Clinical trials: Malaria Infection
Malaria, Falciparum
Efficacy and Safety of Pyronaridine-artesunate for the Treatment in Uncomplicated Falciparum Malaria
This study is a prospective, single arm, open-labelled clinical trial. The total number subjects will be 145 patients to receive Pyronaridine-artesunate once daily for 3 days. Dosing will be according to the body weight.
- Trial name
- NCT02389439
- Testing
- Pyronaridine-artesunate
- Where
- 3 sites in Cambodia
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria, Falciparum, Anemia
The Community Effectiveness of IPTi in Southern Tanzania
The safety and efficacy of Intermittent Preventive Treatment for malaria and anaemia control in Infants (IPTi) have already been documented in Southern Tanzania, affording an opportunity to gain operational experience in…
- Trial name
- NCT00152204
- Testing
- Sulfadoxine-pyrimethamine used for IPTi, IPTi
- Where
- Tanzania
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Malaria (Uncomplicated)
Efficacy of Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Children Under 12 Years at Four Sentinel Sites in Mozambique
This is a classical in vivo clinical trial, following World Health organization's recommendations, ran as a multisite study within Mozambique trying to assess the efficacy and safety in four sites of artemether-lumefantrine (AL)…
- Trial name
- NCT06970600
- Testing
- Artemether-lumefantrine (Coartem)
- Where
- 4 sites in Mozambique
- Volunteers
- 352 people
- Sponsor
- Centro de Investigacao em Saude de Manhica
Malaria
IPT and Efficacy of Sulphadoxine/Pyrimethamine and Chlorproguanil/Dapsone in 6-59 Month Old Children With Malaria.
Intermittent Preventive Treatment of malaria in infants is a promising strategy to reduce incidence of clinical malaria in children under the age of 1 year.
- Trial name
- NCT00361114
- Testing
- sulphadoxine/pyrimethamine, Chlorproguanil/dapsone, Sulfadoxine/pyrimethamine
- Where
- Tanzania
- Volunteers
- 112 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Plasmodium Falciparum Malaria
CQSP in Malawi: Chloroquine and Sulfadoxine-pyrimethamine Efficacy for the Treatment of Malaria in Malawi
The purpose of this research study is to find out how well chloroquine works as a drug to treat malaria in children, compared to the standard malaria treatment in Malawi.
- Trial name
- NCT00125489
- Testing
- chloroquine sulfate, sulfadoxine/pyrimethamine
- Where
- Malawi
- Volunteers
- 210 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria
The purpose of this study is to compare the efficacy and safety of the fixed combination of pyronaridine artesunate (Pyramax®, PA) (180:60 mg) with that of standard chloroquine therapy in children and adults with acute…
- Trial name
- NCT00440999
- Testing
- Pyronaridine artesunate, Chloroquine
- Where
- 5 sites in Cambodia, India and 2 more
- Volunteers
- 456 people
- Sponsor
- Medicines for Malaria Venture
Malaria
Evaluation of Long-Lasting Microbial Larvicides in Reducing Malaria Transmission and Clinical Malaria Incidence
In the past decade, massive scale-up of insecticide-treated nets (ITN) and indoor residual spraying (IRS), together with the introduction of artemisinin-combination treatments, have led to substantial reductions in malaria…
- Trial name
- LLML (NCT02392832)
- Testing
- Fourstar® granule, 90 day and 180 day briquettes Bti/Bs
- Where
- Kenya
- Volunteers
- 240,000 people
- Sponsor
- University of California, Irvine
Falciparum Malaria
Nitrite Infusion in Children With Malaria
The purpose of this study is to assess the safety of intravenous sodium nitrite in African children who have moderately severe malaria.
- Trial name
- NCT04289558
- Testing
- Sodium Nitrite
- Where
- Tanzania
- Sponsor
- Duke University
Falciparum Malaria
Evaluation of the Gametocytocidal Efficacy and Safety of Primaquine in Uncomplicated Falciparum Malaria in Uganda
The purpose of this study is to evaluate the safety and efficacy of lower doses of primaquine compared to the dose recommended by the WHO for reducing P.
- Trial name
- NCT01365598
- Testing
- Primaquine
- Where
- Uganda
- Volunteers
- 468 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, HIV/AIDS
Improving Maternal heAlth by Reducing Malaria in African HIV Women
Trial to evaluate the safety and efficacy of DHA-PPQ for Intermittent Preventive Treatment (IPTp) in HIV-infected pregnant women receiving cotrimoxazole prophylaxis (CTXp) and antiretroviral (ARV) drugs and using long lasting…
- Conditions
- Malaria, HIV/AIDS, Pregnancy Related
- Trial name
- MAMAH (NCT03671109)
- Testing
- Dihydroartemisinin-piperaquine (DHA-PPQ)
- Where
- 2 sites in Gabon, Mozambique
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
P. Falciparum Malaria
Re-exposure of EHMI-8 Human Volunteers to Live Malaria Sporozoites
In the EHMI-8 study (CMO 2006/207) the investigators induced sterile protection against P. falciparum challenge in healthy Dutch volunteers by repeated exposure to infected mosquitoes whilst under chloroquine prophylaxis.
- Trial name
- NCT00757887
- Testing
- Exposure to 5 P. falciparum infected mosquitoes
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria Incidence, Seasonal Malaria Chemoprevention
Leveraging the Seasonal Malaria Chemoprevention Platform to Address Malaria and Malnutrition
In the Sahel, the malaria and malnutrition seasons overlap during the rainy season, from approximately July through October. Malaria transmission increases due to the rain and collection of standing water and malnutrition risk…
- Conditions
- Malaria Incidence, Seasonal Malaria Chemoprevention, Nutrition Assessment, Acute Malnutrition in Childhood
- Trial name
- INSPIRE (NCT06599593)
- Testing
- SQ-LNS, Integrated Nutritional Screening
- Where
- Burkina Faso
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria, Vivax
Safety and Immunogenicity Study of Plasmodium Vivax CS Derived Synthetic Peptides Formulated in Two Adjuvants
This was a phase I double blind controlled vaccine trial, evaluating safety, tolerability and immunogenicity of mixtures of N, R and C LSP derived from the P.
- Trial name
- Fase1B (NCT01081847)
- Testing
- Peptides (N,R&C) formulated in Montanide ISA 720, Peptides (N,R&C) formulated in Montanide ISA 51
- Where
- 2 sites in Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Malaria Vaccine and Drug Development Center
Malaria, Mosquito Repellent
Effect of a Combined Use of Mosquito Repellent and Insecticide Treated Net on Malaria in Ethiopia
The combined use of a mosquito repellent and long lasting insecticidal nets (LLINs) by household members would result in a 40% reduction in malaria prevalence compared with households that only use LLINs.
- Conditions
- Malaria, Mosquito Repellent, Long Lasting Insecticidal Nets
- Trial name
- NCT01160809
- Testing
- Mosquito repellent
- Where
- Ethiopia
- Volunteers
- 6,082 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium, Ethiopia
Malaria, Malaria,Falciparum
A Study to Compare Two Dosing Regimens for a New Malaria Vaccine
Malaria is a major public health problem. There were around 240 million cases of malaria and 627,000 deaths worldwide in 2020. Most of the deaths are in children under five living in Africa.
- Conditions
- Malaria, Malaria,Falciparum, Protozoan Infections, Parasitic Disease
- Trial name
- NCT06141057
- Testing
- Matrix M with RH5.1
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
Ototoxicity of Artemether / Lumefantrine (Coartem) and Other Antimalarials
The purpose of the study is to evaluate the potential side-effects of artemether / lumefantrine and other antimalarials on the auditory function.
- Trial name
- NCT00451139
- Testing
- artemether/lumefantrine, quinine, atovaquone/proguanil
- Where
- Ethiopia
- Sponsor
- Jimma University
Malaria, Matrix M
Adjuvanting Viral Vectored Malaria Vaccines With Matrix M
ChAd63 METRAP and MVA METRAP are investigational vaccines for malaria which have been studied in clinical trials for 4 years, and 10 years, respectively.
- Trial name
- NCT01669512
- Testing
- Control Regimen, Low Dose Matrix M Regimen, Standard Dose Matrix M Regimen
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
A Study to Characterise the Antimalarial and Transmission Blocking Activity of a Single Dose of DSM265 or OZ439 in Healthy Subjects With Induced Blood Stage Plasmodium Falciparum or Plasmodium Vivax Infection
Part A -Cohort 1 DSM265 will be administered as a single dose (400 mg). For cohort 1 only, an additional single dose (400 mg) of DSM265 may be given if gametocytemia develops.
- Trial name
- DSMOZ-2 (NCT02573857)
- Testing
- DSM265, OZ439
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
Community Access to Rectal Artesunate for Malaria
Many malaria deaths occur in places where people have poor access to preventive and curative health services. Prompt access to quality health services is critical in the case of severe childhood diseases, among which severe…
- Trial name
- CARAMAL (NCT03568344)
- Where
- 3 sites in Democratic Republic of the Congo, Nigeria and 1 more
- Volunteers
- 13,758 people
- Sponsor
- Swiss Tropical & Public Health Institute
Malaria, Vivax, Malaria, Falciparum
Therapeutic Efficacy Study of Pyrimethamine/Sulfdoxine (Fansidar®) for the Treatment of Uncomplicated Falciparum Malaria in the Peruvian Amazon
The purpose of this study is to determine the efficacy of pyrimethamine/sulfdoxine (Fansidar®) for the treatment of uncomplicated falciparum malaria in the Peruvian Amazon.
- Trial name
- NCT00951106
- Testing
- Pyrimethamine/sulfdoxine (Fansidar)
- Where
- Peru
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)