Pre-operative Cardiac Imaging in Morbid Obese Patients
Coronary arterial disease is a risk factor for bariatric surgery and might be a predictor for later major adverse coronary events.
- Trial name
- NCT02802579
- Testing
- standard protocol, enhanced protocol, enhanced obesity protocol
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- Cantonal Hospital of St. Gallen
Myocardial Infarction, Myocardial Injury
Colchicine Prevents Myocardial Injury After Non-Cardiac Surgery Pilot Study
Perioperative Myocardial Infarction (PMI) is a major contributor to perioperative mortality and morbidity with overall incidence of 5-16%.
- Conditions
- Myocardial Infarction, Myocardial Injury, Major Adverse Cardiac Events, Infectious Complications
- Trial name
- COPMAN (NCT04139655)
- Testing
- Colchicine 0.6 mg
- Where
- Canada
- Sponsor
- University of British Columbia
Postoperative Delirium (POD), Postoperative Sleep Disturbance
Effects of Esketamine on the Incidence of Postoperative Delirium and Postoperative Sleep Disturbance in Elderly Patients After Major Non-cardiac Surgery
Postoperative delirium (POD) is a common surgical complication.It is associated with a range of negative outcomes such as delayed postoperative recovery,prolonged hospitalization,additional medical expenditures and higher…
- Trial name
- EPISODE (NCT06900205)
- Testing
- Esketamine, 0.9 % saline
- Where
- China
- Sponsor
- RenJi Hospital
Hypovolemia, Surgery
Focused Assessed Echocardiography to Predict Fluid Responsiveness
The aims of the study are: 1. To evaluate the feasibility of echocardiography monitoring in postoperative unit; 2. To assess diagnostic value of different focussed echocardiography parameters to define fluid responsiveness for…
- Conditions
- Hypovolemia, Surgery, Hypotension
- Trial name
- fluidres (NCT03044405)
- Testing
- Fluid challenge, Focused transthoracic echocardiography
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Coronary Artery Disease
The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial
Heart disease remains the leading cause of death in Veterans. Inflammation in the arteries of the heart may increase the risk of cardiac death.
- Trial name
- POPCORN (NCT05618353)
- Testing
- Colchicine
- Where
- 9 sites in United States
- Volunteers
- 700 people
- Sponsor
- VA Office of Research and Development
Predictive Model
A Prediction Model of Postoperative Anxiety Symptom in Elderly Patients Undergoing Major Noncardiac Surgery
A multicentre, prospective observational study to develop and validate a predictive model for postoperative anxiety symptoms in elderly Chinese patients undergoing non-cardiac major surgery.
- Trial name
- NCT06641986
- Where
- China
- Volunteers
- 5,551 people
- Sponsor
- Chinese PLA General Hospital
Cerebrovascular Circulation
NIRS vs TCD for Cerebrovascular Autoregulation During Non-cardiac Surgery
Postoperative neurocognitive disorders (NCD) are of high priority in perioperative management. The risk of suffering from NCD after surgery may be increased due to perioperative impairment of cerebrovascular autoregulation and…
- Trial name
- SONICA (NCT04978558)
- Testing
- Continuous assessment of cerebrovascular autoregulation with NIRS and TCD
- Where
- Germany
- Volunteers
- 509 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf