Clinical trials: Mammary Cancer
Breast Cancer
Evaluation of a 3D Functional Metabolic Imaging and Risk Assessment System in Classifying Women for Likelihood of Breast Cancer
The study objective is to evaluate the added value of MIRA technology as an adjunct to mammography in the detection of malignant breast lesions in women with dense breast and/or at elevated risk of breast cancer.
- Trial name
- NCT03296683
- Testing
- MIRA device imaging
- Where
- Italy
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Real Imaging Ltd.
Metastatic Breast Cancer
Improving the Approach to and Management of the Older Metastatic Breast Cancer Patient
The purpose of this study is to enhance the care of older metastatic breast cancer (MBC) patients by increasing awareness among oncology providers as to the unique aspects of care required for older patients.
- Trial name
- NCT03007641
- Testing
- Didactic session, Comprehensive Geriatric Assessment
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Fox Chase Cancer Center
Metastatic Breast Cancer
Multi-peptide Vaccine With Basilixumab for Breast Cancer
Eligible patients will receive subcutaneous vaccinations of the hTERT/survivin/CMV multipeptide vaccine and GM-CSF over a 24 month period. All patients will receive basiliximab 20 mg 1 day prior to the start of vaccinations.
- Trial name
- NCT01660529
- Testing
- hTERT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Breast Cancer Female
PreOperative Endocrine Therapy for Individualised Care With Abemaciclib
POETIC-A is a phase 3 trial which targets post-menopausal primary breast cancer patients with a high 5-year risk of relapse as determined by a high Ki67 after 2 weeks aromatase inhibitor therapy pre-surgery.
- Trial name
- POETIC-A (NCT04584853)
- Testing
- Abemaciclib, Endocrine therapy (letrozole, anastrozole, exemestane or tamoxifen)
- Where
- 62 sites in United Kingdom
- Volunteers
- 123 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Breast Cancer, Neoadjuvant Therapy
Validation of the CPS+EG, Neo-Bioscore and Modified Neo-Bioscore Staging Systems After PST of BC in China
Prognostic assessment after preoperative systemic therapy (PST) plays a vital role in breast cancer patients. The clinical-pathologic staging system incorporating estrogen receptor (ER)-negative disease and nuclear grade 3 tumor…
- Conditions
- Breast Cancer, Neoadjuvant Therapy, Neoplasm Staging, Estrogen Receptor
- Trial name
- NCT03437837
- Where
- 12 sites in China
- Volunteers
- 1,077 people
- Sponsor
- Peking University First Hospital
Breast Cancer, Estrogen Receptor Positive Tumor
Durvalumab and Endocrine Therapy in ER+/Her2- Breast Cancer After CD8+ Infiltration Effective Immune-Attractant Exposure
This is an open-label, multicentric, international, phase II trial testing aromatase inhibitors in combination with durvalumab in patients with CD8+ T cell infiltration (>10% CD8+ T cells in the tumor).
- Conditions
- Breast Cancer, Estrogen Receptor Positive Tumor, Menopause, Hormone Antagonist
- Trial name
- ULTIMATE (NCT02997995)
- Testing
- Immune-attractant, Durvalumab, Biopsy
- Where
- 29 sites in France, Spain and 1 more
- Volunteers
- 61 people
- Sponsor
- UNICANCER
Fatigue
Intravenous Ascorbic Acid in Women Receiving Adjuvant or Neo-Adjuvant Chemotherapy for Early Stage Breast Cancer
This is a parallel-track, randomized study will observe whether intravenous ascorbic acid reduces the reported fatigue in women receiving adjuvant or neo-adjuvant chemotherapy for early stage breast cancer.
- Trial name
- NCT02521077
- Testing
- Ascorbic Acid, Normal Saline
- Sponsor
- Midwestern Regional Medical Center
Skin Sympathetic Nerve Activity During General Anesthesia in Patients Undergoing Breast Cancer Surgery
Measurement of the Skin Sympathetic Nerve Activity
Sympathetic nerve activity can be measured transcutaneously in awake patients by computer-based filtering of raw signal obtained via skin leads attached on the chest.
- Trial name
- NCT03658057
- Testing
- Rocuronium
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Breast Cancer
10 Year Coronary Heart Disease (CHD) Risk Evaluation and Its Treatment Pattern Analysis in Postmenopausal Early Breast Cancer (EBC) Patients Taking Aromatase Inhibitors (AI)
10-year CHD risk evaluation and its treatment pattern analysis in postmenopausal early breast cancer patients taking aromatase inhibitors.
- Trial name
- NCT00885612
- Where
- 27 sites in South Korea
- Volunteers
- 1,114 people
- Sponsor
- AstraZeneca
Breast Neoplasms
Diagnosis of Pathological Complete Response by Minimal Invasive Biopsy After Neoadjuvant Chemotherapy in Breast Cancer
The study aims to evaluate the ability of representative vacuum-assisted minimal invasive biopsy (VAB) to diagnose pathological complete response (pCR=ypT0) in breast cancer patients after neoadjuvant chemotherapy (NACT).
- Trial name
- NCT02575612
- Testing
- vacuum-assisted biopsy
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heidelberg University
Breast Cancer Females
Dextrose Hydrodissection for Post-Breast Cancer Chest Wall and Axillary Tightness.
The goal of this clinical trial (prospective case series) is to evaluate the feasibility, safety, and preliminary clinical outcomes of ultrasound-guided dextrose prolotherapy in female breast cancer survivors with persistent…
- Trial name
- NCT07378319
- Testing
- ultrasound guided dextrose prolotherapy
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- Taichung Veterans General Hospital
Triple Negative Breast Cancer
A Study of Camrelizumab in Combination With Chemotherapy Regimen Comparative Chemotherapy Regimen for Metastatic Triple-negative Breast Cancer
Approximately 104 subjects with recurrent or metastatic IM triple negative breast cancer were planned to be included in the study, and screened eligible subjects were randomly assigned in a 1:1 ratio to treatment with the…
- Trial name
- NCT05134194
- Testing
- Camrelizumab、Capecitabine/eribulin/gemcitabine/vinorelbine, Capecitabine/eribulin/gemcitabine/vinorelbine
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Breast Cancer
Study of Nivolumab Versus Placebo in Combination With Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy in Participants With High-risk, Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-) Primary Breast Cancer
A randomized multi-arm study evaluating the efficacy and safety of nivolumab versus placebo in combination with neoadjuvant (pre-surgery) chemotherapy and adjuvant (post-surgery) endocrine therapy in participants with high-risk…
- Trial name
- CheckMate 7FL (NCT04109066)
- Testing
- nivolumab, paclitaxel (PTX), anthracycline
- Where
- 240 sites in United States, Argentina and 30 more
- Volunteers
- 521 people
- Sponsor
- Bristol-Myers Squibb
Breast Cancer, Pharmacokinetics
Pharmacokinetics of SPI-2012 (Eflapegrastim) in Breast Cancer Patients Receiving Docetaxel and Cyclophosphamide (TC) Chemotherapy
The purpose of this study is to evaluate the pharmacokinetic (PK) profile of a fixed dose of SPI-2012 in patients with early-stage breast cancer receiving docetaxel and cyclophosphamide (TC) chemotherapy, as measured by the serum…
- Trial name
- NCT03135951
- Testing
- SPI-2012
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
Breast Reconstruction, Breast Cancer
Immediate Breast Reconstruction's Increasing
Mastectomy in breast cancer is still a way of treatment. Nowadays, the goal is to improve reconstruction's technicals. Immediate Breast Reconstruction (IBR) is one of them, largely used in United States but less in France.
- Trial name
- IBRI (NCT04888351)
- Testing
- Comparison of complications between mastectomies with IBR and mastectomies without IBR, To analyze variations of number of patients eligibles to IBR
- Where
- France
- Volunteers
- 215 people
- Sponsor
- Hospices Civils de Lyon
Recurrent Breast Cancer, Metastatic Breast Cancer
Ruxolitinib W/ Preop Chemo For Triple Negative Inflammatory Brca
This phase I/II research study is evaluating a combination of drugs called paclitaxel and ruxolitinib as a possible treatment for inflammatory breast cancer.
- Trial name
- NCT02041429
- Testing
- Ruxolitinib, Paclitaxel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dana-Farber Cancer Institute
Ovarian Cancer, Breast Cancer
Identifying Underserved Individuals inTexas With Hereditary Cancer Risk Using Mobile Mammography Units and Telegenetics.
Identifying women at risk for hereditary cancer potentiates prevention, early detection or personalised treatment against cancer.
- Conditions
- Ovarian Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT05649072
- Testing
- Genetic Testing and Counseling, Screening Form
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- M.D. Anderson Cancer Center
Advanced Solid Tumor, Metastatic Solid Tumor
BGB-43395 Alone or as Part of Combination Therapies in Chinese Participants With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors
This is an open-label, multicenter, phase 1a/1b clinical study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BGB-43395, a cyclin-dependent kinase 4 (CDK4)…
- Conditions
- Advanced Solid Tumor, Metastatic Solid Tumor, Hormone-receptor-positive Breast Cancer, Breast Cancer
- Trial name
- NCT06253195
- Testing
- BGB-43395, Fulvestrant, Letrozole
- Where
- 7 sites in China
- Volunteers
- 33 people
- Sponsor
- BeOne Medicines
ER-positive Breast Cancer
An Observational Study to Assess Response to Tamoxifen in Breast Cancer Patients
CYPTAM-BRUT 2 is a prospective, multicentric study including postmenopausal women receiving tamoxifen for metastatic, locally advanced (stage IIIB/C) or in the neoadjuvant setting for measurable estrogen-receptor positive breast…
- Trial name
- CYPTAMBRUT-2 (NCT00965939)
- Where
- 12 sites in Belgium
- Volunteers
- 300 people
- Sponsor
- Vlaamse Vereniging voor Obstetrie en Gynaecologie
Breast Neoplasms
Regional Anesthesia and Breast Cancer Recurrence
In this multi-center trial, Stage 1-3 patients having mastectomies or isolated lumpectomy with axillary node dissection will be randomly assigned to thoracic epidural or paravertebral anesthesia/analgesia, or to general…
- Trial name
- NCT00418457
- Testing
- General anesthesia and opioids, Regional analgesia and propofol
- Where
- 6 sites in United States, Austria and 4 more
- Volunteers
- 2,108 people
- Sponsor
- The Cleveland Clinic
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