Clinical trials: Malabsorption
Celiac Disease, Small Bowel Disease
Histomolecular Profiling in Small-Bowel Diseases
This prospective cohort study aims to establish reliable histological reference values for normal small-bowel mucosa, improve histological diagnostic quality in celiac disease, and develop an advanced molecular profile for…
- Conditions
- Celiac Disease, Small Bowel Disease, Refractory Celiac Disease
- Trial name
- Deep Bowel (NCT07556328)
- Where
- 3 sites in Finland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Celiac Disease
Glutenfree, Gut Microbiota and Metabolic Regulation
High intake of dietary fiber provides health benefits and reduces the risk of developing cardio-metabolic diseases, such as type 2 diabetes (T2D) and cardiovascular disease (CVD).
- Trial name
- GRAIN (NCT05135923)
- Testing
- Randomized, controlled trial (RCT) with parallel arms and double blinded
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Celiac Disease in Children, Nutritional Assessment
Assessment of Nutritional Status in Celiac Disease Using Muscle Ultrasound in Pediatric Patients.
The aim is to explain that celiac disease (CD) is an autoimmune, familial disease that develops in genetically predisposed individuals as a result of sensitivity to gluten found in grains and grain products, causing…
- Trial name
- NCT07885735
- Testing
- performing muscle ultrasonography on patients
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Short Bowel Syndrome, Parenteral Nutrition Associated Liver Disease
Study of NST-6179 in Healthy Subjects
A double-blind, randomized, placebo controlled, single and multiple oral dose study to assess safety and tolerability of single and multiple doses of NST-6179 in healthy male and female subjects.
- Trial name
- NCT05181085
- Testing
- NST 6179
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- NorthSea Therapeutics B.V.
Protein Malabsorption
Protein Digestion and Amino Acid Absorption in the Aging Gastrointestinal Tract
Rationale: Worldwide, the aging population is increasing. Aging is associated with loss of independence and increased risk of co-morbidity.
- Trial name
- AgingGut (NCT06553794)
- Testing
- Gastroscopy with duodenal mucosal tissue biopsies
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Colorectal Cancer, Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Urine Metabolites in the Diagnosis of Disease
The goal of this observational study is to validate a non-invasive, urine-based diagnostic technology for the detection and differentiation of various gastrointestinal (GI) diseases.
- Conditions
- Colorectal Cancer, Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Crohn Disease, Celiac Disease
- Trial name
- NCT06710067
- Where
- 4 sites in United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Luventix, Inc.
Short Bowel Syndrome
A Study of PJ009 in Healthy Adult Volunteers
The main aim of this clinical trial is to assess the safety of PJ009 in healthy adult volunteers aged 18-45. The main questions it aims to answer are: Is PJ009 safe in healthy adult? Participants will Receive single dose of PJ009…
- Trial name
- NCT06523101
- Testing
- PJ009
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chongqing Peg-Bio Biopharm Co., Ltd.
Protein Malabsorption
The Incorporation of Dietary Protein-Derived Amino Acids in Duodenal Epithelium
Rationale: Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion.This anabolic resistance may be related to decreased postprandial amino acid release in the circulation, due to greater amino…
- Trial name
- GutFeeding (NCT06091852)
- Testing
- Intrinsically labelled milk protein
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Short Bowel Syndrome
Mechanisms of Adaptation in Human Short Bowel Syndrome
This is an observational, natural history trial of mechanisms of gut adaptation in adult short bowel syndrome (SBS). Patients with SBS (< 200 cm small bowel ± colon) will be studied initially 2-9 months after the last small bowel…
- Trial name
- NCT00248573
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Emory University
Intestinal Disease, Inflammatory Bowel Disease
Comparison of Capso Vision SV-1 to PillCam SB2 in the Evaluation of Subjects With Suspected Small Bowel Disease
The purpose of this study is to compare the clinical findings involving the small bowel obtained with the Capso Vision Video Capsule Device to those results obtained with the PillCam SB2.
- Conditions
- Intestinal Disease, Inflammatory Bowel Disease, Crohn Disease, Ulcer
- Trial name
- NCT01787825
- Testing
- PillCam SB2 capsule, CapsoCam SV-1
- Where
- 7 sites in United States, Canada
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Capso Vision, Inc.
Celiac Disease, Diet, Gluten-Free
Improvement Of Physical And Physiological Parameters In Menopausal Or Post-Menopausal Celiac Women
Celiac disease (CD) is an immunological disorder that mainly affects the small intestine, generating an inflammatory process in response to the presence of gluten (a protein).
- Conditions
- Celiac Disease, Diet, Gluten-Free, Exercise, Resistance Training
- Trial name
- NCT05052164
- Testing
- Gluten-free nutrition plan + exercise group, Gluten-free nutrition plan group, Active Comparator: Celiac controls group
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alicante
Celiac Disease, Irritable Bowel Syndrome
Gut Peptides and Intestinal Permeability in Celiac Disease and Irritable Bowel Syndrome
It is well known that the intestinal barrier is altered in celiac disease (CD), an autoimmune disease that develops in genetically predisposed subjects exposed to ingestion of wheat gliadin and of related prolamines of barley and…
- Trial name
- PPCD (NCT01574209)
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Celiac Disease
Simvastatin Metabolism as a Test for CD Activity (IRB 15-007568]
To study the correlation between simvastatin metabolism by the enterocyte and the histologic state of the intestine in treated celiac disease.
- Trial name
- NCT03011931
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Entero Therapeutics
Lactose Malabsorption
Acid Lactase in Combination With Yoghurt Bacteria for Improvement of Lactose Digestion in Lactose Malabsorbers
Fermented dairy products, especially real Yoghurt, are often tolerated better by lactose malabsorbers than unfermented dairy products.
- Trial name
- NCT01593631
- Testing
- Acid lactase, Lyoph. yoghurt bacteria, Acid lactase plus yoghurt bacteria
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vitacare Gmbh & Co. KG
Vitamin B12 Deficiency
Supplementary Vitamin B12 Effects on Elevated Homocysteine Levels of Vegetarians - Clinical Trial
Vegetarians are known to be deficient in vitamin B12, due to a lack or absence of dietary animal produce, which can elevate homocysteine.
- Trial name
- NCT01661309
- Testing
- Inactive lozenge, Methylcobalamin
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of West London
Protein Malabsorption, Nutritional Deficiency
Bioavailability of Proteins From Plant Based Diets
Proteins play an important role as structural and functional components for the human body and prevent stunting. Protein quality has a great importance in meeting the nutritional needs of populations across the world throughout…
- Conditions
- Protein Malabsorption, Nutritional Deficiency, Nutritional Stunting
- Trial name
- NCT04866927
- Testing
- Use of stable isotopic dilution to assess protein digestibility from Faba bean and to evaluate amino acid bioavailability
- Where
- Morocco
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- International Atomic Energy Agency
Coeliac Disease
Diagnostic Accuracy of IgA Anti-transglutaminase Antibodies Measured by CLIA for Predicting Villous Atrophy in Coeliac Disease
Celiac disease (CD) is an autoimmune disorder in which ingestion of gluten leads to immune-mediated damage of the small intestine. Diagnosis has traditionally required histological confirmation of duodenal villous atrophy.
- Trial name
- NCT07364461
- Where
- Spain
- Volunteers
- 765 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Milk Intolerance
Low-grade Inflammation and Gut Symptoms From A2 and Hydrolyzed A1 Milk
The aim of this study is to reveal how different forms of milk casein, lactose and moderate breakdown of proteins affect the symptoms that may arise from milk and markers of inflammation in volunteers receiving symptoms from…
- Trial name
- NCT05305391
- Testing
- Dietary intervention
- Where
- Finland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Turku
Celiac Disease
Study for Identifying Optimal Simvastatin Formulation for Uniform Time to Maximum Plasma Concentration
The inter- and intra-variability in the pharmacokinetic parameters of different formulations and doses of simvastatin in healthy subjects and in subjects with celiac disease in remission will be evaluated.
- Trial name
- NCT01642862
- Testing
- Simvastatin
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Celiac Disease
Mass Screening for the Early Detection of Patients With Celiac Disease.
The use of a home rapid test for the detection of both gluten immunogenic peptides (GIP) in urine and immunoglobulin A (IgA) anti tissue transglutaminase (anti-tTG) antibodies in blood may contribute to the early detection of…
- Trial name
- NCT05186038
- Testing
- iVYCHECK GIP Urine, CeliacDetect
- Where
- 2 sites in Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Biomedal S.L.