Clinical trials: Malaria Prophylaxis
Malaria (Plasmodium Falciparum), Malaria Falciparum
Safety and PK of MMV371 LAI in Healthy Adults and Adolescents in Rwanda
This Phase 1b study will assess the safety, tolerability and pharmacokinetics (PK, this measures the levels of study drug in the body) of a single injection of MMV371 in healthy adult and adolescent participants in Rwanda.
- Conditions
- Malaria (Plasmodium Falciparum), Malaria Falciparum, Malaria Infection, Malaria Prophylaxis
- Trial name
- NCT07548021
- Testing
- MMV371
- Where
- Rwanda
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria, Malaria Prophylaxis
Boosting the Impact of SMC Through Simultaneous Screening and Treatment of Roommates
Malaria represents a major public health concern in sub-Sahara Africa. Seasonal malaria chemoprevention (SMC) is one of the largest preventive measures.
- Conditions
- Malaria, Malaria Prophylaxis, Mass Testing and Treatment
- Trial name
- SMC-RST (NCT04816461)
- Testing
- Amodiaquine Sulfadoxine-Pyrimethamin administration, Dihydroartemisinin-Piperaquine, Standard HRP2-RDT
- Where
- Burkina Faso
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Prophylaxis
Escalating Monthly Doses of Tafenoquine in Healthy Volunteers
In 2018, the U.S. Food and Drug Administration (FDA) and the Australian Therapeutic Goods Administration (TGA) approved tafenoquine for malaria prevention.
- Trial name
- TQ (NCT05203744)
- Testing
- Tafenoquine prophylaxis
- Where
- Vietnam
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Naval Medical Research Center
Prophylaxis Against Plasmodium Falciparum Malaria
A Study of Safety and Immunogenicity of a Malaria Vaccine Candidate
Shanghai Wanxing Bio-Pharmaceuticals is currently evaluating one malaria vaccine candidate, PfCP2.9 adjuvanted with Montanide ISA 720.
- Trial name
- NCT00284973
- Testing
- Plasmodium falciparum Chimeric Prot. 2.9 - Montanide ISA 720
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shanghai Wanxing Bio-Pharmaceutical Co. Ltd.
Malaria Prophylaxis
A Phase 1 Study To Estimate The Relative Bioavailability Of Co-Administered Formulations Of Azithromycin Microsphere And Chloroquine Test Formulation Compared With Co-Administered Immediate Release Individual Azithromycin And Chloroquine Tablets In Healthy Adult Subjects
Estimate the relative bioavailability of co-administered azithromycin microsphere (2000 mg) and the chloroquine (620 mg CQ base) test formulation compared to co-administered immediate release individual tablets of azithromycin…
- Trial name
- AZCQ (NCT01100060)
- Testing
- azithromycin (AZ) microsphere, test chloroquine (CQ) formulation, azithromycin (AZ)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pfizer