Clinical trials: Malabsorption
Environmental Enteric Dysfunction
OCT Guided Trans Nasal Imaging of the Small Intestine in Adults
The investigators are seeking healthy adult participants 18-60 years and healthy pregnant women in their 2nd trimester of pregnancy for a research study to assess a new imaging device.
- Trial name
- NCT04984447
- Testing
- TNIB Catheter
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colitis Ulcerosa, Colitis Ulcerative
Magnesium in Gastrointestinal Disease
Individuals with gastrointestinal diseases - such as Crohn's disease, ulcerative colitis, ileostomy, or bile acid diarrhoea - are at increased risk of magnesium deficiency.
- Conditions
- Colitis Ulcerosa, Colitis Ulcerative, Crohns Disease, Morbus Crohn
- Trial name
- MAGIC (NCT07338565)
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Short Gut Syndrome
Fiber Food Introduction in Pediatric Short Bowel Syndrome
Short bowel syndrome (SBS) is a rare but challenging condition in which patients have insufficient bowel length to meet fluid, electrolyte, and nutrient requirements without parenteral support.
- Trial name
- NCT05432648
- Testing
- Green bean puree
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Hyperhomocysteinemia
Effects of Low-dose Complex B-vitamins on Homocysteine and Framingham Risk Score Among Chinese Elderly
The purpose of this study is to evaluate whether low dose complex B-vitamins (folic acid,vitamin B6 and vitamin B12) can lower the risk of developing hyperhomocysteinemia in an apparently healthy population with low folate/B12…
- Trial name
- NCT00755664
- Testing
- Low-dose complex B-vitamins
- Where
- China
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Peking University
Development and Validation of Gut Permeability Sensor, Permeability; Increased
Fluorescence Spectroscopy for Gut Permeability Assessment
This research aims to develop portable devices - known as fluorescence spectrometers - to monitor the leakage of fluorescent dyes out of the gut into the blood stream.
- Conditions
- Development and Validation of Gut Permeability Sensor, Permeability; Increased, Celiac Disease, Inflammatory Bowel Diseases
- Trial name
- GutPerm (NCT03434639)
- Testing
- Spectroscopic gut permeability test
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Acute Mesenteric Ischemia, Short Bowel Syndrome
Antithrombotic Management of Acute Mesenteric Ischaemia
Guidelines on the acute and long-term pharmacological treatment of acute mesenteric ischaemia (AMI) recommend the use of thrombolytic, antiplatelet or anticoagulant therapy depending on the aetiology of AMI and the use of…
- Trial name
- NCT05706012
- Testing
- Survey
- Where
- Belgium
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Celiac Disease, Diet, Gluten-Free
Improvement Of Physical And Physiological Parameters In Menopausal Or Post-Menopausal Celiac Women
Celiac disease (CD) is an immunological disorder that mainly affects the small intestine, generating an inflammatory process in response to the presence of gluten (a protein).
- Conditions
- Celiac Disease, Diet, Gluten-Free, Exercise, Resistance Training
- Trial name
- NCT05052164
- Testing
- Gluten-free nutrition plan + exercise group, Gluten-free nutrition plan group, Active Comparator: Celiac controls group
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alicante
Celiac Disease
Diagnostic Performance of Urinary Gluten Immunogenic Peptides in Monitoring the Adherence to Gluten-free Diet.
The purpose of the GRRES study is to assess the clinical usefulness of urinary gluten immunogenic peptides test as a marker of gluten-free diet adherence using the rapid immunochromatographic assay based on anti-gliadin 33-mer…
- Trial name
- NCT04477239
- Testing
- Gluten (behaviour)
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Università Politecnica delle Marche
Celiac Disease, Gluten Sensitivity
RCT: Effect of Late vs Early Introduction of Gluten-free Oats on Patients With Newly Diagnosed Celiac Disease.
The investigators are conducting a pilot study to investigate the impact of late compared to early introduction of gluten-free oats on gut symptoms, nutrition status, celiac activity and quality of life in patients with a recent…
- Conditions
- Celiac Disease, Gluten Sensitivity, Gluten Allergy, Gluten Enteropathy
- Trial name
- NCT05803408
- Testing
- gluten-free oats
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Pancreatitis
Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis (EUS-CPN) for Chronic Pancreatitis
Physicians need a tracking system for specific treatment modalities, and data to determine the impact of endoscopic ultrasound pain management for patients with chronic pancreatitis.
- Trial name
- CPN (NCT04403074)
- Testing
- Celiac Plexus Neurolysis
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Indiana University
Celiac Disease
Probiotic Blend for Celiac Disease
The objective of the study is to develop a probiotic product (B. longum CCT 1934; B. lactis CCT 7858; L. rhamnosus CCT 7863; S. thermophilus ATCC 19258) to reduce the symptoms caused by celiac disease and concomitantly improve…
- Trial name
- NCT05646823
- Testing
- Probiotic blend
- Where
- Brazil
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Protein Malabsorption, Nutrition Disorders
Bioavailability of Proteins From Plant Based Diets
The quality of protein intake has an important role within the nutritional needs of people throughout their lives around the world, particularly in developing countries and in particular during pregnancy and early childhood.
- Conditions
- Protein Malabsorption, Nutrition Disorders, Sarcopenia
- Trial name
- NCT03492190
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eduardo Ferriolli
Nutritional Deficiency, Ileostomy; Functional Disturbance
Absorption of Peptides, Fluid, and Electrolytes in Patients With an Ileostomy
Clinical trial, active comparator, cross over, randomised. In total, 12 adults with an ileostomy will be randomised to a sequential 4 weeks intervention with different qualities and sources of protein wish 2-week washout periods.
- Conditions
- Nutritional Deficiency, Ileostomy; Functional Disturbance, Short Bowel Syndrome, Absorption; Disorder, Protein
- Trial name
- ABSOLYT (NCT04141826)
- Testing
- Hydrolysed whey, Intact whey, Caseinate
- Where
- Denmark
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Christian Hvas
Celiac Disease, Healthy
A First-in-human Study to Evaluate the Safety and Tolerability of HB-2121 as a Diagnostic for Celiac Disease
The goal of this clinical trial is to learn about the safety of a single dose of HB-2121 in adults. It will also look at how the body processes the drug.
- Trial name
- NCT07063823
- Testing
- HB-2121
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Nielsen Fernandez-Becker
Celiac Disease
Coeliac Disease in Spain: Determination of Disease Prevalence and Risk Factors
Previous studies have showed that Coeliac Disease (CD) prevalence is significantly higher in children compared with adults. The largest epidemiologic study carried out in Spain to date (n=4230) reported a higher CD prevalence in…
- Trial name
- NCT05094232
- Where
- Spain
- Volunteers
- 4,826 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Intestinal Failure, Short Bowel Syndrome
Resting Energy Expenditure by Gastrointestinal Functional Status
This prospective, comparative interventional study will evaluate resting energy expenditure in adults with different gastrointestinal functional status.
- Trial name
- NCT07714499
- Testing
- Protocol-Defined Metabolic and Body Composition Assessment
- Where
- Slovenia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Institute of Oncology Ljubljana
Short Bowel Syndrome
Mechanisms of Adaptation in Human Short Bowel Syndrome
This is an observational, natural history trial of mechanisms of gut adaptation in adult short bowel syndrome (SBS). Patients with SBS (< 200 cm small bowel ± colon) will be studied initially 2-9 months after the last small bowel…
- Trial name
- NCT00248573
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Emory University
Lactose Malabsorption
Acid Lactase in Combination With Yoghurt Bacteria for Improvement of Lactose Digestion in Lactose Malabsorbers
Fermented dairy products, especially real Yoghurt, are often tolerated better by lactose malabsorbers than unfermented dairy products.
- Trial name
- NCT01593631
- Testing
- Acid lactase, Lyoph. yoghurt bacteria, Acid lactase plus yoghurt bacteria
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vitacare Gmbh & Co. KG
Celiac Disease, Coeliac Disease
Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GSK3915393 in Healthy Participants and to Evaluate the Interaction Between GSK3915393 and Grapefruit Juice and Itraconazole
This is a 3-part first time into human study (FTIH) study for GSK3915393. Parts A and B of the study will evaluate the safety, tolerability and pharmacokinetics (PK) of single ascending and repeat oral doses of GSK3915393 in…
- Trial name
- NCT04604795
- Testing
- GSK3915393 Capsules, GSK3915393 Solution for Infusion, Itraconazole
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline