Clinical trials: Male Hypogonadism
Hypogonadism, Metabolic Syndrome
Testosterone Replacement in Metabolic Syndrome and Inflammation
Hypogonadism (HG) frequently complicates the Metabolic Syndrome (MetS), whether testosterone replacement (TRT) is beneficial has not been clearly ascertained.
- Conditions
- Hypogonadism, Metabolic Syndrome, Obesity, Erectile Dysfunction
- Trial name
- TERMSINFAT (NCT01123278)
- Testing
- Testosterone
- Where
- 2 sites in Italy
- Volunteers
- 82 people
- Sponsor
- University of Roma La Sapienza
Hypogonadism, Erectile Dysfunction
Testosterone for Penile Rehabilitation After Radical Prostatectomy
The purpose of this study is to determine the effectiveness of testosterone replacement therapy (TRT) in men following surgery to remove the prostate in improving erectile function.
- Trial name
- NCT00848497
- Testing
- Testim®, Viagra®
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mohit Khera
Hypogonadism, Male, Infertility, Male
The Effects of Natesto For Treatment Of Hypogonadism
In this prospective study, the investigators plan is to confirm the role of Natesto (intranasal testosterone) to combat hypogonadal symptoms in men trying to recover spermatogenesis following the withdrawal of conventional…
- Conditions
- Hypogonadism, Male, Infertility, Male, Testosterone Deficiency
- Trial name
- NCT04717362
- Testing
- Natesto Nasal Product
- Sponsor
- Baylor College of Medicine
Hypogonadism, Male
Testosterone-Dependent Effects on Protein Biomarkers From Healthy Males
The study is designed to identify and validate new protein biomarkers in blood related to testosterone activity. Thirty healthy young males underwent pharmaceutical castration to lower testosterone levels.
- Trial name
- NCT03541395
- Testing
- GnRH antagonist
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lund University
Hypogonadism
A Clinical Trial to Evaluate the Pharmacokinetic Profiles and Safety of CKD-845
A clinical trial to evaluate the pharmacokinetic profiles and safety of CKD-845.
- Trial name
- NCT04673682
- Testing
- D309, CKD-845
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Metabolic Syndrome, Hypogonadism
Symptoms and Clinical Signs of Hypogonadism in Testicular Cancer Survivors
The purpose of this study is to investigate the prevalence of signs and symptoms of hypogonadism in three groups of testicular cancer survivors.
- Conditions
- Metabolic Syndrome, Hypogonadism, Cardio-vascular Disease
- Trial name
- NCT02240966
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Male Infertility, Male Hypogonadism
Relationship of the Microenvironment and Male Fertility
Although much is known about the microenvironment of the gut and the vagina, very little has been published on the microenvironment of the seminal plasma.
- Trial name
- NCT04704141
- Testing
- Hormone replacement therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Illinois Chicago
Hypogonadotropic Hypogonadism, Kallmann Syndrome
Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH)
The investigators are doing this research study to look at the relationship between testosterone (the main sex hormone in men) and insulin (the hormone that controls blood sugar levels) in men with Idiopathic Hypogonadotropic…
- Trial name
- NCT03118479
- Testing
- Anastrozole Pill, Testosterone
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Klinefelter Syndrome
Klinefelter Fertility Preservation
Klinefelter syndrome occurs in 1 in 600 males and is a common cause of infertility in men. It appears scar tissue forms in these boys' testicles, leading to progressive destruction over their lifetimes.
- Trial name
- NCT01817296
- Testing
- Testicular Biopsy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Boston Children's Hospital
Infertility
Androxal in Male Infertility
This is an exploratory, single center, randomized, parallel, double-blind placebo- and active-controlled trial in adult males ages 18 to 35 years of age who have male infertility of unknown cause.
- Trial name
- NCT02160704
- Testing
- Enclomiphene citrate
- Where
- United States
- Sponsor
- Baylor College of Medicine
Hypogonadism, Contraception
The Effects of Testosterone on Prostate Tissue (ACYP-1)
The purpose of this research study is to understand the effects of testosterone on the prostate. This knowledge will be used to help in the development of a safe male hormonal contraceptive and may impact the development of…
- Trial name
- ACYP-1 (NCT00161486)
- Testing
- Testosterone gel, Acyline
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Washington
Sex Chromosome Disorders
Clinical and Genetic Aspects of Fetuses With Sex-chromosome Disorders
To conduct a comprehensive clinical investigation of electively aborted fetuses with sex chromosome disorders and their placentas, in parallel with analyses of epigenetic alterations and changes in gene expression in these…
- Trial name
- NCT07304193
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Aarhus
Hypogonadotropic Hypogonadism
A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadism
The purpose of this study is to evaluate the effects on serum testosterone after 4 weeks of subcutaneous (SC) dose administration, with different doses and dosing frequencies of TAK-448 to overweight/obese males with…
- Trial name
- NCT02369796
- Testing
- TAK-448
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Takeda
Klinefelter Syndrome, Infertility, Male
Unraveling the Klinefelter's Disease Physiopathology
Organoid Model to unravel Klinefelter Syndrome infertility Klinefelter Syndrome (KS) is characterized by the presence of an extra chromosome X in male (47,XXY), it is the most frequent genetic cause of azoospermia in adult men.
- Trial name
- KLINEFELTER (NCT05997706)
- Testing
- Testicular biopsy
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Male Hypogonadism, Androgen Deficiency
Registry of Hypogonadism in Men
The primary objective of the Registry of HYpogonadism in MEn (RHYME) is to establish and maintain a large, multi-national prospective registry of male patients who have been diagnosed with male hypogonadism (HG), also known as…
- Conditions
- Male Hypogonadism, Androgen Deficiency, Testosterone Deficiency
- Trial name
- RHyMe (NCT00858650)
- Testing
- Standard of Care
- Where
- 25 sites in Germany, Italy and 4 more
- Volunteers
- 999 people
- Sponsor
- Carelon Research
Hypothalamic Obesity
A Trial of Setmelanotide in Acquired Hypothalamic Obesity
The goal of this trial is to learn how well Setmelanotide works to improve weight reduction, hunger, and quality of life in patients 4 years of age and older with acquired Hypothalamic Obesity (HO).
- Trial name
- NCT05774756
- Testing
- Setmelanotide
- Where
- 28 sites in United States, Canada and 4 more
- Volunteers
- 143 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Hypogonadism
A Study of Fortigel Testosterone Gel 2% in Males With Low Testosterone
Low testosterone is a condition that occurs when the body is unable to produce sufficient quantities of testosterone. The medical name for low testosterone is hypogonadism. Hypogonadism can be caused by many factors.
- Trial name
- NCT00522431
- Testing
- Testosterone
- Volunteers
- 149 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Microdeletion Syndromes, Trisomy 21
Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA
The purpose of this study is to collect blood from families with a child who has been diagnosed with a chromosomal disorder including microdeletions in order to further develop a non-invasive prenatal screening test based on…
- Conditions
- Microdeletion Syndromes, Trisomy 21, Trisomy 18, Trisomy 13
- Trial name
- Microdel Triad (NCT02109770)
- Where
- 2 sites in United States
- Volunteers
- 216 people
- Sponsor
- Natera, Inc.
Adult Male Hypogonadism
A Multicenter Extension Trial to Evaluate the Safety of Testosterone Gel
This is a multicenter extension trial in adult hypogonadal males. The purpose of this study is to evaluate the safety of testosterone gel delivered using an applicator over an extended period of time.
- Trial name
- NCT01703741
- Testing
- Testosterone Gel (FE 999093)
- Where
- 18 sites in United States, Canada
- Volunteers
- 145 people
- Sponsor
- Ferring Pharmaceuticals
Hypogonadism, Male
Vogelxo(R) ABPM Study in Hypogandal Men
A Phase 4 ABPM study in Hypogonadal Men
- Trial name
- NCT04558567
- Testing
- Vogelxo
- Where
- 7 sites in United States
- Volunteers
- 122 people
- Sponsor
- Upsher-Smith Laboratories