Clinical trials: Male Circumcision
HIV Infections, Circumcision
Infant Male Circumcision in Gaborone, Botswana, and Surrounding Areas: Feasibility, Safety and Acceptability
Background: Novel HIV prevention approaches are urgently needed in Botswana and elsewhere in sub-Saharan Africa. Although adult male circumcision (MC) has been shown to reduce the heterosexual acquisition of HIV by men by about…
- Trial name
- NCT00971958
- Testing
- Circumcision, Mogen Clamp, Plastibell
- Where
- Botswana
- Volunteers
- 1,235 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Postoperative Pain
Two Different Surgical Techniques on Postoperative Circumcision Pain
To compare the effect of two different surgical techniques, the dorsal slit and double incision technique, on postoperative pain.
- Trial name
- NCT01909765
- Testing
- Dorsal slit, Double incision
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
HIV
Increasing Availability and Acceptability of Circumcision in Zambia
This study proposes to balance supply and demand of male circumcision through a systematic scale-up of coordinated biomedical surgical and behavioral counseling services.
- Trial name
- NCT01688167
- Testing
- MC and sexual risk reduction
- Where
- Zambia
- Volunteers
- 1,468 people, healthy volunteers welcome
- Sponsor
- University of Miami
Circumcision, Lower Abdominal Surgery
Comparison of Caudal Block and Erector Spinae Block for Postoperative Analgesia
Caudal block (CB), a regional anesthesia technique, is the most commonly used neuraxial block method for postoperative pain control in sub-umbilical surgeries in children.
- Trial name
- NCT05284734
- Testing
- Regional anesthesia intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Circumcision
Rapid, Minimally-invasive Voluntary Adult Male Circumcision
This study will evaluate a new, minimally-invasive surgical circumcision technique for men, which is easy to learn and perform, is safe, and is associated with high patient satisfaction and excellent cosmetic results.
- Trial name
- NCT01998360
- Testing
- Surgical Control, Unicirc with tissue adhesive
- Where
- South Africa
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Simunye Primary Health Care
Circumcision Adult, HIV CDC Category B2
Evaluation of Safety and Efficacy of the PrePexTM Device for Rapid Scale up of Adult MC Programs in Zimbabwe
The protocol, approved by the Medical Research Council, was issued to assess the safety and efficacy of the non-surgical device for applying it to the national scale up of adult male circumcision in Zimbabwe
- Conditions
- Circumcision Adult, HIV CDC Category B2, HIV Infections
- Trial name
- ZW-01 (NCT01956396)
- Testing
- PrePex™ device
- Where
- Zimbabwe
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Ministry of Health and Child Welfare, Zimbabwe
Circumcision Adult, HIV CDC Category B2
Safety and Efficacy of the PrePex Device Circumcision When Performed by Nurses
The protocol, approved by the Medical Research Council, was issued to assess the safety and efficacy of the non-surgical device for applying it to the national scale up of adult male circumcision in Zimbabwe
- Trial name
- NCT01956383
- Testing
- PrePex™ device
- Where
- Zimbabwe
- Volunteers
- 603 people, healthy volunteers welcome
- Sponsor
- Ministry of Health and Child Welfare, Zimbabwe
HIV
Strategies to Increase HIV Testing, Linkages to Care, and Male Circumcision in Africa
The purpose of this study is to determine efficient, scalable, evidence-based strategies to link HIV positive individuals to care and HIV negative individuals to prevention measures, such as voluntary male circumcision.
- Trial name
- NCT02038582
- Testing
- POC CD4 Testing, CD4 Referral, Lay Counselor Follow-up
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 2,075 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV
Comparing the PrePex™ Device to Surgical Circumcision for Rapid Scale Up of Male Circumcision in Resource Limited Setting
The World Health Organization and UNAIDS cite that male circumcision can reduce the lifetime risk of HIV infection by 60% in high risk areas such as Sub Saharan Africa.
- Trial name
- NCT01284088
- Testing
- PrePex™ device for adult male circumcision, Surgical circumcision
- Where
- Rwanda
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Pain, Anxiety
Distraction Method on Pain and Anxiety During Circumcision
Circumcision is a common procedure in infants, children and young people around the world for cultural, religious or medical reasons.
- Conditions
- Pain, Anxiety, Urological Nursing
- Trial name
- NCT04220346
- Testing
- Tablet group
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
HIV Infection
The Use of Peer Referral Incentives to Increase Demand for Voluntary Medical Male Circumcision in Zambia
The Centre for Infectious Disease Research in Zambia (CIDRZ) and researchers from the University of North Carolina at Chapel Hill (UNC) have partnered to pilot an peer-referral incentive program to increase voluntary medical male…
- Trial name
- NCT02012816
- Testing
- Peer-referral incentive program to increase VMMC uptake
- Where
- Zambia
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Male Circumcision
Randomized Trial Comparing PrePex Day 7 Foreskin Removal Procedure (FRP) to a Day 0 PrePex FRP .
A Prospective, Randomized, Open Label Trial Comparing PrePex™ Day 7 (FRP) to a PrePex Day 0 FRP of Male Circumcision in Resource Limited Settings.
- Trial name
- NCT03223532
- Testing
- PrePex Day 7 FRP, PrePex Day 0 FRP
- Where
- Kenya
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Nyanza Reproductive Health Society
HIV Infections
Male Circumcision and HIV Rates in Kenya
The Luo tribe of Kisumu, Kenya, does not traditionally practice male circumcision (MC). This study will work with the Luo tribe to test the effectiveness of MC on reducing the risk of HIV infections in young men.
- Trial name
- NCT00059371
- Testing
- male circumcision
- Where
- Kenya
- Volunteers
- 2,887 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Male Circumcision
Safety and Effectiveness of Different ShangRing Device Sizes for Adult Male Circumcision in Lusaka, Zambia
The purpose of this study was to assess the safety, effectiveness and acceptability of providing a reduced number of ShangRing sizes for adult voluntary medical male circumcision (VMMC) within routine service delivery in Lusaka…
- Trial name
- NCT02242565
- Testing
- ShangRing
- Where
- 2 sites in Zambia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- FHI 360
Analgesia, Pain, Postoperative
Comparison Between the Caudal Block and Other Methods of Postoperative Pain Relief in Children Undergoing Circumcision
Prospective, randomized, case-controlled trial study. Observation post-operatively: Aims: This study aimed to compare the effectiveness of the caudal block CB with other methods of postoperative pain release.
- Conditions
- Analgesia, Pain, Postoperative, Pain, Acute
- Trial name
- paincontrol (NCT06086106)
- Testing
- caudal block, Dorsal Penile Nerve Block DPNB, Systemic opioids
- Where
- Bahrain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Salmaniya Medical Complex
Safe Circumcision
Pilot Trial of Novel Circumcision Device
The investigators are testing a novel surgical device to facilitate safe circumcision among adult males. The investigators hypothesize that this device will allow non-medical providers to perform safe surgical circumcision…
- Trial name
- NCT01885286
- Testing
- circumcision with simple circumcision device
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- VA Puget Sound Health Care System
Virtual Reality, Augmented Reality
Virtual Reality to Reduce Pre-Operative Anxiety
This study aims to test the effectiveness of virtual reality (VR) as a non-pharmaceutical intervention to reduce pain and anxiety in children undergoing various procedures in the Ambulatory Surgery Center (ASC) at CHLA, as…
- Conditions
- Virtual Reality, Augmented Reality, IV Stick, Mask Induction
- Trial name
- NCT04268914
- Testing
- Oculus Go VR, Mira Prism VR
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Voluntary Medical Male Circumcision
Assessing the Impact of a Digital VMMC Platform
VMMC has been identified as a crucial intervention by UNAIDS to achieve the 2030 global target of a 90% reduction in new HIV infections compared with 2010 levels.
- Trial name
- VMMC NEXUS (NCT06364891)
- Testing
- VMMC NEXUS Digital application
- Where
- Zambia
- Volunteers
- 150,383 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
HIV Infections, Acquired Immunodeficiency Syndrome
Text Messaging to Improve Adherence to Clinic Visits and Reduce Early Resumption of Sexual Intercourse After Male Circumcision
Male circumcision (MC) reduces, by more than half, the risk of HIV-1 acquisition. WHO and UNAIDS recommend that "male circumcision should be recognized as an efficacious intervention for HIV prevention especially in countries and…
- Conditions
- HIV Infections, Acquired Immunodeficiency Syndrome, Circumcision, Male, Patient Compliance
- Trial name
- NCT01186575
- Testing
- Text Message
- Where
- Kenya
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Washington
Circumcision, Male
Comparison of Outcomes of Circumcision Via Open and Plastibell Methods
Circumcision is considered one of the most common elective surgical procedures, particularly among Muslim and Jewish males. Of all the available techniques, Plastibell is gaining traction amongst surgeons due to its safety in the…
- Trial name
- NCT06120634
- Testing
- Open surgical method, Plastibell method
- Where
- Pakistan
- Volunteers
- 608 people, healthy volunteers welcome
- Sponsor
- Tehsil Headquarter Hospital