Clinical trials: Malaria, completed
Vivax Malaria
Artemether/Lumefantrine and Vivax Malaria
The cure rate of artemether/lumefantrine in the treatment of vivax malaria.
- Trial name
- NCT01625871
- Testing
- tablets artemether/lumefantrine
- Where
- Sudan
- Volunteers
- 38 people
- Sponsor
- University of Khartoum
Malaria
PfSPZ Vaccine: Dose Optimization With Heterologous Challenge in Healthy Malaria-Naïve Adults
This is an open-label evaluation of the safety, tolerability, immunogenicity and efficacy of PfSPZ Vaccine administered by direct venous inoculation (DVI) in healthy, malaria-naïve adult subjects.
- Trial name
- NCT02601716
- Testing
- PfSPZ Vaccine, CHMI (7G8), CHMI (NF135.C10)
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Plasmodium Falciparum Malaria, Plasmodium Vivax Malaria
Malaria in Early Life Study
The purpose of this study is to assess the effectiveness of different malaria control strategies in the first year of life. The effectiveness of delivering an intermittent screening and treatment programme with…
- Trial name
- NCT02001428
- Testing
- dihydroartemisinin-piperaquine
- Where
- Indonesia
- Volunteers
- 757 people
- Sponsor
- Gadjah Mada University
Malaria,Falciparum, Malaria
Efficacy, Effect on Gametocytes and Tolerability of the Addition of Artesunate to Amodiaquine in Colombia
The primary goal of this study is to quantify the benefit of adding artesunate to amodiaquine in treating patients with uncomplicated P. falciparum malaria, in a low transmission area in Colombia.
- Conditions
- Malaria,Falciparum, Malaria, Antimalarials
- Trial name
- NCT00378625
- Testing
- Artesunate
- Where
- Colombia
- Volunteers
- 360 people
- Sponsor
- Centro Internacional de Entrenamiento e Investigaciones Médicas
Malaria
Impact of Enhanced Health Facility Care in Uganda
The investigators propose to assess whether an intervention to build capacity and improve delivery of drugs and diagnostics at government-run health facilities improves the health of children and quality of care delivered, as…
- Trial name
- NCT01024426
- Testing
- Enhanced health facility-based care, Standard care
- Where
- Uganda
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Uganda Malaria Surveillance Project
Malaria
Estivation of Malaria Vector Mosquitoes in the Sahelian Region of Mali
Background: P. falciparum, one of the most virulent forms of malaria, causes more than 300 million episodes of malaria and 1 million deaths each year.
- Trial name
- NCT00863408
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sickle Cell Anemia, Malaria
Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia
Malaria is fatal and increases the risk of death among children with sickle cell anemia. Chemoprophylaxis significantly improves quality of life in these children.
- Trial name
- NCT00399074
- Testing
- sulfadoxine pyrimethamine
- Where
- Uganda
- Volunteers
- 220 people
- Sponsor
- Makerere University
Anemia, Iron-deficiency
Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya
The purpose of the study is to evaluate the effectiveness of household-based distribution of evidence-based health products and to measure the health impact of these combined interventions on a population basis.
- Trial name
- NICHE (NCT01088958)
- Testing
- Micronutrient powders (Sprinkles)
- Where
- Kenya
- Volunteers
- 7,200 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Malaria
Safety and Protective Efficacy of IV Immunization With Cryopreserved PfSPZ Under A/P Chemoprophylaxis
Single center, randomized, placebo-controlled, double-blinded trial using PfSPZ Challenge (NF54) under A/P chemoprophylaxis for immunization and PfSPZ Challenge (NF54) and PfSPZ Challenge (7G8) for repeat CHMI.
- Trial name
- NCT02858817
- Testing
- atovaquone/proguanil 250mg/100mg (A/P), PfSPZ Challenge (NF54), NaCl 0,9%
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Malaria
First-in-Human PfSPZ-LARC2 Vaccination/CHMI
This randomized, double-blind, placebo-controlled, Phase 1 trial will enroll up to 22 malaria-naïve, adult participants to test safety, tolerability, immunogenicity, and efficacy of the genetically attenuated Plasmodium…
- Trial name
- NCT06735209
- Testing
- PfSPZ Vaccine, PfSPZ (7G8) Challenge, Sodium Chloride, 0.9%
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Clinical Trial for Malaria Vaccines to Test for Safety, Immune Response and Protection Against Malaria
The purpose of this study is to test the safety and effectiveness of a new malaria vaccine, the DNA-Ad vaccine. The study is specifically looking at a vaccine regimen against Plasmodium falciparum, the most deadly form of malaria.
- Trial name
- DNA-Ad (NCT00870987)
- Testing
- DNA vaccine prime, adenovirus type 5 vaccine boost
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria
Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites in Healthy African Adults in Mali
Background: Malaria is still a health problem in Sub-Saharan Africa. Death rates are stable and have even increased in some areas. There are malaria vaccines.
- Trial name
- NCT02627456
- Testing
- PfSPZ Vaccine, PfSPZ Challenge Material, PBS and HSA Diluent
- Where
- Mali
- Volunteers
- 409 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Weekly Dosing of Malarone ® for Prevention of Malaria
The purpose of this study is to determine whether Malarone ®, which is a drug approved to prevent malaria when taken daily, will still effectively prevent malaria if taken weekly.
- Trial name
- MALWEEK (NCT00984256)
- Testing
- Atovaquone Proguanil, Procedure - malaria challenge
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria, Falciparum
Safety and Immunogenicity of Recombinant Pichia Pastoris AMA1-DiCo Candidate Malaria Vaccine With GLA-SE and Alhydrogel ® as Adjuvant in Healthy Malaria Non-Exposed European and Malaria Exposed African Adults
The primary objective is to evaluate the safety of 3 doses given at D0, W4, and W26 of 50 µg dosage of AMA1-DiCo adjuvanted either with GLA-SE or Alhydrogel® in healthy European adults not previously exposed to the parasite…
- Trial name
- AMA1-DiCo (NCT02014727)
- Testing
- Group A1 : 50µg AMA1-DiCo + Alhydrogel, Group A2 : 50 µg AMA1-DiCo+ GLA-SE
- Where
- 2 sites in Burkina Faso, France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Malaria
Stimulating Private Sector Malaria Control
Preliminary evidence from ongoing research provides strong indications that protecting farmers from malaria would be profitable for outgrowing agribusinesses in sub-Saharan Africa.
- Trial name
- Outgrowers (NCT01397851)
- Testing
- Insecticide-treated net (BASF Incerceptor)
- Where
- Zambia
- Volunteers
- 81,597 people, healthy volunteers welcome
- Sponsor
- PATH
Malaria, Falciparum, Hookworm Infections
Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma
The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.
- Conditions
- Malaria, Falciparum, Hookworm Infections, Schistosoma Haematobium
- Trial name
- NCT01163877
- Testing
- Fe-57 orally, Fe-58 intravenously
- Where
- Côte d’Ivoire
- Volunteers
- 43 people
- Sponsor
- Swiss Federal Institute of Technology
Malaria in Pregnancy, HIV Infections
Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine
The purpose of this study is to evaluate the efficacy of cotrimoxazole prophylaxis in prevention of malaria during pregnancy in HIV-infected women, compared to intermittent preventive treatment with mefloquine.
- Trial name
- PACOME (NCT00970879)
- Testing
- cotrimoxazole, mefloquine
- Where
- 5 sites in Benin
- Volunteers
- 430 people
- Sponsor
- Institut de Recherche pour le Developpement
Malaria, Malaria Prophylaxis
Boosting the Impact of SMC Through Simultaneous Screening and Treatment of Roommates
Malaria represents a major public health concern in sub-Sahara Africa. Seasonal malaria chemoprevention (SMC) is one of the largest preventive measures.
- Conditions
- Malaria, Malaria Prophylaxis, Mass Testing and Treatment
- Trial name
- SMC-RST (NCT04816461)
- Testing
- Amodiaquine Sulfadoxine-Pyrimethamin administration, Dihydroartemisinin-Piperaquine, Standard HRP2-RDT
- Where
- Burkina Faso
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Malaria
Efficacy of Three ACTs for the Treatment of Falciparum Malaria in Maradi Niger
Study treatments: Artemether-lumefantrine Artesunate-amodiaquine Dihydroartemisinin-piperaquine Location: Maradi, Niger Principal Objective: To measure the clinical and parasitological efficacy of the three artemisinin…
- Trial name
- NCT01755559
- Testing
- Artesunate-amodiaquine, Dihydroartemisinin-piperaquine, Artemether-lumefantrine
- Where
- Niger
- Volunteers
- 663 people
- Sponsor
- Epicentre
Plasmodium Falciparum Malaria
Phase I/II Trial of a Malaria Vaccine in Adults Living in the United States of America
Phase I/II Trial of a Malaria Vaccine, FMP011/AS01B, in Adults Living in the United States of America.
- Trial name
- NCT00312663
- Testing
- Falciparum Malaria Protein 11 with AS01B adjuvant.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
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