Clinical trials: Malignant Biliary Stenosis
Malignant Biliary Obstruction
Evaluation of a New Metal Biliary Stent of 12-mm Diameter: a Case Control Study
Biliary stent allows the drainage of the bile ducts palliatively or preoperatively in the event of malignant biliary stenosis, and a biliary calibration in the event of benign stenosis.
- Trial name
- BIGDIAM (NCT04405752)
- Testing
- 12-mm metallic biliary stent, 10-mm metallic biliary stent
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Institut Paoli-Calmettes
Biliary Stricture
Single-operator Digital Cholangioscopy for the Diagnosis of Malignant and Benign Biliary Strictures
Differentiation between malignant and benign biliary strictures can be challenging. Accurate differentiation of malignant biliary strictures from benign ones is crucial to guide management decisions.
- Trial name
- NCT03307382
- Testing
- SpyGlass DS Cholangioscopy
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Biliary Disease Tract, Biliary Stenosis
Supra-papillary Versus Trans-papillary Biliary Stenting in Malignant Peri-hilar Stenosis
This is a randomized controlled trial comparing patients with obstructive jaundice due to malignancies of the perihilar area of bile ducts and undergoing both preoperative and palliative biliary drainage.
- Conditions
- Biliary Disease Tract, Biliary Stenosis, Biliary Stents
- Trial name
- SupraBilS (NCT07325877)
- Testing
- ERCP with suprapapillary stent placement, ERCP with transpapillary stent placement
- Volunteers
- 70 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Liver Cancer, Bile Duct Cancer
Intra-luminal Radiofrequency Ablation for Inoperable Malignant Biliary Stenosis
Only a small proportion of patients with biliary obstruction caused by hepatopancreatobiliary malignancies are suitable for surgical resection.
- Conditions
- Liver Cancer, Bile Duct Cancer, Pancreatic Cancer
- Trial name
- NCT02841800
- Testing
- 'Intra-luminal radiofrequency ablation (Habib EndoHPB)
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Endoscopic Retrograde Cholangiopancreatography, Klatskin Tumor
Application of Endoscopic Scissors Cutting ENBD Tube in the Treatment of Malignant Hilar Biliary Strictures
The purpose of this study is to evaluate application value of the endoscopic cutting technique in the treatment of malignant hilar biliary strictures.
- Trial name
- ENBD (NCT03353181)
- Testing
- Endoscopic scissors, Biliary stent
- Where
- China
- Sponsor
- Changhai Hospital
Biliary Stricture, Malignant Neoplasms
Patency and Safety of the Drug Eluting Covered Biliary Stent Comparing to the Common Covered Biliary Stent
Paclitaxel covered metal biliary stent extents their patency rate comparing to the Common Covered Metallic Biliary Stent.
- Trial name
- MIRA-cover (NCT01512563)
- Testing
- Biliary stent
- Where
- 3 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- Taewoong Medical Co., Ltd.
Biliary Stricture
A Study of Endobiliary Radiofrequency Ablation in Malignant Biliary Obstructions
The purpose of this study is to assess the impact of temperature-sensitive radiofrequency ablation (RFA) immediately before biliary stent placement on duration of biliary stent patency and re-intervention free survival.
- Trial name
- NCT05826639
- Testing
- Temperature-sensitive radiofrequency ablation, No intervention
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Mayo Clinic
Cholangiocarcinoma, Extrahepatic, Cholangiocarcinoma of the Extrahepatic Bile Duct
Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma - a Pilot Study
Diagnosis of extrahepatic cholangiocarcinoma is challenging because the yield of imaging and tissue sampling is limited. Raman spectroscopy is an optical method based on the analysis of scattered monochromatic light.
- Conditions
- Cholangiocarcinoma, Extrahepatic, Cholangiocarcinoma of the Extrahepatic Bile Duct, Cholangiocarcinoma, Perihilar, Diagnosis
- Trial name
- NCT06964425
- Testing
- Endoscopic retrograde cholangiopancreatography (ERCP)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- University Hospital Olomouc
Malignant Tumor of Extrahepatic Bile Duct
Winged Perimeter Versus Traditional Plastic Biliary Stent for Malignant Bile Duct Obstruction
Strictures in the bile duct cause a blockage of flow of bile. This leads to potential problems including jaundice, itch and infection in the bile duct.
- Trial name
- NCT01514214
- Testing
- WInged perimeter biliary stent insertion (Viaduct), traditional polyethylene stent insertion (Cotton Huibregtse)
- Where
- 2 sites in Canada
- Volunteers
- 58 people
- Sponsor
- University of British Columbia
Pancreatic Neoplasms
Lipidomics, Proteomics, Micro RNAs and Volatile Organic Compounds (VOC)
This is a non-randomized natural history protocol in which patients undergoing surgery or endoscopy for suspected/ diagnosed pancreaticobiliary strictures are assigned to a) control (chronic pancreatitis, no pancreatic neoplasm…
- Trial name
- NCT02531607
- Testing
- blood and bile
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- AdventHealth
Bile Duct Stricture, Malignancy
Performance of FISH for the Diagnosis of Malignant Biliary Strictures in Thai Patients
Fluorescence in situ hybridization (FISH) has improved the diagnostic performance of cytology for evaluation of malignant biliary strictures in the US and Europe.
- Trial name
- NCT02442167
- Volunteers
- 101 people
- Sponsor
- Mayo Clinic
Gastrointestinal Neoplasms, Biliary Tract Neoplasms
Endoscopic Stenting of Gastrointestinal Cancer
Obstruction of the digestive tract is a frequent cause of morbidity in patients with gastrointestinal cancer.Palliative endoscopic treatment with self- expanding metal stents(SEMS)is an alternative to palliative surgery and other…
- Trial name
- NCT00422409
- Testing
- Endoscopic stenting
- Where
- 7 sites in Norway
- Volunteers
- 270 people
- Sponsor
- Ullevaal University Hospital
Malignant Biliary Obstruction
IRS(Irradiation Stent) vs. CS(Conventional Stent) Insertion in Inoperable Malignant Biliary Obstruction
Stenting the malignant biliary obstruction is considered to be the preferred palliation modality to relieve pruritus,cholangitis,pain and jaundice in patients without surgical indications of malignant biliary obstruction.An…
- Trial name
- IRCSMBO (NCT02001779)
- Testing
- Biliary SEMS loaded with 125I seeds, Conventional biliary SEMS
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Zhongda Hospital
Malignant Biliary Stricture
The Efficacy of Plastic Stent Anchoring to Reduce Migration of Metal Stent
The aim of this study is to demonstrate that the group with an additional plastic stent to anchor the fully covered self expandable metal stent (FCSEMS) in patients with malignant biliary stricture has less stent migration than…
- Trial name
- NCT03439020
- Testing
- Plastic stent anchoring, FCSEMS
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Hospital
Pancreatic Cancer, Cholangiocarcinoma
Endoscopic Biliary Radiofrequency Ablation of Malignant Distal Common Bile Duct Strictures
Malignant bile duct obstruction is a common sequela of pancreatic cancers or distal bile duct cancers, and its development can hinder the use of chemotherapy, decrease patient quality of life, and decrease survival.
- Trial name
- NCT01721174
- Testing
- SEMS only, EBRFA and SEMS
- Where
- Hong Kong
- Volunteers
- 42 people
- Sponsor
- Chinese University of Hong Kong
Obstruction of Biliary Tree, Biliary Tract Cancer
Endoscopic Therapy of Malignant Bile Duct Strictures
Patients with malignant bile duct stenosis have poor prognosis and most of the patients are not good candidate for surgery at the time of diagnosis. Placement of the stent is the palliative care for these patients.
- Conditions
- Obstruction of Biliary Tree, Biliary Tract Cancer, Biliary Tract Neoplasms
- Trial name
- NCT01543607
- Testing
- Radiofrequency ablation catheter (Habib EndoHBP)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Malignant Biliary Stenosis
Hot AXIOS™ for Bile Duct Drainage in Malignant Stenosis
The study is designed to highlight the effectiveness of the Hot AXIOS™ stent when used in accordance with standard medical practice on the evolution of the quality of life of patients with malignant biliary stenosis requiring…
- Trial name
- RAINBOW (NCT06750146)
- Testing
- Hot AXIOS™ Stent and Electrocautery Enhanced Delivery System
- Where
- 18 sites in France
- Volunteers
- 162 people
- Sponsor
- Boston Scientific Corporation
Jaundice, Obstructive, Jaundice; Malignant
Microbiological Assessment of Bile in Patients Undergone to Endoscopic Retrograde Cholangiography (ERCP): the "Microbile Registry"
The study is a prospective evaluation of the microbial assessment in patients undergoing to ERC with naive papilla; the population includes all the indication to biliary drainage.
- Conditions
- Jaundice, Obstructive, Jaundice; Malignant, Choledocholithiasis, Biliary Stricture
- Trial name
- Microbile (NCT06115564)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Unità Sanitaria Locale della Romagna
Bile Duct Stricture, Bile Duct Cancer
PTFE Stents for Treatment of Malignant Biliary Strictures
In this randomized trial two two self-expanding metal stents (SEMS) for treatment of malignant biliary strictures are investigated.
- Conditions
- Bile Duct Stricture, Bile Duct Cancer, Pancreas Cancer
- Trial name
- NCT03763214
- Testing
- Stenting with PTFE-coated stent (HILZO)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Johannes Vermehren
Common Bile Duct Stone, Malignant Hepatobiliary Neoplasm
Primary Needle Knife Fistulotomy Versus Conventional Cannulation Method
The aim of this study are to evaluate the feasibility of needle knife fistulotomy (NKF) as an initial procedure for biliary access in patients with biliary disease who are at increased risk for post-endoscopic retrograde…
- Conditions
- Common Bile Duct Stone, Malignant Hepatobiliary Neoplasm, Biliary Stricture, Pancreatic Diseases
- Trial name
- NCT02916199
- Testing
- cannulation of ampulla of Vater
- Where
- 7 sites in South Korea
- Volunteers
- 207 people
- Sponsor
- Gangnam Severance Hospital