Clinical trials: Malignant Pleural Effusions (Mpe)
Lung Cancer
Pleural Catheters Versus Thoracoscopic Pleurodesis
The goal of this clinical research study is to compare 2 different methods for treating a pleural effusion. Researchers also want to learn how the treatment you receive effects your quality of life (your ability to do the things…
- Trial name
- NCT01117740
- Testing
- MDASI Questionnaire
- Where
- United States
- Volunteers
- 445 people
- Sponsor
- M.D. Anderson Cancer Center
Non-expandable Lung, Trapped Lung
ARMSTRONG - Air entRainMent vS sTandard tReatment in nOn-expandable luNG
This is a randomised controlled trial evaluating whether controlled air introduction into pleural space (air entrainment) during pleural effusion drainage reduces pain, improves patient satisfaction, and facilitates more…
- Conditions
- Non-expandable Lung, Trapped Lung, Pleural Effusion, Malignant Pleural Effusions (Mpe)
- Trial name
- ARMSTRONG (NCT06959719)
- Testing
- Air Entrainment - intentional introduction of the atmospheric air into the pleural space.
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Malignant Pleural Effusions (Mpe), Medical Thoracoscopy
Safety and Feasibility of Medical Thoracoscopy Using Single-use Flexible Bronchoscope Versus SemiRigid Pleuroscope in Pleural Effusion
Pleural effusion is a common problem in hospital patients. It may arise from a wide range of diseases. There is a multitude of recognised causes of pleural effusion, and in addition, other pleural conditions such as pleural…
- Conditions
- Malignant Pleural Effusions (Mpe), Medical Thoracoscopy, Pleural Effusion
- Trial name
- FLEXPLEUR2 (NCT07726784)
- Testing
- Single-Use Flexible Bronchoscope, Semi-Rigid Pleuroscope
- Where
- 2 sites in Malaysia
- Volunteers
- 36 people
- Sponsor
- National University of Malaysia
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion
This study investigates whether alteplase can help to improve pleural fluid drainage and dyspnea (breathlessness) in patients with non-draining malignant pleural effusion.
- Trial name
- NCT06184321
- Testing
- Alteplase
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Advanced Cancers, Malignant Pleural Effusions
Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis
The goal of this clinical research study is to compare indwelling pleural catheters (IPC) in combination with saline (the current standard of care) versus IPC in combination with doxycycline as treatment for pleural effusions.
- Trial name
- NCT02623959
- Testing
- Questionnaires, Fentanyl Patch, Fentanyl (IV)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Pleural Effusions (Mpe)
A Phase Ib Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion
A Phase Ib Study to Evaluate the Safety, Tolerance, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion
- Trial name
- NCT06740019
- Testing
- JMKX000197, Tube thoracostomy drainage
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jemincare
Malignant Pleural Effusions (Mpe), Lung Cancer (Diagnosis)
Union-LC-MPE Cohort:A Multicenter Cohort Study on Diagnosis and Prognosis of Malignant Pleural Effusion in Lung Cance
Lung cancer is the malignant tumor with the highest incidence and mortality rates in China. Malignant pleural effusion (MPE) is one of its most common complications, affecting approximately 15%-50% of patients with non-small cell…
- Trial name
- NCT07882758
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Malignant Pleural Effusion, Nonsmall Cell Lung Cancer, Stage IV
A Randomized Study of Primary Tumor Radiotherapy for Patients With MPE Stage IV NSCLC
This randomized phase II study compare survival outcomes and toxicity of malignant pleural effusion stage IV non small-cell lung cancer patients Intrapleural infusion chemotherapy in combination with concurrent thoracic radiation…
- Trial name
- NCT03987087
- Testing
- Radiation, Chemotherapy
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Guizhou Medical University
Malignant Pleural Effusion
Rocket® Pleural Catheters: QOL, Feasibility and Satisfaction in Recurrent MPE Patients
This study will take place in Ottawa, Ontario, and will include 100 patients who are receiving tunnelled pleural catheters to treat their symptoms of MPE.
- Trial name
- NCT03403855
- Testing
- Rocket® IPC- Long External Length, Rocket® IPC- Short External Length
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Pleural Effusion, Malignant, Lung Cancer
Prognostic Factors on Malignant Pleural Effusion
Malignant pleural effusion can occur in up to half of the patients with metastatic disease. It can cause shortness of breath to patients and so far there is no protocol on its management.
- Trial name
- NCT03276715
- Where
- Hong Kong
- Volunteers
- 233 people
- Sponsor
- The University of Hong Kong
Malignant Pleural Effusions (Mpe)
Xuan Yin Ning Plus Bevacizumab for Malignant Pleural Effusion
The goal of this clinical trial is to determine whether the Xuanyin Ning Formula combined with intrapleural injection of bevacizumab via chest tube drainage is effective in treating malignant pleural effusion.
- Trial name
- XYN-Bev MPE (NCT07670338)
- Testing
- Treatment with Xuanyin Ning Formula combined with intrapleural injection of bevacizumab via chest tube drainage
- Where
- 7 sites in China
- Volunteers
- 308 people
- Sponsor
- Shanghai Chest Hospital
Malignant Pleural Effusions (Mpe)
The Outcome of Inserting Intercostal Tube or Pleurodesis for Malignant Pleural Effusion
Approximately half of all patients with metastatic cancer develop a malignant pleural effusion which is likely to lead to a significant reduction in quality of life secondary to symptoms such as dyspnoea and cough.
- Trial name
- NCT06742099
- Testing
- Intercostal chest tube, Pleurodesis
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Malignant Pleural Effusions (Mpe)- Pleurodesis, Pleurodesis
Thoracoscopic Talc Pleurodesis Versus Bleomycin -Tranxemic Acid Mixture Injection in Chest Tube in Malignant Pleural Effusion
Comparing Two Methods to Treat Fluid Build-up in Chest for Cancer Patients:Talc Powder Surgery versus Chest Tube Medicine.
- Trial name
- NCT06744946
- Testing
- thoracoscope
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mohamed Sabry
Non-Small Cell Lung Cancer
Phase II Study of Docetaxel + ZD1839 in Elderly Patients With Non-Small Cell Lung Cancer
This is a Phase II, open-label trial of Taxotere® + ZD1839 in elderly patients with Stage III-b or IV NSCLC who have received no prior chemotherapy for metastatic disease.
- Trial name
- NCT00231465
- Testing
- docetaxel (Taxotere®), ZD1839
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Malignant Pleural Effusions (Mpe)
A Phase II Study to Evaluate JMKX000197 Injection Versus Cisplatin in the Treatment of Malignant Pleural Effusion
This study aims to evaluate the efficacy and safety of intrapleural JMKX000197 compared with intrapleural cisplatin in patients with malignant pleural effusion.
- Trial name
- NCT07649369
- Testing
- JMKX000197, Cisplatin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Jeyou Pharmaceutical Co., Ltd.
Lung Cancer, Breast Cancer
Safety and Effectiveness of MPCD Therapy on the Treatment of Malignant Pleural Effusion
This is a prospective, open-label , multicenter randomized controlled trial, with 248 cases in 50 centers planned for a period of 2 years.
- Conditions
- Lung Cancer, Breast Cancer, Malignant Pleural Effusion
- Trial name
- NCT04131231
- Testing
- microparticles packaging methotrexate (MPs-MTX), recombinant human interleukin-2(rhIL-2)
- Volunteers
- 248 people
- Sponsor
- Peking Union Medical College
Lung Cancer (NSCLC), Malignant Pleural Effusions (Mpe)- Pleurodesis
Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion
This study is designed as a prospective, multi-center investigation to explore the efficacy and safety of furmonertinib combined with upfront thoracic radiotherapy with or without metastatic lesion radiotherapy in subjects with…
- Trial name
- NCT07482605
- Testing
- Furmonertinib, Thoracic Radiotherapy (TRT)
- Volunteers
- 63 people
- Sponsor
- Jiangmen Central Hospital
Lung Adenocarcinoma, Malignant Pleural Effusions (Mpe)
Ex Vivo Drug Response Profiling and Outcome Prediction in Lung Adenocarcinoma
This observational study evaluates if ex-vivo lung cancer drug sensitivity testing results correlate with the driver mutations found by genetic sequencing and if it can predict treatment response.
- Trial name
- NCT07636252
- Testing
- Non-Interventional Study
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Sheba Medical Center
Malignant Pleural Effusions (Mpe)
Impact of Pleural Manometry on the Assessment and Treatment of Malignant Pleural Effusion: A Pilot Clinical Trial
The goal of this clinical trial is to find out if performing a pleural fluid drainage (thoracentesis) together with the measurement of pressure inside the chest (pleural manometry) during the same procedure can help doctors…
- Trial name
- NCT07120867
- Testing
- Pleural manometry
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Malignant Pleural Effusion, Thoracic Cancer
Video Assisted Thoracoscopic Surgery (VATS) - Surgical Pleurodesis vs Tube Drainage in Management of Malignant Pleural Effusion (MPE)
Malignant Pleural Effusion (MPE) is considered to be a common presentation at malignant tumors representing 15% of all cancer cases. It carries a burden on our patients with dyspnea being the most common symptom in most of cases.
- Trial name
- NCT05872126
- Testing
- VATS-Surgical pleurodesis, Tube Drainage
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University