Clinical trials: Malaria, completed
Malaria
Evaluation of Reactive Focal Mass Drug Administration for Malaria Elimination in Swaziland
This is a cluster randomised controlled trial comparing the impact of two community based malaria interventions: reactive case detection (RACD) vs reactive targeted presumptive treatment (focal mass drug administration, fMDA) on…
- Trial name
- fMDA (NCT02315690)
- Testing
- dihydroartemisinin-piperaquine (DHAp), reactive case detection
- Where
- Eswatini
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria
Merozoite Surface Protein 1 Antibody Response in Asymptomatic Human Malaria Infection
The main purpose of this trial is to study whether a certain blood test can reliably identify the presence of malaria in people who have been infected with, but who do not have symptoms of malaria.
- Trial name
- NCT00761020
- Testing
- Mefloquine, Control
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria
Drug Interaction Study of Pyronaridine-artesunate & Metoprolol, & Redosing Study of Pyronaridine-artesunate
The primary objective of the drug-drug interaction study is to evaluate any drug interaction between the CYP2D6 substrate metoprolol and pyronaridine-artesunate in healthy volunteers.
- Trial name
- NCT01523002
- Testing
- Metoprolol and pyronaridine-artesunate, pyronaridine-artesunate
- Where
- Switzerland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Plasmodium Falciparum Malaria
Assessment of Three Formulations of the Candidate Vaccine AMA 1 in Healthy Dutch Adult Volunteers
The objective of this study was to evaluate the safety of a candidate malaria vaccine (PfAMA-1) at 3 doses given at monthly intervals of 2 different dosages of AMA-1 (10 μg or 50 μg ) adjuvanted either with alum hydroxide or…
- Trial name
- NCT00730782
- Testing
- PfAMA-1-FVO[25-545]
- Where
- 2 sites in Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- European Vaccine Initiative
Malaria
A Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetic Profile of a Single Doses of MMV533.
Phase 1, single -centre study in 2 parts. The study designs for each part are well established for first-in-human studies and are appropriate to assess safety, tolerability and preliminary pharmacokinetics.
- Trial name
- NCT04323306
- Testing
- MMV688533
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Plasmodium Falciparum Infection
Study to Investigate the Clinical and Parasiticidal Activity and Pharmacokinetics of Different Doses of Artefenomel and Ferroquine in Patients With Uncomplicated Plasmodium Falciparum Malaria
Primary Objective: To show the contribution of artefenomel (OZ439) to the clinical and parasiticidal effect of OZ439/Ferroquine (FQ) combination by analyzing exposure-response of OZ439 measured by Day 28 polymerase chain reaction…
- Trial name
- NCT03660839
- Testing
- Artefenomel (OZ439), Ferroquine (SSR97193)
- Where
- 7 sites in Benin, Burkina Faso and 3 more
- Volunteers
- 140 people
- Sponsor
- Sanofi
Iron Deficiency, Malaria
Acute vs. Delayed Iron: Effect on Red Cell Iron Incorporation in Severe Malaria
The purpose of this study is to determine whether iron therapy given to iron-deficient Ugandan children with moderate-to-severe anemia and clinical malaria is better absorbed and incorporated into red blood cells if it is given…
- Conditions
- Iron Deficiency, Malaria, Nutrition, Global Health
- Trial name
- NCT01754701
- Testing
- Immediate iron, Delayed iron
- Where
- Uganda
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Malaria, Malnutrition
Evaluation of Vitamin A and Zinc Supplementation on Malarial Morbidity
The purpose of this study was to determine whether young children receiving Vitamin A and Zinc supplements will have a lower incidence of symptomatic malaria than similar children receiving vitamin A supplements alone.
- Trial name
- NCT01782001
- Testing
- vitamin A, vitamin A and zinc
- Where
- Ghana
- Volunteers
- 200 people
- Sponsor
- Kintampo Health Research Centre, Ghana
Malaria, Anemia
Efficacy of Two Dual Active Ingredient Long Lasting Insecticidal Nets for Control of Malaria Transmitted by Pyrethroid Resistant Vectors in Benin
The massive scale-up of Long Lasting Insecticidal Nets (LLIN) has led to a major reduction in malaria burden (up to 50%) in many sub-Saharan African countries.
- Trial name
- NNP (NCT03931473)
- Testing
- Bed nets
- Where
- Benin
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Acute Falciparum Malaria
Efficacy, Safety, and Tolerability of Dihydroartemisinin-piperaquine + Mefloquine Compared to Dihydroartemisinin-piperaquine or Artesunate-mefloquine in Patients With Uncomplicated Falciparum Malaria in Cambodia
Background: Malaria is an illness caused by a parasite that enters people s bodies when a mosquito bites them. It can cause fevers, headaches, body aches, and weakness. If not treated, it can make some people very ill.
- Trial name
- NCT02612545
- Testing
- Dihydroartemisinin-piperaquine (DHA-PPQ), Mefloquine (MQ)
- Where
- Cambodia
- Volunteers
- 216 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Uncomplicated Vivax Malaria
IMPROV (Improving the Radical Cure of Vivax Malaria)
The main determinant of primaquine efficacy is the total dose of primaquine administered, rather than the dosing schedule. Previous trials have demonstrated that the standard low dose regimen of primaquine (3.5 mg/kg total) fails…
- Trial name
- NCT01814683
- Testing
- Primaquine
- Where
- 8 sites in Afghanistan, Ethiopia and 2 more
- Volunteers
- 2,388 people
- Sponsor
- University of Oxford
Sepsis Newborn, Malaria
Immune Dysfunction in Newborn Sepsis
The aim of the project is to study neonatal immune dysfunction associated to the risk of newborn sepsis in a malaria endemic area in Benin.
- Conditions
- Sepsis Newborn, Malaria, Immune Responses
- Trial name
- RECIPAL (NCT03780712)
- Testing
- Non applicable
- Volunteers
- 585 people
- Sponsor
- BioMérieux
Healthy
Impact IPT With Sulfadoxine-pyrimethamine or Sulfadoxine-pyrimethamine Plus Piperaquine in Schoolchildren
Considering the facts that: (i) IPT of malaria provides substantial protection against anaemia and malaria in school children (ii); SP resistance has no significant impact on the prophylactic efficacy (iii) SP-PQ is safe and as…
- Trial name
- PIP-IPT (NCT01722539)
- Testing
- Sulfadoxine-pyrimethamine, Piperaquine, Albendazole
- Where
- Republic of the Congo
- Volunteers
- 616 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Malaria, Malaria Vaccines
Epidemiology Study of Malaria Transmission Intensity in Africa
The aim of this epidemiology study is to characterize in a standardized way malaria transmission intensity at the clinical trial centers participating in study 110021 (NCT00866619).
- Trial name
- NCT01190202
- Testing
- Blood sampling, Assessment of body temperature
- Where
- 8 sites in Burkina Faso, Gabon and 4 more
- Volunteers
- 21,618 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Anemia
Treatment of Iron Deficiency Anemia in Malaria Endemic Ghana
Iron deficiency and iron deficiency anemia (IDA) are the most prevalent micronutrient deficiencies on a worldwide basis, especially in developing countries.
- Trial name
- NCT01001871
- Testing
- Sprinkles®, vitamin/mineral fortificant without iron
- Where
- Ghana
- Volunteers
- 3,880 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Malaria, Falciparum
Amodiaquine Plus Artesunate Versus Lapdap Plus Artesunate in the Treatment of Uncomplicated P. Falciparum Malaria in Malawi
Sulfadoxine-pyrimethamine is the current first-line therapy for uncomplicated malaria in Malawi. Significant resistance of the P.
- Trial name
- NCT00164359
- Testing
- Amodiaquine plus artesunate, chlorproguanil-dapsone plus artesunate
- Where
- 3 sites in Malawi
- Volunteers
- 212 people
- Sponsor
- Centers for Disease Control and Prevention
Malaria
A Study to Assess the Immunogenicity, Tolerability and Safety of a Malaria Vaccine and Also Its Protective Efficacy in a Malaria Challenge Model
The purpose of this study is to assess the safety, tolerability and immunogenicity of two dose levels (1x10^10 and 5x10^10 virus particles (vp)) of the adenovirus serotype (Ad) Ad35.CS.01/Ad26.CS.01 prime-boost malaria candidate…
- Trial name
- NCT01397227
- Testing
- Ad35.CS.01/Ad26.CS.01 low dose (1 x 10^10 vp), Ad 35.CS.01/Ad 26.CS.01 high dose (5 x 10^10 vp)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Malaria, Chemoprophylaxis
Dihydroartemisinin-piperaquine for Seasonal Malaria Chemoprophylaxis in Tanzania
Background: Malaria prevalence has declined globally following the scale-up of the interventions, including insecticide-treated bed-net, indoor residual spraying, and prompt diagnosis and treatment with artemisinin-based…
- Conditions
- Malaria, Chemoprophylaxis, Underfive Children
- Trial name
- SMC-DP (NCT05874869)
- Testing
- Dihydroartemisinin-piperaquine
- Where
- Tanzania
- Volunteers
- 13,800 people
- Sponsor
- Richard Mwaiswelo
Parasitology, Entomology
Malaria Genetic Surveillance in Cambodia
This study is to determine the prevalence and geographical distribution of antimalarial drug resistance-linked genetic mutations in clinical P. falciparum infections in Cambodia
- Conditions
- Parasitology, Entomology, Malaria
- Trial name
- NCT03384472
- Volunteers
- 185 people
- Sponsor
- University of Oxford
Malaria, Falciparum
Artemisinin-based Combination Therapy for Treatment of Plasmodium Falciparum Malaria in North Sumatera, Indonesia
This is a prospective, open label, randomised controlled trial to assess the safety and efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum…
- Trial name
- NCT02325180
- Testing
- Dihydroartemisinin-Piperaquine, Artemether-lumefantrine
- Where
- 3 sites in Indonesia
- Volunteers
- 338 people
- Sponsor
- London School of Hygiene and Tropical Medicine
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