Clinical trials: Malaria Infection
Malaria, Malaria Vaccines
Epidemiology Study of Malaria Transmission Intensity in Africa
The aim of this epidemiology study is to characterize in a standardized way malaria transmission intensity at the clinical trial centers participating in study 110021 (NCT00866619).
- Trial name
- NCT01190202
- Testing
- Blood sampling, Assessment of body temperature
- Where
- 8 sites in Burkina Faso, Gabon and 4 more
- Volunteers
- 21,618 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Prophylactic Activity Against Malaria
Prophylactic Antimalarial Activity of DB289 in Volunteers
To evaluate the prophylactic activity of orally administered DB289 against Plasmodium falciparum in non-immune healthy volunteers who are challenged by the bite of five P. falciparum-infected Anopheles stephensi mosquitoes
- Trial name
- NCT00408369
- Testing
- DB289
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Immtech Pharmaceuticals, Inc
Plasmodium Infection
Reducing Malaria Transmission in Forest-going Mobile and Migrant Populations in Lao PDR and Cambodia
This stepped-wedge cluster-randomized controlled trial with nested mixed methods study will assess the effectiveness, acceptability, feasibility and cost-effectiveness of a personal protection package to reduce malaria…
- Trial name
- NCT05117567
- Testing
- Personal protection package
- Volunteers
- 5,868 people, healthy volunteers welcome
- Sponsor
- Macfarlane Burnet Institute for Medical Research and Public Health Ltd
Malaria
Healthy Volunteer Study of the Pharmacokinetics of Oral Piperaquine With OZ439 + TPGS Formulation in the Fasted State
Piperaquine tablets (coated) + OZ439 granules + TPGS granules will be co-administered in Phase IIb (adults). However, safety and PK data (for OZ439 plus piperaquine) were obtained using piperaquine tablets plus OZ439 as Powder in…
- Trial name
- NCT01853475
- Testing
- PQP tablets 960mg, PQP tablets 1440mg, OZ439+TPGS 800mg
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Parasitemia
Parasitic Clearance and Recurrence Rates Among Patients With Vivax Malaria
This research is intended to study the efficacy of CQ alone for P.vivax infection and also to study the recurrence rate among patients with P.vivax on standard dose of CQ and PQ.
- Trial name
- BCAPES (NCT01784315)
- Testing
- Artemisinin combination therapies (ACT)will be used for Chloroquine resistant P.vivax, Chloroquine and Primaquine
- Where
- 3 sites in Bhutan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Bhutan
Malaria
A Safety and Efficacy Study of ChAdOx1 LS2 and MVA LS2
The purpose of this study is to assess the safety, immunogenicity and efficacy of the candidate malaria vaccines ChAdOx1 LS2 and MVA LS2. Healthy adult volunteers will be recruited and vaccinated in Oxford.
- Trial name
- NCT03203421
- Testing
- ChAdOx1 LS2, MVA LS2
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
MULTIple Doses of IPTi Proposal: a Lifesaving High Yield Intervention
As efforts to control malaria are stalling, and the disease is particularly severe in children under the age of two, it is imperative for countries in sub-Saharan Africa, with areas of moderate-to-high transmissions, to implement…
- Trial name
- MULTIPLY (NCT05085340)
- Testing
- Intermittent preventive treatment of malaria in infants (IPTi) with sulfadoxine-pyrimethamine (SP)
- Where
- 3 sites in Mozambique, Sierra Leone and 1 more
- Volunteers
- 94,252 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Malaria, Mass Drug Administration
Efficacy of Focal Primaquine Mass Administration for Eliminating Plasmodium Vivax Malaria in Northern Myanmar
Plasmodium vivax has become the predominant species in the Greater Mekong Subregion and is a major challenge for regional malaria elimination.
- Conditions
- Malaria, Mass Drug Administration, Myanmar, Plasmodium Vivax
- Trial name
- NCT06392152
- Testing
- Focal Mass Drug Administration with Primaquine
- Where
- Burma
- Volunteers
- 1,208 people, healthy volunteers welcome
- Sponsor
- Pyae Linn Aung
Plasmodium Falciparum Malaria
ICC-1132 - Candidate Vaccine Against P Falciparum Malaria
The purposes of this study are to evaluate the safety and immune responses (the body's defense system) to an investigational malaria vaccine called ICC-1132.
- Trial name
- NCT00587249
- Testing
- Malaria ICC-1132, Alhydrogel
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anemia, Malaria
Perennial Malaria Chemoprevention (PMC) in Cameroon
The Plus Project will assess the impact, operational feasibility, efficacy, effectiveness, and cost-effectiveness of PMC. Specifically, the impact evaluation will involve monitoring a passive cohort of all children in the study…
- Trial name
- NCT05889052
- Testing
- Sulfadoxine pyrimethamine
- Where
- Cameroon
- Volunteers
- 2,138 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Plasmodium Falciparum Infection, Malaria
L9LS MAb in Malian Adults
The purpose of this study is to evaluate the safety and tolerability of a one time SC administration of L9LS in healthy adults in Mali, as well as its protective efficacy against naturally occurring Plasmodium falciparum (Pf)…
- Trial name
- NCT05816330
- Testing
- L9LS (VRC-MALMAB0114-00-AB)
- Where
- 3 sites in Mali
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Malaria,Falciparum
PfSPZ Vaccine Trial in Malian Children
In this randomized, double-blind, placebo-controlled trial, 268 healthy Malian children aged 6-10 years, residing in Bancoumana and surrounding villages, will be administered three doses of 9.0x10^5 Pf sporozoites (PfSPZ) of…
- Trial name
- NCT04940130
- Testing
- Sanaria® PfSPZ Vaccine, Normal Saline
- Where
- Mali
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Malaria, Malaria,Falciparum
Attractive Targeted Sugar Bait Phase III Trial in Zambia
The trial will evaluate the efficacy of ATSB deployment plus universal coverage of a WHO core vector control (VC) interventions over two transmission seasons on a minimum 30% reduction in cohort clinical disease incidence…
- Conditions
- Malaria, Malaria,Falciparum, Vector-Borne Transmission of Infection
- Trial name
- NCT04800055
- Testing
- Attractive Targeted Sugar Bait
- Where
- Zambia
- Volunteers
- 3,480 people, healthy volunteers welcome
- Sponsor
- PATH
Malaria
A Phase Ib Induced Malaria Infection Study With the Combination of OZ439 and DSM265
This is a single-centre, open-label, dose finding study using induced blood stage malaria (IBSM) infection to characterize the pharmacodynamic interaction between OZ439 and DSM265, administered around 120 minutes apart for…
- Trial name
- OZ/DSMCombo (NCT02389348)
- Testing
- DSM265, OZ439
- Where
- Australia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
Malaria Challenge in Healthy Volunteers
The purpose of this study is to determine if sterile, protective immunity to malaria can be induced by malaria parasite exposure limited to the early liver stage of the parasite lifecycle.
- Trial name
- ITV (NCT01500980)
- Testing
- P. falciparum infection, Chloroquine, Primaquine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Malaria, Cerebral
Rehabilitation Program for Cognitive Deficits in Ugandan Children After Cerebral Malaria
The purpose of this study is to determine whether computerised cognitive rehabilitation training improves cognition in children who have had cerebral malaria.
- Trial name
- NCT00658450
- Testing
- Cognitive rehabilitation training
- Where
- Uganda
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Makerere University