Clinical trials: Malignancies Multiple
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Neoplasms, HIV
Potlako: A Programmatic Intervention to Improve Access to Timely Oncology Care
Diagnostic and treatment delays contribute substantially to disparities in cancer morbidity and mortality between low- and middle- income countries (LMICs) and high-income countries.
- Conditions
- Neoplasms, HIV, Healthcare Disparity
- Trial name
- NCT02752061
- Testing
- Potlako intervention
- Where
- Botswana
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary
Differentiation of Benign and Malignant Pulmonary Nodules by Volatile Organic Compounds in Human Exhaled Breath
The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) markers.
- Conditions
- Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary, Lung Cancer
- Trial name
- NCT06518655
- Testing
- Gas chromatography-mass spectrometry(GC-MS) and micro Gas Chromatography-photoionisation detector (μGC-PID) system
- Where
- 15 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- ChromX Health
Cancer Screening
Multi-cancer Joint Screening and Early Diagnosis and Treatment Project Based on the Combination of Chinese Traditional and Western Medicine in Lanxi City
This study conducted a joint screening and early diagnosis and recommended treatment for LCA, LC, UGIC, and CRC among residents aged 45 to 74 in six townships of Lanxi City, Zhejiang Province.
- Trial name
- NCT06200051
- Testing
- Prediction of high risk of cancer
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lanxi Hospital of Traditional Chinese Medicine
Tuberous Sclerosis Complex (TSC), Focal Cortical Dysplasia
Phase 1, Open-label, Drug-drug Interaction Study to Assess Effect Between Radiprodil and the Co-administered Drugs.
This is a Phase 1, open-label, 3-period study to determine radiprodil's potential to act as a perpetrator of cytochrome P-450 (CYP) metabolic pathways and transporter pathways.
- Conditions
- Tuberous Sclerosis Complex (TSC), Focal Cortical Dysplasia, Other Neurological Disorders
- Trial name
- NCT06975605
- Testing
- Radiprodil + co-administered drugs
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GRIN Therapeutics, Inc.
Pain, Pulmonary Nodules
Effect of CYP2D6*10 Gene Mutation on Perioperative Precision Analgesia of Oxycodone in Elderly Patients
The purpose of this prospective study was to determine the effect of CYP2D6 gene polymorphism on perioperative analgesia of oxycodone in elderly patients, and to assign the CYP2D6 phenotype according to the genotype, and to use…
- Conditions
- Pain, Pulmonary Nodules, Oxycodone
- Trial name
- NCT07484867
- Testing
- oxycodone
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Human Immunodeficiency Virus (HIV), Sexually Transmitted Disease (STD)
Steering Together in a New Direction: Reducing the Risk of HIV/STD Among African American Men
African American men have by far the highest rates of HIV in the US, but there are few randomized controlled trials (RCTs) of interventions to dissuade heterosexually active African American men from engaging sexual risk…
- Trial name
- STAND (NCT02572401)
- Testing
- STAND HIV Risk Reduction Intervention, Text Messaging Intervention
- Where
- United States
- Volunteers
- 391 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Parkinson's Disease (PD), Mild to Moderate Parkinson's Disease
A Phase I Study in Healthy Volunteers and Parkinson's Disease (PD) Patients.
The goal of this trial is to learn if MTX325 can be developed as a potential disease-modifying treatment for Parkinson's Disease. Parts 1-4 complete, Part 5 (multiple doses in patients with Parkinson's Disease) in progress.
- Conditions
- Parkinson's Disease (PD), Mild to Moderate Parkinson's Disease, Early Stage Parkinson's Disease
- Trial name
- NCT07630545
- Testing
- MTX325
- Where
- 18 sites in Australia, France and 2 more
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Mission Therapeutics
Irritable Bowel Syndrome
A Phase 1, First Time in Human (FTIH) Study to Evaluate GSK3352589, a REarranged During Transfection (RET) Growth Factor Receptor Tyrosine Kinase Inhibitor, in Healthy Volunteers
This FTIH study is designed to assess the safety, tolerability and pharmacokinetic (PK) of escalating single and repeat oral doses of GSK3352589 in normal healthy volunteers.
- Trial name
- NCT03154086
- Testing
- GSK3352589
- Where
- Australia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malignant Tumor
Establishment of Tongue Image Database and Machine Learning Model for Malignant Tumors Diagnosis
The tongue images of malignant tumors and corresponding healthy people will be collected to establish the tongue image database.
- Trial name
- NCT04793672
- Testing
- Tongue images, coating on the tongue and clinical data of patients with malignant tumors and healthy people will be collected.
- Where
- 2 sites in China
- Volunteers
- 4,100 people, healthy volunteers welcome
- Sponsor
- Zhejiang Cancer Hospital
Multiple Myeloma, Caregiver Subjective Burden
The Burden of Multiple Myeloma on Patients and Caregivers Quality of Life: a Canadian Real-World Study
The purpose of this observational study is to estimate the burden of multiple myeloma on patients and caregivers in terms of QoL.
- Conditions
- Multiple Myeloma, Caregiver Subjective Burden, Quality of Life (QOL)
- Trial name
- NCT06610045
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- PeriPharm
Cancer Survivors, Neoplasms
Eat, Play, Sleep: A Text Message Approach to Promoting Health Behaviors for Cancer Survivors and Their Caregivers
Health behavior text message content will be delivered daily over 4-weeks to cancer survivor/caregiver dyads.
- Trial name
- NCT06234267
- Testing
- Eat, Play, Sleep
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Thyroid Abnormalities, Thyroid
Ultrasound Large-scale Model in Thyroid Field: A Multi-center Study on Medical-Engineering Integration
The goal of this observational study is to evaluate the diagnostic accuracy and clinical workflow integration of an ultrasound intelligent agent (UIA) for thyroid disease management in a real-world multicenter setting.
- Conditions
- Thyroid Abnormalities, Thyroid, Thyroid Cancer
- Trial name
- NCT07296575
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Body Image
Impact of Exposure to Images of the Idealised Physique on Body Satisfaction, Dieting Intentions and Mood in Men.
Every day, people are exposed to huge amounts of media. Research has explored the impact of viewing traditional media and advertising (such as television and magazines) on how a person thinks and feels about their body (body…
- Trial name
- NCT03991351
- Testing
- Exposure to images
- Where
- United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Chemotherapy-Induced Neutropenia
Study to Evaluate the Safety, Tolerability and PK of EC-18 After Oral Administration in Healthy Volunteers
This study is a Dose block-randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Escalation, Phase I clinical trial to assess the safety, tolerability and pharmacokinetics of single-dose and…
- Trial name
- NCT02532712
- Testing
- EC-18
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Enzychem Lifesciences Corporation
Surgery
A Study of Opportunistic Salpingectomy to Prevent Ovarian Cancer
The purpose of this study is to find out how many participants are interested in a surgical preventive procedure after watching an educational video.
- Trial name
- NCT06312124
- Testing
- Educational Module, Salpingectomy
- Where
- 10 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer
"Touch 2 Screen" Multi-media Colorectal Cancer Screening Intervention
The primary purpose of this study is to determine the effectiveness of a multi-media presentation and survey to increase screening for colorectal cancer.
- Trial name
- NCT00594113
- Testing
- Touch 2 Screen, Touch screen intervention
- Where
- United States
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- Allen A. Greiner, MD, MPH
Cervical Cancer, Low-grade Squamous Intraepithelial Lesion,
A Multi-center Survey of HPV in Cervical Intraepithelial Neoplasia (CIN) With Longitudinal Follow-up of LSIL Cases
The aims of this study are: 1. Surveillance of the prevalence of HPV infection in ASCUS, AGCUS and SIL cases pooled from medical centers in Taiwan and analysis of the related epidemiological factors. 2.
- Conditions
- Cervical Cancer, Low-grade Squamous Intraepithelial Lesion,, Human Papillomavirus
- Trial name
- NCT00201370
- Where
- 4 sites in Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Prostate Cancer, Urinary Incontinence, Urge
Effects of Urinary Bladder Hypertrophy on Urge Urine Incontinence After Radical Prostatectomy
This study is designed to evaluate men before radical prostatectomy for the incidence of Overactive Bladder (OAB), as well as urge urine incontinence (UUI) development after the surgery.
- Conditions
- Prostate Cancer, Urinary Incontinence, Urge, Incontinence, Prostatectomy
- Trial name
- NCT03061760
- Testing
- Radical prostatectomy, Initial evaluation, Evaluation after 1,3,6,9,12 months
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Collegium Medicum w Bydgoszczy
Breast Cancer
Case Collection Study to Support Digital Mammography Image Software Change
The primary objective of this study is to compare image processing software to support a new image processing software application for a full-field digital mammography (FFDM) system.
- Trial name
- LIP2SIP (NCT00756496)
- Testing
- Mammography screening and diagnosis
- Volunteers
- 442 people, healthy volunteers welcome
- Sponsor
- Siemens Medical Solutions USA - CSG