Clinical trials: Major Surgery in Adult Patients
Surgery--Complications
Assessment of the Soluble Urokinase Plasminogen Activator Receptor in Non-cardiac Surgery (SPARSE)
In critically ill patients, the soluble urokinase plasminogen activator receptor (suPAR) level is significantly increased. suPAR is an independent prognostic marker, and the change over time correlates with organ dysfunction.
- Trial name
- SPARSE (NCT03851965)
- Testing
- Soluble Urokinase Plasminogen Activator Receptor
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Thessaly
Sarcoma
Sorafenib and Ifosfamide in Treating Patients With High-Grade Soft Tissue Sarcoma or Bone Sarcoma That Can Be Removed by Surgery
RATIONALE: Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00880542
- Testing
- sorafenib, Ifosfamide
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Lower Extremity Fracture
Atropine Versus Glycopyrrolate in Preventing Spinal Anesthesia Induced Hypotension in Lower Limb Surgeries
A study to compare between intravenous atropine and glycopyrrolate in preventing spinal anesthesia induced hypotension in patients undergoing major lower limb orthopedic surgeries.
- Trial name
- NCT03580889
- Testing
- Atropine, Glycopyrrolate, Normal Saline Flush, 0.9% Injectable Solution
- Where
- Nepal
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Oxycodone, Chronic Pain, Postoperative
Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain
The goal of this clinical trial is to learn if the administration of oxycodone for preventive analgesia works to reduce the chronification of acute postoperative pain in adult participants undergoing major abdominal surgery.
- Trial name
- AOPC (NCT06721988)
- Testing
- oxycodone and parecoxib sodium combinations
- Volunteers
- 1,316 people
- Sponsor
- Ailin Luo
Glioblastoma, Glioblastoma Multiforme
The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)
There is no consensus on the optimal treatment of patients with high-grade glioma, especially when patients have limited functioning performance at presentation (KPS ≤70).
- Conditions
- Glioblastoma, Glioblastoma Multiforme, Glioblastoma, IDH-wildtype, Glioblastoma Multiforme, Adult
- Trial name
- PALSUR (NCT06146738)
- Testing
- Palliative Care, Tumor biopsy, Tumor resection
- Where
- 8 sites in United States, Belgium and 3 more
- Volunteers
- 1,015 people
- Sponsor
- Jasper Gerritsen
Frailty, Sarcopenia
Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery
The goal of this observational study is to learn if simple tests for frailty and muscle strength can help predict which older adults (age 65 and older) are at higher risk for problems after major abdominal surgery.
- Conditions
- Frailty, Sarcopenia, Sarcopenia in Elderly, Muscle Strength
- Trial name
- NCT06988176
- Testing
- Frailty assessment, nutrition assessment, cognition assessment, muscle strength testing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Surgical Site Infection After Major Surgery, Surgical Site Infections
Assessing the Effect of the Silver Dressing on Surgical Site Infections in Adult Patients Post Cardiac Surgery: a Single Center Randomized Control Trial
RCT on post-cardiac surgery patients using silver dressings vs. standard care. Conducted in ICU, CCU, telemetry units. Outcomes assessed via checklist \& modified Parsonnet Score.
- Trial name
- NCT07008040
- Testing
- Silver dressing
- Where
- Saudi Arabia
- Volunteers
- 145 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Adult Patient Undergoing Major Surgery
Evaluation of the Accuracy and Precision of the Masimo Labs Pulse-Hemoglobin-Meter Monitor in Surgical Patients
The Masimo monitor can measure hemoglobin level noninvasively and accuratly
- Trial name
- NCT00762398
- Testing
- Masimo hemoglobin-meter, drawing blood sample
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Irvine
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Sarcoma
Chemotherapy, SU5416, Radiation Therapy, and Surgery in Treating Patients With Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Drugs such as SU5416 may stop the growth of cancer by stopping blood flow to the tumor.
- Trial name
- NCT00023738
- Testing
- filgrastim, dacarbazine, doxorubicin hydrochloride
- Where
- 226 sites in United States, Canada
- Sponsor
- Radiation Therapy Oncology Group
Stage I Adult Soft Tissue Sarcoma, Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity
EF5 to Evaluate Tumor Hypoxia in Patients With High-Grade Soft Tissue Sarcoma or Mouth Cancer
This laboratory study is using EF5 to evaluate tumor hypoxia in patients with high-grade soft tissue sarcoma or mouth cancer. Using the drug EF5 to measure the oxygen level in tumor cells may help in planning cancer treatment
- Conditions
- Stage I Adult Soft Tissue Sarcoma, Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage II Adult Soft Tissue Sarcoma, Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity
- Trial name
- NCT00896961
- Testing
- EF5, diagnostic laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute (NCI)
Cohort Studies
The Impact of Preoperative Depression on Postoperative Delirium in Elderly Chinese Patients: A Retrospective Multicenter Observational Study
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of preoperative depression on the incidence of postoperative delirium among elderly Chinese patients…
- Trial name
- NCT07744282
- Volunteers
- 8,000 people
- Sponsor
- Chinese PLA General Hospital
Blood Loss, Surgical
Evaluation of the Clinical Performance of the Quantra System With the Quantra Surgical Cartridge
This study will evaluate the performance of the Quantra System comprised of the Quantra Hemostasis Analyzer with the Quantra Surgical Cartridge in patients undergoing major surgical procedures specifically, major cardiac and…
- Trial name
- NCT03152461
- Testing
- Quantra System
- Where
- 4 sites in United States
- Volunteers
- 302 people
- Sponsor
- HemoSonics LLC
Anaplastic Astrocytoma, Anaplastic Ependymoma
Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma
This pilot phase I clinical trial studies how well lapatinib ditosylate before surgery works in treating patients with high-grade glioma that has come back after a period of time during which the tumor could not be detected.
- Conditions
- Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Oligodendroglioma, Gliosarcoma
- Trial name
- NCT02101905
- Testing
- Laboratory Biomarker Analysis, Lapatinib, Lapatinib Ditosylate
- Where
- 12 sites in United States
- Volunteers
- 29 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Cancer, Kidney Cancer
Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether giving chemotherapy after surgery is more effective than surgery alone in…
- Conditions
- Endometrial Cancer, Kidney Cancer, Ovarian Cancer, Pheochromocytoma
- Trial name
- NCT00002641
- Testing
- filgrastim, doxorubicin hydrochloride, ifosfamide
- Where
- 45 sites in Austria, Belgium and 11 more
- Volunteers
- 350 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Plasma Volume Substitution (Hypovolemia) Including Massive Hemorrhage
Study to Obtain Volume Effect and Safety Data on 6 % Hydroxyethyl Starch 130/0.4 in Pediatric and Adult Patients Undergoing Major Elective Surgery
The study shall evaluate the volume effect and safety of 6 % hydroxyethyl starch 130/0.4 for restoration and maintenance of hemodynamics during the investigational period in patients undergoing major elective surgery.
- Trial name
- NCT01127477
- Testing
- 1: Hydroxyethyl starch 130/0.4, 6 %
- Where
- 4 sites in Japan
- Volunteers
- 20 people
- Sponsor
- Fresenius Kabi Japan
Frailty in Adult Surgery, Frailty Syndrome
Validity of Frailty Screening Tools as a Measure for Postoperative Outcomes
Frailty is a common geriatric syndrome defined as a clinical state of decreased physiologic reserve resulting in increased vulnerability to stressors.
- Conditions
- Frailty in Adult Surgery, Frailty Syndrome, Elective Surgery
- Trial name
- NCT07367828
- Testing
- Intermediate/major elective surgery
- Where
- Iceland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Iceland
Hip or Knee Replacement
CBP-0276 to Reduce Opioid Use in Adults Undergoing Major Orthopedic Surgery
Randomized, double-blind, clinical study to evaluate the safety and efficacy of CBP-0276 at doses of 600 mg/day in reducing opioid use in pain management in adult patients undergoing major orthopedic surgery.
- Trial name
- CBP0276-Opd (NCT07687966)
- Testing
- CBP-0276
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Clarent Biopharma, Inc.
Malignant Neoplasms of Brain
Chemotherapy, Radiation Therapy, and Vaccine Therapy With Basiliximab in Treating Patients With Glioblastoma Multiforme That Has Been Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- ZAP IT (NCT00626015)
- Testing
- PEP-3-KLH conjugate vaccine, daclizumab, temozolomide
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- John Sampson
Airway Complication of Anesthesia
Prevalence of Major Vessels Underlying the Potential Incision Site for Emergency Front of Neck Airway Access in Adult Surgical Patients With Impalpable Neck Anatomy
Patients undergoing general anesthesia require assistance with their breathing and with the delivery of oxygen to their lungs. To achieve this, an anesthesiologist inserts a type of plastic breathing tube into the airway via the…
- Trial name
- NCT06637319
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada