Clinical trials: Mammography Screening, active
Breast Cancer Screening, Artificial Intelligence (AI)
Screening Mammography: Single Reading by One Radiologist With AI vs. Double Reading by Two Radiologists (AI-BCSQ)
A randomized prospective study comparing the evaluation of mammography images in a breast cancer screening programme by a single radiologist with AI support versus standard double reading by two radiologists without AI support.
- Conditions
- Breast Cancer Screening, Artificial Intelligence (AI), Breast Cancer Screening and Diagnosis
- Trial name
- AI-BCSQ (NCT07075679)
- Testing
- Group with AI iCAD version 3, Group without AI
- Where
- Czechia
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Olomouc
Breast Cancer Female, Breast Cancer
Tomosynthesis vs. Contrast-Enhanced Mammography in Women With Personal History of Breast Cancer in Western Pennsylvania
This is a prospective clinical trial that will examine if contrast-enhanced mammography substantially improves breast cancer detection compared to mammography with tomosynthesis, with minimal increase in false-positives, in women…
- Conditions
- Breast Cancer Female, Breast Cancer, Breast Neoplasms, Neoplasms
- Trial name
- TOCEM (NCT04085510)
- Testing
- Contrast-enhanced mammogram
- Where
- 3 sites in United States
- Volunteers
- 1,647 people, healthy volunteers welcome
- Sponsor
- Wendie Berg
Breast Cancer
The C-MERIT Screening Cohort: Contrast-enhanced Mammography for Breast Cancer Screening and Risk Assessment in Women With Dense Breasts
To learn whether a new imaging technology, Contrast-Enhanced Mammography (CEM), compared to standard mammography, can better detect breast cancers in women with dense breasts
- Trial name
- NCT05667532
- Testing
- Contrast Enhanced Mammography
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Individuals on Hormone Therapy Breast Cancer Screening Pilot
This investigation is a prospective breast cancer screening study open to all individuals on hormone therapy. Using a mixed methods approach, the study will 1) gather prospective quantitative breast imaging data in conjunction…
- Trial name
- NCT06383026
- Testing
- Breast Cancer Screening, Survey/Interview, Focus Group
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Breast Cancer Screening, Artificial Intelligence (AI)
A Trial Comparing Screening Mammography With and Without Assistance From Artificial Intelligence for Breast Cancer Detection and Recall Rates in Adult Patients
The goal of this clinical trial is to compare patient-centered outcomes when screening digital breast tomosynthesis (DBT) exams are interpreted with versus without a leading FDA-cleared artificial intelligence (AI)…
- Trial name
- NCT06934239
- Testing
- Artificial intelligence (AI) decision-support tool
- Where
- 6 sites in United States
- Volunteers
- 400,000 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Breast Implant Revision
LTFU of PCL Breast Scaffolds Used in 2021-BRV-004
The objective of this study is to assess the long-term safety and performance of the PCL Breast Scaffold in women who previously underwent breast silicone implant revision and received the PCL Breast Scaffold combined with…
- Trial name
- NCT07383012
- Where
- Australia
- Volunteers
- 19 people
- Sponsor
- BellaSeno Pty Ltd
Breast Cancer Screening, Colon Cancer Screening
Bundled Cancer Screening and Genetic Services Navigation
The goal of this study is to test bundled familial cancer risk assessment + multicancer (colorectal + breast) vs. single (breast) cancer navigation, using a wait list control for colorectal cancer screening referral and…
- Conditions
- Breast Cancer Screening, Colon Cancer Screening, Genetics Predisposition
- Trial name
- NCT07228000
- Testing
- Breast cancer screening navigation, Multicancer screening navigation, Usual care genetics referral
- Where
- 2 sites in United States
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Mammography Screening
Effect of Distraction Technique on Pain and Anxiety During Mammography
One of the non-medical interventions aimed at reducing sensitization is the cognitive-behavioral approach, in which the individual's attention is shifted from a painful stimulus to an external stimulus.
- Trial name
- NCT06682026
- Testing
- listening to music or chatting
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hitit University
Breast Cancer
Optimising Mammography Screening Accuracy With Blood-based Biomarkers
The project aims to investigate whether breast cancer screening can be improved using blood tests, thereby reducing the number of unnecessary clinical mammographies.
- Trial name
- OPTIMA (NCT07049822)
- Where
- 2 sites in Denmark
- Volunteers
- 1,200 people
- Sponsor
- Vejle Hospital
Breast Cancer Screening
Breast Cancer Screening: Digital Breast Tomosynthesis Versus Digital 2D Mammography
This study is a randomized, multicenter, multivendor, controlled, diagnostic superiority trial to compare digital breast tomosynthesis plus synthesized 2D mammograms (DBT+s2D) versus standard 2D full-field digital mammography…
- Trial name
- TOSYMA (NCT03377036)
- Testing
- DBT+s2D, 2D-FFDM
- Where
- 21 sites in Germany
- Volunteers
- 99,689 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Breast Cancer Screening
Project 1: Self-Triage by 2D Full-field Digital Mammography or Synthetic Images
One method of breast cancer screening involves radiologists reading digital tomosynthesis (DBT) images. DBT consists of a 3D stack of x-ray "slices" through the breast.
- Trial name
- NCT05960188
- Testing
- AI Opinion
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Brigham and Women's Hospital
Cancer Screening, Chronic Diseases in Older Adults
Pragmatic Mobile Health Trial to Promote Cancer Screening and Healthy Behaviors
Cancer is the leading cause of death in Singapore, but many people who are eligible for breast, cervical, and colorectal cancer screening do not get screened on time.
- Conditions
- Cancer Screening, Chronic Diseases in Older Adults, Early Cancer Detection, Mammography
- Trial name
- mHEALTH (NCT07725328)
- Testing
- Intensive Engagement, Standard Engagement
- Where
- Singapore
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Breast Cancer
Contrast-enhanced Mammography in Women With a Personal History of Breast Cancer and Dense Breast Tissue: Benefit?
This study aims to assess the effectiveness of Contrast-Enhanced Mammography (CEM)as an alternative to traditional ultrasound for breast cancer screening in women with dense breasts and a personal history of breast cancer.
- Trial name
- CEM (NCT06993246)
- Testing
- Contrast-Enhanced Mammography (CEM)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Jean Seely
Breast Cancer Screening and Diagnosis
Contrast Enhancement Mammography vs MRI for the Surveillance of Women at High Risk of Breast Cancer: Con-trust Randomized Controlled Trial
Women at high risk of breast cancer (BC) should undergo annual magnetic resonance imaging (MRI) and digital mammography (DM) from at least ages 35 to 60.
- Trial name
- CEM (NCT06629896)
- Testing
- Contrast Enhancement Mammography, magnetic resonance imaging (MRI) and digital mammography (DM)
- Where
- Italy
- Volunteers
- 2,200 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Breast Cancer
Supplemental Screening for Women With Extremely Dense Breast Tissue: the DENSE-2 Trial
Women with extremely dense breasts (nearly all glandular and connective tissue, little fatty tissue) have a 3-6 times higher risk of breast cancer than women with very low breast density.
- Trial name
- DENSE-2 (NCT06636370)
- Testing
- Contrast-enhanced mammography (CEM), Abbreviated MRI (AB-MRI)
- Where
- Netherlands
- Volunteers
- 36,000 people, healthy volunteers welcome
- Sponsor
- C.H. van Gils
Routine Screening Mammography
Acquisition and Clinical Image Evaluation of Fujifilm's High Resolution (HR) Digital Breast Tomosynthesis (DBT) Images.
Acquisition and clinical image evaluation of Fujifilm High Resolution (HR) Digital Breast Tomosynthesis (DBT) images.
- Trial name
- NCT07471750
- Testing
- DBT HR mode image acquisition
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Fujifilm Medical Systems USA, Inc.
Breast Cancer Screening, Breast Carcinoma in Situ
Women Informed to Screen Depending on Measures of Risk (Wisdom Study)
Most physicians still use a one-size-fits-all approach to breast screening in which all women, regardless of their personal history, family history or genetics (except BReast CAncer gene (BRCA) carriers) are recommended to have…
- Conditions
- Breast Cancer Screening, Breast Carcinoma in Situ, Breast Cancer
- Trial name
- WISDOM (NCT02620852)
- Testing
- Complete a health questionnaire, Provide a saliva sample for genetic testing, Screening advice based on a comprehensive risk assessment
- Where
- 11 sites in United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Breast Cancer Screening
MADRE (Mammograms Available Due to Research and Education)
The design builds on past studies by integrating social network analysis (SNA) and implementation science (IS) into a longitudinal randomized clinical trial (RCT).
- Trial name
- MADRE (NCT05841355)
- Testing
- Educate, Empower
- Where
- 2 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Mammography Screening, Breast Density
Mammogram Pretreatment With Ulipristal Acetate
This phase II trial tests whether taking ulipristal acetate prior to a mammogram decreases breast density for people with a history of dense breast tissue.
- Trial name
- NCT07434128
- Testing
- Biospecimen Collection, Magnetic Resonance Imaging, Mammogram
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- OHSU Knight Cancer Institute
Breast Cancer Screening and Diagnosis
National Mammography Database
The National Mammography Database (NMD) leverages data that radiology practices are already collecting under federal mandate by providing them with comparative information for national and regional benchmarking.
- Trial name
- NCT01900821
- Where
- United States
- Volunteers
- 8,000,000 people, healthy volunteers welcome
- Sponsor
- American College of Radiology