Clinical trials: Malignant Neuroleptic
Rhabdomyolysis, Myopathy
Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients
1. Analyze the various causes of breakdown of muscle fibers in hospitalized patients. 2. Analyze the characteristics of these patients in Taiwan (including the drugs history, risk factors and the incidence of complications).
- Conditions
- Rhabdomyolysis, Myopathy, Acute Renal Failure, Neuroleptic Malignant Syndrome
- Trial name
- NCT01022450
- Where
- Taiwan
- Volunteers
- 2,500 people
- Sponsor
- National Taiwan University Hospital
Parkinson Disease, Parkinson's Disease and Parkinsonism
STEM-Parkinson's Disease
This is a double-blinded, controlled, and randomized clinical trial (RCT) to establish the safety and efficacy of a non-invasive neuromodulation device for treating symptoms associated with Parkinson's disease.
- Trial name
- STEM-PD (NCT04797611)
- Testing
- TNM Device
- Where
- 23 sites in United States, United Kingdom
- Volunteers
- 188 people
- Sponsor
- Scion NeuroStim
Advanced Parkinson's Disease
A Study to Examine the Effect of Levodopa-Carbidopa Intestinal Gel (LCIG) Therapy Relative to That of Optimized Medical Treatment (OMT) on Non-motor Symptoms (NMS) Associated With Advanced Parkinson's Disease (PD)
The primary objective of this study is to examine the effect of LCIG relative to that of OMT on NMS associated with PD.
- Trial name
- NCT02549092
- Testing
- Optimized Medical Treatment, Levodopa-Carbidopa Intestinal Gel, Nasojejunal (NJ) tube
- Where
- 38 sites in United States, Australia and 7 more
- Volunteers
- 89 people
- Sponsor
- AbbVie
Parkinson's Disease
Mindfulness Based Intervention (MBI) on the Quality of Life and Non-Motor Symptoms (NMS) of Persons With PD
Scientific Abstract: The investigators propose a study to examine the impact of a Mindfulness Based Intervention (MBI) on the quality of life and Non-Motor Symptoms (NMS) of persons with Parkinson's disease (PD).
- Trial name
- NCT01607697
- Testing
- Mindfulness Training
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- University Hospital, Antwerp
Neuromuscular Scoliosis, Adolescent Idiopathic Scoliosis
Postoperative Steroid Use in Adolescent Idiopathic Scoliosis and Neuromuscular Scoliosis Patients
The goal of this randomized clinical trial is to compare the immediate use of steroids after surgery for accelerated discharge in adolescent idiopathic scoliosis and neuromuscular scoliosis after a posterior spinal fusion.
- Trial name
- NCT06023043
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's Hospital Los Angeles
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
We and others have shown that many younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), i.e., they can't tolerate prolonged standing.
- Conditions
- Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Systemic Exertion Intolerance Disease (SEID), Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT02854683
- Testing
- Normal Saline, Oral Rehydration Solution
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Schizophrenia
Transcutaneous Non-invasive Vagus Nerve Stimulation (t-VNS) in the Treatment of Schizophrenia
Randomized, controlled, double-blind, two-armed clinical investigation to show the efficacy and safety of transcutaneous vagus nerve stimulation (t-VNS), applied at the left auricle, in schizophrenia.
- Trial name
- 02VNS2009 (NCT01176721)
- Testing
- t-VNS verum
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- cerbomed GmbH
Depression, Catatonia
Survey on Pre-ECT Evaluation and ECT Application
The aim of this study is to identify specifics of pre-ECT assessments and ECT application in European psychiatric services. We will engage European centres that provide ECT for psychiatric patients and for psychiatric…
- Conditions
- Depression, Catatonia, Schizophrenia, Schizoaffective Disorder
- Trial name
- NCT04335916
- Where
- Croatia
- Volunteers
- 30 people
- Sponsor
- Klinički Bolnički Centar Zagreb
Parkinson Disease
Patient Engagement Investigation of NMS Assist
Parkinson's can cause a wide range of non-motor symptoms (NMS), including pain and problems with mental health, memory and sleep. These affect the quality of life of people with Parkinson's (PwP) and their care partners (CP).
- Trial name
- NCT07038486
- Testing
- NMS Assist
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Newcastle University
Vitamin D
Correlation Between Vitamin D and Symptoms Severity of Autonomic Nervous Mediated Syncope Child and it 's RAAS
children ; autonomic nervous mediated syncope； vitamin D ; symptom score ; renin-angiotensin-aldosterone-system
- Trial name
- NCT04844957
- Testing
- Vitamin D, Full automatic chemiluminescence measuring instrument
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kongyujie
Parkinson Disease, Parkinson's Disease and Parkinsonism
STEM-PD Open Label Extension (OLE)
This study seeks to establish the safety and efficacy of extended twice daily time-varying caloric vestibular stimulation treatments for treating symptoms associated with Parkinson's disease.
- Trial name
- NCT04799418
- Testing
- Open Label Extension Study
- Where
- 15 sites in United States
- Volunteers
- 148 people
- Sponsor
- Scion NeuroStim
Migraine
Occipital Nerve Stimulation in the Treatment of Migraine
The objective of this proof-of-concept study is to generate initial safety and effectiveness data for the neuro-modulation stimulation (NMS) E-Box in patients with chronic migraine in an acute setting.
- Trial name
- Verona (NCT01855672)
- Testing
- Stimulation of the Occipital Nerves
- Where
- 4 sites in United States
- Volunteers
- 1 people
- Sponsor
- Ethicon, Inc.
Parkinson
Clinical Investigation of NMS Assist
Parkinson's can cause a wide range of non-motor symptoms (NMS), including pain and problems with mental health, memory and sleep. These affect the quality of life of people with Parkinson's (PwP) and their care partners (CP).
- Trial name
- NCT05414071
- Testing
- NMS Assist
- Sponsor
- University of Plymouth
Major Depressive Disorder
Open Label Optimization Study
The goal of this observational study is to demonstrate effectiveness in the treatment of Major Depressive Disorder The primary objective is to assess the effectiveness in the treatment of Major Depressive Disorder using the CGI-I…
- Trial name
- OLO (NCT05819021)
- Testing
- SAINT® Neuromodulation System (NMS)
- Where
- 7 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Magnus Medical
NSCLC Adenocarcinoma, Solid Tumor
Atamparib in Patients With Advanced Solid Tumors
This is a multi-part, open-label, non-randomized phase Ib/II clinical trial designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of atamparib, an investigational agent, in patients…
- Trial name
- PARP7 (NCT07374419)
- Testing
- atamparib escalation levels, atamparib RP2D
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Nerviano Medical Sciences (Shanghai) Ltd.
Hip Fractures, Mobility Limitation
Validation of the French Version of the New Mobility Score (NMS)
The incidence of hip fractures in France is 50,000 cases per year among women and 16,000 among men, with a 1-year mortality rate of 20-24%. After a fracture, 10-30% of patients become functionally dependent.
- Conditions
- Hip Fractures, Mobility Limitation, Independence, Autonomy
- Trial name
- MOB-SCORE (NCT07622095)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon