Clinical trials: Malaria
Malaria,Falciparum
Cohort Event Monitoring Study of Pyramax®
The study is to be performed in public health facilities in Central and West Africa where Pyramax will be used as treatment of uncomplicated malaria episodes, including repeat episodes.
- Trial name
- NCT03201770
- Testing
- pyronaridine artesunate
- Where
- 5 sites in Cameroon, Côte d’Ivoire and 3 more
- Volunteers
- 8,572 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Vivax Malaria
Study on the Treatment of Vivax Malaria
This is a randomised open label trial with follow up for 1 year. 660 adults and children above 6 months diagnosed with acute Plasmodium vivax will be randomised into 3 groups, either chloroquine, artesunate, or…
- Trial name
- VHX (NCT01074905)
- Testing
- Artesunate, Chloroquine, Chloroquine/Primaquine
- Where
- Thailand
- Volunteers
- 655 people
- Sponsor
- University of Oxford
Splenectomy
Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations
Human splenic physiology remains poorly understood due to lack of functional exploration. However, through its ability to recognize alterations or modifications in circulating cells and to trigger an innate and adaptive response…
- Trial name
- SPLEENVIVO (NCT06418256)
- Testing
- Spleen, blood and plasma collection
- Where
- 5 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Plasmodium Vivax Malaria, Malaria
FocaL Mass Drug Administration for Vivax Malaria Elimination
FLAME is an open-label cluster-randomized controlled trial that aims to determine the effectiveness of focal mass drug administration (fMDA) to reduce the incidence of Plasmodium vivax malaria in the Loreto Department in Peru.
- Trial name
- FLAME (NCT05690841)
- Testing
- Focal Mass Drug Administration (fMDA)
- Where
- Peru
- Volunteers
- 7,530 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria, Severe Anemia
Delivery of Malaria Chemoprevention in the Post-discharge Management of Children With Severe Anaemia in Malawi
Background and rationale: Children hospitalised with severe anaemia in Africa are at high risk of readmission or death within 6 months after discharge. No strategy specifically addresses this post-discharge period.
- Trial name
- PMC (NCT02721420)
- Testing
- dihydroartemisinin-piperaquine, message(SMS) reminder, Health worker reminder
- Where
- Malawi
- Volunteers
- 375 people
- Sponsor
- Kamuzu University of Health Sciences
Malaria, Filariasis
Medical Implications of Coinfection With Malaria and Filariasis Parasites
This study will examine the clinical, immunological and epidemiological effects of concurrent infections with P. falciparum and W. bancrofti or M.
- Trial name
- NCT00471666
- Where
- Mali
- Volunteers
- 1,039 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anaemia, Schistosomiasis Infection
Assessment of Anaemia Attributable to Schistosomiasis in School Children in Kenya: Mechanisms and Effect of Treatment
The purpose of this study is to determine the extend and the nature of anemia in school children and the correlation between anemia and schistosomiasis infections, malaria infections and/or malnutrition (iron deficiency).
- Conditions
- Anaemia, Schistosomiasis Infection, Malaria, Iron Deficiency
- Trial name
- NCT00414479
- Testing
- praziquantl, iron, ACT
- Where
- Kenya
- Volunteers
- 1,500 people
- Sponsor
- DBL -Institute for Health Research and Development
Malaria
Malaria Survey in Mbarara District, Uganda 2010
Malaria is one of the major public health problems in Sub-Saharan Africa. In response to this threat, Roll Back Malaria (RBM) has rolled back a strategy using ACT as first line therapy for malaria episode, a wide distribution of…
- Trial name
- NCT01062386
- Where
- Uganda
- Volunteers
- 2,320 people, healthy volunteers welcome
- Sponsor
- Epicentre
Uncomplicated Malaria
Amodiaquine+Artesunate vs. Artemether-Lumefantrine for Uncomplicated Malaria in Ghanaian Children
Artemisinin combination therapies (ACT) are currently recommended for malaria treatment. Artemether-lumefantrine(A-L) and Artesunate+amodiaquine (A+A) have been the most commonly adopted of the recommended ACT regimens.
- Trial name
- NCT00406146
- Testing
- amodiaquine+artesunate/artemether-lumefantrine
- Where
- Ghana
- Sponsor
- University of Ghana Medical School
Falciparum Malaria
Safety and Efficacy Study of Adjunctive Rosiglitazone in the Treatment of Uncomplicated Falciparum Malaria
The purpose of this study is to examine the safety, tolerability, and efficacy of adjunctive rosiglitazone in the treatment of uncomplicated P.falciparum malaria.
- Trial name
- NCT00149383
- Testing
- Rosiglitazone
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Mahidol University
Malaria
Intermittent Preventive Treatment in Infant in Mali
Studies have shown that Intermittent preventive treatment in infants (IPTi) with Sulfadoxine-pyrimethamine (SP)reduced the incidence of clinical malaria and anemia without modifying infants' serological response to EPI vaccines.
- Trial name
- NCT00766662
- Testing
- Sulfadoxine pyrimethamine
- Where
- Mali
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Bamako
Vaccine Reaction
A Trial For The Study of Falciparum Malaria Protein 014 Administered Via Intramuscular Injection in Healthy Adults
A Phase 1, open label clinical study to evaluate the safety, immunogenicity, tolerability and efficacy of Plasmodium falciparum Malaria Protein 014 (FMP014) combined with (ALF with QS-21), saponin molecule derived from the bark…
- Trial name
- NCT04296279
- Testing
- FMP014, ALFQ
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria, Malaria in Pregnancy
ERASE - Impact of COVID-19 on Malaria Control
Objective: Measure incidence of malaria and malaria-related outcomes, evaluating potential impact of the SARS-CoV2 epidemic and of antimalarial resistance in Oyam and Kole district, Uganda with focus on pregnant women.
- Trial name
- ERASE (NCT05348746)
- Testing
- Advanced Analysis of Polymorphism
- Volunteers
- 300 people
- Sponsor
- Doctors with Africa - CUAMM
Malaria
Cluster Randomized Trial of Peer Health Education in Malaria in The Gambia
Health promotion in schools aims to improve the health and well being of students by empowering them with the knowledge, skills and confidence to take responsibility for their own health.
- Trial name
- NCT00269178
- Testing
- Peer Health Education Programme
- Where
- The Gambia
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Safety, Attenuation and Immunogenicity of GAP3KO Administered Via A Stephensi Mosquitoes
Study designed to evaluate safety and tolerability of a genetically attenuated P. falciparum (GAP3KO) that arrests early in the liver stage of the parasite life cycle.
- Trial name
- NCT02313376
- Testing
- GAP3KO
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Malaria
Reducing the Effects of Malaria in Children by Administering Repeated Preventive Doses
The general goal of the project is to assess the infectious status and immunity of mothers and children living in a malaria region.
- Trial name
- NCT00167843
- Testing
- sulfadoxine-pyrimethamine
- Where
- Gabon
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- Albert Schweitzer Hospital
Anemia, Malaria
Perennial Malaria Chemoprevention (PMC) in Cameroon
The Plus Project will assess the impact, operational feasibility, efficacy, effectiveness, and cost-effectiveness of PMC. Specifically, the impact evaluation will involve monitoring a passive cohort of all children in the study…
- Trial name
- NCT05889052
- Testing
- Sulfadoxine pyrimethamine
- Where
- Cameroon
- Volunteers
- 2,138 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria,Falciparum
Effectiveness and Safety of Artesunate-Amodiaquine and Artemether-Lumefantrine for the Treatment of Malaria in Yaounde
Artesunate-amodiaquine and artemether-lumfantrine are currently being used for the treatment of uncomplicated Plasmodium falciparum in Cameroon.
- Trial name
- NCT04565184
- Testing
- Artesunate-amodiaquine combination, Artemether, Lumefantrine Drug Combination
- Where
- Cameroon
- Volunteers
- 242 people
- Sponsor
- University of Yaounde 1
Plasmodium Falciparum
NMRC-M3V-Ad-PfCA Vaccine - Clinical Trial 1
The purpose of this study is to determine whether a new investigational malaria vaccine is safe, well tolerated and effective against experimental exposure to malaria when given to healthy people with no previous exposure to…
- Trial name
- NCT00392015
- Testing
- NMRC-M3V-Ad-PfCA, NMRC-MV-Ad-PfC, NMRC-M3V-Ad-PfCA
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Healthy Women of Child Bearing Potential
Assessment of Safety, Immunogenicity and Efficacy of R21/Matrix-M1 Malaria Vaccine in Healthy WOCBP in Mali
This will be a double-blind, individually randomised trial, to assess the safety, tolerability, immunogenicity, and protective efficacy of two and three doses of the R21/Matrix-M1 malaria vaccine or placebo given at 4 week…
- Trial name
- NCT06080243
- Testing
- R21/Matrix-M1, Saline and R21/Matrix-M1, Sterile isotonic (0.9%) normal saline
- Where
- Mali
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Oxford