Clinical trials: Malignant Colorectal Neoplasm
Colon Cancer
Intracorporeal Anastomosis Versus Extracorporeal Anastomosis for Left Colon Cancer
This study aims to investigate the effects of intracorporeal anastomosis and extracorporeal anastomosis in laparoscopic-assisted radical left hemicolectomy on surgical site infection.
- Trial name
- NCT04201717
- Testing
- laparoscopic assisted left colectomy (extracorporeal anastomosis group), total laparoscopic left colectomy (intracorporeal anastomosis group)
- Where
- 12 sites in China
- Volunteers
- 350 people
- Sponsor
- Jilin University
Anxiety Disorder, Cognitive/Functional Effects
Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer
RATIONALE: Participating in a physical activity program designed to increase free time physical activity and receiving written health education materials may influence the chance of cancer recurring as well as impact on physical…
- Conditions
- Anxiety Disorder, Cognitive/Functional Effects, Colorectal Cancer, Depression
- Trial name
- CHALLENGE (NCT00819208)
- Testing
- exercise intervention, counseling intervention, educational intervention
- Where
- 47 sites in United States, Australia and 4 more
- Volunteers
- 889 people
- Sponsor
- Canadian Cancer Trials Group
Colon Cancer, Rectum Cancer
The Value of Laparoscopic Ultrasound in Patients Undergoing Laparoscopic Resection for Cancer of the Colon or Rectum
The following project deals with a Danish multicenter trial that evaluates the value of Laparoscopic Ultrasound examination (LUS) in laparoscopic surgery for colon and rectum cancer (CRC).
- Conditions
- Colon Cancer, Rectum Cancer, Liver Metastases
- Trial name
- NCT02079389
- Testing
- Lap+Lus
- Where
- 4 sites in Denmark
- Volunteers
- 280 people
- Sponsor
- Odense University Hospital
Colon Cancer, Inflammatory Bowel Diseases
Functional Restoration After Abdominal and Pelvic Laparoscopic Surgery: Effect of Perioperative Intravenous Lidocaine
This is a blinded randomized controlled trial in patients undergoing laparoscopic colon surgery. The aim of this study is to assess whether perioperative intravenous lidocaine has an impact on the early post operative physical…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT00982618
- Testing
- Lidocaine, Epidural Block, PCA Morphine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Breast Cancer, Melanoma
Immunological Variables Associated to ICI Toxicity in Cancer Patients
This is a monocentric, prospective, pilot study that will enrol 435 subjects with solid tumours that are treated with immune checkpoint inhibitor(s) (ICI) alone or in combination with chemotherapy or targeted therapy.
- Conditions
- Breast Cancer, Melanoma, Non Small Cell Lung Cancer, Non-melanoma Skin Cancer
- Trial name
- NCT05429866
- Testing
- Checkpoint Blockade, Immune
- Where
- Belgium
- Volunteers
- 441 people
- Sponsor
- Jules Bordet Institute
Breast Cancer, Colon Cancer
Understanding Patient Perspectives on the Risks of Ionizing Radiation Used for Medical Imaging
Risks from imaging-related radiation exposure have become a popular topic in the media. Because these tests are commonly applied to patients at a cancer center, it is important to understand what patients know, how they feel…
- Conditions
- Breast Cancer, Colon Cancer, Lung Cancer, Neuroblastoma
- Trial name
- NCT01482741
- Testing
- Focus Group Sessions
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Gallbladder Cancer
Visceral Lymphatic Mapping Using Isosulfan Blue in Patients With Cancer of the Pancreas, Colon, Stomach, Small Intestine, or Gallbladder
RATIONALE: Diagnostic procedures, such as visceral lymphatic mapping using isosulfan blue, may help find cancer of the pancreas, colon, stomach, small intestine, or gallbladder and find out how far the disease has spread.
- Conditions
- Colorectal Cancer, Gallbladder Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT00489515
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Wake Forest University Health Sciences
Abdominal Pain, Black Stools
The Auxiliary Effect of Artificial Intelligence in the Detection of Precancerous Lesions in Proximal Colon Cancer
The investigators conducted a multicenter randomized controlled trial to explore the adjuvant effect of artificial intelligence in the detection of precancerous lesions in the proximal colon.This is a prospective, multicenter…
- Conditions
- Abdominal Pain, Black Stools, Constipation, Diarrhea
- Trial name
- NCT07338643
- Testing
- AI group, Serial group, Standard colonoscopy group
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Limian Er
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery
This phase I trial is studying the side effects and best dose of resveratrol in treating patients with colorectal cancer that can be removed by surgery.
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Stage I Colon Cancer, Stage I Rectal Cancer
- Trial name
- NCT00433576
- Testing
- resveratrol, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Colon Cancer (High-risk Stage III: pT4N1 or pT1 to 4 N2)
IRinotecan and Oxaliplatin for Colon Cancer in Adjuvant Setting
The trial is a phase III, multicenter, open-labeled randomized trial comparing the association of 5-fluorouracil (5-FU), folinic acid, irinotecan, and oxaliplatin (mFOLFIRINOX) versus oxaliplatin, folinic acid, and 5-FU (mFOLFOX…
- Trial name
- IROCAS (NCT02967289)
- Testing
- Irinotecan, Folfox Protocol
- Where
- 17 sites in Canada, France
- Volunteers
- 792 people
- Sponsor
- UNICANCER
Recurrent Colon Cancer, Liver Metastases
Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the Liver
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving them in different ways may kill more tumor cells.
- Conditions
- Recurrent Colon Cancer, Liver Metastases, Stage IV Rectal Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00019760
- Testing
- floxuridine, leucovorin calcium, melphalan
- Where
- United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
Male Breast Cancer, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity
Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors
This phase I trial is studying the side effects and best dose of alvespimycin hydrochloride in treating patients with metastatic or unresectable solid tumors.
- Conditions
- Male Breast Cancer, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity, Recurrent Basal Cell Carcinoma of the Lip, Recurrent Breast Cancer
- Trial name
- NCT00089362
- Testing
- alvespimycin hydrochloride, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer
Combination Chemotherapy and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00628810
- Testing
- bevacizumab, fluorouracil, irinotecan hydrochloride
- Where
- 32 sites in France
- Volunteers
- 86 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Colon Cancer
Comparison of Limb Size of Transverse Coloplasty Pouch
The aim of the study is the comparison of pouch function with two different sizes of limb of transverse coloplasty pouch after rectal resection and total mesorectal excision.
- Trial name
- NCT01071824
- Testing
- Transverse coloplasty pouch (Long limb), Transverse coloplasty pouch (Short limb)
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Kantonsspital Liestal
Colon Cancer
Colometer - A Real Time Quality Improvement Feedback System for Screening Colonoscopy
Our team has created an automated, real-time software based image analysis tool called Colometer to improve screening colonoscopy providing real time visual feedback on image quality. There are three components to this study.
- Trial name
- NCT01969292
- Testing
- Colometer
- Where
- Canada
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Christopher Andrews
ColoRectal Cancer
Community Engaged Colon Cancer Screening Patient Navigator Program
The goal of the project is to increase colorectal cancer screening within the priority population of female and male adults age 50 to 85 in Northern Nevada.
- Trial name
- NCT03031171
- Testing
- Screening patient navigation, Non-Navigated
- Where
- United States
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Colorectal Cancer
Radiation Therapy Plus Irinotecan in Treating Patients With Colon Cancer
RATIONALE: Radiation therapy uses high energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00003344
- Testing
- irinotecan hydrochloride, radiation therapy
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Medical University of South Carolina
Colo-rectal Cancer
Evaluation of the Natera Colorectal Cancer Screening Test in an Average Risk Population (FIND-CRC)
The FIND-CRC study is a prospective collection of samples and data from participants who are at average risk of developing colorectal cancer (CRC).
- Trial name
- FIND-CRC (NCT07046585)
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Breast Cancer, Prostate Cancer
Survivorship Promotion In Reducing IGF-1 Trial
This is a prospective, single-center randomized trial with three arms, and an allocation ratio of 1:1:1. The study design is an efficacy study to evaluate the effect of metformin and coach-directed behavioral weight loss versus…
- Conditions
- Breast Cancer, Prostate Cancer, Lung Cancer, Colon Cancer
- Trial name
- SPIRIT (NCT02431676)
- Testing
- Metformin, Coach Directed Behavioral Weight Loss, Self-control weight loss
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Advanced Adult Primary Liver Cancer, Carcinoma of the Appendix
EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer
This clinical trial is studying the amount of EF5 and motexafin lutetium present in tumor cells and/or normal tissues of patients with abdominal (such as ovarian, colon, or stomach cancer) or non-small cell lung cancer.
- Conditions
- Advanced Adult Primary Liver Cancer, Carcinoma of the Appendix, Fallopian Tube Cancer, Gastrointestinal Stromal Tumor
- Trial name
- NCT00087191
- Testing
- EF5, motexafin lutetium, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)