Clinical trials: Malnutrition, Child
Intestinal Failure, Short Bowel Syndrome
Safety and Dosing Study of Glucagon-like Peptide 2 (GLP-2) in Infants and Children With Intestinal Failure
This protocol outlines a randomized,open label trial examining the safety, pharmacology and efficacy of Glucagon like peptide 2 (GLP-2) in infants and children with intestinal failure.
- Trial name
- GLP-2-01 (NCT01573286)
- Testing
- Glucagon-Like Peptide 2, Glucagon like peptide-2
- Where
- 4 sites in Canada
- Volunteers
- 13 people
- Sponsor
- Alberta Children's Hospital
Quality of Life, Malnutrition
Clinical Study of Novel Probiotic Microbial Composite™ to Treat Undernourished Young Children
This study is to determine if a novel bio-fermented Microbiotic Composite™ can improve the digestive health and subsequent growth and quality of life parameters in a selected group of children in a district in India.
- Conditions
- Quality of Life, Malnutrition, Growth Arrest
- Trial name
- NCT03150927
- Testing
- Probiotic Microbial Composite
- Where
- India
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Biowish Technologies, Inc.
Sickle Cell Disease, Vitamin D Deficiency
High Dose Vitamin D Supplementation in Children With Sickle Cell Disease
Suboptimal vitamin D status is well reported in sickle cell disease (SCD) patients and associated with a negative impact on health-related quality of life (HRQL).
- Conditions
- Sickle Cell Disease, Vitamin D Deficiency, Health Related Quality of Life, Hand Grip Strength
- Trial name
- NCT06274203
- Testing
- Vitamin D3
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Nutrition Poor, Aflatoxins Toxicity
One Nutrition in Complex Environments (ONCE)
This study asks the research question "Does enabling families (particularly mothers and other caregivers) to 'assess and act' on drivers of malnutrition through a targeted SBC+ package succeed in a sustained reduction of risk…
- Conditions
- Nutrition Poor, Aflatoxins Toxicity, Water-Related Diseases
- Trial name
- ONCE (NCT04209569)
- Testing
- Nutrition Impact and Positive Practice Circle (NIPP)
- Where
- Uganda
- Volunteers
- 1,834 people, healthy volunteers welcome
- Sponsor
- Tufts University
Severe Acute Malnutrition
Comparison of Treatment of SAM in Children 6-59 Months With RUTF and RUSF in Umerkot, Sindh, Pakistan
In Pakistan, around 15% of children under five are wasted, which is almost twice that of the global prevalence 7.5%. There is a demand for a reliable and consistent locally available severe acute malnutrition (SAM) treatment…
- Trial name
- NCT04174846
- Testing
- Ready-to-use therapeutic food (RUTF), Ready-to-use-supplementary food (RUSF)
- Where
- Pakistan
- Sponsor
- Aga Khan University
Malnutrition
Acceptability of Nutrient Supplements Among Women and Children in Bangladesh
The study aims to confirm the acceptability of lipid-based nutrient supplements (LNS) for use as nutritional supplements for pregnant and lactating women (PLW) or infants and young children (IYC) and micronutrient powder (MNP)…
- Trial name
- NCT01129089
- Testing
- Lipid-based nutrient supplement, Micronutrient powder
- Where
- Bangladesh
- Volunteers
- 144 people
- Sponsor
- University of California, Davis
Marasmus, Kwashiorkor
Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers
PRIMARY OBJECTIVE : To determine whether mothers, given minimal group training, are capable of using a MUAC (mid-upper arm circumference) bracelet to screen their children for malnutrition and categorise them into one of three…
- Conditions
- Marasmus, Kwashiorkor, Malnutrition; Degree, Moderate, Malnutrition
- Trial name
- MUAC (NCT01790815)
- Where
- Niger
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Alliance for International Medical Action
Child Malnutrition
7-Day vs 1-Day Packaging for Small Quantity Lipid-Based Nutrient Supplements in Ghana (SQLNS:7D-1D Comparison)
This cluster-randomized crossover trial evaluates whether the packaging format of small-quantity lipid-based nutrient supplements (SQ-LNS) affects caregiver adherence and acceptability when SQ-LNS are delivered through routine…
- Trial name
- SQLNS:7Dv1D (NCT07129109)
- Testing
- small-quantity lipid-based nutrient supplements (SQ-LNS)
- Where
- Ghana
- Volunteers
- 505 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Small Intestine Bacterial Overgrowth
Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children
The purpose of this Phase IIa study is to identify the most effective antibiotic regimen to treat small intestine bacterial overgrowth (SIBO) in impoverished Bangladeshi children.
- Trial name
- NCT07451171
- Testing
- Trimethoprim-sulfamethoxazole (TMP/SMX), Metronidazole, Amoxicillin-Clavulanate (4:1 formulation)
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Child Development
Strengthening Bangladeshi Babies Brains (SBBB)
This study aims to establish a sustainable programme whereby early childhood development activities are integrated into the routine activities of community clinics in rural Bangladesh for undernourished children by developing a…
- Trial name
- BUDHI/SBBB (NCT04093934)
- Testing
- Psychosocial stimulation
- Where
- Bangladesh
- Volunteers
- 480 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Child Malnutrition
Strategies to Increase Milk Consumption by Young Nepali Children
Dairy animals are an important source of income, food and nutrition security at the household level. However, substandard animal husbandry practices and limited understanding of disease prevention and control may limit dairy…
- Trial name
- NCT03886467
- Testing
- Community-based nutrition education
- Where
- Nepal
- Volunteers
- 368 people
- Sponsor
- Tufts University
Protein-energy Malnutrition, Kwashiorkor
Study of Antioxidants and Oxidants in Malnourished Children
It is believed that the organs of severely malnourished children malfunction because harmful compounds called oxidants injure the tissues in these organs.
- Conditions
- Protein-energy Malnutrition, Kwashiorkor, Marasmus
- Trial name
- NCT00069134
- Testing
- sulfur amino acids
- Where
- Jamaica
- Volunteers
- 86 people
- Sponsor
- Baylor College of Medicine
Malnutrition
Effects of Fortified Complementary Foods on Vitamin A Status and Body Pool Size in Ghanaian Infants.
This study tried to prove that children given food supplements containing vitamin A would have better liver vitamin A stores than children given food supplements without vitamin A over a 5 month period.
- Trial name
- vitapool (NCT01751009)
- Testing
- Vitamin A supplements, Sprinkles without Vitamin A
- Where
- Ghana
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Kintampo Health Research Centre, Ghana
Vitamin D Deficiency
Effects of Vitamin D Dose and Genotype of the Binding Protein in Infants and Children
The purpose of this study is to determine if the vitamin D binding protein genotype influences circulating vitamin D levels and if it may have functional consequences on vitamin D activity.
- Trial name
- VitaD (NCT01050387)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Yale University
Severe Acute Malnutrition
The Effect of Routine Antibiotic Use in the Outpatient Treatment of Severely Malnourished Children Without Complications
This study will be conducted as a randomized, double-blind, placebo-controlled trial to compare routine antibiotic prescription vs.
- Trial name
- NCT01613547
- Testing
- Amoxicillin
- Where
- Niger
- Volunteers
- 2,412 people
- Sponsor
- Epicentre
Malnutrition
Comparison of a Two Ready-to-use Supplementary Foods of Differing Protein Quality for the Treatment of MAM.
This is a prospective, randomised, double-blinded, controlled clinical effectiveness trial of two supplementary foods in the treatment of MAM. The setting will be 21 rural sites in southern Malawi.
- Trial name
- NCT03549156
- Testing
- C-RUSF, HIPRO RUSF
- Where
- Malawi
- Volunteers
- 1,858 people
- Sponsor
- Washington University School of Medicine
Malnutrition
Effectiveness Trial on Alleviation of Infant Malnutrition With Fortified Spread or Maize-Soy Flour Food Supplements
This study tests the hypothesis that moderately underweight but not severely wasted 6-17-month old infants receiving fortified spread or maize-spy flour as a food supplement for 12 weeks grow better during the supplementation…
- Trial name
- NCT00420758
- Testing
- Food supplement: fortified spread, Food supplement: maize-soy flour
- Where
- Malawi
- Volunteers
- 299 people
- Sponsor
- Tampere University
Severe Acute Malnutrition
Modified Dosage for Severe Acute Malnutrition
Protocols for the community-based management of acute malnutrition (CMAM) have not changed significantly for more than 20 years, with relatively complex treatment protocols and persistent supply chain challenges that have limited…
- Trial name
- MODAM-SAM (NCT06061484)
- Testing
- ready-to-use therapeutic food (RUTF), Amoxicillin
- Where
- 3 sites in Ethiopia
- Volunteers
- 2,400 people
- Sponsor
- Action Against Hunger USA
Malnutrition
Whey Permeate Study
This is a prospective, randomized, double-blinded, controlled clinical effectiveness trial of two supplementary foods in the treatment of MAM.
- Trial name
- NCT01790048
- Testing
- Whey permeate RUSF, Soy Protein RUSF
- Where
- Malawi
- Volunteers
- 2,259 people
- Sponsor
- Washington University School of Medicine
Well-Being, Psychological, Breastfeeding
Relaxation Intervention to Improve Newborn Growth and Maternal Well-being
The goal of this clinical trial is to learn if listening to a relaxation audiorecording during breastfeeding improves breastfeeding and infant outcomes and maternal well-being in a low-income country setting.
- Conditions
- Well-Being, Psychological, Breastfeeding, Low Birth Weight, Undernutrition
- Trial name
- RING-MW (NCT07774793)
- Testing
- Relaxation audiorecording, Control audio device without relaxation audiorecording
- Where
- Uganda
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco