Clinical trials: Malaria, completed
Malaria, Falciparum
Artemisinin-based Combination Therapy for Treatment of Plasmodium Falciparum Malaria in North Sumatera, Indonesia
This is a prospective, open label, randomised controlled trial to assess the safety and efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum…
- Trial name
- NCT02325180
- Testing
- Dihydroartemisinin-Piperaquine, Artemether-lumefantrine
- Where
- 3 sites in Indonesia
- Volunteers
- 338 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Proof-of-Concept Study of MSP3-LSP Vaccine to Protect Against Malaria in Africa
Hypothesis: The MSP3-LSP/Alum vaccine, administered to children will have a protective efficacy of at least 30% (lower bound of confidence interval of 0) against malaria disease occurring during a period beginning from 14 days…
- Trial name
- MSP3-POC (NCT01341704)
- Testing
- MSP3-LSP/AlOH, Verorab Vaccine, 0.9% NaCl/Normal Saline
- Where
- Mali
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Vac4All
Malaria
Effectiveness of OZ439 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Volunteers
A single centre, open, controlled study using Blood Stage Plasmodium falciparum challenge inoculum (BSPC) as a model to assess the effectiveness of three dose levels of the experimental anti-malarial product, OZ439.
- Trial name
- NCT02453581
- Testing
- OZ439
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis
Malaria, a disease caused by the parasite Plasmodium, is one of the world's major infectious diseases. With approximately 627.000 deaths a year, there is desperate need for an effective vaccine.
- Trial name
- BMGF1 (NCT02080026)
- Testing
- CPS-immunization, Controlled Human Malaria Infection, chloroquine
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria
Community Point Distribution of Insecticide Treated Bed Nets
All households in three zones in Zambia's Eastern Province were invited to attend a community point distribution of insecticide treated bed nets (ITNs).
- Trial name
- NCT02517879
- Testing
- Community point distribution, Community health worker hang-up visit
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- IDinsight
Malaria
In Vivo and in Vitro Efficacy of Antimalarial Treatments in Children in Burkina Faso
Resistance to antimalarial drugs represents a major obstacle for controlling malaria in endemic countries, so that most sub-Saharan countries have changed their antimalarial drug policy to the new Artemisinin Containing…
- Trial name
- NCT00808951
- Testing
- Artesunate-amodiaquine, Artemether-lumefantrine
- Where
- Burkina Faso
- Volunteers
- 440 people
- Sponsor
- Centre Muraz
Uncomplicated P. Falciparum Malaria in Children
Artemether-lumefantrine (AL) Versus Artesunate + Amodiaquine (ASAQ) for the Treatment of Uncomplicated Falciparum Malaria in Burkina Faso
Several countries in Africa have changed their first-line treatment for uncomplicated malaria to an ACT. Burkina Faso has changed its policy to Artemether-Lumefantrine (AL) and Artesunate-Amodiaquine (AQ+AS).
- Trial name
- ACTE (NCT01017770)
- Testing
- Artesunate-amodiaquine, Artemether-lumefantrine
- Where
- 4 sites in Burkina Faso
- Volunteers
- 340 people
- Sponsor
- Centre Muraz
Uncomplicated Malaria
Amodiaquine+Artesunate for Uncomplicated Malaria Treatment
This is a phase IV one-arm study aiming at recruiting 50 patients to assess the efficacy of AQ+AS in patients with a positive RDT diagnosis of malaria in Nanoro, Burkina Faso.
- Trial name
- ASAQ-MAL (NCT01213433)
- Testing
- Artesunate-Amodiaquine
- Where
- Burkina Faso
- Volunteers
- 150 people
- Sponsor
- Centre Muraz
Malaria
Pharmacovigilance for ACTs in Africa
This is a phase IV open label study assessing the safety and effectiveness of artemisinin derivatives-based combination therapy (ACT) when used on a large scale and under "real life" conditions.
- Trial name
- PVACT (NCT01232530)
- Where
- Burkina Faso
- Volunteers
- 3,176 people
- Sponsor
- Centre Muraz
Malaria
Amodiaquine-Artesunate & Artemether-Lumefantrine Efficacy in Burkina Faso
This is a two-arm study aiming at recruiting 150 patients to assess the efficacy of Amodiaquine-Artesunate (ASAQ) and Artemether-Lumefantrine (AL) in patients with a microscopy positive diagnosis of malaria in Nanoro, Burkina…
- Trial name
- NCT01697787
- Testing
- Amodiaquine-Artesunate, Artemether-lumefantrine
- Where
- Burkina Faso
- Volunteers
- 150 people
- Sponsor
- Centre Muraz
Malaria
ANC & Malaria Diagnostic in Pregnancy
The program's overall objective is to assess the impact of a package of interventions aimed at reducing malaria-related mortality and morbidity in pregnant women and newborns by ensuring access to a package of interventions…
- Trial name
- AQUAMOD (NCT01703884)
- Testing
- ASAQ
- Where
- Burkina Faso
- Volunteers
- 5,254 people
- Sponsor
- Centre Muraz
Acute Uncomplicated Falciparum Malaria
Efficacy, Safety and Pharmacokinetics of Artemether-lumefantrine Dispersible Tablet in the Treatment of Malaria in Infants < 5 kg
The purpose of the study is to obtain efficacy, safety and pharmacokinetic (PK) data following treatment with artemether-lumefantrine dispersible tablet in infants < 5 kg of body weight (BW) with uncomplicated falciparum malaria.
- Trial name
- NCT01619878
- Testing
- Artemether-lumefantrine (COA566)
- Where
- 7 sites in Benin, Burkina Faso and 3 more
- Volunteers
- 20 people
- Sponsor
- Novartis Pharmaceuticals
Malaria
A Study to Determine Whether 2 Investigational Malaria Vaccines Are Safe, Protective Against Malaria in Adults
The purpose of this study is to determine whether 2 investigational malaria vaccines are safe as well as protective against malaria in adults living in the United States
- Trial name
- NCT00385047
- Testing
- Group A FMP2.1/AS01B, Group B FMP2.1/AS02A
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Anemia, Inflammation
Acute vs. Delayed Iron Therapy: Effect on Iron Status, Anemia and Cognition
The research questions to be answered by this study are: 1. Is treatment with iron more effective at improving anemia if given at the time of a malaria episode or 1 month after the episode? 2.
- Conditions
- Anemia, Inflammation, Malaria Morbidity, Cognitive Development
- Trial name
- NCT01093989
- Testing
- Ferrous Sulphate Syrup
- Where
- Uganda
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Falciparum Malaria
Tracking Resistance to Artemisinin (TRAC)
Because the artemisinins are the most potent antimalarial drugs, the reduction in parasite numbers is rapid. Therefore, early measures of reducing parasite counts are needed.
- Trial name
- TRAC (NCT01350856)
- Testing
- Artesunate 2, Artesunate 4
- Where
- 19 sites in Bangladesh, Burma and 8 more
- Volunteers
- 1,700 people
- Sponsor
- University of Oxford
Anaemia
Parenteral Artesunate Compared to Quinine as a Cause of Late Anaemia in African Children With Malaria
Delayed anaemia has been reported in European travellers with malaria cured by artesunate. Although no deaths related to this delayed anaemia have been reported so far, blood transfusion has been necessary in some affected…
- Trial name
- DHART (NCT02092766)
- Testing
- artesunate, quinine
- Where
- Democratic Republic of the Congo
- Volunteers
- 217 people
- Sponsor
- University of Oxford
Malaria
A Study to Determine the Effects of an Investigational Malaria Vaccine Given to Adults Living in the United States and Thereafter to Adults Living in Kenya
The purpose of this study is to determine whether an investigational malaria vaccine is safe and induces an immune response against malaria when tested in adults living in the United States.
- Trial name
- NCT00666380
- Testing
- Plasmodium falciparum Malaria Protein 010 (FMP010)
- Where
- 2 sites in United States, Kenya
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
HIV Infections, Human Immunodeficiency Virus
Effect of Bednets and a Water Purification Device on HIV Disease Progression Among ART naïve Patients in Kenya
In many areas of the world most severely affected by the HIV/AIDS pandemic, insect and water-borne diseases such as malaria and diarrheal disease are common causes of illness and death.
- Conditions
- HIV Infections, Human Immunodeficiency Virus, Malaria, Plasmodium Falciparum
- Trial name
- ITN (NCT00914225)
- Testing
- Bednets and Water Purification
- Where
- 2 sites in Kenya
- Volunteers
- 500 people
- Sponsor
- University of Washington
Malaria
Trial to Compare Effectiveness of 2 Insecticides in Preventing Malaria
Twenty-four (24) clusters, each containing between 250-300 houses were selected throughout Bioko Island to be sprayed with either a long lasting pyrethroid insecticide, K-Othrine SC 62.5, or a bendiocarb insecticide, FICAM.
- Trial name
- NCT02458066
- Testing
- IRS: bendiocarb, IRS: deltamethrin
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Medical Care Development, Inc.
Malaria
A Study to Assess Safety, Immunogenicity and Parasite Growth Inhibition of an Asexual Blood Stage Vaccine for P. Falciparum Malaria
Malaria is a parasite, infection with which kills over 2 million people each year. It is a major problem for those who live in endemic areas and for travellers. There is a great need for a safe effective malaria vaccine.
- Trial name
- NCT00984763
- Testing
- AMA1-C1/Alhydrogel® + CPG 7909
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Oxford