Clinical trials: Malaria
Plasmodium Falciparum Malaria
Mass Screening and Treatment for Reduction of Falciparum Malaria
In this project, the investigators aim at an operational research deployment of Ultrasensitive Rapid Diagnostic Test (URDT) -based Mass Screening and Treatment (MSAT) in the Malaria Elimination Task Force (METF) elimination…
- Trial name
- MSAT (NCT04093765)
- Testing
- Ultrasensitive Rapid Diagnostic Test (URDT), Antimalarials
- Where
- Thailand
- Volunteers
- 5,542 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
An Extended Follow up of a RTS,S/AS01E Malaria Vaccine Trial
Malaria is one of the leading causes of deaths in children below five years old. Despite antimalarial drugs and insecticide treated bed nets, the established means of treatment and protection, malaria still continues to affect…
- Trial name
- MAL059 (NCT00872963)
- Testing
- RTS,S/AS01E
- Where
- Kenya
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- KEMRI-Wellcome Trust Collaborative Research Program
Plasmodium Falciparum Malaria
Time to Infection With Malaria Parasites
This study will attempt to find out what effect mosquito insecticides have on the transmission of malaria in The Gambia. Eight hundred healthy men and women, aged 18 to 40 years, living in selected villages east of Farafenni town…
- Trial name
- NCT00322738
- Where
- The Gambia
- Volunteers
- 2,558 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Parasitic Diseases
Malaria Elimination Pilot Study in Military Forces in Cambodia
Antimalarial drug resistance has reached critical levels on the Thai-Cambodian border. Many have begun advocating for concerted malaria elimination efforts in Cambodia.
- Trial name
- NCT02653898
- Testing
- DHA-PIP, Primaquine, Artesunate + Mefloquine
- Where
- Cambodia
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Armed Forces Research Institute of Medical Sciences, Thailand
Malaria
Correlates of Protection in Ghana
Malaria is a sickness passed from one person to the other by the bite of a mosquito. In areas of frequent malaria infection, children may develop natural protection against malaria and they are less likely to become sick or die…
- Trial name
- NCT00138307
- Where
- 2 sites in Ghana
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Malaria,Falciparum
PfSPZ Vaccine Trial in Malian Children
In this randomized, double-blind, placebo-controlled trial, 268 healthy Malian children aged 6-10 years, residing in Bancoumana and surrounding villages, will be administered three doses of 9.0x10^5 Pf sporozoites (PfSPZ) of…
- Trial name
- NCT04940130
- Testing
- Sanaria® PfSPZ Vaccine, Normal Saline
- Where
- Mali
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Malaria, Hiv
OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa
A longitudinal study with four parallel cohorts with each participant followed for 2 years: two cohorts in Busia (high malaria transmission site) and two cohorts in Kampala (low malaria transmission).
- Trial name
- OPTIMAH (NCT06967519)
- Testing
- Artemether-lumefantrine (AL), artesunate-amodiaquine (AS-AQ)
- Where
- 2 sites in Uganda
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Yale University
Plasmodium Falciparum Malaria
A Challenge Study to Assess the Protective Efficacy of Two Malaria Vaccine Candidates
This study aims to assess the safety and effectiveness of four new candidate malaria vaccines; ChAd63 CS, ChAd63 ME-TRAP, MVA CS \& MVA ME-TRAP.
- Trial name
- VAC045 (NCT01623557)
- Testing
- ChAd63-MVA CS, ChAd63-MVA ME-TRAP, Controlled Human Malaria Infection Administered by Mosquito Bite
- Where
- 3 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pregnancy, Malaria
Evaluation of Alternative Antimalarial Drugs for Malaria in Pregnancy
The study aims at comparing the safety, tolerability and efficacy of Mefloquine (MQ) to Sulfadoxine-Pyrimethamine (SP) as Interment Preventive Treatment in pregnancy (IPTp) for the prevention of malaria effects on the mother and…
- Conditions
- Pregnancy, Malaria, HIV Infections
- Trial name
- MiPPAD (NCT00811421)
- Testing
- Sulphadoxine-pyrimethamine, Mefloquine (full dose), Mefloquine (split dose)
- Where
- 5 sites in Benin, Gabon and 3 more
- Volunteers
- 5,820 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Malaria
Malaria Candidate Vaccines FP9 Circumsporozoite (CS) and MVA CS in Adult Gambian Men
Animal and human studies have shown that the prime-boost immunization strategy using malaria antigens expressed in plasmid or viral vectors induces strong cellular immune responses.
- Trial name
- NCT00121771
- Testing
- FP9 CS, MVA CS
- Where
- The Gambia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Mass Drug Administration of Ivermectin and Dihydroartemisinin-piperaquine as an Additional Intervention for Malaria Elimination
This is a community-based cluster-randomized trial in which a novel approach to interrupt residual malaria transmission by mass drug administration (MDA) with ivermectin (IVM) combined with dihydroartemisinin-piperaquine (DP)…
- Trial name
- MASSIV (NCT03576313)
- Testing
- dihydroartemisinin-piperaquine (DP), ivermectin (IVM), standard malaria control interventions only
- Where
- The Gambia
- Volunteers
- 4,939 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Efavirenz
This study assessed the effect of multiple doses of a moderate inducer of cytochrome P450 (CYP) 3A4 (efavirenz) on the pharmacokinetics (PK) of ganaplacide and lumefantrine combination.
- Trial name
- NCT05330273
- Testing
- Ganaplacide, Lumefantrine, Efavirenz
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Anemia, Inflammation
Acute vs. Delayed Iron Therapy: Effect on Iron Status, Anemia and Cognition
The research questions to be answered by this study are: 1. Is treatment with iron more effective at improving anemia if given at the time of a malaria episode or 1 month after the episode? 2.
- Conditions
- Anemia, Inflammation, Malaria Morbidity, Cognitive Development
- Trial name
- NCT01093989
- Testing
- Ferrous Sulphate Syrup
- Where
- Uganda
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Malaria
Study Assessing Pharmacokinetics and Bioavailability of Three Novel Triazine Compounds
Open-label, randomized, microdose study
- Trial name
- NCT03436160
- Testing
- WR826647, WR909388, WR909390
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria
VAC063C: A Study to Assess Repeat Blood-stage P. Falciparum Infection
This is a clinical study to assess the safety of primary, secondary and tertiary blood-stage controlled human Plasmodium falciparum malaria infection of healthy malaria-naïve UK adults, as well as to evaluate any effect of prior…
- Trial name
- NCT03906474
- Testing
- Blood-stage controlled human P. falciparum malaria infection
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria,Falciparum, Neglected Tropical Diseases
Adjunctive Ivermectin Mass Drug Administration for Malaria Control
This is a cluster-randomized placebo-controlled clinical trial to evaluate the additive benefit of Ivermectin (IVM) (or Placebo) mass drug administration (MDA) to dihydroartemisinin-piperaquine (DP) MDA for malaria control in a…
- Conditions
- Malaria,Falciparum, Neglected Tropical Diseases, Strongyloidiasis, Lymphatic Filariasis
- Trial name
- MATAMAL (NCT04844905)
- Testing
- Ivermectin, Dihydroartemisinin-piperaquine
- Where
- Guinea-Bissau
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Characterisation of the Immune Responses of 2 Experimental Malaria Vaccines
In this study, two experimental malaria vaccines (with adjuvants) are tested to evaluate and characterise how the vaccine exactly works on the immune system by comparing it to a control (without adjuvant).
- Trial name
- NCT00443131
- Testing
- GSK Malaria vaccine 257049
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria
Malaria Clinical Trials Center General Screening
The purpose of this study is to identify and screen potential subjects for preliminary eligibility to participate in a malaria related clinical trial conducted at the Seattle Malaria Clinical Trials Center (Seattle MCTC) or one…
- Trial name
- GS (NCT02119312)
- Where
- United States
- Volunteers
- 2,101 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Plasmodium Falciparum, Malaria
Comparison of Three Plasmodium Falciparum Isolates in an Experimental Human Malaria Infection
Plasmodium falciparum isolates display a wide genetic diversity with possibly different properties to induce immune responses. These properties could directly influence the ability to induce protective efficacy.
- Trial name
- TIP1 (NCT01002833)
- Testing
- Exposure to Plasmodium falciparum infected mosquitoes
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria
Examine Safety and Immune Responses of GSK 257049 Vaccine When Administered to Infants Living in a Malaria-endemic Region
GSK Biologicals is developing in partnership with the Program for Appropriate Technology in Health (PATH) Malaria Vaccine Initiative a candidate malaria vaccine for the routine immunization of infants and children living in…
- Trial name
- NCT00197028
- Testing
- RTS,S/AS02D, TETRActHib™, Engerix-B®
- Where
- Mozambique
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline