Clinical trials: Malignant Pleural Effusions
Pleural Effusion, Malignant, Prognosis
Longitudinal Follow up of Patients With Pleural Effusion
This study aims to evaluate the clinical course of patients diagnosed with pleural effusion and determine various clinical factors and biomarkers associated that can predict the diagnosis and clinical outcome and prognosis of…
- Trial name
- NCT04670562
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Seoul National University Bundang Hospital
Pleural Effusion, Malignant
Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion
Iodopovidone is safe when using as a pleurodesis sclerosing agent for malignant pleural effusion, with minimal adverse events, especially reducing dose.
- Trial name
- NCT01670786
- Testing
- pleurodesis
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Grupo de Pesquisa em Pleura e Oncologia Toracica
Pleural Effusion, Malignant, Pleural Effusion
A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer.
Pleural fluid can be caused by cancer. Patients with repeated presentation of pleural fluid where initial diagnostic tests have been inconclusive are the focus of this trial.
- Conditions
- Pleural Effusion, Malignant, Pleural Effusion, Pleura; Exudate
- Trial name
- NCT04233359
- Testing
- Local anesthetic thoracoscopy, US-guided pleural biopsy
- Where
- 2 sites in Denmark
- Volunteers
- 4 people
- Sponsor
- Naestved Hospital
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Malignant Pleural Effusion, Respiratory Disease
AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion
The purpose of this study is to determine if an indwelling catheter is more effective than surgical pleurodosis in treating malignant pleural effusion.
- Conditions
- Malignant Pleural Effusion, Respiratory Disease, Cancer
- Trial name
- AMPLE-3 (NCT04322136)
- Testing
- Pleurodesis via Video-assisted thoracoscopic surgery, Indwelling pleural catheter (with talc pleurodesis if suitable)
- Where
- Australia
- Volunteers
- 158 people
- Sponsor
- The University of Western Australia
Pleural Effusion
Using Pleural Effusions to Diagnose Cancer
Pleural effusions (PE) are common conditions that signal either infection or cancer. The investigators aim to develop, validate, and prospectively assess the MAPED score, a clinical score that predicts malignancy at admission.
- Trial name
- MAPED (NCT03319472)
- Where
- Greece
- Volunteers
- 439 people
- Sponsor
- University of Patras
Suspected Malignant Lung Neoplasm, Pleural Effusion
First Local Anaesthesia Thoracoscopy for Pleural Effusion Diagnosis.
Non randomized study with two groups. The study group includes patients with suspected malignant pleural effusion, in whom the investigation of pleural effusion begins directly with pleural biopsy by Local Anesthesia Thoracoscopy…
- Conditions
- Suspected Malignant Lung Neoplasm, Pleural Effusion, Pleural Effusion, Malignant, Mesothelioma, Malignant
- Trial name
- FLAT (NCT06946498)
- Testing
- Local Anesthesia Thoracoscopy, Pleuroscopy with Rigid Thoracoscope and Forceps biopsies
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Malignant Pleural Effusion, Malignancy
Feasibility of Ambulatory Talc. Pleurodesis
Patients with malignant pleural disease often experience a significant symptom burden and a short life expectancy. The cornerstone of their treatment is relieving breathlessness by draining fluid from around the lungs and…
- Conditions
- Malignant Pleural Effusion, Malignancy, Palliative Care
- Trial name
- NCT06682936
- Testing
- ambulatory chest drain and talc pleurodesis
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- David Rollins
Pleural Effusion, Malignant, Breast Cancer
Intrapleural Bevacizumab After Pleural Drainage in the Context of Breast Cancer
Metastatic pleural effusion is a common complication of late-stage cancer and reduces the quality of life and survival of patients.
- Trial name
- BEVAP (NCT02250118)
- Testing
- Bevacizumab
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Institut Curie
Pleural Effusion, Malignant Pleural Effusions
Quantitative C-Reactive Protein for Differentiating Tuberculous and Malignant Pleural Effusion: a Cross-Sectional Study
The goal of this observational study is to evaluate the role of pleural fluid Quantitative C-Reactive Protein (Q-CRP) levels in distinguishing between tuberculous and malignant pleural effusion in adult patients with lymphocytic…
- Conditions
- Pleural Effusion, Malignant Pleural Effusions, Tuberculous Pleural Effusion
- Trial name
- NCT06729931
- Testing
- Pleural Fluid Quantitative C-Reactive Protein (Q-CRP) Measurement
- Where
- Nepal
- Volunteers
- 81 people
- Sponsor
- Maharajgunj Medical Campus
Pleural Effusion, Malignant
IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and Ascites
The purpose of this study was to evaluate the efficacy of IFN- Y combined with T cells in the treatment of refractory malignant pleural effusion and acties, using a multicenter, single-arm, open design.
- Trial name
- NCT05268172
- Testing
- IFN-γ and CIK cells, Tcm cells or CAR T cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital of Jiangnan University
Pleural Diseases
Analysis of Metabonomics for Pleural Effusion
This is a multicenter retrospective study that collected diagnostic information of patients with pleural effusion. The overall survival (OS) time of malignant patients was followed up, defined as the time from diagnosis to death.
- Trial name
- NCT05906823
- Testing
- Detection of pleural effusion
- Volunteers
- 300 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Tuberculosis, Tuberculous Pleurisy
Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion
Connective tissue growth factor (CTGF) is known to be a fibrogenic cytokine, it could be expressed in various fibrosis diseases. But, recent research showed that CTGF also be considered to be a tumor suppressive gene.
- Conditions
- Tuberculosis, Tuberculous Pleurisy, Malignant Pleural Effusion, Empyema
- Trial name
- NCT00313066
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Taichung Veterans General Hospital
Non Small Cell Lung Cancer
Efficacy and Safety Study of Medical Thoracoscope Cryotherapy Combined Standard First-line Treatment of Advanced Non-small Cell Lung Cancer and Malignant Pleural Effusion
This study intends to investigate the efficacy and safety of medical thoracoscopic cryotherapy combined with standard first-line treatment of advanced non-small cell lung cancer with malignant pleural effusion through a…
- Trial name
- NCT05291403
- Testing
- Medical thoracoscopic cryotherapy combined with standard first-line therapy for advanced non-cell lung cancer, Sequential intrathoracic injection of cisplatin/erythromycin combined with standard first-line therapy for advanced non-cell lung cancer, Standard first-line therapy for advanced non-cell lung cancer without intrathoracic treatment
- Where
- China
- Volunteers
- 141 people
- Sponsor
- Qianfoshan Hospital
Malignant Pleural Effusion
Cytological Examination of Malignant Pleural Effusion in Breast Cancer
Malignant pleural effusion (MPE) is characterized by the presence of malignant cells. It can occur in 15% of patients with cancer and is a common manifestation in patients with metastatic disease.
- Trial name
- NCT06657638
- Testing
- Thoracentesis
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University Hospital
Malignant Pleural Effusions
Biomarker Levels During Indwelling Pleural cAtheter Sample Testing
Some patients that have a tunneled pleural catheter will not have the pleural fluid (water around the lung) return after some time (pleurodesis).
- Trial name
- BLAST (NCT02092155)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Johns Hopkins University
Malignant Pleural Effusions (Mpe)
The Outcome of Inserting Intercostal Tube or Pleurodesis for Malignant Pleural Effusion
Approximately half of all patients with metastatic cancer develop a malignant pleural effusion which is likely to lead to a significant reduction in quality of life secondary to symptoms such as dyspnoea and cough.
- Trial name
- NCT06742099
- Testing
- Intercostal chest tube, Pleurodesis
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Advanced Cancer, Pleural Effusion
Intrapleural Catheter Daily Versus Three Times a Week Drainage
The goal of this clinical research study is to learn if draining the IPC every day is better at than draining it 3 times a week.
- Trial name
- NCT00761618
- Testing
- Intrapleural catheter (IPC) drained, IPC Placement, Chest X-Ray
- Where
- United States
- Volunteers
- 257 people
- Sponsor
- M.D. Anderson Cancer Center
Pleural Effusion
The Effectiveness and Safety of Ultrasound Elastography Guided Pleural Biopsy in the Differential Diagnosis of Benign and Malignant Pleural Effusion
The goal of this clinical trial is to evaluate the diagnostic effcacy and safety of ultrasound elastography guided pleural biopsy in the differential diagnosis of benign and malignant pleural effusion.
- Trial name
- NCT05781659
- Testing
- Ultrasound elastography guided pleural biopsy, Traditional ultrasound guided pleural biopsy
- Where
- 9 sites in China
- Volunteers
- 592 people
- Sponsor
- China-Japan Friendship Hospital
Solid Tumor, Immune Response
Clinical Study on Intraluminal Injection of FOLactis
This clinical study is a single arm, prospective, single center clinical study on the safety, tolerability, and preliminary efficacy of a novel FOLactis in situ vaccine in the treatment of advanced solid tumors with malignant…
- Conditions
- Solid Tumor, Immune Response, Pleural Effusion, Malignant, Peritoneal Effusion
- Trial name
- NCT06512896
- Testing
- FOLactis
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School