Clinical trials: Malaria, completed
Anemia
Treatment of Iron Deficiency Anemia in Malaria Endemic Ghana
Iron deficiency and iron deficiency anemia (IDA) are the most prevalent micronutrient deficiencies on a worldwide basis, especially in developing countries.
- Trial name
- NCT01001871
- Testing
- Sprinkles®, vitamin/mineral fortificant without iron
- Where
- Ghana
- Volunteers
- 3,880 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Falciparum Malaria, Vivax Malaria
A Randomized Trial of Coartemether and Artekin for the Treatment of Uncomplicated Malaria in Papua, Indonesia.
This open randomized, parallel group, 6 week trial in two rural outpatient clinics will compare the safety and efficacy of a six dose coartemether regimen with 3 dose artekin regimen for the treatment of acute, uncomplicated…
- Trial name
- NCT00157833
- Testing
- Artekin / Coartemther
- Where
- Indonesia
- Volunteers
- 750 people
- Sponsor
- Menzies School of Health Research
Severe Sepsis, Malaria
Monitoring of Perfusion in Sepsis and Malaria
Sepsis and severe malaria together contribute to an estimated 13 million deaths annually, a great burden of which is in low-income countries.
- Trial name
- PERFuSE (NCT03641534)
- Testing
- Lung Ultrasound examination, Compression ultrasonography (CUS), Echocardiography
- Where
- Bangladesh
- Volunteers
- 103 people
- Sponsor
- University of Oxford
Malaria
Parasite Clearance and Protection From Infection (PCPI) in Cameroon
The Cameroon PCPI study will measure the effect of the parasite genotypes associated with SP resistance on parasite clearance and protection from infection when exposed to SP.
- Trial name
- NCT06173206
- Testing
- SP (Macleods Pharmaceuticals Ltd), SPAQ (Guilin Pharmaceuticals), AS (Guilin Pharmaceuticals)
- Where
- Cameroon
- Volunteers
- 902 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Surveillance of Effectiveness/Safety of Artemether-lumefantrine in Patients With Malaria
The purpose of this study is to describe the pediatric and adult patients (U.S. and foreign residents) diagnosed with malaria and treated with artemether-lumefantrine with regard to their demographics, including evaluation of…
- Trial name
- NCT01228344
- Testing
- Artemether-lumefantrine
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Novartis Pharmaceuticals
Plasmodium Falciparum Malaria
Safety and Preliminary Protective Efficacy of Genetically Attenuated GA2 Parasites.
This study will consist of two phases and be aimed at assessing the safety and tolerability of the new genetically attenuated GA2 malaria parasite (Phase 1) and its preliminary protective efficacy against controlled human malaria…
- Trial name
- NCT04577066
- Testing
- GA2, GA1
- Where
- Netherlands
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Plasmodium Falciparum Malaria, Malaria Diagnosis
Additional Screening With Sensitives RDTs and Malaria
National malaria control strategies in pregnant women relies primarily on effective case management along with the use of long lasting insecticide-treated nets (LLINs)throughout pregnancy and intermittent preventive treatment…
- Trial name
- ASSERMalaria (NCT04147546)
- Testing
- Additional screening using ultra sensitive RDTs, Dihydroartemisinin-piperaquin, Reminders
- Where
- Burkina Faso
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Malaria, Pregnancy
A New Approach to Deliver Malaria Preventions to Pregnant Women at a Community Level in Uganda
SUMMARY Background: Malaria is the leading cause of morbidity and mortality among pregnant women in Uganda. Although effective tools for prevention and control of malaria exist, their delivery presents a problem.
- Conditions
- Malaria, Pregnancy, Anemia
- Trial name
- NCT00118027
- Testing
- sulphadoxine-pyrimethamine intermittent preventive treatment
- Where
- Uganda
- Volunteers
- 2,150 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria (Uncomplicated)
Efficacy of Sulphadoxine-pyrimethamine and Artemisinin-containing Combination Therapy for Malaria
This is an ongoing monitoring activity of efficacy of sulfadoxine-pyrimethamine (SP), which is the current national treatment of choice for uncomplicated malaria in Tanzania, and a combination of SP and artesunate among children…
- Trial name
- NCT00140361
- Testing
- Sulfadoxine-pyrimethamine, sulfadoxine-pyrimethamine plus artesunate, lumefantrine plus artemether
- Where
- 3 sites in Tanzania
- Volunteers
- 390 people
- Sponsor
- Centers for Disease Control and Prevention
Malaria, Sepsis
Optimal Fluid Management in Adult Severe Malaria
Optimal fluid therapy in severe falciparum malaria has not been well defined, especially in resource poor settings where access to mechanical ventilation is limited.
- Trial name
- DRIPICCO (NCT01936766)
- Where
- Bangladesh
- Volunteers
- 156 people
- Sponsor
- University of Oxford
Malaria, Stillbirths
The Impact of Sulphadoxine-Pyrimethamine Use At Scale on Newborn Outcomes in Nigeria
The purpose of this study is to test the feasibility of the scale-up of sulphadoxine- pyrimethamine (SP) for the preventive treatment of malaria in pregnancy in three Local Government Areas (LGAs) in Sokoto State, Nigeria.
- Trial name
- MIPP-NG (NCT02758353)
- Testing
- Community distribution of SP
- Volunteers
- 31,493 people, healthy volunteers welcome
- Sponsor
- JSI Research & Training Institute, Inc.
Malaria
Trial of Artemether-Lumefantrine Alone and in Combination With Ivermectin to Reduce Post-Treatment Malaria Transmission
The purpose of this study is to determine the safety and impact of ivermectin, administered as single or repeated dose, in combination with artemether-lumefantrine in reducing the proportion of mosquitoes that survive and become…
- Trial name
- ACTIVE (NCT01603251)
- Testing
- Artemether-lumefantrine combination, Artemether-lumefantrine combination + single dose Ivermectin, Artemether-lumefantrine combination + repeated dose Ivermectin
- Where
- Burkina Faso
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Respiratory Infections
A Trial of Seasonal Malaria Chemoprevention Plus Azithromycin in African Children
The primary objective of this study is to determine whether addition of azithromycin (AZ) to Seasonal Malaria Chemoprevention (SMC) using sulphadoxine/pyrimethamine (SP) +amodiaquine (AQ) will provide an additional reduction in…
- Trial name
- SMCAZ (NCT02211729)
- Testing
- Sulphadoxine-Pyrimethamine+ Amodiaquine+ Azithromycin
- Where
- 2 sites in Burkina Faso, Mali
- Volunteers
- 22,090 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Efavirenz
This study assessed the effect of multiple doses of a moderate inducer of cytochrome P450 (CYP) 3A4 (efavirenz) on the pharmacokinetics (PK) of ganaplacide and lumefantrine combination.
- Trial name
- NCT05330273
- Testing
- Ganaplacide, Lumefantrine, Efavirenz
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Malaria
Efficacy, Safety, Tolerability and Pharmacokinetics of KAE609 in Adult Patients With Acute, Uncomplicated Plasmodium Falciparum or Vivax Malaria Mono-infection
This study will assess efficacy, safety , tolerability and PK in uncomplicated adult malaria patients with P. vivax or P. falciparum infection after 3 day dosing with KAE609 at 30 mg/day
- Trial name
- NCT01524341
- Testing
- KAE609
- Where
- 3 sites in Thailand
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Malaria, Vivax
Artesunate Plus Sulfadoxine-Pyrimethamine Versus Chloroquine for Vivax Malaria
The purpose of this study was to determine whether the proposed first line treatment for falciparum malaria in this region (sulfadoxine-pyrimethamine + artesunate) would be no worse a treatment for vivax malaria that the standard…
- Trial name
- NCT00486694
- Testing
- Sulfadoxine-pyrimethamine + artesunate, Chloroquine
- Volunteers
- 190 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Infections, Vector Borne Diseases
Phase 1b MMV367 PK/PD and Safety in Healthy Adult Volunteers Experimentally Infected With Blood Stage P. Falciparum
This is an open-label, adaptive study using the P. falciparum induced blood stage malaria (IBSM) model to characterise the pharmacokinetic/pharmacodynamic (PK/PD) profile and safety of MMV367 (the IMP).
- Conditions
- Infections, Vector Borne Diseases, Systemic Inflammatory Response Syndrome, Inflammation
- Trial name
- NCT05979207
- Testing
- MMV367 3mg, P. falciparum IBSM infection, MMV367 5mg
- Where
- 2 sites in Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
P. Falciparum Malaria
Assessment of the Therapeutic Efficacy and Tolerability of the Artesunate/Amodiaquina Combination and Artemether/Lumefantrine Combination, Treatment of Uncomplicated P. Falciparum Malaria in the Department of Chocó (Colombia)
Background: Malaria by P falciparum is a public health problem in more than 100 municipalities of Colombia. The country is using the artemether+lumefantrine (AM+L) fixed combination for uncomplicated P falciparum malaria but it…
- Trial name
- UNAL MALARIA (NCT04877626)
- Testing
- Artemeter plus lumefantrina vs artesunato plus amodiquina
- Where
- Colombia
- Volunteers
- 210 people
- Sponsor
- Universidad Nacional de Colombia
Malaria, Anemia
Intermittent Preventive Treatment With Antimalarials in Kenyan Infants
The purpose of the study is to see whether antimalarial drugs administered at the time of routine infant vaccinations prevents malaria and anemia in the first year of life.
- Trial name
- NCT00111163
- Testing
- sulfadoxine-pyrimethamine with artesunate, amodiaquine with artesunate, chlorproguanil-dapsone
- Where
- Kenya
- Volunteers
- 1,516 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Malaria
Impact of Insecticide-treated Curtains on Antimalarial Drug Resistance
Attempts to understand the relationship malaria transmission intensity and antimalarial drug resistance had rested mainly on mathematical models.
- Trial name
- NCT00169078
- Testing
- Chloroquine
- Where
- Burkina Faso
- Volunteers
- 1,035 people
- Sponsor
- London School of Hygiene and Tropical Medicine
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