Clinical trials: Malignant Tumor
Healthy Subject, Hematologic and Lymphocytic Disorder
Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers
This research trial collects and stores blood, tissue, and bone marrow specimens from patients with cancer or blood disorders, and healthy volunteers to study the immune system in a variety of different types of experiments, as…
- Conditions
- Healthy Subject, Hematologic and Lymphocytic Disorder, Hematopoietic and Lymphoid Cell Neoplasm, Immune System Disorder
- Trial name
- NCT03207854
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- United States
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Genital Wart, Penile Cancer
A Phase III Study to Evaluate the Efficacy, Immunogenicity and Safety of the 9-valent HPV Vaccine in Chinese Males
This study is designed to evaluate the vaccine efficacy, immunogenicity and safety of the 9-valent (Types 6, 11, 16, 18, 31, 33, 45, 52 and 58) Human Papillomavirus (HPV) Recombinant Vaccine (Hansenula Polymorpha) in Chinese male…
- Conditions
- Genital Wart, Penile Cancer, Anal Cancer, PIN-1
- Trial name
- NCT06465914
- Testing
- 9-valent Human Papillomavirus (Types 6, 11, 16, 18, 31, 33, 45, 52 and 58) Recombinant Vaccine (Hansenula Polymorpha)
- Where
- 5 sites in China
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Advanced Malignancies
Safety Study of Two Oral Formulations of MGCD265 Administered in Healthy Subjects in the Fasting State
In this study two MGCD265 oral formulations at dose level of 100 mg are administered to healthy male and female subjects under fasting conditions.
- Trial name
- NCT01930006
- Testing
- MGCD265
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mirati Therapeutics Inc.
Renal Tumor Histology, Cutaneous Leiomyoma
Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer
This study will investigate what causes hereditary leiomyomatosis renal (kidney) cell cancer, or HLRCC, and how the disease is related to the development of kidney tumors.
- Conditions
- Renal Tumor Histology, Cutaneous Leiomyoma, Kidney Cancer
- Trial name
- NCT00050752
- Where
- United States
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Qualitative Techniques to Define Meaningful Within-Patient Change in Symptoms of Advanced Cancer Patients
This study examines qualitative techniques in defining meaningful within patients changes in symptoms in patients with cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the…
- Trial name
- NCT06104657
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Colorectal Cancer, Colorectal Neoplasms
Early Onset Colorectal Cancer Detection
Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma, Colorectal Cancer Stage I
- Trial name
- ENCODE (NCT06342401)
- Testing
- ENCODE
- Where
- 13 sites in United States, Italy and 2 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
WAGR Syndrome, Wilm's Tumor
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions
This study will explore conditions caused by the absence of certain genes on chromosome 11. These conditions include WAGR syndrome, which is characterized by a kidney tumor called Wilm s tumor, aniridia (absence of the iris of…
- Conditions
- WAGR Syndrome, Wilm's Tumor, Aniridia, Urogenital Abnormalities
- Trial name
- NCT00758108
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Malignant Brain Tumors
PRESENCE Project: An Early Palliative Care Intervention in Brain Tumors
The purpose of this pilot study is to investigate the feasibility of an early palliative care intervention (PRESENCE: Providing Resources Education, Support, and Enabling New brain tumor patients to Cope Effectively) and the…
- Trial name
- NCT01652768
- Testing
- Research Questionnaires, Palliative Care Team, Educational Information Session for Patients and Caregivers
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Neoplasms, Solid Tumor
Methylation Profile Test (Methylscape) in Body Fluids for Multi-Cancer Detection and Monitoring in Colombia
DNA methylation changes occur early and broadly during carcinogenesis. Methylscape is a rapid assay that detects global DNA methylation patterns in body fluids (blood, urine, and saliva) and may detect a cancer signal and predict…
- Conditions
- Neoplasms, Solid Tumor, Breast Neoplasms, Lung Neoplasms
- Trial name
- METHYLSCAPE-CO (NCT07741435)
- Testing
- Methylscape DNA methylation assay
- Where
- Colombia
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Atypical Squamous Cell of Undetermined Significance, Cervical Carcinoma
Home-Based or Clinic-Based Human Papillomavirus (HPV) Screening
This randomized clinical trial studies home-based HPV or clinic-based Pap screening for cervical cancer. It is not yet known whether home-based screening is more effective, cost-effective, and/or acceptable than clinic-based…
- Conditions
- Atypical Squamous Cell of Undetermined Significance, Cervical Carcinoma, Cervical Intraepithelial Neoplasia Grade 2/3, Health Status Unknown
- Trial name
- NCT01550783
- Testing
- Cervical Papanicolaou Test, Cytology Specimen Collection Procedure, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 1,335 people, healthy volunteers welcome
- Sponsor
- University of Washington
Triamcinolone, Pentoxifylline
Comparison of Triamcinolone With Pentoxifylline and Vitamin- E Efficacy in the Treatment of Stage 2 and 3 Oral Submucous Fibrosis
To compare the efficacy of Triamcinolone with Pentoxifylline and Vitamin E in patients with stage two and three oral submucous fibrosis.
- Conditions
- Triamcinolone, Pentoxifylline, Vitamin E, Oral Submucosa Fibrosis
- Trial name
- NCT05660694
- Testing
- Triamcinolone, Pentoxifylline with Vitamin E
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Solid Tumor
An Bioequivalence Study to Compare 10mg & 20mg of Senaparib Capsules in Healthy Chinese Subjects Under Fasting Condition
An Open-label, Randomized, Single-dose, Two-way Crossover Bioequivalence Study to Compare Two Strengths (10 mg and 20 mg) of Senaparib Capsules in Healthy Chinese Subjects Following Oral Administration Under Fasting Condition
- Trial name
- NCT07019194
- Testing
- Senaparib capsules(20mg), Senaparib capsules(10mg)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Impact Therapeutics, Inc.
Chronic Myelomonocytic Leukemia
The Expression of PTEN Protein and mRNA in Malignant Cells of Chronic Myelomonocytic Leukemia
The purpose of this study is to evaluate the level of a specific protein (PTEN) in the cancer cells of chronic myelomonocytic leukemia (CMML) patients.
- Trial name
- NCT01010256
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Infections, Papillomavirus
Dose-Comparison Study to Evaluate the Safety and Immunogenicity of MEDI-517 (GSK 580299) in Healthy Adult Females
The purpose of this Phase II study is to provide data regarding the safety and immunogenicity for a range of dose levels of MEDI-517 in women who are HPV-16/18 seronegative and negative for high-risk HPV DNA.
- Trial name
- NCT00693966
- Testing
- MEDI-517 HPV-16/18 VLP AS04 vaccine (Formulation 1), MEDI-517 HPV-16/18 VLP AS04 vaccine (Formulation 2), MEDI-517 HPV-16/18 VLP AS04 vaccine (Formulation 3)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Solid Tumor
IMP4297 Food Effect Trial in Healthy Volunteers
A phase I, single-site, open-label, randomized, single-dose, two-way crossover study to evaluate the effect of food on the pharmacokinetic characteristics of IMP4297 capsules in China
- Trial name
- NCT04057729
- Testing
- IMP4297
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Impact Therapeutics, Inc.
Bladder Tumor
Assessment of the Uro-C Cystoscope for Use in Diagnostic Cystoscopy Procedures
This is a prospective, multicenter, single-arm, open-label clinical usability study in subjects who are candidates for office diagnostic cystoscopy.
- Trial name
- NCT03331705
- Testing
- Uro-C (Use of new cystoscope)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- UroSee Corporation
Ovarian Cancer
Glycan Analysis in Diagnosing Cancer in Women With Ovarian Epithelial Cancer and in Healthy Female Participants
RATIONALE: New diagnostic procedures, such as glycan analysis, may be effective in finding ovarian epithelial cancer. PURPOSE: This clinical trial is studying how well glycan analysis works in diagnosing cancer in women with…
- Trial name
- NCT00628654
- Where
- United States
- Volunteers
- 581 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Oral Mucositis
Lactobacillus Rhamnosus GG Alleviates Oral Mucositis in Patients Undergoing Radiotherapy
Radiation therapy is a common treatment modality in the management of head and neck malignancies. However, head and neck tumors often have some adverse reactions when receiving radiation therapy, such as dry mouth, change of…
- Trial name
- NCT06390176
- Testing
- Lactobacillus rhamnosus GG, Radiotherapy
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Human Papilloma Virus Infection
Clinical Evaluation of the APTIMA® HPV Assay Using the PANTHER™ System
The objective is to establish that APTIMA HPV Assay performance on the PANTHER System is comparable to performance on the TIGRIS System.
- Trial name
- NCT01446198
- Where
- 3 sites in United States
- Volunteers
- 11,816 people, healthy volunteers welcome
- Sponsor
- Gen-Probe, Incorporated
Cervical Cancer, Human Papillomavirus Infection
Prospective Evaluation of Self-Testing to Increase Screening
Regularly attending for Pap test cervical cancer screening in a clinic is often unfeasible and/or unacceptable to many women. This study evaluates if mailing and testing self-sampled kits for high-risk human papillomavirus (HPV)…
- Trial name
- PRESTIS (NCT03898167)
- Testing
- Telephone Recall, Mailed HPV Self-Sampling Kit, Patient Navigation
- Where
- United States
- Volunteers
- 2,474 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
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