Clinical trials: Malaria Incidence
Anaemia, Malaria
Intermittent Preventive Treatment for Malaria in Infants in Navrongo Ghana
Evaluation of the safety and effectiveness of malaria intermittent chemotherapy and iron supplementation delivered through Expanded Programme on Immunisation vaccination clinics.
- Trial name
- NCT00857077
- Testing
- Sulfadoxine-pyrimethamine
- Where
- Ghana
- Volunteers
- 2,485 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Impact of Artemisinin-based Combination Therapy and Quinine on Treatment Failure and Resistance in Uncomplicated Malaria
This is a bi-centric phase IIIb, randomized, open label, 3-arm clinical trial performed to investigate the impact of retreatment with an Artemisinin-Based Combination (ACT), for example Arthemeter-Lumefantrine (AL) in Uganda (Ug)…
- Trial name
- QuinAct (NCT01374581)
- Testing
- Artemether/Lumefantrine, Artesunate/Amodiaquine, Quinine + Clindamycin
- Where
- 2 sites in Republic of the Congo, Uganda
- Volunteers
- 2,117 people
- Sponsor
- Universiteit Antwerpen
Malaria (Plasmodium Falciparum), Malaria Incidence
Insecticide-Treated Baby Wraps for the Prevention of Malaria
The objective is to test the protective effect of permethrin-treated and etofenprox-treated lesus against malaria in young children
- Trial name
- NCT07773350
- Testing
- Permethrin-treated lesu, Etofenprox-treated lesu, Untreated lesu
- Where
- Uganda
- Volunteers
- 1,296 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Malaria
LLIN Evaluation in Uganda Project (LLINEUP3)
In Uganda, the National Malaria Control Division (NMCD) and implementing partners are planning to deliver long-lasting insecticidal nets (LLINs) nationwide, through a mass distribution campaign in 2023.
- Trial name
- NCT05950191
- Testing
- long lasting insecticidal nets with chlorfenapyr-pyrethroid (PermaNet Dual), long lasting insecticidal nets with PBO-pyrethroid (PermaNet), Social Behavior Change Communication
- Where
- Uganda
- Volunteers
- 215,903 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria
Spatial Repellents for Malaria Control
The primary objective of the study is to demonstrate and quantify the effectiveness of a spatial repellent (SR) product, in reducing malaria infection in humans under operational program conditions in a humanitarian assistance…
- Trial name
- AEGIS Uganda (NCT06122142)
- Testing
- Transfluthrin - delivery by paid study personnel, Transfluthrin - delivery by voucher system, Transfluthrin - delivery by village health teams
- Where
- 2 sites in Uganda
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Notre Dame
Malaria
A Community Setting Study of Malaria After Systematic Treatment of Symptomatic Carriers of P. Falciparum With COA566 (Coartem®)
This study assessed the impact of the systematic detection by Rapid Diagnostic Test (RDT) and treatment of asymptomatic carriers of malaria parasites (P.
- Trial name
- NCT01256658
- Testing
- COA566
- Where
- 3 sites in Burkina Faso
- Volunteers
- 14,075 people
- Sponsor
- Novartis
Plasmodium Falciparum Malaria
Malaria Prevalence in Children
The purpose of this pilot study is to evaluate the use of (1) 'malaria prevalence', (2) 'malaria incidence' and (3) 'malaria mortality' as a measure of malaria transmission in The Gambia, while mosquito insecticides (larvicides)…
- Trial name
- NCT00322816
- Where
- The Gambia
- Volunteers
- 2,552 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Plasmodium Falciparum Malaria
Mass Screening and Treatment for Reduction of Falciparum Malaria
In this project, the investigators aim at an operational research deployment of Ultrasensitive Rapid Diagnostic Test (URDT) -based Mass Screening and Treatment (MSAT) in the Malaria Elimination Task Force (METF) elimination…
- Trial name
- MSAT (NCT04093765)
- Testing
- Ultrasensitive Rapid Diagnostic Test (URDT), Antimalarials
- Where
- Thailand
- Volunteers
- 5,542 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria Infection, Malaria Falciparum
IGHID 12334 - After the Flood: Optimal Strategies to Prevent Malaria Epidemics Caused by Severe Flooding
The purpose of this study is to test different ways to prevent malaria infections after flooding. To accomplish this, the investigators will assign villages to different control strategies and measure the number of malaria…
- Trial name
- IGHID12334 (NCT06870344)
- Testing
- Dihydroartemisinin piperaquine, Dihydroartemisinin piperaquine + Bacillus thuringiensis israelensis, Long-lasting Insecticidal Net
- Where
- Uganda
- Volunteers
- 36,000 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
LLIN, PBO LLIN, IRS, Larviciding
Adaptive Interventions for Optimizing Malaria Control: a Cluster-Randomized SMART Trial
In the past decade, massive scale-up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) have led to significant reductions in malaria mortality and morbidity.
- Trial name
- NCT04182126
- Testing
- Regular long-lasting insecticidal nets, LLIN plus Piperonyl butoxide-treated LLIN, Long-lasting microbial larvicide
- Where
- 2 sites in United States, Kenya
- Volunteers
- 122,872 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Malaria, Falciparum, Plasmodium Falciparum
Pilot Study to Estimate the Burden and Distribution of Plasmodium Falciparum Malaria in Kalifabougou, Mali in Preparation for a Prospective Cohort Study of Naturally-Acquired Malaria Immunity
Plasmodium falciparum malaria remains a global public health threat. Leading malaria vaccine candidates confer only partial short-lived protection at best.
- Trial name
- NCT01160562
- Where
- Mali
- Volunteers
- 1,719 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diarrhea, Malaria
Zinc Supplementation to Reduce Diarrhea Rates in Adults in Western Kenya.
Zinc deficiency is prevalent in children in developing countries. Zinc-supplementation is proven to reduce the duration and severity of childhood diarrhea in randomized controlled trials.
- Trial name
- NCT01166815
- Testing
- Zinc sulphate
- Where
- 3 sites in United States, Kenya
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Malaria
Net Transition Initiative: Efficacy of Two Next-generation Nets for Control of Malaria in Cote d'Ivoire
The investigator plan to conduct a three-arm cluster-randomized control trial which compares two next generation of long-lasting Insecticidal Nets (LLINs); Veeralin®LLIN (PBO-py LLIN), Interceptor G2 (chlorfenapyr-py LLIN) to a…
- Trial name
- NCT05796193
- Testing
- Alpha-cypermethrin and PBO LLIN, Alpha-cypermethrin and Clorfenapyr LLIN, Alpha-cypermethrin only LLIN
- Where
- Côte d’Ivoire
- Volunteers
- 1,650 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Spatial Repellents for the Prevention of Malaria in Kenya
Spatial repellents are chemical-based devices that when placed in a room, make that room non-conducive for mosquitoes. These tools can be used to help in the fight against vector borne diseases such as malaria and dengue.
- Trial name
- AEGIS Kenya (NCT04766879)
- Testing
- Transfluthrin
- Where
- 2 sites in Kenya
- Volunteers
- 5,984 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Malaria Infection, Malaria Incidence
Malaria Incidence in Infants in Bancoumana, Mali
This study, conducted by the Malaria Research and Training Center at the Faculty of Medicine in Bamako and the NIAID will measure the frequency of occurrence of malaria in infants in Bancoumana, Mali.
- Conditions
- Malaria Infection, Malaria Incidence, Anemia
- Trial name
- NCT00508417
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Evaluation of Insecticide Treated Nets and Wall Liners for the Prevention of Malaria
The purpose of this study is to determine whether insecticide treated wall liners, in combination with insecticide treated nets, reduce the incidence of malaria infections compared to insecticide treated nets alone.
- Trial name
- MTC-ITWL (NCT01043796)
- Testing
- Insecticide treated nets and wall liners, Insecticide treated nets alone
- Where
- Kenya
- Volunteers
- 1,730 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Malaria, Malaria, Falciparum
Mass Drug Administration With Dihydroartemisinin + Piperaquine for Reducing Malaria in Southern Zambia
To quantify the relative effectiveness, cost, and cost-effectiveness of fMDA and MDA with DHAp against no mass treatment for reducing P.
- Trial name
- NCT02329301
- Testing
- MDA with DHAp (Eurartesim), Focal MDA with DHAp (Eurartesim)
- Where
- Zambia
- Volunteers
- 2,430 people, healthy volunteers welcome
- Sponsor
- PATH
Malaria, Vivax
Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria
This is a prospective, double-blind, double-dummy, multicenter, comparative study. A total of 300 subjects will be randomized to treatment on Day 1, of which a minimum of 50 female subjects must be enrolled that display moderate…
- Trial name
- NCT02216123
- Testing
- Tafenoquine, Chloroquine, Primaquine
- Where
- 10 sites in Brazil, Colombia and 4 more
- Volunteers
- 251 people
- Sponsor
- GlaxoSmithKline
Malaria
Spatial Repellents for Vector Control
The primary objective of the study is to demonstrate and quantify the protective efficacy of a single Spatial Repellent (SR) product, in reducing malaria infection in a human cohort.
- Trial name
- AEGIS Mali (NCT04795648)
- Testing
- Transfluthrin
- Where
- 2 sites in Mali
- Volunteers
- 1,911 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Maternal Malaria During Pregnancy - Baby Not Yet Delivered
Malaria Burden in Pregnant Women and the Incidence of Pregnancy in a Cohort of Nulligravida
The overarching aims of this study are to longitudinally determine the occurrence of pregnancy in a cohort of nulligravida at the community level and to estimate the burden of malaria infection during the course of the pregnancy…
- Trial name
- EPI-PAM (NCT06162078)
- Where
- Burkina Faso
- Volunteers
- 2,390 people, healthy volunteers welcome
- Sponsor
- Groupe de Recherche Action en Sante